Development Level

Tbio 34 | 11,651
Tchem 5 | 1,388
Tclin 1 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal bone mineralization 2 | 38
cataract 2 | 92
decreased lymphocyte cell numb... 2 | 83
edema 2 | 59
enlarged heart 2 | 210
increased circulating choleste... 2 | 66
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
thrombocytosis 2 | 27
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal forelimb morphology 1 | 2
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal hindbrain morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
absent testes 1 | 6
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating triglyce... 1 | 79
decreased prepulse inhibition 1 | 82
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
increased B cell number 1 | 9
increased CD4-positive, alpha ... 1 | 4
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
mammalian phenotype 1 | 17
short tibia 1 | 97
small superior vagus ganglion 1 | 74
syndactyly 1 | 23

Disease

Carcinoma 30 | 11,493
ovarian cancer 21 | 8,520
Cancer 20 | 2,499
osteosarcoma 20 | 7,950
psoriasis 20 | 6,694
lung cancer 19 | 4,740
glioblastoma 17 | 5,792
medulloblastoma, large-cell 16 | 6,241
atypical teratoid / rhabdoid tumor 15 | 5,112
astrocytic glioma 14 | 2,597
ependymoma 14 | 4,679
primitive neuroectodermal tumor 14 | 3,035
Breast cancer 13 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
malignant mesothelioma 11 | 3,232
oligodendroglioma 11 | 2,850
invasive ductal carcinoma 10 | 2,951
pancreatic cancer 10 | 2,398
Astrocytoma, Pilocytic 9 | 3,081
breast carcinoma 9 | 1,638
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
lung carcinoma 8 | 2,843
non-small cell lung cancer 8 | 2,890
Epilepsy 7 | 792
Kidney cancer 7 | 2,613
Seizures 7 | 596
astrocytoma 7 | 1,146
group 3 medulloblastoma 7 | 4,104
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
pituitary cancer 7 | 1,972
subependymal giant cell astrocytoma 7 | 2,287
Bipolar Disorder 6 | 666
Cleft Palate 6 | 271
Hypogonadism, Isolated Hypogonadotropic 6 | 71
Hypogonadotropic hypogonadism 6 | 89
Multiple myeloma 6 | 1,332
Pick disease 6 | 1,894
Polycystic ovary syndrome 6 | 360
Schizophrenia 6 | 1,160
Short stature 6 | 531
Uranostaphyloschisis 6 | 167
acute quadriplegic myopathy 6 | 1,158
adult high grade glioma 6 | 3,801
colon cancer 6 | 1,478
cystic fibrosis 6 | 1,696
diabetes mellitus 6 | 1,728
group 4 medulloblastoma 6 | 1,855
Breast Neoplasms 5 | 445
Cognitive delay 5 | 608
Colorectal Neoplasms 5 | 243
Congenital hypoplasia of penis 5 | 176
Cryptorchidism 5 | 296
Global developmental delay 5 | 608
Intellectual disability 5 | 1,016
Mental and motor retardation 5 | 608
Osteoporosis 5 | 363
Strabismus 5 | 270
adrenocortical carcinoma 5 | 1,428
esophageal adenocarcinoma 5 | 737
interstitial cystitis 5 | 2,312
juvenile dermatomyositis 5 | 1,187
lung adenocarcinoma 5 | 2,716
medulloblastoma 5 | 720
pediatric high grade glioma 5 | 1,064
Alzheimer's disease 4 | 658
Animal Mammary Neoplasms 4 | 136
Colonic Neoplasms 4 | 142
Gynecomastia 4 | 64
Immune system cancer 4 | 140
Liver cancer 4 | 604
Lung Neoplasms 4 | 232
Lymphoid leukemia 4 | 160
Mammary Neoplasms 4 | 425
Mammary Neoplasms, Animal 4 | 136
Mammary Neoplasms, Experimental 4 | 154
Muscle hypotonia 4 | 571
Obesity 4 | 678
Sclerocystic Ovaries 4 | 17
Small head 4 | 374
Testicular hypogonadism 4 | 21
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
Acquired scoliosis 3 | 281
Curvature of spine 3 | 282
Endometrial cancer 3 | 311
Failure to gain weight 3 | 365
Male infertility 3 | 206
Pediatric failure to thrive 3 | 365
Prostatic Neoplasms 3 | 495
Ventricular Septal Defects 3 | 119
Waldenstrons macroglobulinemia 3 | 765
acute myeloid leukemia 3 | 783
cutaneous lupus erythematosus 3 | 1,057
hepatocellular carcinoma 3 | 547
nasopharyngeal carcinoma 3 | 1,058
primary Sjogren syndrome 3 | 735
primary pancreatic ductal adenocarcinoma 3 | 1,109
tuberculosis 3 | 2,010
ulcerative colitis 3 | 1,819

Tissue

Endocrine System 40 | 18,159
Nervous System 40 | 16,725
Digestive Tract 39 | 17,369
Female tissues 39 | 17,400
Male tissues 39 | 17,142
Respiratory system 39 | 16,393
Skin and soft tissues 39 | 17,230
Blood and immune system 38 | 16,909
Cardiovascular System 38 | 15,192
Liver and Pancreas 38 | 16,750
Urinary Tract 38 | 16,678

Target Family

Non-IDG 20 | 12,091
Transcription Factor 13 | 1,400
Epigenetic 5 | 242
Enzyme 2 | 4,145
Kinase 1 | 634

Reactome Pathway

Deactivation of the beta-caten... 41 | 41
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pygopus homolog 2 PYGO2 Tbio Epigenetic -1.26911 24.4 92
Chromodomain-helicase-DNA-binding protein 8 CHD8 Tbio Epigenetic -1.64766 47.4 81
Pygopus homolog 1 PYGO1 Tdark Epigenetic -0.48368 2.66 135
B-cell CLL/lymphoma 9-like protein BCL9L Tbio Non-IDG -1.02513 10.8 100
Protein chibby homolog 1 CBY1 Tbio Non-IDG -2.29880 197.7 79
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.59435 390.4 689
Lymphoid enhancer-binding factor 1 LEF1 Tchem Transcription Factor -2.60971 375.2 591
Transcription factor 7-like 1 TCF7L1 Tbio Transcription Factor -1.20549 17.1 109
Histone deacetylase 1 HDAC1 Tclin Epigenetic -3.03775 954.3 1201
Adenomatous polyposis coli protein APC Tbio Non-IDG -1.90646 66.5 508