Development Level

Tbio 15 | 11,651
Tchem 9 | 1,388
Tclin 4 | 612

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased body weight 3 | 161
decreased circulating creatini... 2 | 39
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal lens morphology 1 | 81
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating glucose ... 1 | 24
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
thin ventricular wall 1 | 24

Disease

Carcinoma 22 | 11,493
Cancer 20 | 2,499
osteosarcoma 19 | 7,950
ovarian cancer 17 | 8,520
lung cancer 15 | 4,740
psoriasis 13 | 6,694
glioblastoma 12 | 5,792
medulloblastoma, large-cell 11 | 6,241
lung carcinoma 10 | 2,843
group 4 medulloblastoma 9 | 1,855
invasive ductal carcinoma 9 | 2,951
juvenile dermatomyositis 9 | 1,187
subependymal giant cell astrocytoma 9 | 2,287
Kidney cancer 8 | 2,613
interstitial cystitis 8 | 2,312
pancreatic cancer 8 | 2,398
Astrocytoma, Pilocytic 7 | 3,081
Epilepsy 7 | 792
Schizophrenia 7 | 1,160
Seizures 7 | 596
astrocytoma 7 | 1,146
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,291
non-small cell lung cancer 7 | 2,890
ulcerative colitis 7 | 1,819
Autosomal recessive predisposition 6 | 1,442
Delayed bone age 6 | 136
Frontal bossing 6 | 157
Hypoplastic mandible condyle 6 | 275
Mandibular hypoplasia 6 | 275
Melanoma 6 | 711
Micrognathism 6 | 275
Orbital separation excessive 6 | 244
atypical teratoid / rhabdoid tumor 6 | 5,112
cutaneous lupus erythematosus 6 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
primary Sjogren syndrome 6 | 735
Big calvaria 5 | 147
Blepharoptosis 5 | 231
Breast cancer 5 | 3,578
Byzanthine arch palate 5 | 194
Concave bridge of nose 5 | 195
Depressed nasal bridge 5 | 195
Depressed nasal root/bridge 5 | 195
Diarrhea 5 | 253
Downward slant of palpebral fissure 5 | 158
Electroencephalogram abnormal 5 | 101
Excess nuchal skin 5 | 30
Failure to gain weight 5 | 365
Fatigue 5 | 182
High forehead 5 | 102
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Joint hyperflexibility 5 | 78
Multiple myeloma 5 | 1,332
Muscle hypotonia 5 | 571
Pediatric failure to thrive 5 | 365
Short stature 5 | 531
Stomach Neoplasms 5 | 300
Tall forehead 5 | 102
Telecanthus 5 | 62
Ventricular Septal Defects 5 | 119
Waldenstrons macroglobulinemia 5 | 765
breast carcinoma 5 | 1,638
dermatomyositis 5 | 966
ductal carcinoma in situ 5 | 1,745
lung adenocarcinoma 5 | 2,716
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109
Acquired scoliosis 4 | 281
Adenocarcinoma of lung 4 | 142
Basal cell carcinoma 4 | 54
Carcinoma, Hepatocellular 4 | 228
Cardiac Arrhythmia 4 | 103
Cardiac conduction abnormalities 4 | 78
Cerebellar hypoplasia and atrophy 4 | 41
Conduction disorder of the heart 4 | 79
Congenital Epicanthus 4 | 177
Curvature of spine 4 | 282
Depressive disorder 4 | 409
Dilated ventricles (finding) 4 | 121
EKG abnormalities 4 | 78
Electrocardiogram abnormal 4 | 81
Electrocardiogram change 4 | 78
Endometrial cancer 4 | 311
Hemangioma, Cavernous 4 | 20
Isolated cases 4 | 72
Liver carcinoma 4 | 240
Melanocytic nevus 4 | 43
Noncancerous mole 4 | 28
Pectus excavatum 4 | 100
Strabismus 4 | 270
Triangular face 4 | 58
diabetes mellitus 4 | 1,728
nasopharyngeal carcinoma 4 | 1,058
oligodendroglioma 4 | 2,850
pancreatic carcinoma 4 | 562
pediatric high grade glioma 4 | 1,064
tuberculosis 4 | 2,010

Tissue

Blood and immune system 27 | 16,909
Digestive Tract 27 | 17,369
Endocrine System 27 | 18,159
Female tissues 27 | 17,400
Liver and Pancreas 27 | 16,750
Male tissues 27 | 17,142
Nervous System 27 | 16,725
Respiratory system 27 | 16,393
Skin and soft tissues 27 | 17,230
Urinary Tract 27 | 16,678
Cardiovascular System 26 | 15,192

Target Family

Non-IDG 13 | 12,091
Enzyme 8 | 4,145
Kinase 7 | 634

Reactome Pathway

DAP12 signaling 28 | 28
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Guanine nucleotide exchange factor VAV3 VAV3 Tbio Non-IDG -1.82116 74.0 249
Ras-related C3 botulinum toxin substrate 1 RAC1 Tbio Enzyme -1.94674 87.1 452
Guanine nucleotide exchange factor VAV2 VAV2 Tbio Non-IDG -1.81793 64.6 227
Triggering receptor expressed on myeloid cells 2 TREM2 Tbio Non-IDG -2.42594 269.9 370
TYRO protein tyrosine kinase-binding protein TYROBP Tbio Enzyme -2.32694 213.9 206
Growth factor receptor-bound protein 2 GRB2 Tchem Non-IDG -3.02404 981.4 501
Tyrosine-protein kinase BTK BTK Tclin Kinase -3.07545 1199.5 810
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.51919 316.4 758
HLA class I histocompatibility antigen, alpha chain E HLA-E Tbio Non-IDG 0.00000 0