Development Level

Tbio 13 | 11,178
Tchem 6 | 1,885
Tclin 4 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
decreased circulating magnesiu... 1 | 13
decreased grip strength 1 | 116
decreased neutrophil cell numb... 1 | 42
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123

Disease

Carcinoma 17 | 11,192
medulloblastoma, large-cell 17 | 6,086
atypical teratoid / rhabdoid tumor 15 | 4,971
glioblastoma 15 | 5,635
ovarian cancer 14 | 8,297
osteosarcoma 13 | 7,766
psoriasis 13 | 6,514
adult high grade glioma 12 | 3,701
astrocytic glioma 11 | 2,530
Astrocytoma, Pilocytic 10 | 3,006
oligodendroglioma 10 | 2,768
ependymoma 9 | 4,559
malignant mesothelioma 9 | 3,135
primitive neuroectodermal tumor 9 | 2,957
subependymal giant cell astrocytoma 9 | 2,230
Depressive disorder 7 | 401
Schizophrenia 7 | 1,136
group 3 medulloblastoma 7 | 4,002
invasive ductal carcinoma 7 | 2,867
lung cancer 7 | 4,607
Breast cancer 6 | 3,469
Cancer 6 | 2,388
Carney complex 6 | 24
Pick disease 6 | 1,856
Waldenstrons macroglobulinemia 6 | 742
lung adenocarcinoma 6 | 2,627
pancreatic cancer 6 | 2,322
tuberculosis 6 | 1,963
Atopic dermatitis 5 | 915
Cognitive delay 5 | 596
Global developmental delay 5 | 596
Mental Depression 5 | 325
Mental and motor retardation 5 | 596
Multiple myeloma 5 | 1,296
colon cancer 5 | 1,428
group 4 medulloblastoma 5 | 1,806
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,902
Acrodysostosis 4 | 12
Aphthous ulcer of mouth 4 | 7
Asthma 4 | 370
Autistic Disorder 4 | 358
Autosomal recessive predisposition 4 | 1,407
Bipolar Disorder 4 | 646
COPD Associated with Chronic Bronchitis 4 | 11
Dull intelligence 4 | 634
Dysuria 4 | 26
Increased Urinary Frequency 4 | 11
Intellectual disability 4 | 998
Low intelligence 4 | 634
Mental Retardation 4 | 634
Mental deficiency 4 | 634
Nocturia 4 | 9
Open mouth 4 | 44
Orbital separation excessive 4 | 240
Parkinson's disease 4 | 378
Poor school performance 4 | 634
Primary pigmented nodular adrenocortical disease 4 | 13
Severe chronic obstructive pulmonary disease 4 | 4
Suprapubic pain 4 | 8
Urgent desire to urinate 4 | 11
Urinary Incontinence 4 | 49
Urinary Tract Irritation 4 | 24
aldosterone-producing adenoma 4 | 646
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,911
ulcerative colitis 4 | 1,765
Anteverted nostril 3 | 186
Chronic obstructive pulmonary disease 3 | 175
Hirsutism 3 | 46
Hydrocephalus 3 | 148
Hypogonadism 3 | 169
Myocardial Ischemia 3 | 162
Obesity 3 | 655
Prostatic Neoplasms 3 | 472
Rheumatoid arthritis 3 | 1,156
Short stature 3 | 514
active Crohn's disease 3 | 882
acute quadriplegic myopathy 3 | 1,133
adrenocortical carcinoma 3 | 1,385
diabetes mellitus 3 | 1,683
ductal carcinoma in situ 3 | 1,686
hereditary spastic paraplegia 3 | 313
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,872
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,204
lung carcinoma 3 | 2,755
medulloblastoma 3 | 702
non primary Sjogren syndrome sicca 3 | 861
non-small cell lung cancer 3 | 2,799
pancreatic carcinoma 3 | 555
Abnormally-shaped vertebrae 2 | 31
Cholangiocarcinoma 2 | 35
Congenital deafness 2 | 180
Downward slant of palpebral fissure 2 | 158
Ecchymosis 2 | 64
Fatigue 2 | 176
Hearing Loss, Partial 2 | 180
Heart failure 2 | 157
Increased tendency to bruise 2 | 64
Muscle Weakness 2 | 168
hearing impairment 2 | 194
sarcoidosis 2 | 357

Tissue

Endocrine System 23 | 18,159
Male tissues 23 | 17,142
Blood and immune system 22 | 16,909
Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678

Target Family

Enzyme 18 | 4,145
Kinase 4 | 634
Non-IDG 1 | 12,091

Reactome Pathway

DARPP-32 events 23 | 23
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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