Development Level

Tbio 13 | 10,625
Tchem 11 | 1,890

IMPC Term

preweaning lethality, complete... 6 | 633
embryonic lethality prior to o... 3 | 148
abnormal embryo size 2 | 112
embryonic lethality prior to t... 2 | 187
increased circulating alkaline... 2 | 119
abnormal bone structure 1 | 131
abnormal craniofacial morpholo... 1 | 12
abnormal cranium morphology 1 | 32
abnormal forebrain development 1 | 18
abnormal hindbrain development 1 | 24
abnormal lens morphology 1 | 73
abnormal lung morphology 1 | 15
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal spinal cord morpholog... 1 | 8
cataract 1 | 26
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 32
decreased circulating sodium l... 1 | 18
decreased lean body mass 1 | 195
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
impaired glucose tolerance 1 | 52
increased erythrocyte cell num... 1 | 26
increased red blood cell distr... 1 | 21
increased thermal nociceptive ... 1 | 9

Disease

ovarian cancer 21 | 8,484
Multiple myeloma 13 | 1,327
lung cancer 11 | 4,466
psoriasis 11 | 6,685
glioblastoma 8 | 5,572
medulloblastoma, large-cell 8 | 6,234
Cancer 7 | 2,346
astrocytoma 7 | 1,493
Charcot-Marie-Tooth disease 6 | 74
Neurodegenerative disease 6 | 383
Neuropathy 6 | 210
colon cancer 6 | 1,475
dermatomyositis 6 | 933
diabetes mellitus 6 | 1,663
Waldenstrons macroglobulinemia 5 | 765
juvenile dermatomyositis 5 | 1,189
osteosarcoma 5 | 7,933
sonic hedgehog group medulloblastoma 5 | 1,482
Epilepsy 4 | 346
Myositis 4 | 24
Pick disease 4 | 1,893
acute quadriplegic myopathy 4 | 1,157
non-small cell lung cancer 4 | 2,798
Breast cancer 3 | 3,094
acute myeloid leukemia 3 | 780
lung adenocarcinoma 3 | 2,713
non primary Sjogren syndrome sicca 3 | 840
oligodendroglioma 3 | 2,849
pancreatic cancer 3 | 2,300
pediatric high grade glioma 3 | 2,712
Carcinoma 2 | 2,147
Chronic Lymphocytic Leukemia 2 | 242
Leukodystrophy 2 | 30
Subcutaneous panniculitis-like T-cell lymphoma 2 | 16
active Crohn's disease 2 | 918
adult high grade glioma 2 | 2,148
astrocytic glioma 2 | 2,241
atypical teratoid / rhabdoid tumor 2 | 4,369
breast carcinoma 2 | 1,614
ependymoma 2 | 2,514
group 3 medulloblastoma 2 | 2,254
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
invasive ductal carcinoma 2 | 2,950
malignant mesothelioma 2 | 3,162
medulloblastoma 2 | 1,524
primary pancreatic ductal adenocarcinoma 2 | 1,271
primitive neuroectodermal tumor 2 | 3,031
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis 2 | 1,557
tuberculosis and treatment for 6 months 2 | 686
Alcohol dependence 1 | 107
Anemia 1 | 252
Autistic Disorder 1 | 320
Basal ganglia calcification 1 | 17
Cerebrovascular disease 1 | 231
Childhood disintegrative disease 1 | 4
Cholera 1 | 33
Common cold 1 | 63
Cowpox 1 | 15
Dermatitis 1 | 107
Emery-Dreifuss muscular dystrophy 1 | 24
Endophthalmitis 1 | 10
Filariasis 1 | 21
Friedreich ataxia 1 | 23
Gastroesophageal reflux disease 1 | 37
Gaucher disease type 1 1 | 171
Glycine encephalopathy 1 | 28
Herpes zoster 1 | 7
Homocystinuria 1 | 23
Hyperhomocysteinemia 1 | 34
IGA Glomerulonephritis 1 | 454
Impetigo 1 | 9
Inflammatory myofibroblastic tumor 1 | 8
Leishmaniasis 1 | 49
MYELODYSPLASTIC SYNDROME 1 | 36
Microcephaly 1 | 149
Muscular atrophy 1 | 67
Neuritis 1 | 6
Nonsyndromic deafness 1 | 121
Patellofemoral pain syndrome 1 | 9
Pellagra 1 | 25
Pulmonary alveolar proteinosis 1 | 13
Q fever 1 | 11
Renal Cell Carcinoma 1 | 199
Retinal detachment 1 | 33
Retinitis pigmentosa 1 | 153
Scrapie 1 | 15
Sleeping sickness 1 | 37
Theileriasis 1 | 13
Toxocariasis 1 | 6
Variant Creutzfeldt-Jakob disease 1 | 17
atypical teratoid/rhabdoid tumor 1 | 1,095
head and neck cancer and chronic obstructive pulmonary disease 1 | 237
hereditary spastic paraplegia 1 | 313
interstitial lung disease 1 | 291
progressive supranuclear palsy 1 | 674
sarcoidosis 1 | 358
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 24 | 17,995
Cardiovascular System 24 | 17,958
Digestive Tract 24 | 18,473
Endocrine System 24 | 18,512
Female tissues 24 | 18,647
Liver and Pancreas 24 | 18,136
Male tissues 24 | 17,969
Nervous System 24 | 18,561
Respiratory system 24 | 17,484
Skin and soft tissues 24 | 18,115
Urinary Tract 24 | 18,444

Target Family

Enzyme 23 | 4,146
Non-IDG 1 | 11,971

Reactome Pathway

Cytosolic tRNA aminoacylation 24 | 24
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 AIMP1 Tbio Enzyme -2.04569 136.6 321
Tryptophan--tRNA ligase, cytoplasmic WARS Tbio Enzyme -2.98787 974.3 154
Cysteine--tRNA ligase, cytoplasmic CARS Tbio Enzyme -2.93390 867.8 123
Alanine--tRNA ligase, cytoplasmic AARS Tbio Enzyme -2.41191 251.4 123
Serine--tRNA ligase, cytoplasmic SARS Tbio Enzyme -2.33647 218.9 181
Asparagine--tRNA ligase, cytoplasmic NARS Tbio Enzyme -1.91736 87.4 110
Aspartate--tRNA ligase, cytoplasmic DARS Tbio Enzyme -1.83964 70.7 111
Threonine--tRNA ligase, cytoplasmic TARS Tchem Enzyme -2.57726 386.1 114
Valine--tRNA ligase VARS Tchem Enzyme -1.94333 86.9 101
Histidine--tRNA ligase, cytoplasmic HARS Tchem Enzyme -1.84080 63.9 190