Development Level

Tbio 12 | 11,651
Tchem 11 | 1,388

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 3 | 239
abnormal embryo size 2 | 220
decreased grip strength 2 | 116
embryonic lethality prior to t... 2 | 278
impaired glucose tolerance 2 | 75
abnormal QT variability 1 | 10
abnormal bone structure 1 | 187
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
increased circulating alkaline... 1 | 122
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased red blood cell distr... 1 | 34
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134

Disease

Carcinoma 21 | 11,493
ovarian cancer 20 | 8,520
Multiple myeloma 13 | 1,332
lung cancer 11 | 4,740
psoriasis 10 | 6,694
Autosomal recessive predisposition 8 | 1,442
glioblastoma 8 | 5,792
medulloblastoma, large-cell 8 | 6,241
Cancer 7 | 2,499
diabetes mellitus 7 | 1,728
astrocytoma 6 | 1,146
colon cancer 6 | 1,478
dermatomyositis 6 | 966
Charcot-Marie-Tooth disease 5 | 62
Cognitive delay 5 | 608
Distal sensory impairment 5 | 52
Epilepsy 5 | 792
Global developmental delay 5 | 608
Mental and motor retardation 5 | 608
Neurodegenerative disease 5 | 414
Neuropathy 5 | 261
Waldenstrons macroglobulinemia 5 | 765
juvenile dermatomyositis 5 | 1,187
osteosarcoma 5 | 7,950
Breast cancer 4 | 3,578
Kidney cancer 4 | 2,613
Pick disease 4 | 1,894
Progressive disorder 4 | 142
acute quadriplegic myopathy 4 | 1,158
non-small cell lung cancer 4 | 2,890
sonic hedgehog group medulloblastoma 4 | 467
Anemia 3 | 365
Autosomal recessive Robinow syndrome 3 | 27
Congenital pes cavus 3 | 88
Failure to gain weight 3 | 365
Gait, Drop Foot 3 | 24
Hypoplasia of corpus callosum 3 | 90
Myositis 3 | 30
Pediatric failure to thrive 3 | 365
Small head 3 | 374
acute myeloid leukemia 3 | 783
atypical teratoid / rhabdoid tumor 3 | 5,112
ependymoma 3 | 4,679
group 3 medulloblastoma 3 | 4,104
lung adenocarcinoma 3 | 2,716
non primary Sjogren syndrome sicca 3 | 891
oligodendroglioma 3 | 2,850
pancreatic cancer 3 | 2,398
pediatric high grade glioma 3 | 1,064
tuberculosis 3 | 2,010
Absent reflex 2 | 92
Absent tendon reflex 2 | 92
Axial hypotonia 2 | 46
CNS hypomyelination 2 | 17
Chronic Lymphocytic Leukemia 2 | 262
Congenital deafness 2 | 185
Deafness 2 | 198
Decreased tendon reflex 2 | 122
Distal amyotrophy 2 | 51
Distal limb muscle weakness due to peripheral neuropathy 2 | 62
Distal muscle weakness 2 | 62
Elevated hepatic transaminases 2 | 81
Foot dorsiflexor weakness 2 | 27
Foot-drop 2 | 27
Hearing Loss, Partial 2 | 185
Hemoglobin low 2 | 124
Hepatic enzyme increased 2 | 81
Hepatomegaly 2 | 285
Highly variable severity 2 | 157
Hyperreflexia 2 | 209
Hypomyelination 2 | 17
Leukodystrophy 2 | 55
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Low Vision 2 | 174
Muscle hypotonia 2 | 571
Nystagmus 2 | 317
Reflex, Deep Tendon, Absent 2 | 92
Seizures 2 | 596
Slow progression 2 | 89
Steatohepatitis 2 | 44
Subclinical abnormal liver function tests 2 | 81
Subcutaneous panniculitis-like T-cell lymphoma 2 | 16
Transaminases increased 2 | 81
Variable expressivity 2 | 157
Visual Impairment 2 | 174
active Crohn's disease 2 | 922
adult high grade glioma 2 | 3,801
astrocytic glioma 2 | 2,597
breast carcinoma 2 | 1,638
hearing impairment 2 | 199
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
invasive ductal carcinoma 2 | 2,951
primitive neuroectodermal tumor 2 | 3,035
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 6 months 2 | 409

Tissue

Blood and immune system 23 | 16,909
Cardiovascular System 23 | 15,192
Digestive Tract 23 | 17,369
Endocrine System 23 | 18,159
Female tissues 23 | 17,400
Liver and Pancreas 23 | 16,750
Male tissues 23 | 17,142
Nervous System 23 | 16,725
Respiratory system 23 | 16,393
Skin and soft tissues 23 | 17,230
Urinary Tract 23 | 16,678

Target Family

Enzyme 22 | 4,145
Non-IDG 1 | 12,091

Reactome Pathway

Cytosolic tRNA aminoacylation 23 | 23
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 AIMP2 Tbio Enzyme -1.35413 26.1 138
Serine--tRNA ligase, cytoplasmic SARS Tbio Enzyme -2.37540 230.1 178
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 AIMP1 Tbio Enzyme -2.05952 138.6 386
Lysine--tRNA ligase KARS Tchem Enzyme -2.45716 282.5 150
Glutamine--tRNA ligase QARS Tchem Enzyme -1.63877 42.2 77
Leucine--tRNA ligase, cytoplasmic LARS Tchem Enzyme -3.18894 1507.3 68
Tryptophan--tRNA ligase, cytoplasmic WARS Tbio Enzyme -2.74520 518.6 163
Methionine--tRNA ligase, cytoplasmic MARS Tchem Enzyme -1.75152 50.3 88
Valine--tRNA ligase VARS Tchem Enzyme -1.98726 93.0 112
Threonine--tRNA ligase, cytoplasmic TARS Tchem Enzyme -2.61174 405.9 120