Development Level

Tbio 4 | 11,445
Tchem 2 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal retinal inner nuclear... 1 | 8
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating iron lev... 1 | 32
decreased lactate dehydrogenas... 1 | 16
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged spleen 1 | 41
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
long tibia 1 | 25
polydactyly 1 | 7
preweaning lethality, complete... 1 | 979

Disease

osteosarcoma 5 | 7,950
ovarian cancer 4 | 8,520
Carcinoma 3 | 11,493
Cancer 2 | 2,499
Melanoma 2 | 711
adult high grade glioma 2 | 3,801
diabetes mellitus 2 | 1,728
glioblastoma 2 | 5,792
group 3 medulloblastoma 2 | 4,104
malignant mesothelioma 2 | 3,232
oligodendroglioma 2 | 2,850
psoriasis 2 | 6,694
Abnormality of the lymphatic system 1 | 14
Acquired metabolic disease 1 | 336
Adenoma 1 | 167
Alcoholic Intoxication, Chronic 1 | 289
Astrocytoma, Pilocytic 1 | 3,081
BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 14 1 | 1
Barrett Esophagus 1 | 16
Barrett's esophagus 1 | 182
Body Weight 1 | 14
Brain Neoplasms 1 | 33
Breast Neoplasms 1 | 445
Breast cancer 1 | 3,578
Carcinoma, squamous cell of head and neck 1 | 31
Chronic obstructive pulmonary disease 1 | 184
Dental pulp necrosis 1 | 10
Depressive disorder 1 | 409
Diabetes Mellitus, Non-Insulin-Dependent 1 | 145
Diabetes Mellitus, Type 2 1 | 142
Distal arthrogryposis 1 | 42
Dry skin 1 | 75
Endometrial cancer 1 | 311
Esophageal Squamous Cell Carcinoma 1 | 77
Esophageal carcinoma 1 | 16
Freckles 1 | 33
Giant Cell Glioblastoma 1 | 12
Glioma 1 | 74
Growth Retardation, Developmental Delay, Coarse Facies, And Early Death 1 | 1
Growth Retardation, Developmental Delay, and Facial Dysmorphism 1 | 1
Hair shaft abnormalities 1 | 30
Hereditary Melanoma 1 | 12
Intellectual disability 1 | 1,016
Kidney cancer 1 | 2,613
Leukemia 1 | 104
Liver Cirrhosis, Experimental 1 | 769
Lymphatic Diseases 1 | 14
MELANOMA, CUTANEOUS MALIGNANT, 1 1 | 13
Mammary Neoplasms 1 | 425
Melanocytic nevus 1 | 43
Mental Depression 1 | 333
Metabolic syndrome X 1 | 52
Micronuclei, Chromosome-Defective 1 | 25
Mood Disorders 1 | 184
Mouth Neoplasms 1 | 55
Necrosis 1 | 53
Neurodegenerative disease 1 | 414
Nevus 1 | 19
Obesity 1 | 678
Orofaciodigital syndrome 1 | 21
Osteoarthritis 1 | 184
Pediatric Obesity 1 | 4
Photosensitive trichothiodystrophy 1 | 30
Polycystic ovary syndrome 1 | 360
Precancerous Conditions 1 | 80
RETINITIS PIGMENTOSA 43 1 | 4
Recurrence 1 | 33
Retinitis pigmentosa 71 1 | 2
SPINAL MUSCULAR ATROPHY WITH CONGENITAL BONE FRACTURES 2 1 | 1
Somatic mutation 1 | 61
Squamous cell carcinoma of esophagus 1 | 77
Squamous cell carcinoma of the head and neck 1 | 29
Type 2 diabetes mellitus 1 | 272
Weight Gain 1 | 100
Xeroderma pigmentosum group D 1 | 33
Xerosis 1 | 75
active Crohn's disease 1 | 922
acute myeloid leukemia 1 | 783
astrocytic glioma 1 | 2,597
atypical teratoid / rhabdoid tumor 1 | 5,112
ependymoma 1 | 4,679
familial melanoma 1 | 10
gliosarcoma 1 | 18
hair abnormalities (non-specific) 1 | 30
interstitial cystitis 1 | 2,312
lung adenocarcinoma 1 | 2,716
lung cancer 1 | 4,740
non-small cell lung cancer 1 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
primitive neuroectodermal tumor 1 | 3,035
subependymal giant cell astrocytoma 1 | 2,287
tuberculosis 1 | 2,010

Tissue

Blood and immune system 7 | 16,909
Cardiovascular System 7 | 15,192
Digestive Tract 7 | 17,369
Endocrine System 7 | 18,159
Female tissues 7 | 17,400
Liver and Pancreas 7 | 16,750
Male tissues 7 | 17,142
Nervous System 7 | 16,725
Respiratory system 7 | 16,393
Skin and soft tissues 7 | 17,230
Urinary Tract 7 | 16,678

Target Family

Enzyme 4 | 4,145
Non-IDG 3 | 12,091

Reactome Pathway

DNA Damage Reversal 7 | 7
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Methylated-DNA--protein-cysteine methyltransferase MGMT Tchem Enzyme -3.13356 1426.9 560
RNA demethylase ALKBH5 ALKBH5 Tbio Enzyme -1.60956 36.8 72
Alpha-ketoglutarate-dependent dioxygenase FTO FTO Tbio Enzyme -3.13021 1342.0 318
Activating signal cointegrator 1 complex subunit 1 ASCC1 Tbio Non-IDG -0.22831 2.48 95
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 ALKBH3 Tchem Enzyme -1.51372 33.2 194
Activating signal cointegrator 1 complex subunit 2 ASCC2 Tdark Non-IDG -0.46489 2.71 85
Activating signal cointegrator 1 complex subunit 3 ASCC3 Tbio Non-IDG -1.59830 30.3 55