Development Level

Tbio 40 | 10,625
Tdark 9 | 7,003
Tchem 4 | 1,890

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 8 | 633
embryonic lethality prior to o... 4 | 148
preweaning lethality, incomple... 4 | 260
abnormal lens morphology 2 | 73
abnormal retina morphology 2 | 100
decreased NK cell number 2 | 16
decreased grip strength 2 | 123
embryonic lethality prior to t... 2 | 187
increased grip strength 2 | 83
abnormal behavior 1 | 226
abnormal bone structure 1 | 131
abnormal coat-hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal heart morphology 1 | 51
abnormal lumbar vertebrae morp... 1 | 6
abnormal retinal pigmentation 1 | 61
abnormal snout morphology 1 | 18
aorta dilation 1 | 3
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased KLRG1-positive NK ce... 1 | 9
decreased Ly6C high monocyte n... 1 | 18
decreased T-helper cell number 1 | 4
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 49
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased lean body mass 1 | 195
decreased lumbar vertebrae num... 1 | 62
decreased monocyte cell number 1 | 28
decreased rib number 1 | 59
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
enlarged heart 1 | 111
improved glucose tolerance 1 | 56
increased CD4-positive, CD25-p... 1 | 18
increased CD4-positive, alpha ... 1 | 15
increased CD5-positive gamma-d... 1 | 1
increased KLRG1+ CD4 alpha bet... 1 | 5
increased NK cell number 1 | 19
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased circulating alkaline... 1 | 119
increased circulating iron lev... 1 | 25
increased circulating total pr... 1 | 20
increased effector memory CD4-... 1 | 15
increased exploration in new e... 1 | 56
increased gamma-delta T cell n... 1 | 16
increased granulocyte number 1 | 8
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
increased red blood cell distr... 1 | 21
increased rib number 1 | 41
male infertility 1 | 62
prenatal lethality prior to he... 1 | 64
short snout 1 | 4
vertebral transformation 1 | 12

Disease

osteosarcoma 33 | 7,933
ovarian cancer 31 | 8,491
medulloblastoma, large-cell 16 | 6,234
glioblastoma 15 | 5,572
group 3 medulloblastoma 14 | 2,254
lung cancer 14 | 4,473
psoriasis 14 | 6,685
oligodendroglioma 10 | 2,849
atypical teratoid / rhabdoid tumor 9 | 4,369
group 4 medulloblastoma 9 | 1,875
Multiple myeloma 8 | 1,327
astrocytic glioma 8 | 2,241
astrocytoma 8 | 1,493
ependymoma 8 | 2,514
Carcinoma 7 | 2,147
acute quadriplegic myopathy 7 | 1,157
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,988
primitive neuroectodermal tumor 7 | 3,031
Waldenstrons macroglobulinemia 6 | 764
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,289
malignant mesothelioma 6 | 3,163
pancreatic cancer 6 | 2,300
Breast cancer 5 | 3,098
Cancer 5 | 2,346
acute myeloid leukemia 5 | 785
diabetes mellitus 5 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
invasive ductal carcinoma 5 | 2,950
atypical teratoid/rhabdoid tumor 4 | 1,095
lung adenocarcinoma 4 | 2,714
non-small cell lung cancer 4 | 2,798
pediatric high grade glioma 4 | 2,712
sonic hedgehog group medulloblastoma 4 | 1,482
spina bifida 4 | 1,064
subependymal giant cell astrocytoma 4 | 2,287
tuberculosis and treatment for 6 months 4 | 686
Intellectual disability 3 | 573
Neurodegenerative disease 3 | 383
Rheumatoid Arthritis 3 | 1,170
Spinocerebellar ataxia type 2 3 | 19
aldosterone-producing adenoma 3 | 664
dermatomyositis 3 | 966
juvenile dermatomyositis 3 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
pilocytic astrocytoma 3 | 3,086
primary pancreatic ductal adenocarcinoma 3 | 1,271
tuberculosis 3 | 1,563
Amyotrophic Lateral Sclerosis 2 | 432
Diarrhea 2 | 155
Dyskeratosis congenita 2 | 24
Polycystic Ovary Syndrome 2 | 334
Pontocerebellar Hypoplasia Type 1 2 | 5
Pontocerebellar hypoplasia 2 | 29
Primary biliary cirrhosis 2 | 45
Trichohepatoenteric syndrome 1 2 | 2
X-linked cerebral adrenoleukodystrophy 2 | 115
adrenocortical carcinoma 2 | 1,427
adult high grade glioma 2 | 2,148
breast carcinoma 2 | 1,614
colon cancer 2 | 1,475
glioblastoma multiforme 2 | 347
medulloblastoma 2 | 1,524
nasopharyngeal carcinoma 2 | 1,056
pancreatic carcinoma 2 | 567
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 1,511
posterior fossa group B ependymoma 2 | 1,530
primary Sjogren syndrome 2 | 788
relapsing-remitting multiple sclerosis 2 | 18
Acquired immunodeficiency syndrome 1 | 164
Age related macular degeneration 1 | 84
Amenorrhea 1 | 60
Anemia 1 | 252
Bladder Neoplasm 1 | 109
Brachydactyly 1 | 52
Carcinoma, Transitional Cell 1 | 31
Cleft palate 1 | 125
Dental caries 1 | 67
Dental fluorosis 1 | 16
Disease of metabolism 1 | 15
Fragile X syndrome 1 | 31
Gaucher disease type 1 1 | 171
HIV Infections 1 | 99
Heart conduction disease 1 | 65
Hemolytic anemia 1 | 70
Infant length 1 | 11
Liver neoplasms 1 | 108
Mammary Neoplasms 1 | 410
Muscular atrophy 1 | 67
Neoplasm Metastasis 1 | 138
Orchitis 1 | 16
Parkinson's disease 1 | 364
Pneumonia 1 | 133
Renal Cell Carcinoma 1 | 199
Syringomyelia 1 | 9
Systemic scleroderma 1 | 66
Thalassemia 1 | 46
gliosarcoma 1 | 19
interstitial lung disease 1 | 292
sarcoidosis 1 | 368

Tissue

Blood and immune system 53 | 17,994
Cardiovascular System 53 | 17,957
Digestive Tract 53 | 18,472
Endocrine System 53 | 18,511
Female tissues 53 | 18,646
Liver and Pancreas 53 | 18,135
Male tissues 53 | 17,968
Nervous System 53 | 18,560
Urinary Tract 53 | 18,443
Respiratory system 52 | 17,483
Skin and soft tissues 52 | 18,114

Target Family

Non-IDG 36 | 11,969
Enzyme 16 | 4,146
Kinase 1 | 634

Reactome Pathway

Deadenylation-dependent mRNA d... 53 | 53
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
CCR4-NOT transcription complex subunit 6 CNOT6 Tchem Non-IDG -1.22516 17.4 101
Probable ATP-dependent RNA helicase DDX6 DDX6 Tbio Enzyme -1.77534 57.8 244
Exosome complex component RRP4 EXOSC2 Tdark Non-IDG -0.28065 2.13 102
CCR4-NOT transcription complex subunit 2 CNOT2 Tbio Non-IDG -2.82588 600.8 267
Tetratricopeptide repeat protein 37 TTC37 Tbio Non-IDG -2.27405 184.5 9
Poly(A)-specific ribonuclease PARN PARN Tbio Enzyme -1.84496 71.5 141
182 kDa tankyrase-1-binding protein TNKS1BP1 Tbio Enzyme -0.17884 2.13 137
mRNA-decapping enzyme 1A DCP1A Tbio Non-IDG 0.00000 256
Exosome complex component RRP46 EXOSC5 Tbio Enzyme -1.31759 21.1 84
Exosome complex component RRP40 EXOSC3 Tbio Non-IDG -1.10621 12.8 135