Development Level

Tbio 43 | 11,178
Tchem 10 | 1,885
Tdark 3 | 6,569

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
abnormal behavior 2 | 298
abnormal embryo size 2 | 220
decreased body weight 2 | 161
preweaning lethality, complete... 2 | 979
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal rib morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal vocalization 1 | 21
corneal opacity 1 | 32
decreased body length 1 | 101
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
increased body length 1 | 32
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased erythrocyte cell num... 1 | 39
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
long tibia 1 | 25
small adrenal glands 1 | 16
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 38 | 11,192
ovarian cancer 29 | 8,297
osteosarcoma 26 | 7,766
Cancer 23 | 2,388
lung cancer 21 | 4,607
Breast cancer 18 | 3,469
psoriasis 17 | 6,514
glioblastoma 15 | 5,635
atypical teratoid / rhabdoid tumor 13 | 4,971
group 3 medulloblastoma 13 | 4,002
medulloblastoma, large-cell 13 | 6,086
ependymoma 12 | 4,559
malignant mesothelioma 12 | 3,135
breast carcinoma 11 | 1,589
lung adenocarcinoma 11 | 2,627
Nijmegen breakage syndrome 10 | 23
invasive ductal carcinoma 10 | 2,867
non-small cell lung cancer 10 | 2,799
Ataxia telangiectasia 9 | 33
Breast Neoplasms 9 | 423
Mammary Neoplasms 9 | 403
Kidney cancer 8 | 2,548
Multiple myeloma 8 | 1,296
adult high grade glioma 8 | 3,701
astrocytic glioma 8 | 2,530
ductal carcinoma in situ 8 | 1,686
intraductal papillary-mucinous carcinoma (IPMC) 8 | 2,902
intraductal papillary-mucinous neoplasm (IPMN) 8 | 3,204
lung carcinoma 8 | 2,755
oligodendroglioma 8 | 2,768
subependymal giant cell astrocytoma 8 | 2,230
Pick disease 7 | 1,856
Short stature 7 | 514
pancreatic cancer 7 | 2,322
pituitary cancer 7 | 1,915
Alzheimer's disease 6 | 640
Amyotrophic lateral sclerosis 6 | 437
Autosomal recessive predisposition 6 | 1,407
Cleft Palate 6 | 265
Hereditary Breast and Ovarian Cancer Syndrome 6 | 13
Intellectual disability 6 | 998
Schizophrenia 6 | 1,136
primitive neuroectodermal tumor 6 | 2,957
ulcerative colitis 6 | 1,765
Astrocytoma, Pilocytic 5 | 3,006
Dull intelligence 5 | 634
Fanconi anemia 5 | 56
Hypoplastic mandible condyle 5 | 273
Low intelligence 5 | 634
Mandibular hypoplasia 5 | 273
Mental Retardation 5 | 634
Mental deficiency 5 | 634
Micrognathism 5 | 273
Poor school performance 5 | 634
Prostatic Neoplasms 5 | 472
Stomach Neoplasms 5 | 287
Waldenstrons macroglobulinemia 5 | 742
progressive supranuclear palsy 5 | 656
Epilepsy 4 | 775
Microcephaly 4 | 166
Neurodegenerative disease 4 | 402
Pancreatic Neoplasm 4 | 82
Seizures 4 | 584
Small head 4 | 366
Strabismus 4 | 265
Uranostaphyloschisis 4 | 162
acute myeloid leukemia 4 | 760
adrenocortical carcinoma 4 | 1,385
astrocytoma 4 | 1,113
colon cancer 4 | 1,428
cutaneous lupus erythematosus 4 | 1,016
cystic fibrosis 4 | 1,629
group 4 medulloblastoma 4 | 1,806
nasopharyngeal carcinoma 4 | 1,024
Anemia 3 | 353
Attention deficit hyperactivity disorder 3 | 272
Bladder Neoplasm 3 | 106
Colonic Neoplasms 3 | 133
Large auricle 3 | 85
Large dysplastic ears 3 | 85
Large pinnae 3 | 85
Large prominent ears 3 | 85
Large protruding ears 3 | 85
Large, floppy ears 3 | 85
Liver cancer 3 | 589
Macrotia 3 | 85
Male infertility 3 | 199
Melanoma 3 | 689
Muscle Spasticity 3 | 192
Pancreatic Neoplasms 3 | 82
Polycystic ovary syndrome 3 | 348
Precursor Cell Lymphoblastic Leukemia-Lymphoma 3 | 47
Rheumatoid arthritis 3 | 1,156
Urinary Bladder Neoplasms 3 | 108
diabetes mellitus 3 | 1,683
gastric carcinoma 3 | 781
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,872
medulloblastoma 3 | 702
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,911
sonic hedgehog group medulloblastoma 3 | 459

Tissue

Endocrine System 56 | 18,159
Blood and immune system 55 | 16,909
Cardiovascular System 55 | 15,192
Digestive Tract 55 | 17,369
Female tissues 55 | 17,400
Liver and Pancreas 55 | 16,750
Male tissues 55 | 17,142
Nervous System 55 | 16,725
Respiratory system 55 | 16,393
Skin and soft tissues 55 | 17,230
Urinary Tract 55 | 16,678

Target Family

Non-IDG 39 | 12,091
Enzyme 6 | 4,145
Epigenetic 5 | 242
Kinase 3 | 634
Transcription Factor 2 | 1,400
TF/Epigenetic 1 | 38

Reactome Pathway

DNA Double Strand Break Respon... 56 | 56
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Histone H3.1t HIST3H3 Tbio Non-IDG -1.05426 10.9 1265
Histone H2B type 3-B HIST3H2BB Tbio Non-IDG -0.72238 5.02 53
Histone H2B type 1-K HIST1H2BK Tbio Non-IDG -0.50219 4.04 29
Serine/threonine-protein phosphatase 5 PPP5C Tchem Enzyme -1.59075 41.9 338
Eyes absent homolog 3 EYA3 Tbio Non-IDG -0.93756 7.66 93
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Histone H2B type 1-B HIST1H2BB Tbio Non-IDG -0.04628 0.67 115