Development Level

Tbio 40 | 10,625
Tdark 9 | 7,003
Tchem 4 | 1,890

IMPC Term

preweaning lethality, complete... 8 | 633
embryonic lethality prior to o... 4 | 148
preweaning lethality, incomple... 4 | 260
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
decreased NK cell number 2 | 16
decreased grip strength 2 | 123
embryonic lethality prior to t... 2 | 187
increased grip strength 2 | 83
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal heart morphology 1 | 51
abnormal lumbar vertebrae morp... 1 | 6
abnormal retinal pigmentation 1 | 61
abnormal snout morphology 1 | 18
aorta dilation 1 | 3
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased T-helper cell number 1 | 4
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased monocyte cell number 1 | 28
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
enlarged heart 1 | 111
improved glucose tolerance 1 | 56
increased CD4-positive, CD25-p... 1 | 18
increased CD4-positive, alpha ... 1 | 15
increased CD5-positive gamma-d... 1 | 1
increased KLRG1+ CD4 alpha bet... 1 | 5
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased circulating alkaline... 1 | 119
increased circulating iron lev... 1 | 25
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased exploration in new e... 1 | 56
increased gamma-delta T cell n... 1 | 16
increased granulocyte number 1 | 8
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
increased red blood cell distr... 1 | 21
increased rib number 1 | 41
male infertility 1 | 62
prenatal lethality prior to he... 1 | 64
short snout 1 | 4
vertebral transformation 1 | 12

Disease

osteosarcoma 33 | 7,933
ovarian cancer 31 | 8,484
medulloblastoma, large-cell 16 | 6,234
glioblastoma 15 | 5,572
group 3 medulloblastoma 14 | 2,254
lung cancer 14 | 4,466
psoriasis 14 | 6,685
oligodendroglioma 10 | 2,849
atypical teratoid / rhabdoid tumor 9 | 4,369
group 4 medulloblastoma 9 | 1,875
Multiple myeloma 8 | 1,327
astrocytic glioma 8 | 2,241
astrocytoma 8 | 1,493
ependymoma 8 | 2,514
Carcinoma 7 | 2,147
acute quadriplegic myopathy 7 | 1,157
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
primitive neuroectodermal tumor 7 | 3,031
Waldenstrons macroglobulinemia 6 | 765
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
malignant mesothelioma 6 | 3,162
pancreatic cancer 6 | 2,300
Breast cancer 5 | 3,094
Cancer 5 | 2,346
acute myeloid leukemia 5 | 780
diabetes mellitus 5 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
invasive ductal carcinoma 5 | 2,950
atypical teratoid/rhabdoid tumor 4 | 1,095
lung adenocarcinoma 4 | 2,713
non-small cell lung cancer 4 | 2,798
pediatric high grade glioma 4 | 2,712
sonic hedgehog group medulloblastoma 4 | 1,482
spina bifida 4 | 1,064
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis and treatment for 6 months 4 | 686
Intellectual disability 3 | 573
Neurodegenerative disease 3 | 383
Rheumatoid Arthritis 3 | 1,160
Spinocerebellar ataxia type 2 3 | 19
aldosterone-producing adenoma 3 | 664
dermatomyositis 3 | 933
juvenile dermatomyositis 3 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
pilocytic astrocytoma 3 | 3,086
primary pancreatic ductal adenocarcinoma 3 | 1,271
tuberculosis 3 | 1,557
Amyotrophic Lateral Sclerosis 2 | 431
Diarrhea 2 | 155
Dyskeratosis congenita 2 | 24
Polycystic Ovary Syndrome 2 | 332
Pontocerebellar Hypoplasia Type 1 2 | 5
Pontocerebellar hypoplasia 2 | 29
Primary biliary cirrhosis 2 | 43
X-linked cerebral adrenoleukodystrophy 2 | 115
adrenocortical carcinoma 2 | 1,427
adult high grade glioma 2 | 2,148
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
glioblastoma multiforme 2 | 347
medulloblastoma 2 | 1,524
nasopharyngeal carcinoma 2 | 1,056
pancreatic carcinoma 2 | 567
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 1,511
posterior fossa group B ependymoma 2 | 1,530
primary Sjogren syndrome 2 | 789
relapsing-remitting multiple sclerosis 2 | 18
Anemia 1 | 252
Bladder Neoplasm 1 | 109
Brachydactyly 1 | 52
Carcinoma, Transitional Cell 1 | 31
Cleft palate 1 | 125
Disease Progression 1 | 125
Disease of metabolism 1 | 15
Fragile X syndrome 1 | 31
Gaucher disease type 1 1 | 171
HIV Infections 1 | 100
Heart conduction disease 1 | 65
Hemolytic anemia 1 | 66
Leukemia 1 | 88
Liver neoplasms 1 | 109
Mammary Neoplasms 1 | 410
Metabolic syndrome X 1 | 155
Muscular atrophy 1 | 67
Neoplasm Metastasis 1 | 138
Orchitis 1 | 16
Parkinson's disease 1 | 364
Peripheral Neuropathy 1 | 303
Peripheral vascular disease 1 | 90
Pneumonia 1 | 133
Stomach Neoplasms 1 | 282
Syringomyelia 1 | 9
Thalassemia 1 | 46
gliosarcoma 1 | 19
interleukin-7 receptor alpha deficiency 1 | 16
interstitial lung disease 1 | 291
non-small cell lung carcinoma 1 | 413
sarcoidosis 1 | 358
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 53 | 17,995
Cardiovascular System 53 | 17,958
Digestive Tract 53 | 18,473
Endocrine System 53 | 18,512
Female tissues 53 | 18,647
Liver and Pancreas 53 | 18,136
Male tissues 53 | 17,969
Nervous System 53 | 18,561
Urinary Tract 53 | 18,444
Respiratory system 52 | 17,484
Skin and soft tissues 52 | 18,115

Target Family

Non-IDG 36 | 11,971
Enzyme 16 | 4,146
Kinase 1 | 634

Reactome Pathway

Deadenylation-dependent mRNA d... 53 | 53
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
m7GpppN-mRNA hydrolase DCP2 Tbio Enzyme -1.89749 80.7 139
5'-3' exoribonuclease 1 XRN1 Tbio Enzyme -2.06818 114.2 45
CCR4-NOT transcription complex subunit 3 CNOT3 Tbio Non-IDG -2.75148 523.8 179
Polyadenylate-binding protein-interacting protein 1 PAIP1 Tbio Non-IDG -0.89795 6.40 122
mRNA-decapping enzyme 1B DCP1B Tdark Non-IDG -0.31186 1.45 90
Eukaryotic initiation factor 4A-III EIF4A3 Tbio Non-IDG -2.21804 176.4 137
CCR4-NOT transcription complex subunit 6 CNOT6 Tchem Non-IDG -1.21486 17.4 101
CCR4-NOT transcription complex subunit 11 CNOT11 Tdark Non-IDG -1.14014 14.7 48
U6 snRNA-associated Sm-like protein LSm7 LSM7 Tbio Non-IDG -0.95781 6.58 82
CCR4-NOT transcription complex subunit 1 CNOT1 Tbio Non-IDG -2.08441 115.0 30