Development Level

Tbio 13 | 10,625
Tchem 6 | 1,890
Tclin 4 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

abnormal retinal pigmentation 1 | 61
decreased circulating magnesiu... 1 | 11
decreased neutrophil cell numb... 1 | 37
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
male infertility 1 | 62

Disease

medulloblastoma, large-cell 17 | 6,234
glioblastoma 15 | 5,572
ovarian cancer 14 | 8,484
osteosarcoma 13 | 7,933
psoriasis 13 | 6,685
atypical teratoid / rhabdoid tumor 12 | 4,369
oligodendroglioma 10 | 2,849
pilocytic astrocytoma 10 | 3,086
malignant mesothelioma 9 | 3,162
primitive neuroectodermal tumor 9 | 3,031
subependymal giant cell astrocytoma 9 | 2,287
adult high grade glioma 7 | 2,148
astrocytic glioma 7 | 2,241
ependymoma 7 | 2,514
invasive ductal carcinoma 7 | 2,950
lung cancer 7 | 4,466
Breast cancer 6 | 3,094
Cancer 6 | 2,346
Carney complex 6 | 23
Pick disease 6 | 1,893
Waldenstrons macroglobulinemia 6 | 765
lung adenocarcinoma 6 | 2,713
medulloblastoma 6 | 1,524
pancreatic cancer 6 | 2,300
pediatric high grade glioma 6 | 2,712
tuberculosis 6 | 1,557
Atopic dermatitis 5 | 944
Multiple myeloma 5 | 1,327
astrocytoma 5 | 1,493
colon cancer 5 | 1,475
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
Acrodysostosis 4 | 9
Aphthous ulcer of mouth 4 | 7
Asthma 4 | 349
COPD Associated with Chronic Bronchitis 4 | 11
Dysuria 4 | 24
Increased Urinary Frequency 4 | 11
Nocturia 4 | 8
Parkinson's disease 4 | 364
Schizophrenia 4 | 501
Severe chronic obstructive pulmonary disease 4 | 4
Suprapubic pain 4 | 8
Urgent desire to urinate 4 | 11
Urinary Tract Irritation 4 | 24
Urinary incontinence 4 | 13
aldosterone-producing adenoma 4 | 664
ulcerative colitis 4 | 2,087
Chronic obstructive pulmonary disease 3 | 146
Myocardial Ischemia 3 | 169
Primary pigmented nodular adrenocortical disease 3 | 12
Prostatic Neoplasms 3 | 471
Rheumatoid Arthritis 3 | 1,160
active Crohn's disease 3 | 918
acute quadriplegic myopathy 3 | 1,157
adrenocortical carcinoma 3 | 1,427
atypical teratoid/rhabdoid tumor 3 | 1,095
ductal carcinoma in situ 3 | 1,745
group 3 medulloblastoma 3 | 2,254
group 4 medulloblastoma 3 | 1,875
hereditary spastic paraplegia 3 | 313
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,289
lung carcinoma 3 | 2,844
non primary Sjogren syndrome sicca 3 | 840
non-small cell lung cancer 3 | 2,798
pancreatic carcinoma 3 | 567
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
primary pancreatic ductal adenocarcinoma 3 | 1,271
sonic hedgehog group medulloblastoma 3 | 1,482
Amphetamine-Related Disorders 2 | 74
Amyotrophic Lateral Sclerosis 2 | 431
Asthma management 2 | 20
Autistic Disorder 2 | 320
Bipolar Disorder 2 | 266
Brachydactyly 2 | 52
Carcinoma 2 | 2,147
Cholangiocarcinoma 2 | 32
Crohn's disease 2 | 304
Cushing's syndrome 2 | 47
Down syndrome 2 | 548
Duchenne muscular dystrophy 2 | 602
Gaucher disease type 3 2 | 76
Intellectual disability 2 | 573
Left Ventricular Hypertrophy 2 | 24
Malignant neoplasm of breast 2 | 63
Melancholia 2 | 12
Peripheral Neuropathy 2 | 303
Pulmonary emphysema 2 | 34
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
breast carcinoma 2 | 1,614
chronic rhinosinusitis 2 | 512
cystic fibrosis 2 | 1,665
fibroadenoma 2 | 557
interstitial cystitis 2 | 2,299
interstitial lung disease 2 | 291
pituitary cancer 2 | 1,972
posterior fossa group A ependymoma 2 | 1,511
sarcoidosis 2 | 358
severe Alzheimer's disease 2 | 49
tuberculosis and treatment for 6 months 2 | 686

Tissue

Blood and immune system 23 | 17,995
Cardiovascular System 23 | 17,958
Digestive Tract 23 | 18,473
Endocrine System 23 | 18,512
Female tissues 23 | 18,647
Liver and Pancreas 23 | 18,136
Male tissues 23 | 17,969
Nervous System 23 | 18,561
Respiratory system 23 | 17,484
Skin and soft tissues 23 | 18,115
Urinary Tract 23 | 18,444

Target Family

Enzyme 18 | 4,146
Kinase 4 | 634
Non-IDG 1 | 11,971

Reactome Pathway

DARPP-32 events 23 | 23
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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