Development Level

Tbio 54 | 10,625
Tchem 20 | 1,890
Tclin 7 | 602
Tdark 2 | 7,003

IMPC Phenotype

preweaning lethality, complete... 10 | 633
embryonic lethality prior to o... 2 | 148
abnormal lens morphology 1 | 73
cataract 1 | 26
decreased body length 1 | 108
decreased caudal vertebrae num... 1 | 49
decreased circulating alanine ... 1 | 53
embryonic lethality prior to t... 1 | 187
increased circulating sodium l... 1 | 71
increased grip strength 1 | 83
increased heart weight 1 | 37
increased mean corpuscular vol... 1 | 91
prenatal lethality prior to he... 1 | 64

Disease

ovarian cancer 59 | 8,491
lung cancer 44 | 4,473
psoriasis 40 | 6,685
osteosarcoma 35 | 7,933
glioblastoma 33 | 5,572
malignant mesothelioma 32 | 3,163
Multiple myeloma 30 | 1,327
medulloblastoma, large-cell 29 | 6,234
non-small cell lung cancer 28 | 2,798
group 3 medulloblastoma 24 | 2,254
Cancer 22 | 2,346
Breast cancer 20 | 3,098
adrenocortical carcinoma 19 | 1,427
primitive neuroectodermal tumor 19 | 3,031
atypical teratoid / rhabdoid tumor 18 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
pediatric high grade glioma 18 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
lung adenocarcinoma 17 | 2,714
Waldenstrons macroglobulinemia 15 | 764
invasive ductal carcinoma 15 | 2,950
HIV Infections 14 | 99
dermatomyositis 12 | 966
posterior fossa group A ependymoma 12 | 1,511
astrocytoma 11 | 1,493
colon cancer 11 | 1,475
nasopharyngeal carcinoma 11 | 1,056
oligodendroglioma 10 | 2,849
ductal carcinoma in situ 9 | 1,745
Meier-Gorlin syndrome 8 | 12
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,956
Atopic dermatitis 7 | 944
diabetes mellitus 7 | 1,663
non primary Sjogren syndrome sicca 7 | 840
pancreatic cancer 7 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
primary Sjogren syndrome 7 | 788
EAR, PATELLA, SHORT STATURE SYNDROME 6 | 6
Endometriosis 6 | 535
Seckel syndrome 6 | 35
pilocytic astrocytoma 6 | 3,086
Mantle cell lymphoma 5 | 20
Pick disease 5 | 1,893
atypical teratoid/rhabdoid tumor 5 | 1,095
breast carcinoma 5 | 1,614
esophageal adenocarcinoma 5 | 737
inflammatory breast cancer 5 | 404
lung carcinoma 5 | 2,844
sonic hedgehog group medulloblastoma 5 | 1,482
subependymal giant cell astrocytoma 5 | 2,287
tuberculosis 5 | 1,563
ulcerative colitis 5 | 2,087
acute myeloid leukemia 4 | 785
astrocytic glioma 4 | 2,241
interstitial cystitis 4 | 2,299
juvenile dermatomyositis 4 | 1,189
primary pancreatic ductal adenocarcinoma 4 | 1,271
IGA Glomerulonephritis 3 | 454
Microcephaly 3 | 149
Peripheral Neuropathy 3 | 303
active Crohn's disease 3 | 918
adult high grade glioma 3 | 2,148
cutaneous lupus erythematosus 3 | 1,056
ependymoma 3 | 2,514
gastric carcinoma 3 | 832
glioblastoma multiforme 3 | 347
medulloblastoma 3 | 1,524
progressive supranuclear palsy 3 | 674
tuberculosis and treatment for 6 months 3 | 686
Acute lymphoid leukemia 2 | 25
Acute myeloid leukemia, disease 2 | 16
Acute promyelocytic leukemia, FAB M3 2 | 10
Adenocarcinoma of pancreas 2 | 12
Alzheimer's disease 2 | 644
Cervix endometriosis 2 | 3
DiGeorge syndrome 2 | 46
Lymphomatous meningitis 2 | 3
Malignant tumor of ovary 2 | 25
Melanoacanthoma 2 | 2
Melanoma 2 | 261
Meningeal Leukemia 2 | 7
Menopause present (finding) 2 | 20
Metastatic Breast Carcinoma 2 | 21
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Osteoporosis 2 | 259
Pick's disease 2 | 14
Polycystic Ovary Syndrome 2 | 334
Pulmonary emphysema 2 | 34
Rheumatoid Arthritis 2 | 1,170
Rothmund-Thomson syndrome 2 | 22
Squamous cell carcinoma of esophagus 2 | 82
chronic kidney disease 2 | 90
cystic fibrosis 2 | 1,670
gastric cancer 2 | 436
group 4 medulloblastoma 2 | 1,875
hepatocellular carcinoma 2 | 550
pituitary cancer 2 | 1,972
Animal Mammary Neoplasms 1 | 135
Mammary Neoplasms, Experimental 1 | 149

Tissue

Blood and immune system 83 | 17,994
Digestive Tract 83 | 18,472
Endocrine System 83 | 18,511
Female tissues 83 | 18,646
Liver and Pancreas 83 | 18,135
Male tissues 83 | 17,968
Nervous System 83 | 18,560
Urinary Tract 83 | 18,443
Cardiovascular System 82 | 17,957
Respiratory system 82 | 17,483
Skin and soft tissues 82 | 18,114

Target Family

Enzyme 47 | 4,146
Non-IDG 31 | 11,969
Transcription Factor 3 | 1,400
Kinase 2 | 634

Reactome Pathway

DNA Replication Pre-Initiation 83 | 83
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
26S proteasome non-ATPase regulatory subunit 13 PSMD13 Tchem Enzyme -1.05639 9.70 94
26S proteasome non-ATPase regulatory subunit 3 PSMD3 Tbio Enzyme -1.21151 15.4 162
DNA polymerase epsilon subunit 3 POLE3 Tbio Enzyme -0.73319 5.86 173
Transcription factor E2F1 E2F1 Tchem Transcription Factor -2.27364 187.2 928
Protein MCM10 homolog MCM10 Tbio Non-IDG -1.62619 49.9 70
Replication protein A 30 kDa subunit RPA4 Tbio Non-IDG -1.32394 20.7 110
DNA polymerase epsilon subunit 4 POLE4 Tdark Enzyme -0.36530 2.18 29
Geminin GMNN Tchem Non-IDG -2.19865 171.0 230
Cyclin-dependent kinase 2 CDK2 Tchem Kinase -3.41871 2399.0 886
DNA replication factor Cdt1 CDT1 Tbio Non-IDG -2.17234 139.2 105