Development Level

Tbio 217 | 10,625
Tchem 43 | 1,890
Tdark 21 | 7,003
Tclin 5 | 602

IMPC Term

preweaning lethality, complete... 26 | 633
embryonic lethality prior to o... 13 | 148
embryonic lethality prior to t... 8 | 187
decreased body weight 6 | 174
abnormal behavior 5 | 226
preweaning lethality, incomple... 5 | 260
hypoactivity 4 | 89
abnormal embryo size 3 | 112
decreased circulating glucose ... 3 | 121
increased mean corpuscular hem... 3 | 25
polydactyly 3 | 22
abnormal bone structure 2 | 131
abnormal coat/hair pigmentatio... 2 | 54
abnormal gait 2 | 51
abnormal retinal inner nuclear... 2 | 5
abnormal vocalization 2 | 21
decreased body length 2 | 108
decreased circulating HDL chol... 2 | 77
decreased circulating aspartat... 2 | 27
decreased circulating choleste... 2 | 85
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
hyperactivity 2 | 108
increased body length 2 | 20
increased body weight 2 | 42
increased bone mineral density 2 | 52
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased heart weight 2 | 37
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
narrow eye opening 2 | 15
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal pericardium morpholog... 1 | 11
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal tail movements 1 | 12
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased KLRG1-positive NK ce... 1 | 9
decreased basophil cell number 1 | 11
decreased bone mineral content 1 | 157
decreased circulating LDL chol... 1 | 37
decreased circulating iron lev... 1 | 25
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased hematocrit 1 | 25
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
long tibia 1 | 13
male infertility 1 | 62
pale yolk sac 1 | 12
prenatal lethality prior to he... 1 | 64
small adrenal glands 1 | 15
small testis 1 | 37
straub tail 1 | 26
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 175 | 8,484
osteosarcoma 145 | 7,933
Cancer 106 | 2,346
psoriasis 99 | 6,685
lung cancer 95 | 4,466
medulloblastoma, large-cell 90 | 6,234
glioblastoma 78 | 5,572
malignant mesothelioma 75 | 3,162
group 3 medulloblastoma 72 | 2,254
Breast cancer 65 | 3,094
primitive neuroectodermal tumor 59 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 57 | 3,289
atypical teratoid / rhabdoid tumor 51 | 4,369
non-small cell lung cancer 51 | 2,798
lung adenocarcinoma 43 | 2,713
Carcinoma 42 | 2,147
pediatric high grade glioma 42 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,988
invasive ductal carcinoma 41 | 2,950
Fanconi's anemia 38 | 50
Multiple myeloma 35 | 1,327
oligodendroglioma 34 | 2,849
Cockayne syndrome 33 | 54
nasopharyngeal carcinoma 33 | 1,056
Xeroderma pigmentosum 31 | 41
Waldenstrons macroglobulinemia 29 | 765
colon cancer 29 | 1,475
ductal carcinoma in situ 28 | 1,745
sonic hedgehog group medulloblastoma 28 | 1,482
atypical teratoid/rhabdoid tumor 27 | 1,095
breast carcinoma 26 | 1,614
ependymoma 26 | 2,514
pancreatic cancer 25 | 2,300
Pick disease 24 | 1,893
diabetes mellitus 24 | 1,663
Bloom syndrome 23 | 30
adrenocortical carcinoma 23 | 1,427
astrocytic glioma 23 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,956
pituitary cancer 23 | 1,972
Mammary Neoplasms 22 | 410
Peripheral Neuropathy 21 | 303
adult high grade glioma 21 | 2,148
astrocytoma 21 | 1,493
tuberculosis 21 | 1,557
Neoplastic Syndromes, Hereditary 20 | 48
acute myeloid leukemia 20 | 780
subependymal giant cell astrocytoma 20 | 2,287
Anemia 19 | 252
Nijmegen breakage syndrome 19 | 23
posterior fossa group A ependymoma 19 | 1,511
dermatomyositis 18 | 933
Fanconi Anemia 17 | 19
Intellectual disability 17 | 573
Rheumatoid Arthritis 17 | 1,160
lung carcinoma 17 | 2,844
pilocytic astrocytoma 17 | 3,086
ulcerative colitis 17 | 2,087
Ataxia telangiectasia 16 | 31
Photosensitive trichothiodystrophy 16 | 24
juvenile dermatomyositis 16 | 1,189
Alzheimer's disease 15 | 644
Prostatic Neoplasms 15 | 471
Werner syndrome 15 | 29
posterior fossa group B ependymoma 15 | 1,530
Stomach Neoplasms 14 | 282
non primary Sjogren syndrome sicca 14 | 840
Colorectal Neoplasms 13 | 217
Lynch syndrome 13 | 33
Neurodegenerative disease 13 | 383
acute quadriplegic myopathy 13 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
Atopic dermatitis 12 | 944
Endometriosis 12 | 535
Hereditary Breast and Ovarian Cancer Syndrome 12 | 14
Malignant neoplasm of breast 12 | 63
Seckel syndrome 12 | 34
medulloblastoma 12 | 1,524
tuberculosis and treatment for 6 months 12 | 686
IGA Glomerulonephritis 11 | 454
hepatocellular carcinoma 11 | 532
progressive supranuclear palsy 11 | 674
Melanoma 10 | 261
Microcephaly 10 | 149
cutaneous lupus erythematosus 10 | 1,056
group 4 medulloblastoma 10 | 1,875
interstitial cystitis 10 | 2,299
spina bifida 10 | 1,064
Adenoma 9 | 165
Aplastic anemia 9 | 18
Bladder Neoplasm 9 | 109
ovarian neoplasm 9 | 97
pancreatic carcinoma 9 | 567
Familial adenomatous polyposis 8 | 31
Lung Neoplasms 8 | 171
Prostate cancer 8 | 172
active Crohn's disease 8 | 918
cystic fibrosis 8 | 1,665
inflammatory breast cancer 8 | 404
non-small cell lung carcinoma 8 | 413

Tissue

Blood and immune system 286 | 17,995
Cardiovascular System 286 | 17,958
Digestive Tract 286 | 18,473
Endocrine System 286 | 18,512
Female tissues 286 | 18,647
Male tissues 286 | 17,969
Nervous System 286 | 18,561
Urinary Tract 286 | 18,444
Liver and Pancreas 285 | 18,136
Respiratory system 285 | 17,484
Skin and soft tissues 282 | 18,115

Target Family

Non-IDG 164 | 11,971
Enzyme 98 | 4,146
Kinase 9 | 634
Epigenetic 8 | 242
Transcription Factor 7 | 1,400

Reactome Pathway

DNA Repair 286 | 286
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Probable crossover junction endonuclease EME2 EME2 Tbio Enzyme -1.53403 32.3 56
Fanconi anemia group B protein FANCB Tbio Non-IDG -2.31383 203.9 74
DNA-directed RNA polymerase II subunit RPB7 POLR2G Tbio Enzyme -1.74939 59.4 153
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.75991 594.0 437
Protein artemis DCLRE1C Tbio Non-IDG -1.63807 45.4 225
Single-strand selective monofunctional uracil DNA glycosylase SMUG1 Tbio Enzyme -4.25142 18890.7 165