Development Level

Tbio 186 | 10,625
Tchem 99 | 1,890
Tclin 54 | 602
Tdark 7 | 7,003

Collection

Kinase: IDG Consortium (Targets) 5 | 125
Kinase: IDG Consortium (Complete/Control) 2 | 37

IMPC Phenotype

preweaning lethality, complete... 15 | 633
decreased body weight 13 | 174
decreased total body fat amoun... 9 | 186
decreased circulating choleste... 7 | 85
decreased lean body mass 6 | 195
embryonic lethality prior to t... 6 | 187
abnormal behavior 5 | 226
abnormal embryo size 5 | 112
decreased circulating HDL chol... 5 | 77
decreased lumbar vertebrae num... 5 | 62
enlarged heart 5 | 111
abnormal bone structure 4 | 131
abnormal retina morphology 4 | 100
abnormal retinal pigmentation 4 | 61
decreased body length 4 | 108
decreased bone mineral content 4 | 157
decreased circulating LDL chol... 4 | 37
decreased circulating alanine ... 4 | 53
decreased circulating triglyce... 4 | 83
increased mean corpuscular hem... 4 | 93
thrombocytopenia 4 | 46
abnormal bone mineralization 3 | 55
decreased bone mineral density 3 | 126
decreased circulating glucose ... 3 | 121
decreased circulating total pr... 3 | 41
decreased grip strength 3 | 123
decreased kidney weight 3 | 7
increased circulating alkaline... 3 | 119
abnormal coat-hair pigmentatio... 2 | 54
abnormal cornea morphology 2 | 24
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal lens morphology 2 | 73
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
abnormal seminal vesicle morph... 2 | 47
cataract 2 | 26
decreased circulating chloride... 2 | 32
decreased circulating creatini... 2 | 31
decreased circulating serum al... 2 | 79
decreased circulating sodium l... 2 | 18
decreased heart weight 2 | 44
decreased lactate dehydrogenas... 2 | 14
decreased neutrophil cell numb... 2 | 37
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased thoracic vertebrae n... 2 | 7
dilated heart left ventricle 2 | 10
hypoactivity 2 | 89
impaired pupillary reflex 2 | 14
increased CD4-positive, alpha ... 2 | 15
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating LDL chol... 2 | 15
increased circulating phosphat... 2 | 24
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased mean corpuscular vol... 2 | 91
increased sacral vertebrae num... 2 | 62
increased startle reflex 2 | 38
male infertility 2 | 62
prenatal lethality prior to he... 2 | 64
abnormal behavioral response t... 1 | 52
abnormal body wall morphology 1 | 7
abnormal gait 1 | 51
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 51
abnormal respiratory quotient 1 | 9
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating potassiu... 1 | 17
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased exploration in new e... 1 | 9
decreased total retina thickne... 1 | 20
enlarged spleen 1 | 26
female infertility 1 | 34
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased body length 1 | 20
increased body weight 1 | 42
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating potassiu... 1 | 31
increased mean platelet volume 1 | 19
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
short tibia 1 | 82
thrombocytosis 1 | 23
tremors 1 | 34
vertebral fusion 1 | 23

Disease

osteosarcoma 201 | 7,933
ovarian cancer 194 | 8,491
psoriasis 149 | 6,685
glioblastoma 147 | 5,572
medulloblastoma, large-cell 145 | 6,234
Cancer 143 | 2,346
lung cancer 132 | 4,473
atypical teratoid / rhabdoid tumor 101 | 4,369
pilocytic astrocytoma 86 | 3,086
Breast cancer 83 | 3,098
malignant mesothelioma 83 | 3,163
oligodendroglioma 82 | 2,849
subependymal giant cell astrocytoma 80 | 2,287
Carcinoma 79 | 2,147
invasive ductal carcinoma 79 | 2,950
pediatric high grade glioma 76 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 75 | 3,289
ependymoma 73 | 2,514
lung carcinoma 73 | 2,844
interstitial cystitis 71 | 2,299
lung adenocarcinoma 71 | 2,714
astrocytic glioma 66 | 2,241
primitive neuroectodermal tumor 64 | 3,031
ulcerative colitis 64 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 62 | 2,956
non-small cell lung cancer 62 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 61 | 2,988
pancreatic cancer 57 | 2,300
diabetes mellitus 55 | 1,663
Multiple myeloma 52 | 1,327
group 4 medulloblastoma 51 | 1,875
pituitary cancer 50 | 1,972
tuberculosis 50 | 1,563
Pick disease 47 | 1,893
astrocytoma 47 | 1,493
group 3 medulloblastoma 47 | 2,254
cystic fibrosis 44 | 1,670
Rheumatoid Arthritis 43 | 1,170
medulloblastoma 43 | 1,524
ductal carcinoma in situ 40 | 1,745
adult high grade glioma 38 | 2,148
breast carcinoma 38 | 1,614
pancreatic ductal adenocarcinoma liver metastasis 37 | 1,795
colon cancer 36 | 1,475
juvenile dermatomyositis 36 | 1,189
cutaneous lupus erythematosus 34 | 1,056
Schizophrenia 31 | 503
primary pancreatic ductal adenocarcinoma 31 | 1,271
Prostatic Neoplasms 30 | 471
Mammary Neoplasms 29 | 410
atypical teratoid/rhabdoid tumor 28 | 1,095
primary Sjogren syndrome 28 | 788
Parkinson's disease 27 | 364
spina bifida 27 | 1,064
Alzheimer's disease 26 | 644
Waldenstrons macroglobulinemia 26 | 764
adrenocortical carcinoma 26 | 1,427
dermatomyositis 26 | 966
gastric carcinoma 26 | 832
posterior fossa group B ependymoma 26 | 1,530
Obesity 24 | 616
Intellectual disability 23 | 573
non-small cell lung carcinoma 23 | 413
posterior fossa group A ependymoma 23 | 1,511
Lung Neoplasms 22 | 171
Vascular disease 22 | 281
pancreatic carcinoma 22 | 567
Liver carcinoma 21 | 217
Asthma 20 | 349
acute quadriplegic myopathy 20 | 1,157
HIV Infections 19 | 99
Melanoma 19 | 261
Renal Cell Carcinoma 19 | 199
esophageal adenocarcinoma 19 | 737
non primary Sjogren syndrome sicca 19 | 840
Anemia 18 | 252
Autistic Disorder 18 | 320
Polycystic Ovary Syndrome 18 | 334
Stomach Neoplasms 18 | 282
nasopharyngeal carcinoma 18 | 1,056
tuberculosis and treatment for 6 months 18 | 686
Down syndrome 17 | 548
Kidney disease 17 | 397
hepatocellular carcinoma 17 | 550
sarcoidosis 17 | 368
sonic hedgehog group medulloblastoma 17 | 1,482
Adenoma 16 | 165
Kidney cancer 16 | 121
Multiple Sclerosis 16 | 498
Osteoporosis 16 | 259
acute myeloid leukemia 16 | 785
progressive supranuclear palsy 16 | 674
Amyotrophic Lateral Sclerosis 15 | 432
Duchenne muscular dystrophy 15 | 602
Hypersensitivity reaction type II disease 15 | 235
IGA Glomerulonephritis 15 | 454
Neoplasm Invasiveness 15 | 127
Noonan Syndrome 15 | 33
Peripheral Neuropathy 15 | 303
gastric cancer 15 | 436

Tissue

Endocrine System 346 | 18,511
Female tissues 346 | 18,646
Nervous System 346 | 18,560
Digestive Tract 345 | 18,472
Urinary Tract 345 | 18,443
Liver and Pancreas 344 | 18,135
Blood and immune system 343 | 17,994
Cardiovascular System 342 | 17,957
Male tissues 341 | 17,968
Skin and soft tissues 341 | 18,114
Respiratory system 336 | 17,483

Target Family

Non-IDG 151 | 11,969
Enzyme 112 | 4,146
Kinase 69 | 634
Ion Channel 8 | 341
Transcription Factor 5 | 1,400
Nuclear Receptor 1 | 48

Reactome Pathway

DAP12 signaling 346 | 346
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
Ras/Rap GTPase-activating protein SynGAP SYNGAP1 Tbio Enzyme -1.86167 72.3 167
Ras GTPase-activating protein nGAP RASAL2 Tbio Enzyme -1.50499 28.6 91
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
Trinucleotide repeat-containing gene 6B protein TNRC6B Tbio Non-IDG -0.97375 6.84 59
Fibroblast growth factor receptor substrate 3 FRS3 Tbio Non-IDG -0.89335 9.09 133
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
Ras GTPase-activating protein 4 RASA4 Tbio Enzyme -2.46005 289.6 46