Development Level

Tbio 31 | 11,445
Tdark 4 | 6,588
Tclin 2 | 613

IMPC Phenotype

embryonic lethality prior to o... 4 | 239
preweaning lethality, complete... 4 | 979
embryonic lethality prior to t... 3 | 278
abnormal seminal vesicle morph... 2 | 114
increased body weight 2 | 25
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal heart shape 1 | 5
abnormal liver size 1 | 5
abnormal pericardium morpholog... 1 | 26
abnormal retinal inner nuclear... 1 | 8
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
abnormal urinary bladder morph... 1 | 11
abnormal vocalization 1 | 21
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating serum al... 1 | 82
decreased fluid intake 1 | 3
decreased prepulse inhibition 1 | 82
decreased total retina thickne... 1 | 17
enlarged heart 1 | 210
hydrometra 1 | 53
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 36
pale yolk sac 1 | 25
small seminal vesicle 1 | 10
small spleen 1 | 19
small superior vagus ganglion 1 | 74
small thymus 1 | 16

Disease

ovarian cancer 26 | 8,520
Carcinoma 19 | 11,493
lung cancer 14 | 4,740
osteosarcoma 13 | 7,950
medulloblastoma, large-cell 11 | 6,241
Cancer 10 | 2,499
Multiple myeloma 9 | 1,332
atypical teratoid / rhabdoid tumor 9 | 5,112
glioblastoma 9 | 5,792
psoriasis 9 | 6,694
malignant mesothelioma 8 | 3,232
Xeroderma pigmentosum 7 | 43
ependymoma 7 | 4,679
group 3 medulloblastoma 7 | 4,104
Cockayne syndrome 6 | 60
acute myeloid leukemia 6 | 783
adult high grade glioma 6 | 3,801
Breast cancer 5 | 3,578
Disease Progression 5 | 136
Waldenstrons macroglobulinemia 5 | 765
lung adenocarcinoma 5 | 2,716
oligodendroglioma 5 | 2,850
Alzheimer's disease 4 | 658
Intellectual disability 4 | 1,016
Stevens-Johnson syndrome 4 | 92
astrocytic glioma 4 | 2,597
primitive neuroectodermal tumor 4 | 3,035
tuberculosis and treatment for 6 months 4 | 409
Anemia 3 | 365
Cryptorchidism 3 | 296
Hypogonadism 3 | 173
Melanoma 3 | 711
Obesity 3 | 678
Pick disease 3 | 1,894
Stomach Neoplasms 3 | 300
acute quadriplegic myopathy 3 | 1,158
astrocytoma 3 | 1,146
diabetes mellitus 3 | 1,728
group 4 medulloblastoma 3 | 1,855
non-small cell lung cancer 3 | 2,890
spina bifida 3 | 1,074
Arthralgia 2 | 90
Arts syndrome 2 | 26
Astrocytoma, Pilocytic 2 | 3,081
Basal cell carcinoma 2 | 54
Carcinoma in situ of fallopian tube 2 | 4
Conjunctival telangiectasis 2 | 14
Dental abnormalities 2 | 60
Developmental regression 2 | 95
Dry skin 2 | 75
Electroencephalogram abnormal 2 | 101
Entropion 2 | 22
Epilepsy 2 | 792
Erythema 2 | 58
Failure to gain weight 2 | 365
Fatigue 2 | 182
Fever 2 | 138
Flushing 2 | 60
Freckles 2 | 33
HIV Infections 2 | 102
Hyperkeratosis 2 | 50
Hyperpigmented macules 2 | 42
Impaired cognition 2 | 96
Keratitis 2 | 62
Loss of developmental milestones 2 | 95
Malignant epithelial tumor of ovary 2 | 5
Malignant tumor of ovary 2 | 25
Malignant tumor of peritoneum 2 | 6
Mental deterioration in childhood 2 | 95
Mental impairment 2 | 95
Neurodevelopmental regression 2 | 95
Pediatric failure to thrive 2 | 365
Photodysphoria 2 | 121
Photophobia 2 | 121
Prostatic Neoplasms 2 | 495
Psychomotor regression 2 | 95
Psychomotor regression beginning in infancy 2 | 95
Psychomotor regression in infants 2 | 95
Psychomotor regression, progressive 2 | 95
Schizophrenia 2 | 1,160
Seizures 2 | 596
Sensorineural Hearing Loss (disorder) 2 | 284
Strabismus 2 | 270
Telangiectasia of the skin 2 | 39
Telangiectasis 2 | 36
Thin skin 2 | 47
Tooth Abnormalities 2 | 69
Xerosis 2 | 75
colon cancer 2 | 1,478
dermatomyositis 2 | 966
hepatocellular carcinoma 2 | 547
hereditary spastic paraplegia 2 | 318
hypopigmented skin patch 2 | 59
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
juvenile dermatomyositis 2 | 1,187
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
progressive supranuclear palsy 2 | 676
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Blood and immune system 37 | 16,909
Cardiovascular System 37 | 15,192
Digestive Tract 37 | 17,369
Endocrine System 37 | 18,159
Female tissues 37 | 17,400
Liver and Pancreas 37 | 16,750
Male tissues 37 | 17,142
Nervous System 37 | 16,725
Respiratory system 37 | 16,393
Skin and soft tissues 37 | 17,230
Urinary Tract 37 | 16,678

Target Family

Non-IDG 32 | 12,091
Enzyme 4 | 4,145
Transcription Factor 1 | 1,400

Reactome Pathway

DNA Damage Recognition in GG-N... 37 | 37
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
COP9 signalosome complex subunit 4 COPS4 Tbio Non-IDG -0.91181 7.39 88
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Nuclear factor related to kappa-B-binding protein NFRKB Tbio Non-IDG -0.80125 6.11 82
INO80 complex subunit E INO80E Tdark Non-IDG -0.13868 1.38 8
COP9 signalosome complex subunit 7a COPS7A Tbio Non-IDG -1.50943 32.2 154
TCF3 fusion partner TFPT Tbio Non-IDG -1.80833 63.1 123
INO80 complex subunit D INO80D Tdark Non-IDG -0.39378 1.30 38