Development Level

Tbio 45 | 11,651
Tdark 6 | 6,593
Tchem 3 | 1,388

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 5 | 239
abnormal embryo size 3 | 220
abnormal bone structure 2 | 187
abnormal embryo turning 2 | 31
decreased bone mineral content 2 | 151
decreased caudal vertebrae num... 2 | 53
decreased grip strength 2 | 116
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
increased lean body mass 2 | 172
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal vitreous body morphol... 1 | 10
aorta dilation 1 | 3
cataract 1 | 92
corneal opacity 1 | 32
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
enlarged heart 1 | 210
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
thin ventricular wall 1 | 24
vertebral transformation 1 | 12

Disease

osteosarcoma 34 | 7,950
Carcinoma 31 | 11,493
ovarian cancer 31 | 8,520
group 3 medulloblastoma 21 | 4,104
glioblastoma 17 | 5,792
lung cancer 16 | 4,740
medulloblastoma, large-cell 15 | 6,241
psoriasis 13 | 6,694
atypical teratoid / rhabdoid tumor 11 | 5,112
ependymoma 11 | 4,679
oligodendroglioma 10 | 2,850
astrocytic glioma 9 | 2,597
Kidney cancer 8 | 2,613
Multiple myeloma 8 | 1,332
astrocytoma 8 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,291
primitive neuroectodermal tumor 8 | 3,035
Autosomal recessive predisposition 7 | 1,442
acute quadriplegic myopathy 7 | 1,158
group 4 medulloblastoma 7 | 1,855
pancreatic cancer 7 | 2,398
Breast cancer 6 | 3,578
Cancer 6 | 2,499
Waldenstrons macroglobulinemia 6 | 765
acute myeloid leukemia 6 | 783
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
malignant mesothelioma 6 | 3,232
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
diabetes mellitus 5 | 1,728
invasive ductal carcinoma 5 | 2,951
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 2,010
Failure to gain weight 4 | 365
Pediatric failure to thrive 4 | 365
Rheumatoid arthritis 4 | 1,191
lung adenocarcinoma 4 | 2,716
non-small cell lung cancer 4 | 2,890
Amyotrophic lateral sclerosis 3 | 451
Astrocytoma, Pilocytic 3 | 3,081
Cerebral atrophy 3 | 178
Feeding difficulties 3 | 127
Fetal Growth Retardation 3 | 189
Infant, Small for Gestational Age 3 | 176
Intellectual disability 3 | 1,016
Intrauterine retardation 3 | 176
Low set ears 3 | 181
Microstomia 3 | 78
Neurodegenerative disease 3 | 414
Perlman syndrome 3 | 9
Short stature 3 | 531
Sparse hair 3 | 59
Spinocerebellar ataxia type 2 3 | 23
Thin, sparse hair 3 | 59
adult high grade glioma 3 | 3,801
aldosterone-producing adenoma 3 | 665
dermatomyositis 3 | 966
juvenile dermatomyositis 3 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962
pediatric high grade glioma 3 | 1,064
primary pancreatic ductal adenocarcinoma 3 | 1,109
spina bifida 3 | 1,074
Anemia 2 | 365
Brachydactyly 2 | 156
Bulging forehead 2 | 66
Cataract 7 2 | 32
Cholestasis 2 | 155
Dental caries 2 | 164
Diarrhea 2 | 253
Dyskeratosis congenita 2 | 24
Hepatomegaly 2 | 285
Immunologic Deficiency Syndromes 2 | 113
Kinky hair texture 2 | 13
Liver Cirrhosis 2 | 181
Liver cancer 2 | 604
Low Birth Weights 2 | 69
Polycystic ovary syndrome 2 | 360
Polyhydramnios 2 | 108
Pontocerebellar Hypoplasia Type 1 2 | 5
Pontocerebellar hypoplasia 2 | 36
Prenatal onset 2 | 139
Primary biliary cirrhosis 2 | 51
Prominent forehead 2 | 66
Small for gestational age (disorder) 2 | 69
Spinal muscular atrophy 2 | 34
Wide nose 2 | 35
Wooly hair 2 | 17
X-linked cerebral adrenoleukodystrophy 2 | 116
adrenocortical carcinoma 2 | 1,428
atypical teratoid/rhabdoid tumor 2 | 357
breast carcinoma 2 | 1,638
colon cancer 2 | 1,478
nasopharyngeal carcinoma 2 | 1,058
pancreatic carcinoma 2 | 562
pituitary cancer 2 | 1,972
primary Sjogren syndrome 2 | 735
substance-related disorder 2 | 162
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 53 | 16,909
Cardiovascular System 53 | 15,192
Digestive Tract 53 | 17,369
Endocrine System 53 | 18,159
Female tissues 53 | 17,400
Liver and Pancreas 53 | 16,750
Male tissues 53 | 17,142
Nervous System 53 | 16,725
Respiratory system 53 | 16,393
Skin and soft tissues 53 | 17,230
Urinary Tract 53 | 16,678

Target Family

Non-IDG 35 | 12,091
Enzyme 18 | 4,145
Kinase 1 | 634

Reactome Pathway

Deadenylation-dependent mRNA d... 54 | 54
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Poly(A)-specific ribonuclease PARN PARN Tbio Enzyme -1.87605 76.4 263
U6 snRNA-associated Sm-like protein LSm5 LSM5 Tdark Non-IDG -0.98876 8.80 46
CCR4-NOT transcription complex subunit 11 CNOT11 Tbio Non-IDG -1.18963 14.4 52
HBS1-like protein HBS1L Tbio Non-IDG -2.55785 357.2 263
PAN2-PAN3 deadenylation complex catalytic subunit PAN2 PAN2 Tbio Enzyme -0.66901 4.14 87
Probable ATP-dependent RNA helicase DDX6 DDX6 Tbio Enzyme -1.81481 65.6 302
CCR4-NOT transcription complex subunit 6 CNOT6 Tbio Non-IDG -1.27015 19.4 125
U6 snRNA-associated Sm-like protein LSm7 LSM7 Tbio Non-IDG -0.95219 6.58 100
CCR4-NOT transcription complex subunit 7 CNOT7 Tchem Non-IDG -1.18731 15.5 147
Exosome complex component CSL4 EXOSC1 Tbio Non-IDG -2.07438 110.2 129