Development Level

Tbio 28 | 10,625
Tdark 5 | 7,003
Tchem 3 | 1,890
Tclin 2 | 602

IMPC Term

preweaning lethality, complete... 5 | 633
embryonic lethality prior to o... 4 | 148
abnormal behavior 2 | 226
embryonic lethality prior to t... 2 | 187
hypoactivity 2 | 89
increased body weight 2 | 42
preweaning lethality, incomple... 2 | 260
abnormal QRS complex 1 | 25
abnormal embryo size 1 | 112
abnormal liver size 1 | 4
abnormal locomotor activation 1 | 26
abnormal pericardium morpholog... 1 | 11
abnormal retinal inner nuclear... 1 | 5
abnormal seminal vesicle morph... 1 | 47
abnormal vocalization 1 | 21
decreased body weight 1 | 174
decreased circulating serum al... 1 | 79
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased total retina thickne... 1 | 20
increased body length 1 | 20
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 25
pale yolk sac 1 | 12
straub tail 1 | 26

Disease

ovarian cancer 27 | 8,484
lung cancer 14 | 4,466
osteosarcoma 14 | 7,933
Cancer 13 | 2,346
medulloblastoma, large-cell 12 | 6,234
Multiple myeloma 10 | 1,327
glioblastoma 10 | 5,572
psoriasis 9 | 6,685
atypical teratoid / rhabdoid tumor 8 | 4,369
malignant mesothelioma 8 | 3,162
Xeroderma pigmentosum 7 | 41
acute myeloid leukemia 6 | 780
group 3 medulloblastoma 6 | 2,254
lung adenocarcinoma 6 | 2,713
Alzheimer's disease 5 | 644
Breast cancer 5 | 3,094
Cockayne syndrome 5 | 54
Intellectual disability 5 | 573
Waldenstrons macroglobulinemia 5 | 765
ependymoma 5 | 2,514
oligodendroglioma 5 | 2,849
primitive neuroectodermal tumor 5 | 3,031
Disease Progression 4 | 125
Stevens-Johnson syndrome 4 | 78
adult high grade glioma 4 | 2,148
astrocytic glioma 4 | 2,241
astrocytoma 4 | 1,493
pediatric high grade glioma 4 | 2,712
tuberculosis and treatment for 6 months 4 | 686
Pick disease 3 | 1,893
Stomach Neoplasms 3 | 282
acute quadriplegic myopathy 3 | 1,157
dermatomyositis 3 | 933
diabetes mellitus 3 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
medulloblastoma 3 | 1,524
non-small cell lung cancer 3 | 2,798
pancreatic cancer 3 | 2,300
pilocytic astrocytoma 3 | 3,086
primary pancreatic ductal adenocarcinoma 3 | 1,271
spina bifida 3 | 1,064
Carcinoma in situ of fallopian tube 2 | 2
Craniofacial Abnormalities 2 | 147
Epithelial tumor of ovary 2 | 3
HIV Infections 2 | 100
Liver carcinoma 2 | 217
Lung Neoplasms 2 | 171
Malignant epithelial tumor of ovary 2 | 3
Malignant tumor of ovary 2 | 25
Malignant tumor of peritoneum 2 | 4
Myofibrillar myopathy 1 2 | 5
Myofibrillar myopathy 3 2 | 4
Peripheral Neuropathy 2 | 303
Pick's disease 2 | 14
Prostatic Neoplasms 2 | 471
Rheumatoid Arthritis 2 | 1,160
atypical teratoid/rhabdoid tumor 2 | 1,095
colon cancer 2 | 1,475
group 4 medulloblastoma 2 | 1,875
hepatocellular carcinoma 2 | 532
hereditary spastic paraplegia 2 | 313
invasive ductal carcinoma 2 | 2,950
juvenile dermatomyositis 2 | 1,189
lung carcinoma 2 | 2,844
posterior fossa group B ependymoma 2 | 1,530
progressive supranuclear palsy 2 | 674
sonic hedgehog group medulloblastoma 2 | 1,482
subependymal giant cell astrocytoma 2 | 2,287
Alopecia 1 | 55
Anemia 1 | 252
Animal Mammary Neoplasms 1 | 136
Anoxia 1 | 33
Atherosclerosis 1 | 275
Autistic Disorder 1 | 320
Cardiomyopathies 1 | 90
Cerebrovascular disease 1 | 231
Degenerative polyarthritis 1 | 93
Dermatitis 1 | 107
Dystonia 1 | 77
Eye disease 1 | 55
Gaucher disease type 3 1 | 76
IGA Glomerulonephritis 1 | 454
Inflammation 1 | 109
Kidney Diseases 1 | 86
Kidney disease 1 | 396
Machado-Joseph disease 1 | 18
Mammary Neoplasms 1 | 410
Mammary Neoplasms, Experimental 1 | 150
Neurodegenerative disease 1 | 383
Persistent hyperplastic primary vitreous 1 | 20
Pneumonia 1 | 133
Retinitis pigmentosa 1 | 153
Scabies 1 | 7
Toxic encephalopathy 1 | 131
Uterine Cervical Neoplasm 1 | 21
cystic fibrosis and chronic rhinosinusitis 1 | 213
fascioscapulohumeral muscular dystrophy 1 | 100
head and neck cancer and chronic obstructive pulmonary disease 1 | 237
substance-related disorder 1 | 105

Tissue

Blood and immune system 38 | 17,995
Cardiovascular System 38 | 17,958
Digestive Tract 38 | 18,473
Endocrine System 38 | 18,512
Female tissues 38 | 18,647
Liver and Pancreas 38 | 18,136
Male tissues 38 | 17,969
Nervous System 38 | 18,561
Respiratory system 38 | 17,484
Skin and soft tissues 38 | 18,115
Urinary Tract 38 | 18,444

Target Family

Non-IDG 33 | 11,971
Enzyme 4 | 4,146
Transcription Factor 1 | 1,400

Reactome Pathway

DNA Damage Recognition in GG-N... 38 | 38
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transcriptional repressor protein YY1 YY1 Tbio Transcription Factor -2.75991 594.0 437
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
E3 ubiquitin-protein ligase RBX1 RBX1 Tbio Enzyme -1.88715 67.2 211
COP9 signalosome complex subunit 2 COPS2 Tbio Non-IDG -0.87368 7.80 293
DNA repair protein complementing XP-C cells XPC Tbio Non-IDG -2.19755 151.0 193
Nuclear factor related to kappa-B-binding protein NFRKB Tbio Non-IDG -0.76654 5.89 78
INO80 complex subunit E INO80E Tdark Non-IDG 0.75 0.09 6
Cullin-4A CUL4A Tchem Non-IDG -1.85960 71.2 245
Cullin-4B CUL4B Tbio Non-IDG -1.58988 46.3 205