Development Level

Tbio 36 | 10,625
Tchem 7 | 1,890
Tclin 2 | 602
Tdark 2 | 7,003

IMPC Phenotype

preweaning lethality, complete... 6 | 633
embryonic lethality prior to o... 3 | 148
increased mean corpuscular vol... 2 | 91
abnormal behavior 1 | 226
abnormal coat appearance 1 | 25
abnormal coat- hair morphology 1 | 18
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal gait 1 | 51
abnormal hair texture 1 | 4
abnormal pharyngeal arch morph... 1 | 2
decreased basophil cell number 1 | 11
decreased body weight 1 | 174
decreased circulating triglyce... 1 | 83
decreased total body fat amoun... 1 | 186
embryonic growth retardation 1 | 28
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
hypoactivity 1 | 89
increased circulating HDL chol... 1 | 63
increased circulating triglyce... 1 | 24
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased mean corpuscular hem... 1 | 93
increased mean corpuscular hem... 1 | 25
limb grasping 1 | 35
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
preweaning lethality, incomple... 1 | 260

Disease

ovarian cancer 33 | 8,491
osteosarcoma 20 | 7,933
psoriasis 19 | 6,685
lung cancer 17 | 4,473
group 3 medulloblastoma 16 | 2,254
medulloblastoma, large-cell 16 | 6,234
glioblastoma 15 | 5,572
malignant mesothelioma 15 | 3,163
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
primitive neuroectodermal tumor 13 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
Breast cancer 9 | 3,098
Cancer 9 | 2,346
non-small cell lung cancer 9 | 2,798
pediatric high grade glioma 9 | 2,712
oligodendroglioma 8 | 2,849
Multiple myeloma 7 | 1,327
atypical teratoid / rhabdoid tumor 7 | 4,369
atypical teratoid/rhabdoid tumor 7 | 1,095
invasive ductal carcinoma 7 | 2,950
juvenile dermatomyositis 7 | 1,189
Waldenstrons macroglobulinemia 6 | 764
acute myeloid leukemia 6 | 785
astrocytoma 6 | 1,493
dermatomyositis 6 | 966
ependymoma 6 | 2,514
lung adenocarcinoma 6 | 2,714
posterior fossa group A ependymoma 6 | 1,511
astrocytic glioma 5 | 2,241
nasopharyngeal carcinoma 5 | 1,056
Carcinoma 4 | 2,147
IGA Glomerulonephritis 4 | 454
Influenza 4 | 142
Xeroderma pigmentosum 4 | 41
acute quadriplegic myopathy 4 | 1,157
adrenocortical carcinoma 4 | 1,427
adult high grade glioma 4 | 2,148
ductal carcinoma in situ 4 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
pilocytic astrocytoma 4 | 3,086
pituitary cancer 4 | 1,972
progressive supranuclear palsy 4 | 674
Cockayne syndrome 3 | 54
Colorectal Neoplasms 3 | 217
Inclusion body myopathy with Paget disease of bone and frontotemporal dementia 3 | 10
Mammary Paget's disease 3 | 3
Pick disease 3 | 1,893
Stevens-Johnson syndrome 3 | 91
breast carcinoma 3 | 1,614
chronic lymphocytic leukemia 3 | 244
diabetes mellitus 3 | 1,663
esophageal adenocarcinoma 3 | 737
glioblastoma multiforme 3 | 347
interstitial cystitis 3 | 2,299
lung carcinoma 3 | 2,844
pancreatic cancer 3 | 2,300
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
sonic hedgehog group medulloblastoma 3 | 1,482
spina bifida 3 | 1,064
subependymal giant cell astrocytoma 3 | 2,287
tuberculosis 3 | 1,563
Acute lymphoid leukemia 2 | 25
Acute myeloid leukemia, disease 2 | 16
Acute promyelocytic leukemia, FAB M3 2 | 10
Adenocarcinoma of pancreas 2 | 12
Alzheimer's disease 2 | 644
Amyotrophic Lateral Sclerosis 2 | 432
Aplastic anemia 2 | 19
Atopic dermatitis 2 | 944
Colonic Neoplasms 2 | 126
Endometriosis 2 | 535
Familial adenomatous polyposis 2 | 33
Frontotemporal dementia 2 | 47
Inflammatory dermatosis 2 | 38
Intellectual disability 2 | 573
Lymphomatous meningitis 2 | 3
Lynch syndrome 2 | 35
Malignant tumor of ovary 2 | 25
Meningeal Leukemia 2 | 7
Metastatic Breast Carcinoma 2 | 21
Multiple Sclerosis 2 | 498
Myofibrillar myopathy 1 2 | 6
Neurodegenerative disease 2 | 383
Nijmegen breakage syndrome 2 | 23
Pick's disease 2 | 14
Progeria 2 | 22
Rheumatoid Arthritis 2 | 1,170
Seckel syndrome 2 | 35
active Crohn's disease 2 | 918
colon cancer 2 | 1,475
cutaneous lupus erythematosus 2 | 1,056
cystic fibrosis and chronic rhinosinusitis 2 | 213
group 4 medulloblastoma 2 | 1,875
hepatocellular carcinoma 2 | 550
non primary Sjogren syndrome sicca 2 | 840
posterior fossa group B ependymoma 2 | 1,530
primary Sjogren syndrome 2 | 788
primary pancreatic ductal adenocarcinoma 2 | 1,271
tuberculosis and treatment for 6 months 2 | 686
ulcerative colitis 2 | 2,087

Tissue

Blood and immune system 47 | 17,994
Cardiovascular System 47 | 17,957
Digestive Tract 47 | 18,472
Endocrine System 47 | 18,511
Female tissues 47 | 18,646
Liver and Pancreas 47 | 18,135
Male tissues 47 | 17,968
Nervous System 47 | 18,560
Respiratory system 47 | 17,483
Skin and soft tissues 47 | 18,114
Urinary Tract 47 | 18,443

Target Family

Non-IDG 27 | 11,969
Enzyme 19 | 4,146
Transcription Factor 1 | 1,400

Reactome Pathway

DNA Damage Bypass 47 | 47
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Denticleless protein homolog DTL Tbio Non-IDG -1.60626 45.3 123
Ubiquitin-conjugating enzyme E2 B UBE2B Tbio Non-IDG -1.56365 38.8 140
DNA polymerase iota POLI Tbio Enzyme -3.21852 1616.9 231
Ubiquitin-like protein ISG15 ISG15 Tbio Non-IDG -2.43466 301.8 323
DNA polymerase epsilon subunit 3 POLE3 Tbio Enzyme -0.73319 5.86 173
DNA polymerase epsilon subunit 4 POLE4 Tdark Enzyme -0.36530 2.18 29
Ubiquitin carboxyl-terminal hydrolase 43 USP43 Tdark Enzyme 0.48 0.33 107
DNA polymerase zeta catalytic subunit REV3L Tbio Enzyme -2.19003 154.8 36
DNA polymerase epsilon catalytic subunit A POLE Tclin Enzyme -2.17213 141.2 65
SprT-like domain-containing protein Spartan SPRTN Tbio Non-IDG -2.17934 150.6 58