Development Level

Tbio 37 | 10,625
Tdark 12 | 7,003
Tchem 10 | 1,890

IMPC Term

abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal heart morphology 1 | 51
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased body weight 1 | 174
decreased caudal vertebrae num... 1 | 49
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating insulin ... 1 | 75
decreased leukocyte cell numbe... 1 | 54
decreased rib number 1 | 59
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 32 | 8,484
psoriasis 29 | 6,685
lung cancer 27 | 4,466
Breast cancer 25 | 3,094
Cancer 21 | 2,346
lung adenocarcinoma 20 | 2,713
malignant mesothelioma 19 | 3,162
osteosarcoma 19 | 7,933
glioblastoma 16 | 5,572
ductal carcinoma in situ 14 | 1,745
invasive ductal carcinoma 14 | 2,950
medulloblastoma, large-cell 14 | 6,234
non-small cell lung cancer 14 | 2,798
atypical teratoid / rhabdoid tumor 12 | 4,369
breast carcinoma 12 | 1,614
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
Mammary Neoplasms 9 | 410
adrenocortical carcinoma 9 | 1,427
pancreatic cancer 9 | 2,300
Multiple myeloma 8 | 1,327
cystic fibrosis 8 | 1,665
non-small cell lung carcinoma 8 | 413
oligodendroglioma 8 | 2,849
pediatric high grade glioma 8 | 2,712
subependymal giant cell astrocytoma 8 | 2,287
ulcerative colitis 8 | 2,087
Endometriosis 7 | 535
pituitary cancer 7 | 1,972
posterior fossa group A ependymoma 7 | 1,511
primitive neuroectodermal tumor 7 | 3,031
Liver carcinoma 6 | 217
Pick disease 6 | 1,893
colon cancer 6 | 1,475
cutaneous lupus erythematosus 6 | 1,056
diabetes mellitus 6 | 1,663
gastric cancer 6 | 430
pilocytic astrocytoma 6 | 3,086
sonic hedgehog group medulloblastoma 6 | 1,482
Ataxia telangiectasia 5 | 31
Bladder Neoplasm 5 | 109
Carcinoma 5 | 2,147
Melanoma 5 | 261
Nijmegen breakage syndrome 5 | 23
Prostatic Neoplasms 5 | 471
group 3 medulloblastoma 5 | 2,254
hepatocellular carcinoma 5 | 532
interstitial cystitis 5 | 2,299
nasopharyngeal carcinoma 5 | 1,056
progressive supranuclear palsy 5 | 674
Adenoma 4 | 165
Atopic dermatitis 4 | 944
Chronic Lymphocytic Leukemia 4 | 242
Cleft palate 4 | 125
Lupus erythematosus 4 | 80
Multiple Sclerosis 4 | 498
Neoplastic Syndromes, Hereditary 4 | 48
Rheumatoid Arthritis 4 | 1,160
Squamous cell carcinoma of esophagus 4 | 82
Stomach Neoplasms 4 | 282
acute quadriplegic myopathy 4 | 1,157
astrocytoma 4 | 1,493
dermatomyositis 4 | 933
ependymoma 4 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
medulloblastoma 4 | 1,524
non primary Sjogren syndrome sicca 4 | 840
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
Adenoid Cystic Carcinoma 3 | 99
Anemia 3 | 252
Connective tissue disease 3 | 59
Dyskeratosis congenita 3 | 24
Hereditary Breast and Ovarian Cancer Syndrome 3 | 14
IGA Glomerulonephritis 3 | 454
Kidney cancer 3 | 118
Leishmaniasis 3 | 49
Lung Neoplasms 3 | 171
Lymphoid leukemia 3 | 69
Microcephaly 3 | 149
Pancreatic Neoplasm 3 | 79
Polycystic Ovary Syndrome 3 | 332
Sezary Syndrome 3 | 26
Urinary bladder cancer 3 | 31
Waldenstrons macroglobulinemia 3 | 765
acute myeloid leukemia 3 | 780
astrocytic glioma 3 | 2,241
atypical teratoid/rhabdoid tumor 3 | 1,095
group 4 medulloblastoma 3 | 1,875
juvenile dermatomyositis 3 | 1,189
lung carcinoma 3 | 2,844
pancreatic carcinoma 3 | 567
posterior fossa group B ependymoma 3 | 1,530
primary Sjogren syndrome 3 | 789
tuberculosis 3 | 1,557
Male infertility 2 | 170
adult high grade glioma 2 | 2,148
aldosterone-producing adenoma 2 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
inflammatory breast cancer 2 | 404
spina bifida 2 | 1,064

Tissue

Female tissues 59 | 18,647
Male tissues 59 | 17,969
Blood and immune system 58 | 17,995
Cardiovascular System 58 | 17,958
Digestive Tract 58 | 18,473
Endocrine System 58 | 18,512
Nervous System 58 | 18,561
Urinary Tract 58 | 18,444
Liver and Pancreas 57 | 18,136
Respiratory system 57 | 17,484
Skin and soft tissues 51 | 18,115

Target Family

Non-IDG 49 | 11,971
Transcription Factor 5 | 1,400
Enzyme 2 | 4,146
Kinase 2 | 634
Epigenetic 1 | 242

Reactome Pathway

DNA Damage/Telomere Stress Ind... 59 | 59
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Cyclin-dependent kinase inhibitor 1 CDKN1A Tbio Enzyme -3.43357 2997.4 1177
Histone H2B type 1-C/E/F/G/I HIST1H2BC Tbio Non-IDG -1.35785 22.1 103
Calcineurin-binding protein cabin-1 CABIN1 Tbio Non-IDG -3.32776 2068.0 44
Histone H2A.V H2AFV Tdark Non-IDG -1.20240 14.0 30
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.36 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.48218 30.2 48
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.12825 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2A.J H2AFJ Tdark Non-IDG 0.28 0.61 90