Development Level

Tbio 109 | 11,178
Tchem 25 | 1,885
Tdark 5 | 6,569
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 16 | 979
embryonic lethality prior to o... 9 | 239
embryonic lethality prior to t... 7 | 278
preweaning lethality, incomple... 6 | 499
abnormal embryo size 4 | 220
abnormal embryo turning 3 | 31
decreased circulating glucose ... 3 | 126
abnormal behavior 2 | 298
abnormal blood vessel morpholo... 2 | 5
abnormal bone structure 2 | 187
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal pharyngeal arch morph... 2 | 8
corneal opacity 2 | 32
decreased body weight 2 | 161
decreased circulating triglyce... 2 | 79
embryonic growth retardation 2 | 106
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 39
increased mean corpuscular hem... 2 | 96
increased mean corpuscular vol... 2 | 92
increased total body fat amoun... 2 | 134
abnormal chorioallantoic fusio... 1 | 8
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo development 1 | 7
abnormal eye size 1 | 7
abnormal forebrain development 1 | 20
abnormal hindbrain development 1 | 16
abnormal kidney morphology 1 | 65
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal placement of pupils 1 | 6
abnormal retinal inner nuclear... 1 | 8
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal somite shape 1 | 5
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal vocalization 1 | 21
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
decreased vertical activity 1 | 208
edema 1 | 59
enlarged heart 1 | 210
female infertility 1 | 60
hyperactivity 1 | 148
hypoactivity 1 | 132
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating creatini... 1 | 38
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 36
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
long tibia 1 | 25
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small adrenal glands 1 | 16
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 95 | 11,192
ovarian cancer 87 | 8,297
osteosarcoma 78 | 7,766
Cancer 63 | 2,388
lung cancer 58 | 4,607
psoriasis 58 | 6,514
group 3 medulloblastoma 56 | 4,002
Breast cancer 53 | 3,469
medulloblastoma, large-cell 51 | 6,086
glioblastoma 48 | 5,635
malignant mesothelioma 47 | 3,135
atypical teratoid / rhabdoid tumor 40 | 4,971
non-small cell lung cancer 40 | 2,799
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,204
primitive neuroectodermal tumor 31 | 2,957
adult high grade glioma 29 | 3,701
ependymoma 29 | 4,559
invasive ductal carcinoma 29 | 2,867
lung adenocarcinoma 27 | 2,627
colon cancer 25 | 1,428
Short stature 24 | 514
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,902
nasopharyngeal carcinoma 24 | 1,024
ductal carcinoma in situ 23 | 1,686
Fanconi anemia 22 | 56
Kidney cancer 22 | 2,548
breast carcinoma 22 | 1,589
Intellectual disability 21 | 998
Autosomal recessive predisposition 20 | 1,407
Breast Neoplasms 20 | 423
Mammary Neoplasms 20 | 403
Small head 19 | 366
adrenocortical carcinoma 19 | 1,385
Bloom syndrome 18 | 29
Nijmegen breakage syndrome 18 | 23
oligodendroglioma 18 | 2,768
Dull intelligence 17 | 634
Low intelligence 17 | 634
Mental Retardation 17 | 634
Mental deficiency 17 | 634
Poor school performance 17 | 634
astrocytic glioma 17 | 2,530
Ataxia telangiectasia 16 | 33
Xeroderma pigmentosum 15 | 42
pancreatic cancer 15 | 2,322
Cognitive delay 14 | 596
Global developmental delay 14 | 596
Mental and motor retardation 14 | 596
Waldenstrons macroglobulinemia 14 | 742
diabetes mellitus 14 | 1,683
pituitary cancer 14 | 1,915
Hypoplastic mandible condyle 13 | 273
Mandibular hypoplasia 13 | 273
Micrognathism 13 | 273
Multiple myeloma 13 | 1,296
Werner syndrome 13 | 29
lung carcinoma 13 | 2,755
subependymal giant cell astrocytoma 13 | 2,230
Hereditary Breast and Ovarian Cancer Syndrome 12 | 13
Schizophrenia 12 | 1,136
non primary Sjogren syndrome sicca 12 | 861
Astrocytoma, Pilocytic 11 | 3,006
Chromosome Breakage 11 | 35
Pick disease 11 | 1,856
Seckel syndrome 11 | 34
ulcerative colitis 11 | 1,765
Anemia 10 | 353
Increased chromosomal breakage 10 | 27
Prostatic Neoplasms 10 | 472
tuberculosis 10 | 1,963
Acquired scoliosis 9 | 274
Alzheimer's disease 9 | 640
Colorectal Neoplasms 9 | 235
Curvature of spine 9 | 275
Fetal Growth Retardation 9 | 186
Infant, Small for Gestational Age 9 | 174
Intrauterine retardation 9 | 174
Melanoma 9 | 689
Neurodegenerative disease 9 | 402
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,872
Cockayne syndrome 8 | 59
Convex nasal ridge 8 | 36
Cryptorchidism 8 | 287
Microcephaly 8 | 166
Narrow face 8 | 54
Photosensitivity of skin 8 | 51
Rheumatoid arthritis 8 | 1,156
Stomach Neoplasms 8 | 287
Thin face 8 | 54
Thrombocytopenia 8 | 193
acute myeloid leukemia 8 | 760
acute quadriplegic myopathy 8 | 1,133
astrocytoma 8 | 1,113
cutaneous lupus erythematosus 8 | 1,016
pediatric high grade glioma 8 | 1,035
Atopic dermatitis 7 | 915
Cleft Palate 7 | 265
Endometriosis 7 | 521
Strabismus 7 | 265
cystic fibrosis 7 | 1,629

Tissue

Endocrine System 143 | 18,159
Blood and immune system 142 | 16,909
Digestive Tract 142 | 17,369
Female tissues 142 | 17,400
Male tissues 142 | 17,142
Nervous System 142 | 16,725
Respiratory system 142 | 16,393
Skin and soft tissues 142 | 17,230
Urinary Tract 142 | 16,678
Liver and Pancreas 141 | 16,750
Cardiovascular System 140 | 15,192

Target Family

Non-IDG 85 | 12,091
Enzyme 42 | 4,145
Kinase 7 | 634
Epigenetic 6 | 242
Transcription Factor 2 | 1,400
TF/Epigenetic 1 | 38

Reactome Pathway

DNA Double-Strand Break Repair 143 | 143
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Non-homologous end-joining factor 1 NHEJ1 Tbio Non-IDG -1.93558 91.5 270
Histone H3.1t HIST3H3 Tbio Non-IDG -1.05426 10.9 1265
Histone H2B type 3-B HIST3H2BB Tbio Non-IDG -0.72238 5.02 53
DNA polymerase kappa POLK Tbio Enzyme -2.42142 256.3 224
DNA repair-scaffolding protein SPIDR Tbio Non-IDG -0.75333 5.57 24
Histone H2B type 1-K HIST1H2BK Tbio Non-IDG -0.50219 4.04 29
Serine/threonine-protein phosphatase 5 PPP5C Tchem Enzyme -1.59075 41.9 338
E3 ubiquitin-protein ligase RNF4 RNF4 Tbio Enzyme -1.86505 77.1 80
Eyes absent homolog 3 EYA3 Tbio Non-IDG -0.93756 7.66 93