Development Level

Tbio 37 | 10,625
Tdark 12 | 7,003
Tchem 10 | 1,890

IMPC Phenotype

abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal heart morphology 1 | 51
abnormal neural tube closure 1 | 37
abnormal neural tube morpholog... 1 | 8
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
decreased body weight 1 | 174
decreased caudal vertebrae num... 1 | 49
decreased circulating alkaline... 1 | 41
decreased circulating calcium ... 1 | 33
decreased circulating insulin ... 1 | 75
decreased leukocyte cell numbe... 1 | 54
decreased rib number 1 | 59
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
small testis 1 | 37

Disease

ovarian cancer 32 | 8,491
psoriasis 29 | 6,685
lung cancer 27 | 4,473
Breast cancer 25 | 3,098
Cancer 21 | 2,346
lung adenocarcinoma 20 | 2,714
malignant mesothelioma 19 | 3,163
osteosarcoma 19 | 7,933
glioblastoma 16 | 5,572
ductal carcinoma in situ 14 | 1,745
invasive ductal carcinoma 14 | 2,950
medulloblastoma, large-cell 14 | 6,234
non-small cell lung cancer 14 | 2,798
atypical teratoid / rhabdoid tumor 12 | 4,369
breast carcinoma 12 | 1,614
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
Mammary Neoplasms 9 | 410
adrenocortical carcinoma 9 | 1,427
pancreatic cancer 9 | 2,300
Multiple myeloma 8 | 1,327
cystic fibrosis 8 | 1,670
non-small cell lung carcinoma 8 | 413
oligodendroglioma 8 | 2,849
pediatric high grade glioma 8 | 2,712
subependymal giant cell astrocytoma 8 | 2,287
ulcerative colitis 8 | 2,087
Endometriosis 7 | 535
hepatocellular carcinoma 7 | 550
pituitary cancer 7 | 1,972
posterior fossa group A ependymoma 7 | 1,511
primitive neuroectodermal tumor 7 | 3,031
Liver carcinoma 6 | 217
Pick disease 6 | 1,893
colon cancer 6 | 1,475
cutaneous lupus erythematosus 6 | 1,056
diabetes mellitus 6 | 1,663
gastric cancer 6 | 436
pilocytic astrocytoma 6 | 3,086
sonic hedgehog group medulloblastoma 6 | 1,482
Ataxia telangiectasia 5 | 32
Bladder Neoplasm 5 | 109
Carcinoma 5 | 2,147
Melanoma 5 | 261
Nijmegen breakage syndrome 5 | 23
Prostatic Neoplasms 5 | 471
group 3 medulloblastoma 5 | 2,254
interstitial cystitis 5 | 2,299
nasopharyngeal carcinoma 5 | 1,056
progressive supranuclear palsy 5 | 674
Adenoma 4 | 165
Atopic dermatitis 4 | 944
Cleft palate 4 | 125
Kidney cancer 4 | 121
Lupus erythematosus 4 | 80
Multiple Sclerosis 4 | 498
Neoplastic Syndromes, Hereditary 4 | 48
Rheumatoid Arthritis 4 | 1,170
Squamous cell carcinoma of esophagus 4 | 82
Stomach Neoplasms 4 | 282
acute quadriplegic myopathy 4 | 1,157
astrocytoma 4 | 1,493
chronic lymphocytic leukemia 4 | 244
dermatomyositis 4 | 966
ependymoma 4 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
medulloblastoma 4 | 1,524
non primary Sjogren syndrome sicca 4 | 840
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
Adenoid Cystic Carcinoma 3 | 99
Anemia 3 | 252
Connective tissue disease 3 | 59
Dyskeratosis congenita 3 | 24
Hereditary Breast and Ovarian Cancer Syndrome 3 | 14
IGA Glomerulonephritis 3 | 454
Leishmaniasis 3 | 49
Lung Neoplasms 3 | 171
Lymphoid leukemia 3 | 69
Microcephaly 3 | 149
Pancreatic Neoplasm 3 | 79
Polycystic Ovary Syndrome 3 | 334
Sezary Syndrome 3 | 26
Urinary bladder cancer 3 | 34
Waldenstrons macroglobulinemia 3 | 764
acute myeloid leukemia 3 | 785
astrocytic glioma 3 | 2,241
atypical teratoid/rhabdoid tumor 3 | 1,095
group 4 medulloblastoma 3 | 1,875
juvenile dermatomyositis 3 | 1,189
lung carcinoma 3 | 2,844
pancreatic carcinoma 3 | 567
posterior fossa group B ependymoma 3 | 1,530
primary Sjogren syndrome 3 | 788
tuberculosis 3 | 1,563
Alzheimer's disease 2 | 644
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
Male infertility 2 | 170
adult high grade glioma 2 | 2,148
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
inflammatory breast cancer 2 | 404

Tissue

Female tissues 59 | 18,646
Male tissues 59 | 17,968
Blood and immune system 58 | 17,994
Cardiovascular System 58 | 17,957
Digestive Tract 58 | 18,472
Endocrine System 58 | 18,511
Nervous System 58 | 18,560
Urinary Tract 58 | 18,443
Liver and Pancreas 57 | 18,135
Respiratory system 57 | 17,483
Skin and soft tissues 51 | 18,114

Target Family

Non-IDG 49 | 11,969
Transcription Factor 5 | 1,400
Enzyme 2 | 4,146
Kinase 2 | 634
Epigenetic 1 | 242

Reactome Pathway

DNA Damage/Telomere Stress Ind... 59 | 59
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 10
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.16 0.33 20
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 42
Histone H2B type 1-N HIST1H2BN Tdark Non-IDG -1.51554 30.2 48
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.26707 18.9 109
Telomeric repeat-binding factor 2-interacting protein 1 TERF2IP Tchem Non-IDG -0.74218 5.60 257
E1A-binding protein p400 EP400 Tbio Non-IDG -1.45388 26.7 53
Telomeric repeat-binding factor 1 TERF1 Tbio Transcription Factor -2.59468 394.2 416
Protein HIRA HIRA Tbio Non-IDG -1.62174 39.5 170
Ubinuclein-1 UBN1 Tbio Non-IDG -1.50664 26.5 73