Development Level

Tbio 13 | 11,445
Tchem 6 | 1,598
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
decreased circulating magnesiu... 1 | 13
decreased grip strength 1 | 116
decreased neutrophil cell numb... 1 | 42
increased neutrophil cell numb... 1 | 46
male infertility 1 | 123

Disease

Carcinoma 17 | 11,493
medulloblastoma, large-cell 17 | 6,241
atypical teratoid / rhabdoid tumor 15 | 5,112
glioblastoma 15 | 5,792
ovarian cancer 14 | 8,520
osteosarcoma 13 | 7,950
psoriasis 13 | 6,694
adult high grade glioma 12 | 3,801
astrocytic glioma 11 | 2,597
Astrocytoma, Pilocytic 10 | 3,081
oligodendroglioma 10 | 2,850
ependymoma 9 | 4,679
malignant mesothelioma 9 | 3,232
primitive neuroectodermal tumor 9 | 3,035
subependymal giant cell astrocytoma 9 | 2,287
Depressive disorder 7 | 409
Schizophrenia 7 | 1,160
group 3 medulloblastoma 7 | 4,104
invasive ductal carcinoma 7 | 2,951
lung cancer 7 | 4,740
Breast cancer 6 | 3,578
Cancer 6 | 2,499
Carney complex 6 | 25
Pick disease 6 | 1,894
Waldenstrons macroglobulinemia 6 | 765
lung adenocarcinoma 6 | 2,716
pancreatic cancer 6 | 2,398
tuberculosis 6 | 2,010
Atopic dermatitis 5 | 952
Cognitive delay 5 | 608
Global developmental delay 5 | 608
Mental Depression 5 | 333
Mental and motor retardation 5 | 608
Multiple myeloma 5 | 1,332
colon cancer 5 | 1,478
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
Acrodysostosis 4 | 12
Aphthous ulcer of mouth 4 | 7
Asthma 4 | 385
Autistic Disorder 4 | 364
Autosomal recessive predisposition 4 | 1,442
Bipolar Disorder 4 | 666
COPD Associated with Chronic Bronchitis 4 | 11
Dull intelligence 4 | 645
Dysuria 4 | 26
Increased Urinary Frequency 4 | 11
Intellectual disability 4 | 1,016
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Nocturia 4 | 9
Open mouth 4 | 45
Orbital separation excessive 4 | 244
Parkinson's disease 4 | 392
Poor school performance 4 | 645
Primary pigmented nodular adrenocortical disease 4 | 13
Severe chronic obstructive pulmonary disease 4 | 4
Suprapubic pain 4 | 8
Urgent desire to urinate 4 | 11
Urinary Incontinence 4 | 50
Urinary Tract Irritation 4 | 24
aldosterone-producing adenoma 4 | 665
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
ulcerative colitis 4 | 1,819
Anteverted nostril 3 | 191
Chronic obstructive pulmonary disease 3 | 184
Hirsutism 3 | 47
Hydrocephalus 3 | 152
Hypogonadism 3 | 173
Myocardial Ischemia 3 | 169
Obesity 3 | 678
Prostatic Neoplasms 3 | 495
Rheumatoid arthritis 3 | 1,191
Short stature 3 | 531
active Crohn's disease 3 | 922
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
diabetes mellitus 3 | 1,728
ductal carcinoma in situ 3 | 1,745
hereditary spastic paraplegia 3 | 318
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung carcinoma 3 | 2,843
medulloblastoma 3 | 720
non primary Sjogren syndrome sicca 3 | 891
non-small cell lung cancer 3 | 2,890
pancreatic carcinoma 3 | 562
Abnormally-shaped vertebrae 2 | 31
Congenital deafness 2 | 185
Deafness 2 | 198
Downward slant of palpebral fissure 2 | 158
Ecchymosis 2 | 66
Fatigue 2 | 182
Hearing Loss, Partial 2 | 185
Heart failure 2 | 162
Increased tendency to bruise 2 | 66
Muscle Weakness 2 | 170
hearing impairment 2 | 199
sarcoidosis 2 | 370

Tissue

Endocrine System 23 | 18,159
Male tissues 23 | 17,142
Blood and immune system 22 | 16,909
Cardiovascular System 22 | 15,192
Digestive Tract 22 | 17,369
Female tissues 22 | 17,400
Liver and Pancreas 22 | 16,750
Nervous System 22 | 16,725
Respiratory system 22 | 16,393
Skin and soft tissues 22 | 17,230
Urinary Tract 22 | 16,678

Target Family

Enzyme 18 | 4,145
Kinase 4 | 634
Non-IDG 1 | 12,091

Reactome Pathway

DARPP-32 events 23 | 23
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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