Development Level

Tbio 217 | 10,625
Tchem 43 | 1,890
Tdark 21 | 7,003
Tclin 5 | 602

IMPC Phenotype

preweaning lethality, complete... 26 | 633
embryonic lethality prior to o... 13 | 148
embryonic lethality prior to t... 8 | 187
decreased body weight 6 | 174
abnormal behavior 5 | 226
preweaning lethality, incomple... 5 | 260
hypoactivity 4 | 89
abnormal embryo size 3 | 112
decreased circulating glucose ... 3 | 121
increased mean corpuscular hem... 3 | 25
polydactyly 3 | 22
abnormal bone structure 2 | 131
abnormal coat-hair pigmentatio... 2 | 54
abnormal gait 2 | 51
abnormal retinal inner nuclear... 2 | 5
abnormal vocalization 2 | 21
decreased body length 2 | 108
decreased circulating HDL chol... 2 | 77
decreased circulating aspartat... 2 | 27
decreased circulating choleste... 2 | 85
decreased circulating total pr... 2 | 41
decreased circulating triglyce... 2 | 83
hyperactivity 2 | 108
increased body length 2 | 20
increased body weight 2 | 42
increased bone mineral density 2 | 52
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased heart weight 2 | 37
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
narrow eye opening 2 | 15
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal coat appearance 1 | 25
abnormal coat- hair morphology 1 | 18
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal kidney morphology 1 | 30
abnormal locomotor activation 1 | 26
abnormal pericardium morpholog... 1 | 11
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal tail movements 1 | 12
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
cataract 1 | 26
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased KLRG1-positive NK ce... 1 | 9
decreased basophil cell number 1 | 11
decreased bone mineral content 1 | 157
decreased circulating LDL chol... 1 | 37
decreased circulating iron lev... 1 | 25
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased hematocrit 1 | 25
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
enlarged spleen 1 | 26
hydrops fetalis 1 | 22
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased circulating potassiu... 1 | 31
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased fasted circulating g... 1 | 68
increased hematocrit 1 | 36
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
long tibia 1 | 13
male infertility 1 | 62
pale yolk sac 1 | 12
prenatal lethality prior to he... 1 | 64
small adrenal glands 1 | 15
small testis 1 | 37
straub tail 1 | 26
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 177 | 8,491
osteosarcoma 145 | 7,933
Cancer 106 | 2,346
psoriasis 99 | 6,685
lung cancer 96 | 4,473
medulloblastoma, large-cell 90 | 6,234
glioblastoma 78 | 5,572
malignant mesothelioma 75 | 3,163
group 3 medulloblastoma 72 | 2,254
Breast cancer 65 | 3,098
primitive neuroectodermal tumor 59 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 57 | 3,289
atypical teratoid / rhabdoid tumor 51 | 4,369
non-small cell lung cancer 51 | 2,798
lung adenocarcinoma 44 | 2,714
Carcinoma 42 | 2,147
pediatric high grade glioma 42 | 2,712
intraductal papillary-mucinous carcinoma (IPMC) 41 | 2,988
invasive ductal carcinoma 41 | 2,950
Fanconi's anemia 38 | 50
Multiple myeloma 35 | 1,327
oligodendroglioma 34 | 2,849
Cockayne syndrome 33 | 54
nasopharyngeal carcinoma 33 | 1,056
Xeroderma pigmentosum 31 | 41
Waldenstrons macroglobulinemia 29 | 764
colon cancer 29 | 1,475
ductal carcinoma in situ 28 | 1,745
sonic hedgehog group medulloblastoma 28 | 1,482
atypical teratoid/rhabdoid tumor 27 | 1,095
breast carcinoma 26 | 1,614
ependymoma 26 | 2,514
pancreatic cancer 25 | 2,300
Pick disease 24 | 1,893
diabetes mellitus 24 | 1,663
Bloom syndrome 23 | 30
adrenocortical carcinoma 23 | 1,427
astrocytic glioma 23 | 2,241
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,956
pituitary cancer 23 | 1,972
Mammary Neoplasms 22 | 410
Peripheral Neuropathy 21 | 303
adult high grade glioma 21 | 2,148
astrocytoma 21 | 1,493
tuberculosis 21 | 1,563
Fanconi Anemia 20 | 22
Neoplastic Syndromes, Hereditary 20 | 48
acute myeloid leukemia 20 | 785
subependymal giant cell astrocytoma 20 | 2,287
Anemia 19 | 252
Nijmegen breakage syndrome 19 | 23
posterior fossa group A ependymoma 19 | 1,511
dermatomyositis 18 | 966
Intellectual disability 17 | 573
Rheumatoid Arthritis 17 | 1,170
lung carcinoma 17 | 2,844
pilocytic astrocytoma 17 | 3,086
ulcerative colitis 17 | 2,087
Ataxia telangiectasia 16 | 32
Photosensitive trichothiodystrophy 16 | 24
esophageal atresia/tracheoesophageal fistula 16 | 19
juvenile dermatomyositis 16 | 1,189
Alzheimer's disease 15 | 644
Prostatic Neoplasms 15 | 471
Werner syndrome 15 | 29
posterior fossa group B ependymoma 15 | 1,530
Lynch syndrome 14 | 35
Stomach Neoplasms 14 | 282
non primary Sjogren syndrome sicca 14 | 840
Colorectal Neoplasms 13 | 217
Neurodegenerative disease 13 | 383
acute quadriplegic myopathy 13 | 1,157
hepatocellular carcinoma 13 | 550
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
Atopic dermatitis 12 | 944
Endometriosis 12 | 535
Hereditary Breast and Ovarian Cancer Syndrome 12 | 14
Malignant neoplasm of breast 12 | 63
Seckel syndrome 12 | 35
medulloblastoma 12 | 1,524
tuberculosis and treatment for 6 months 12 | 686
IGA Glomerulonephritis 11 | 454
progressive supranuclear palsy 11 | 674
Melanoma 10 | 261
Microcephaly 10 | 149
cutaneous lupus erythematosus 10 | 1,056
group 4 medulloblastoma 10 | 1,875
interstitial cystitis 10 | 2,299
spina bifida 10 | 1,064
Adenoma 9 | 165
Aplastic anemia 9 | 19
Bladder Neoplasm 9 | 109
Fanconi Anemia, Complementation Group a 9 | 9
ovarian neoplasm 9 | 97
pancreatic carcinoma 9 | 567
Prostate cancer 8 | 172
active Crohn's disease 8 | 918
cystic fibrosis 8 | 1,670
gastric cancer 8 | 436
inflammatory breast cancer 8 | 404

Tissue

Blood and immune system 286 | 17,994
Cardiovascular System 286 | 17,957
Digestive Tract 286 | 18,472
Endocrine System 286 | 18,511
Female tissues 286 | 18,646
Male tissues 286 | 17,968
Nervous System 286 | 18,560
Urinary Tract 286 | 18,443
Liver and Pancreas 285 | 18,135
Respiratory system 285 | 17,483
Skin and soft tissues 282 | 18,114

Target Family

Non-IDG 164 | 11,969
Enzyme 98 | 4,146
Kinase 9 | 634
Epigenetic 8 | 242
Transcription Factor 7 | 1,400

Reactome Pathway

DNA Repair 286 | 286
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.47495 286.5 135
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Tumor suppressor p53-binding protein 1 TP53BP1 Tbio Epigenetic -2.65153 422.5 514
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.74239 5756.8 1322
UV-stimulated scaffold protein A UVSSA Tbio Non-IDG -0.81845 7.77 23
DNA repair protein XRCC2 XRCC2 Tbio Non-IDG -2.73754 465.9 235
DNA repair protein XRCC3 XRCC3 Tbio Non-IDG -2.49911 286.4 377
X-ray repair cross-complementing protein 5 XRCC5 Tbio Non-IDG -2.67147 456.7 712