Development Level

Tbio 40 | 11,445
Tchem 10 | 1,598
Tdark 9 | 6,588

IMPC Phenotype

abnormal embryo size 2 | 220
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
preweaning lethality, complete... 2 | 979
preweaning lethality, incomple... 2 | 499
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased body weight 1 | 161
decreased circulating alkaline... 1 | 46
decreased circulating calcium ... 1 | 36
decreased circulating insulin ... 1 | 76
decreased leukocyte cell numbe... 1 | 73
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hemorrhage 1 | 23
increased mean corpuscular hem... 1 | 96
small seminal vesicle 1 | 10
small testis 1 | 58

Disease

ovarian cancer 32 | 8,520
Carcinoma 30 | 11,493
lung cancer 29 | 4,740
psoriasis 29 | 6,694
Breast cancer 26 | 3,578
Cancer 24 | 2,499
lung adenocarcinoma 20 | 2,716
malignant mesothelioma 19 | 3,232
osteosarcoma 19 | 7,950
glioblastoma 17 | 5,792
atypical teratoid / rhabdoid tumor 16 | 5,112
medulloblastoma, large-cell 15 | 6,241
non-small cell lung cancer 15 | 2,890
ductal carcinoma in situ 14 | 1,745
invasive ductal carcinoma 14 | 2,951
breast carcinoma 13 | 1,638
ependymoma 11 | 4,679
group 3 medulloblastoma 11 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 11 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
pancreatic cancer 10 | 2,398
Breast Neoplasms 9 | 445
Mammary Neoplasms 9 | 425
Schizophrenia 9 | 1,160
adrenocortical carcinoma 9 | 1,428
Multiple myeloma 8 | 1,332
cystic fibrosis 8 | 1,696
oligodendroglioma 8 | 2,850
Ataxia telangiectasia 7 | 34
Endometriosis 7 | 540
Intellectual disability 7 | 1,016
Short stature 7 | 531
adult high grade glioma 7 | 3,801
colon cancer 7 | 1,478
hepatocellular carcinoma 7 | 547
non-small cell lung carcinoma 7 | 317
pituitary cancer 7 | 1,972
primitive neuroectodermal tumor 7 | 3,035
subependymal giant cell astrocytoma 7 | 2,287
ulcerative colitis 7 | 1,819
Astrocytoma, Pilocytic 6 | 3,081
Carcinoma, Hepatocellular 6 | 228
Cleft Palate 6 | 271
Kidney cancer 6 | 2,613
Liver carcinoma 6 | 240
Melanoma 6 | 711
Nijmegen breakage syndrome 6 | 24
Pick disease 6 | 1,894
cutaneous lupus erythematosus 6 | 1,057
diabetes mellitus 6 | 1,728
gastric cancer 6 | 459
Autosomal recessive predisposition 5 | 1,442
Bladder Neoplasm 5 | 112
Chronic Lymphocytic Leukemia 5 | 262
Immune system cancer 5 | 140
Lymphoid leukemia 5 | 160
Multiple Sclerosis 5 | 540
Polycystic ovary syndrome 5 | 360
Prostatic Neoplasms 5 | 495
Urinary Bladder Neoplasms 5 | 114
interstitial cystitis 5 | 2,312
nasopharyngeal carcinoma 5 | 1,058
progressive supranuclear palsy 5 | 676
Adenoma 4 | 167
Atopic dermatitis 4 | 952
Cerebellar Ataxia 4 | 304
Dull intelligence 4 | 645
Esophageal Squamous Cell Carcinoma 4 | 77
Fetal Growth Retardation 4 | 189
Hereditary Breast and Ovarian Cancer Syndrome 4 | 14
Infant, Small for Gestational Age 4 | 176
Intrauterine retardation 4 | 176
Liver cancer 4 | 604
Low intelligence 4 | 645
Lung Neoplasms 4 | 232
Lupus erythematosus 4 | 57
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Microcephaly 4 | 166
Poor school performance 4 | 645
Rheumatoid arthritis 4 | 1,191
Small head 4 | 374
Squamous cell carcinoma of esophagus 4 | 77
Stomach Neoplasms 4 | 300
acute quadriplegic myopathy 4 | 1,158
astrocytic glioma 4 | 2,597
dermatomyositis 4 | 966
group 4 medulloblastoma 4 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
medulloblastoma 4 | 720
non primary Sjogren syndrome sicca 4 | 891
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Male infertility 3 | 206
Precursor Cell Lymphoblastic Leukemia-Lymphoma 3 | 49
Waldenstrons macroglobulinemia 3 | 765
acute myeloid leukemia 3 | 783
astrocytoma 3 | 1,146
juvenile dermatomyositis 3 | 1,187
lung carcinoma 3 | 2,843
primary Sjogren syndrome 3 | 735

Tissue

Endocrine System 59 | 18,159
Blood and immune system 58 | 16,909
Digestive Tract 58 | 17,369
Female tissues 58 | 17,400
Skin and soft tissues 58 | 17,230
Liver and Pancreas 57 | 16,750
Male tissues 57 | 17,142
Nervous System 57 | 16,725
Respiratory system 57 | 16,393
Urinary Tract 57 | 16,678
Cardiovascular System 56 | 15,192

Target Family

Non-IDG 49 | 12,091
Transcription Factor 5 | 1,400
Enzyme 2 | 4,145
Kinase 2 | 634
Epigenetic 1 | 242

Reactome Pathway

DNA Damage/Telomere Stress Ind... 59 | 59
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A.J H2AFJ Tdark Non-IDG -0.00172 0.83 99
Histone H2B type 1-N HIST1H2BN Tbio Non-IDG -1.51422 30.2 60
Histone H2B type 1-L HIST1H2BL Tdark Non-IDG 0.35 0.40 48
Histone H2B type 1-M HIST1H2BM Tdark Non-IDG 0.17 0.33 21
Histone H2A type 1-J HIST1H2AJ Tdark Non-IDG -0.13212 1.19 16
Histone H1.3 HIST1H1D Tbio Non-IDG -1.83212 63.8 66
Histone H1.5 HIST1H1B Tbio Non-IDG -2.13224 134.1 103
Histone H1.2 HIST1H1C Tbio Non-IDG -2.01718 95.3 142
Histone H2A type 1-B/E HIST1H2AB Tbio Non-IDG -1.27041 18.5 133
Telomeric repeat-binding factor 2-interacting protein 1 TERF2IP Tchem Non-IDG -0.75509 5.75 308