Development Level

Tbio 32 | 10,625
Tchem 17 | 1,890
Tclin 1 | 602

IMPC Phenotype

preweaning lethality, complete... 3 | 633
embryonic lethality prior to t... 2 | 187
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal vibrissa morphology 1 | 17
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating fructosa... 1 | 31
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased startle reflex 1 | 48
enlarged heart 1 | 111
increased body weight 1 | 42
small superior vagus ganglion 1 | 20

Disease

ovarian cancer 35 | 8,491
osteosarcoma 27 | 7,933
Cancer 26 | 2,346
glioblastoma 25 | 5,572
psoriasis 24 | 6,685
lung cancer 19 | 4,473
atypical teratoid / rhabdoid tumor 14 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
lung carcinoma 14 | 2,844
medulloblastoma, large-cell 13 | 6,234
pilocytic astrocytoma 13 | 3,086
malignant mesothelioma 11 | 3,163
ulcerative colitis 11 | 2,087
ependymoma 10 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
juvenile dermatomyositis 10 | 1,189
oligodendroglioma 10 | 2,849
pediatric high grade glioma 10 | 2,712
subependymal giant cell astrocytoma 10 | 2,287
cutaneous lupus erythematosus 9 | 1,056
dermatomyositis 9 | 966
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
Breast cancer 8 | 3,098
Multiple Sclerosis 8 | 498
interstitial cystitis 8 | 2,299
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
tuberculosis 8 | 1,563
Hypersensitivity reaction type II disease 7 | 235
Rheumatoid Arthritis 7 | 1,170
acute myeloid leukemia 7 | 785
acute quadriplegic myopathy 7 | 1,157
adult high grade glioma 7 | 2,148
colon cancer 7 | 1,475
diabetes mellitus 7 | 1,663
primitive neuroectodermal tumor 7 | 3,031
Multiple myeloma 6 | 1,327
astrocytic glioma 6 | 2,241
astrocytoma 6 | 1,493
cystic fibrosis 6 | 1,670
group 3 medulloblastoma 6 | 2,254
hepatocellular carcinoma 6 | 550
non-small cell lung cancer 6 | 2,798
pancreatic cancer 6 | 2,300
pituitary cancer 6 | 1,972
posterior fossa group A ependymoma 6 | 1,511
primary pancreatic ductal adenocarcinoma 6 | 1,271
spina bifida 6 | 1,064
Alzheimer's disease 5 | 644
Amyotrophic Lateral Sclerosis 5 | 432
Autoimmune Lymphoproliferative Syndrome 5 | 12
Crohn's disease 5 | 304
Leukemia 5 | 88
Pick disease 5 | 1,893
Prostatic Neoplasms 5 | 471
atypical teratoid/rhabdoid tumor 5 | 1,095
posterior fossa group B ependymoma 5 | 1,530
sonic hedgehog group medulloblastoma 5 | 1,482
tuberculosis and treatment for 6 months 5 | 686
Arthritis 4 | 248
Atopic dermatitis 4 | 944
Bipolar Disorder 4 | 266
Diabetes Mellitus, Non-Insulin-Dependent 4 | 161
Juvenile rheumatoid arthritis 4 | 105
Liver carcinoma 4 | 217
Liver disease 4 | 219
Lung Neoplasms 4 | 171
Melanoma 4 | 261
Pancreatic Neoplasm 4 | 79
Stomach Neoplasms 4 | 282
active Crohn's disease 4 | 918
gastric carcinoma 4 | 832
group 4 medulloblastoma 4 | 1,875
primary Sjogren syndrome 4 | 788
systemic lupus erythematosus 4 | 172
Adenocarcinoma 3 | 115
Ankylosing spondylitis 3 | 138
Bladder Neoplasm 3 | 109
Carcinoma 3 | 2,147
Cardiomyopathies 3 | 90
Colonic Neoplasms 3 | 126
Colorectal Neoplasms 3 | 217
Dermatitis 3 | 141
Diabetes Mellitus, Experimental 3 | 106
Drug allergy 3 | 36
Esophageal Neoplasms 3 | 67
Gaucher disease type 3 3 | 76
Hypohidrotic ectodermal dysplasia 3 | 14
Inflammatory bowel disease 3 | 142
Lung disease 3 | 136
Mammary Neoplasms 3 | 410
Neoplasm Metastasis 3 | 138
Polycystic Ovary Syndrome 3 | 334
Vascular disease 3 | 281
Waldenstrons macroglobulinemia 3 | 764
adrenocortical carcinoma 3 | 1,427
aldosterone-producing adenoma 3 | 664
chronic lymphocytic leukemia 3 | 244
esophageal adenocarcinoma 3 | 737
lung adenocarcinoma 3 | 2,714
non-small cell lung carcinoma 3 | 413

Tissue

Blood and immune system 50 | 17,994
Cardiovascular System 50 | 17,957
Digestive Tract 50 | 18,472
Female tissues 50 | 18,646
Liver and Pancreas 50 | 18,135
Male tissues 50 | 17,968
Nervous System 50 | 18,560
Urinary Tract 50 | 18,443
Endocrine System 49 | 18,511
Respiratory system 49 | 17,483
Skin and soft tissues 48 | 18,114

Target Family

Non-IDG 27 | 11,969
Enzyme 17 | 4,146
Kinase 6 | 634

Reactome Pathway

Death Receptor Signalling 50 | 50
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

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