Development Level

Tbio 106 | 10,625
Tchem 24 | 1,890
Tdark 9 | 7,003
Tclin 5 | 602

IMPC Term

preweaning lethality, complete... 14 | 633
embryonic lethality prior to o... 6 | 148
embryonic lethality prior to t... 4 | 187
decreased body weight 3 | 174
decreased circulating glucose ... 3 | 121
abnormal behavior 2 | 226
abnormal bone structure 2 | 131
abnormal embryo size 2 | 112
decreased body length 2 | 108
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased circulating total pr... 2 | 41
increased bone mineral density 2 | 52
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
preweaning lethality, incomple... 2 | 260
abnormal behavioral response t... 1 | 52
abnormal blood vessel morpholo... 1 | 2
abnormal bone mineralization 1 | 55
abnormal coat/hair pigmentatio... 1 | 54
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal gait 1 | 51
abnormal kidney morphology 1 | 30
abnormal pharyngeal arch morph... 1 | 2
abnormal placement of pupils 1 | 4
abnormal posture 1 | 5
abnormal retinal inner nuclear... 1 | 5
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal tail movements 1 | 12
abnormal vocalization 1 | 21
anophthalmia 1 | 20
cardiovascular system phenotyp... 1 | 35
corneal opacity 1 | 25
decreased KLRG1-positive NK ce... 1 | 9
decreased circulating alkaline... 1 | 41
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased memory-marker CD4-ne... 1 | 4
decreased rib number 1 | 59
decreased thoracic vertebrae n... 1 | 7
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
hydrops fetalis 1 | 22
hyperactivity 1 | 108
hypoactivity 1 | 89
immune system phenotype 1 | 17
increased CD4-negative NK T ce... 1 | 4
increased body length 1 | 20
increased circulating HDL chol... 1 | 63
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased effector memory CD4-... 1 | 15
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
increased mean corpuscular vol... 1 | 91
increased monocyte cell number 1 | 27
increased or absent threshold ... 1 | 128
increased total body fat amoun... 1 | 57
narrow eye opening 1 | 15
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
small adrenal glands 1 | 15
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 87 | 8,484
osteosarcoma 80 | 7,933
Cancer 63 | 2,346
psoriasis 58 | 6,685
lung cancer 55 | 4,466
medulloblastoma, large-cell 51 | 6,234
Breast cancer 49 | 3,094
malignant mesothelioma 46 | 3,162
glioblastoma 44 | 5,572
group 3 medulloblastoma 39 | 2,254
non-small cell lung cancer 38 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,289
primitive neuroectodermal tumor 32 | 3,031
invasive ductal carcinoma 28 | 2,950
atypical teratoid / rhabdoid tumor 26 | 4,369
lung adenocarcinoma 26 | 2,713
Carcinoma 25 | 2,147
colon cancer 25 | 1,475
nasopharyngeal carcinoma 25 | 1,056
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
pediatric high grade glioma 24 | 2,712
ductal carcinoma in situ 23 | 1,745
sonic hedgehog group medulloblastoma 22 | 1,482
Fanconi's anemia 21 | 50
Mammary Neoplasms 20 | 410
breast carcinoma 19 | 1,614
Nijmegen breakage syndrome 18 | 23
adrenocortical carcinoma 18 | 1,427
atypical teratoid/rhabdoid tumor 18 | 1,095
oligodendroglioma 18 | 2,849
Bloom syndrome 17 | 30
Ataxia telangiectasia 15 | 31
astrocytic glioma 15 | 2,241
pancreatic cancer 15 | 2,300
Neoplastic Syndromes, Hereditary 14 | 48
Waldenstrons macroglobulinemia 14 | 765
ependymoma 14 | 2,514
pituitary cancer 14 | 1,972
ulcerative colitis 14 | 2,087
Werner syndrome 13 | 29
diabetes mellitus 13 | 1,663
lung carcinoma 13 | 2,844
Hereditary Breast and Ovarian Cancer Syndrome 12 | 14
Multiple myeloma 12 | 1,327
Peripheral Neuropathy 12 | 303
Seckel syndrome 12 | 34
adult high grade glioma 12 | 2,148
non primary Sjogren syndrome sicca 12 | 840
posterior fossa group A ependymoma 12 | 1,511
subependymal giant cell astrocytoma 12 | 2,287
Pick disease 11 | 1,893
astrocytoma 11 | 1,493
tuberculosis 11 | 1,557
Xeroderma pigmentosum 10 | 41
posterior fossa group B ependymoma 10 | 1,530
Alzheimer's disease 9 | 644
Intellectual disability 9 | 573
Malignant neoplasm of breast 9 | 63
Prostatic Neoplasms 9 | 471
Rheumatoid Arthritis 9 | 1,160
acute myeloid leukemia 9 | 780
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
Anemia 8 | 252
Breast Cancer, Familial 8 | 12
Cockayne syndrome 8 | 54
Colorectal Neoplasms 8 | 217
Neurodegenerative disease 8 | 383
acute quadriplegic myopathy 8 | 1,157
cutaneous lupus erythematosus 8 | 1,056
non-small cell lung carcinoma 8 | 413
pilocytic astrocytoma 8 | 3,086
Endometriosis 7 | 535
Microcephaly 7 | 149
Stomach Neoplasms 7 | 282
cystic fibrosis 7 | 1,665
ovarian neoplasm 7 | 97
tuberculosis and treatment for 6 months 7 | 686
Atopic dermatitis 6 | 944
Fanconi Anemia 6 | 19
IGA Glomerulonephritis 6 | 454
Lynch syndrome 6 | 33
Melanoma 6 | 261
Prostate cancer 6 | 172
dermatomyositis 6 | 933
interstitial cystitis 6 | 2,299
juvenile dermatomyositis 6 | 1,189
progressive supranuclear palsy 6 | 674
Amyotrophic Lateral Sclerosis 5 | 431
Aplastic anemia 5 | 18
Asthma 5 | 349
Chronic Lymphocytic Leukemia 5 | 242
DNA ligase IV deficiency 5 | 6
Li-Fraumeni Syndrome 5 | 13
Malignant neoplasm of prostate 5 | 67
Pancreatic Neoplasm 5 | 79
group 4 medulloblastoma 5 | 1,875
inflammatory breast cancer 5 | 404
pancreatic carcinoma 5 | 567
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
medulloblastoma 4 | 1,524

Tissue

Blood and immune system 144 | 17,995
Cardiovascular System 144 | 17,958
Digestive Tract 144 | 18,473
Endocrine System 144 | 18,512
Female tissues 144 | 18,647
Male tissues 144 | 17,969
Nervous System 144 | 18,561
Urinary Tract 144 | 18,444
Liver and Pancreas 143 | 18,136
Respiratory system 143 | 17,484
Skin and soft tissues 140 | 18,115

Target Family

Non-IDG 86 | 11,971
Enzyme 42 | 4,146
Kinase 8 | 634
Epigenetic 6 | 242
Transcription Factor 2 | 1,400

Reactome Pathway

DNA Double-Strand Break Repair 144 | 144
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Probable crossover junction endonuclease EME2 EME2 Tbio Enzyme -1.53403 32.3 56
Protein artemis DCLRE1C Tbio Non-IDG -1.63807 45.4 225
Small ubiquitin-related modifier 1 SUMO1 Tbio Non-IDG -2.69547 474.2 685
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Lysine-specific demethylase 4A KDM4A Tchem Epigenetic -3.00912 1030.2 233
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.34287 19.7 194