Development Level

Tbio 235 | 11,651
Tchem 35 | 1,388
Tdark 14 | 6,593
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 31 | 979
embryonic lethality prior to o... 17 | 239
embryonic lethality prior to t... 13 | 278
preweaning lethality, incomple... 9 | 499
abnormal embryo size 6 | 220
abnormal behavior 4 | 298
decreased body weight 4 | 161
increased mean corpuscular hem... 4 | 36
abnormal bone structure 3 | 187
abnormal embryo turning 3 | 31
abnormal eye morphology 3 | 68
abnormal heart morphology 3 | 162
abnormal seminal vesicle morph... 3 | 114
corneal opacity 3 | 32
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 126
decreased circulating triglyce... 3 | 79
embryonic growth retardation 3 | 106
enlarged heart 3 | 210
hypoactivity 3 | 132
increased mean corpuscular vol... 3 | 92
abnormal blood vessel morpholo... 2 | 5
abnormal coat-hair pigmentatio... 2 | 64
abnormal forebrain development 2 | 20
abnormal pharyngeal arch morph... 2 | 8
abnormal retinal inner nuclear... 2 | 8
abnormal spleen morphology 2 | 55
abnormal vocalization 2 | 21
anophthalmia 2 | 33
decreased bone mineral content 2 | 151
decreased total body fat amoun... 2 | 207
hydrometra 2 | 53
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 39
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
long tibia 2 | 25
male infertility 2 | 123
pale yolk sac 2 | 25
small superior vagus ganglion 2 | 74
abnormal chorioallantoic fusio... 1 | 8
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal gait 1 | 69
abnormal lens morphology 1 | 81
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal somite shape 1 | 5
abnormal urinary bladder morph... 1 | 11
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal vitreous body morphol... 1 | 10
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased fluid intake 1 | 3
decreased heart rate variabili... 1 | 13
decreased lean body mass 1 | 135
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged spleen 1 | 41
increased anti-nuclear antigen... 1 | 19
increased bone mineral content 1 | 108
increased circulating HDL chol... 1 | 80
increased circulating creatini... 1 | 38
increased circulating potassiu... 1 | 29
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean platelet volume 1 | 45
increased startle reflex 1 | 112
iris synechia 1 | 3
limb grasping 1 | 41
small spleen 1 | 19
small testis 1 | 58
small thymus 1 | 16
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 183 | 11,493
ovarian cancer 179 | 8,520
osteosarcoma 146 | 7,950
Cancer 112 | 2,499
lung cancer 103 | 4,740
psoriasis 101 | 6,694
group 3 medulloblastoma 99 | 4,104
medulloblastoma, large-cell 92 | 6,241
glioblastoma 87 | 5,792
malignant mesothelioma 79 | 3,232
Breast cancer 74 | 3,578
atypical teratoid / rhabdoid tumor 72 | 5,112
primitive neuroectodermal tumor 60 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 59 | 3,291
non-small cell lung cancer 55 | 2,890
ependymoma 54 | 4,679
adult high grade glioma 49 | 3,801
Intellectual disability 46 | 1,016
lung adenocarcinoma 46 | 2,716
Autosomal recessive predisposition 45 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 43 | 2,989
invasive ductal carcinoma 43 | 2,951
Kidney cancer 42 | 2,613
Short stature 42 | 531
Fanconi anemia 41 | 56
Cockayne syndrome 40 | 60
Small head 38 | 374
Dull intelligence 37 | 645
Low intelligence 37 | 645
Mental Retardation 37 | 645
Mental deficiency 37 | 645
Multiple myeloma 37 | 1,332
Poor school performance 37 | 645
Xeroderma pigmentosum 36 | 43
oligodendroglioma 35 | 2,850
breast carcinoma 34 | 1,638
nasopharyngeal carcinoma 34 | 1,058
Waldenstrons macroglobulinemia 30 | 765
colon cancer 30 | 1,478
ductal carcinoma in situ 30 | 1,745
Cognitive delay 29 | 608
Global developmental delay 29 | 608
Mental and motor retardation 29 | 608
astrocytic glioma 27 | 2,597
pancreatic cancer 27 | 2,398
adrenocortical carcinoma 25 | 1,428
diabetes mellitus 25 | 1,728
Pick disease 24 | 1,894
Acquired scoliosis 23 | 281
Anemia 23 | 365
Bloom syndrome 23 | 29
Breast Neoplasms 23 | 445
Chromosome Breakage 23 | 36
Cryptorchidism 23 | 296
Curvature of spine 23 | 282
Mammary Neoplasms 23 | 425
hypopigmented skin patch 23 | 59
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
pituitary cancer 23 | 1,972
Astrocytoma, Pilocytic 22 | 3,081
Increased chromosomal breakage 21 | 27
Nijmegen breakage syndrome 21 | 24
Strabismus 21 | 270
subependymal giant cell astrocytoma 21 | 2,287
tuberculosis 21 | 2,010
Epilepsy 20 | 792
Melanoma 20 | 711
Seizures 20 | 596
Stomach Neoplasms 19 | 300
Thrombocytopenia 19 | 197
acute myeloid leukemia 19 | 783
Ataxia telangiectasia 18 | 34
Decreased platelet count 18 | 111
Leukopenia 18 | 72
Muscle hypotonia 18 | 571
Photosensitive trichothiodystrophy 18 | 30
dermatomyositis 18 | 966
Almond-shaped eyes 17 | 23
Hypoplastic mandible condyle 17 | 275
Mandibular hypoplasia 17 | 275
Micrognathism 17 | 275
Prostatic Neoplasms 17 | 495
Schizophrenia 17 | 1,160
astrocytoma 17 | 1,146
lung carcinoma 17 | 2,843
Alzheimer's disease 16 | 658
Esophageal atresia with or without tracheoesophageal fistula 16 | 21
Irregular hyperpigmentation 16 | 33
Photosensitivity of skin 16 | 51
Pyridoxine-responsive sideroblastic anemia 16 | 17
Radial aplasia/hypoplasia 16 | 29
Rheumatoid arthritis 16 | 1,191
Sensorineural Hearing Loss (disorder) 16 | 284
Short palpebral fissure 16 | 38
Xeroderma pigmentosum group F 16 | 22
esophageal atresia/tracheoesophageal fistula 16 | 22
juvenile dermatomyositis 16 | 1,187
pediatric high grade glioma 16 | 1,064
Cataract 15 | 297
non primary Sjogren syndrome sicca 15 | 891

Tissue

Endocrine System 287 | 18,159
Blood and immune system 286 | 16,909
Digestive Tract 286 | 17,369
Female tissues 286 | 17,400
Male tissues 286 | 17,142
Nervous System 286 | 16,725
Respiratory system 286 | 16,393
Skin and soft tissues 286 | 17,230
Urinary Tract 286 | 16,678
Liver and Pancreas 285 | 16,750
Cardiovascular System 280 | 15,192

Target Family

Non-IDG 165 | 12,091
Enzyme 99 | 4,145
Epigenetic 8 | 242
Kinase 8 | 634
Transcription Factor 7 | 1,400
TF/Epigenetic 1 | 38

Reactome Pathway

DNA Repair 288 | 288
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Alpha-ketoglutarate-dependent dioxygenase FTO FTO Tbio Enzyme -3.13021 1342.0 318
INO80 complex subunit B INO80B Tbio Non-IDG -1.16370 15.1 53
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 ALKBH3 Tchem Enzyme -1.51372 33.2 194
BRISC and BRCA1-A complex member 1 BABAM1 Tbio Non-IDG -1.20557 16.7 162
Cell cycle checkpoint control protein RAD9B RAD9B Tdark Non-IDG -0.07767 1.44 35
BRCA1-A complex subunit RAP80 UIMC1 Tbio Non-IDG -1.69622 52.7 176
DNA helicase INO80 INO80 Tbio Enzyme -2.54124 327.2 47
Serine/threonine-protein phosphatase 4 regulatory subunit 2 PPP4R2 Tbio Enzyme -0.78829 5.38 130
ATR-interacting protein ATRIP Tbio Non-IDG -1.60828 43.0 359