Development Level

Tbio 32 | 10,625
Tchem 17 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 3 | 633
embryonic lethality prior to t... 2 | 187
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal vibrissa morphology 1 | 17
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased startle reflex 1 | 48
enlarged heart 1 | 111
increased body weight 1 | 42
small superior vagus ganglion 1 | 20

Disease

ovarian cancer 35 | 8,484
osteosarcoma 27 | 7,933
Cancer 26 | 2,346
glioblastoma 25 | 5,572
psoriasis 24 | 6,685
lung cancer 18 | 4,466
atypical teratoid / rhabdoid tumor 14 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
lung carcinoma 14 | 2,844
medulloblastoma, large-cell 13 | 6,234
pilocytic astrocytoma 13 | 3,086
malignant mesothelioma 11 | 3,162
ulcerative colitis 11 | 2,087
ependymoma 10 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
juvenile dermatomyositis 10 | 1,189
oligodendroglioma 10 | 2,849
pediatric high grade glioma 10 | 2,712
subependymal giant cell astrocytoma 10 | 2,287
cutaneous lupus erythematosus 9 | 1,056
dermatomyositis 9 | 933
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
Breast cancer 8 | 3,094
Multiple Sclerosis 8 | 498
interstitial cystitis 8 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
tuberculosis 8 | 1,557
Hypersensitivity reaction type II disease 7 | 235
Rheumatoid Arthritis 7 | 1,160
acute myeloid leukemia 7 | 780
acute quadriplegic myopathy 7 | 1,157
adult high grade glioma 7 | 2,148
colon cancer 7 | 1,475
diabetes mellitus 7 | 1,663
primitive neuroectodermal tumor 7 | 3,031
Multiple myeloma 6 | 1,327
astrocytic glioma 6 | 2,241
astrocytoma 6 | 1,493
cystic fibrosis 6 | 1,665
group 3 medulloblastoma 6 | 2,254
non-small cell lung cancer 6 | 2,798
pancreatic cancer 6 | 2,300
pituitary cancer 6 | 1,972
posterior fossa group A ependymoma 6 | 1,511
primary pancreatic ductal adenocarcinoma 6 | 1,271
spina bifida 6 | 1,064
Alzheimer's disease 5 | 644
Amyotrophic Lateral Sclerosis 5 | 431
Autoimmune Lymphoproliferative Syndrome 5 | 12
Crohn's disease 5 | 304
Leukemia 5 | 88
Pick disease 5 | 1,893
Prostatic Neoplasms 5 | 471
atypical teratoid/rhabdoid tumor 5 | 1,095
hepatocellular carcinoma 5 | 532
posterior fossa group B ependymoma 5 | 1,530
sonic hedgehog group medulloblastoma 5 | 1,482
tuberculosis and treatment for 6 months 5 | 686
Arthritis 4 | 248
Atopic dermatitis 4 | 944
Bipolar Disorder 4 | 266
Diabetes Mellitus, Non-Insulin-Dependent 4 | 157
Juvenile rheumatoid arthritis 4 | 104
Liver carcinoma 4 | 217
Liver disease 4 | 219
Lung Neoplasms 4 | 171
Melanoma 4 | 261
Pancreatic Neoplasm 4 | 79
Stomach Neoplasms 4 | 282
active Crohn's disease 4 | 918
gastric carcinoma 4 | 832
group 4 medulloblastoma 4 | 1,875
primary Sjogren syndrome 4 | 789
Adenocarcinoma 3 | 115
Ankylosing spondylitis 3 | 138
Bladder Neoplasm 3 | 109
Carcinoma 3 | 2,147
Cardiomyopathies 3 | 90
Chronic Lymphocytic Leukemia 3 | 242
Colonic Neoplasms 3 | 126
Colorectal Neoplasms 3 | 217
Dermatitis 3 | 107
Diabetes Mellitus, Experimental 3 | 106
Drug allergy 3 | 36
Esophageal Neoplasms 3 | 67
Gaucher disease type 3 3 | 76
Hypohidrotic ectodermal dysplasia 3 | 13
Inflammatory bowel disease 3 | 142
Lung disease 3 | 132
Mammary Neoplasms 3 | 410
Neoplasm Metastasis 3 | 138
Polycystic Ovary Syndrome 3 | 332
Vascular disease 3 | 281
Waldenstrons macroglobulinemia 3 | 765
adrenocortical carcinoma 3 | 1,427
aldosterone-producing adenoma 3 | 664
esophageal adenocarcinoma 3 | 737
lung adenocarcinoma 3 | 2,713
non-small cell lung carcinoma 3 | 413
systemic lupus erythematosus 3 | 156

Tissue

Blood and immune system 50 | 17,995
Cardiovascular System 50 | 17,958
Digestive Tract 50 | 18,473
Female tissues 50 | 18,647
Liver and Pancreas 50 | 18,136
Male tissues 50 | 17,969
Nervous System 50 | 18,561
Urinary Tract 50 | 18,444
Endocrine System 49 | 18,512
Respiratory system 49 | 17,484
Skin and soft tissues 48 | 18,115

Target Family

Non-IDG 27 | 11,971
Enzyme 17 | 4,146
Kinase 6 | 634

Reactome Pathway

Death Receptor Signalling 50 | 50
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.27492 2052.7 1794
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 TAB2 Tbio Enzyme -1.83055 69.0 145
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
CASP8 and FADD-like apoptosis regulator CFLAR Tchem Non-IDG -2.85930 837.3 538
Sharpin SHARPIN Tbio Non-IDG -1.20569 20.0 110
Tumor necrosis factor ligand superfamily member 10 TNFSF10 Tbio Non-IDG -2.82315 627.1 855
NF-kappa-B essential modulator IKBKG Tchem Kinase -3.03588 1121.7 849
Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK Tchem Kinase -2.35199 201.1 1028