Development Level

Tbio 52 | 11,445
Tchem 16 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
preweaning lethality, incomple... 3 | 499
decreased circulating sodium l... 2 | 22
increased circulating free fat... 2 | 20
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal hair growth 1 | 10
abnormal head morphology 1 | 10
abnormal skin coloration 1 | 25
abnormal skin condition 1 | 6
abnormal startle reflex 1 | 15
absent vibrissae 1 | 12
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased thermal nociceptive ... 1 | 2
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
female infertility 1 | 60
increased blood urea nitrogen ... 1 | 48
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased leukocyte cell numbe... 1 | 47
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
premature death 1 | 5
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 39 | 11,493
ovarian cancer 38 | 8,520
lung cancer 34 | 4,740
osteosarcoma 30 | 7,950
Cancer 28 | 2,499
glioblastoma 21 | 5,792
psoriasis 21 | 6,694
medulloblastoma, large-cell 20 | 6,241
Breast cancer 17 | 3,578
ependymoma 16 | 4,679
Kidney cancer 15 | 2,613
atypical teratoid / rhabdoid tumor 15 | 5,112
Multiple myeloma 14 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
lung carcinoma 14 | 2,843
subependymal giant cell astrocytoma 14 | 2,287
group 3 medulloblastoma 12 | 4,104
Autosomal recessive predisposition 10 | 1,442
adult high grade glioma 10 | 3,801
astrocytoma 10 | 1,146
breast carcinoma 10 | 1,638
juvenile dermatomyositis 10 | 1,187
lung adenocarcinoma 10 | 2,716
oligodendroglioma 10 | 2,850
Schizophrenia 9 | 1,160
acute quadriplegic myopathy 9 | 1,158
astrocytic glioma 9 | 2,597
diabetes mellitus 9 | 1,728
group 4 medulloblastoma 9 | 1,855
primitive neuroectodermal tumor 9 | 3,035
Astrocytoma, Pilocytic 8 | 3,081
Intellectual disability 8 | 1,016
Rheumatoid arthritis 8 | 1,191
acute myeloid leukemia 8 | 783
interstitial cystitis 8 | 2,312
invasive ductal carcinoma 8 | 2,951
malignant mesothelioma 8 | 3,232
non-small cell lung cancer 8 | 2,890
pancreatic cancer 8 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,962
ulcerative colitis 8 | 1,819
Asthma 7 | 385
Cognitive delay 7 | 608
Dull intelligence 7 | 645
Global developmental delay 7 | 608
Inflammatory bowel disease 7 | 151
Influenza 7 | 142
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental and motor retardation 7 | 608
Mental deficiency 7 | 645
Multiple Sclerosis 7 | 540
Poor school performance 7 | 645
Strabismus 7 | 270
Waldenstrons macroglobulinemia 7 | 765
colon cancer 7 | 1,478
cutaneous lupus erythematosus 7 | 1,057
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
pituitary cancer 7 | 1,972
tuberculosis 7 | 2,010
Alzheimer's disease 6 | 658
Arthritis 6 | 290
Epilepsy 6 | 792
Frontal bossing 6 | 157
Immunologic Deficiency Syndromes 6 | 113
Lung disease 6 | 142
Pick disease 6 | 1,894
Seizures 6 | 596
Short stature 6 | 531
Small head 6 | 374
Systemic lupus erythematosus 6 | 194
dermatomyositis 6 | 966
intraductal papillary-mucinous carcinoma (IPMC) 6 | 2,989
Adenocarcinoma of lung 5 | 142
Atopic dermatitis 5 | 952
Bipolar Disorder 5 | 666
Brain Ischemia 5 | 110
Brain disease 5 | 96
Disease Models, Animal 5 | 155
Dysarthria 5 | 192
Highly variable severity 5 | 157
Hyperreflexia 5 | 209
Hypersensitivity reaction type II disease 5 | 253
Hypodontia 5 | 81
Hypoplastic mandible condyle 5 | 275
Mandibular hypoplasia 5 | 275
Micrognathism 5 | 275
Muscle Spasticity 5 | 195
Obesity 5 | 678
Progressive disorder 5 | 142
Variable expressivity 5 | 157
Vascular disease 5 | 319
cystic fibrosis 5 | 1,696
primary pancreatic ductal adenocarcinoma 5 | 1,109
Anemia 4 | 365
Attention deficit hyperactivity disorder 4 | 278
Broad flat nasal bridge 4 | 236
Endometrial cancer 4 | 311
Nasal bridge wide 4 | 236
active Crohn's disease 4 | 922

Tissue

Blood and immune system 67 | 16,909
Digestive Tract 67 | 17,369
Endocrine System 67 | 18,159
Male tissues 67 | 17,142
Skin and soft tissues 67 | 17,230
Cardiovascular System 66 | 15,192
Female tissues 66 | 17,400
Liver and Pancreas 66 | 16,750
Nervous System 66 | 16,725
Respiratory system 66 | 16,393
Urinary Tract 66 | 16,678

Target Family

Enzyme 29 | 4,145
Non-IDG 24 | 12,091
Kinase 7 | 634
Transcription Factor 7 | 1,400
Epigenetic 2 | 242

Reactome Pathway

Cytosolic sensors of pathogen-... 69 | 69
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase III subunit RPC8 POLR3H Tbio Enzyme -1.32118 21.0 104
DNA-directed RNA polymerase III subunit RPC2 POLR3B Tbio Enzyme -1.25377 19.0 105
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.13403 13.5 180
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.90716 7.36 65
NF-kappa-B inhibitor-interacting Ras-like protein 1 NKIRAS1 Tbio Enzyme -0.82896 5.23 242
DNA-directed RNA polymerase III subunit RPC1 POLR3A Tbio Enzyme -2.25632 178.2 99
Protein POLR1D, isoform 2 POLR1D Tbio Non-IDG -1.52326 49.2 0
DNA-directed RNA polymerases I and III subunit RPAC2 POLR1D Tbio Enzyme -1.52326 49.2 0