Development Level

Tbio 33 | 10,625
Tchem 7 | 1,890
Tclin 1 | 602
Tdark 1 | 7,003

IMPC Phenotype

abnormal bone mineralization 2 | 55
decreased lean body mass 2 | 195
increased circulating alkaline... 2 | 119
increased mean corpuscular vol... 2 | 91
thrombocytosis 2 | 23
abnormal bone structure 1 | 131
abnormal forelimb morphology 1 | 2
abnormal glucose homeostasis 1 | 5
abnormal head morphology 1 | 10
abnormal respiratory quotient 1 | 9
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal skin morphology 1 | 23
abnormal startle reflex 1 | 14
cataract 1 | 26
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased body length 1 | 108
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating choleste... 1 | 85
decreased circulating fructosa... 1 | 31
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased total body fat amoun... 1 | 186
enlarged heart 1 | 111
enlarged lymph nodes 1 | 27
hydrops fetalis 1 | 22
increased B cell number 1 | 23
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 25
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
syndactyly 1 | 4

Disease

ovarian cancer 22 | 8,491
Cancer 20 | 2,346
osteosarcoma 20 | 7,933
psoriasis 20 | 6,685
lung cancer 17 | 4,473
glioblastoma 16 | 5,572
medulloblastoma, large-cell 16 | 6,234
atypical teratoid / rhabdoid tumor 14 | 4,369
primitive neuroectodermal tumor 14 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,988
Breast cancer 11 | 3,098
ependymoma 11 | 2,514
oligodendroglioma 11 | 2,849
astrocytic glioma 10 | 2,241
astrocytoma 10 | 1,493
group 4 medulloblastoma 10 | 1,875
invasive ductal carcinoma 10 | 2,950
malignant mesothelioma 10 | 3,163
Carcinoma 9 | 2,147
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,289
pediatric high grade glioma 9 | 2,712
pilocytic astrocytoma 9 | 3,086
breast carcinoma 8 | 1,614
ductal carcinoma in situ 8 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
lung carcinoma 8 | 2,844
non-small cell lung cancer 8 | 2,798
diabetes mellitus 7 | 1,663
pancreatic cancer 7 | 2,300
pituitary cancer 7 | 1,972
subependymal giant cell astrocytoma 7 | 2,287
Colorectal Neoplasms 6 | 217
Multiple myeloma 6 | 1,327
Pick disease 6 | 1,893
acute quadriplegic myopathy 6 | 1,157
colon cancer 6 | 1,475
cystic fibrosis 6 | 1,670
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,795
Alzheimer's disease 5 | 644
Intellectual disability 5 | 573
Mammary Neoplasms 5 | 410
Obesity 5 | 616
adrenocortical carcinoma 5 | 1,427
esophageal adenocarcinoma 5 | 737
interstitial cystitis 5 | 2,299
juvenile dermatomyositis 5 | 1,189
lung adenocarcinoma 5 | 2,714
Adenoma 4 | 165
Animal Mammary Neoplasms 4 | 135
Colonic Neoplasms 4 | 126
Lung Neoplasms 4 | 171
Mammary Neoplasms, Experimental 4 | 149
Osteoporosis 4 | 259
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
ovarian neoplasm 4 | 97
primary pancreatic ductal adenocarcinoma 4 | 1,271
sonic hedgehog group medulloblastoma 4 | 1,482
46, XX Testicular Disorders of Sex Development 3 | 3
46,Xx Sex Reversal 1 3 | 3
Adenocarcinoma 3 | 115
Amyotrophic Lateral Sclerosis 3 | 432
Campomelic dysplasia 3 | 7
Carcinoma of colon 3 | 32
Colon Carcinoma 3 | 25
Colorectal Cancer 3 | 62
Familial adenomatous polyposis 3 | 33
Gonadoblastoma 3 | 27
Hypogonadism 3 | 70
Kabuki syndrome 3 | 29
Kidney disease 3 | 397
Liver disease 3 | 219
Prostatic Neoplasms 3 | 471
Rheumatoid Arthritis 3 | 1,170
Squamous cell carcinoma 3 | 96
Waldenstrons macroglobulinemia 3 | 764
XX males 3 | 3
acute myeloid leukemia 3 | 785
cutaneous lupus erythematosus 3 | 1,056
hepatocellular carcinoma 3 | 550
medulloblastoma 3 | 1,524
nasopharyngeal carcinoma 3 | 1,056
non-inflammatory breast cancer 3 | 208
primary Sjogren syndrome 3 | 788
ulcerative colitis 3 | 2,087
Autistic Disorder 2 | 320
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
Hyperplasia 2 | 26
Inflammatory bowel disease 2 | 142
Leukemia 2 | 88
Liver carcinoma 2 | 217
Metabolic syndrome X 2 | 155
Microphthalmia 2 | 79
Multiple Sclerosis 2 | 498
Pancreatic Neoplasm 2 | 79
Parkinson's disease 2 | 364
Polycystic Ovary Syndrome 2 | 334
Vascular disease 2 | 281
chronic lymphosyte leukemia 2 | 232
progressive supranuclear palsy 2 | 674
urothelial carcinoma 2 | 318

Tissue

Blood and immune system 42 | 17,994
Cardiovascular System 42 | 17,957
Digestive Tract 42 | 18,472
Endocrine System 42 | 18,511
Female tissues 42 | 18,646
Liver and Pancreas 42 | 18,135
Male tissues 42 | 17,968
Nervous System 42 | 18,560
Skin and soft tissues 42 | 18,114
Urinary Tract 42 | 18,443
Respiratory system 41 | 17,483

Target Family

Non-IDG 20 | 11,969
Transcription Factor 13 | 1,400
Epigenetic 5 | 242
Enzyme 2 | 4,146
Kinase 2 | 634

Reactome Pathway

Deactivation of the beta-caten... 42 | 42
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.55872 362.3 648
Transcription factor SOX-13 SOX13 Tbio Transcription Factor -1.40951 26.8 141
Transcription factor 7-like 2 TCF7L2 Tbio Transcription Factor -2.60797 439.7 281
Transcription factor SOX-6 SOX6 Tbio Transcription Factor -2.03329 110.3 157
Sex-determining region Y protein SRY Tbio Transcription Factor -3.48868 2924.7 136
Histone-lysine N-methyltransferase 2D KMT2D Tbio Epigenetic -2.00559 97.4 117
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.10500 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.62947 56.7 150
Transcription factor SOX-9 SOX9 Tbio Transcription Factor -3.09917 1202.5 546
Transcription factor 7 TCF7 Tbio Transcription Factor -1.67786 39.6 295