Development Level

Tbio 11 | 11,445
Tclin 1 | 613

IMPC Phenotype

increased circulating sodium l... 1 | 71
preweaning lethality, complete... 1 | 979

Disease

Carcinoma 6 | 11,493
psoriasis 6 | 6,694
Xeroderma pigmentosum group D 5 | 33
ovarian cancer 5 | 8,520
Cancer 4 | 2,499
osteosarcoma 4 | 7,950
Atrophic condition of skin 3 | 25
group 3 medulloblastoma 3 | 4,104
primitive neuroectodermal tumor 3 | 3,035
Anemia 2 | 365
Autosomal recessive predisposition 2 | 1,442
Breast cancer 2 | 3,578
Cerebral atrophy 2 | 178
Cockayne syndrome 2 | 60
Cognitive delay 2 | 608
Colorectal Neoplasms 2 | 243
Contracture 2 | 96
Contracture of joint 2 | 93
Cryptorchidism 2 | 296
Deafness 2 | 198
Dull intelligence 2 | 645
Failure to gain weight 2 | 365
Fetal Growth Retardation 2 | 189
Flexion contracture 2 | 93
Flexion contractures of joints 2 | 93
Global developmental delay 2 | 608
Hyperpigmented macules 2 | 42
Hypogonadism 2 | 173
Hypoplastic mandible condyle 2 | 275
Infant, Small for Gestational Age 2 | 176
Intellectual disability 2 | 1,016
Intrauterine retardation 2 | 176
Low intelligence 2 | 645
Mandibular hypoplasia 2 | 275
Mental Retardation 2 | 645
Mental and motor retardation 2 | 608
Mental deficiency 2 | 645
Micrognathism 2 | 275
Muscle Hypertonia 2 | 88
Pediatric failure to thrive 2 | 365
Photosensitive trichothiodystrophy 2 | 30
Poor school performance 2 | 645
Sensorineural Hearing Loss (disorder) 2 | 284
Short stature 2 | 531
Small head 2 | 374
Spider Veins 2 | 17
Telangiectasia of the skin 2 | 39
Telangiectasis 2 | 36
Warsaw breakage syndrome 2 | 11
Xeroderma pigmentosum 2 | 43
atypical teratoid / rhabdoid tumor 2 | 5,112
glioblastoma 2 | 5,792
hypopigmented skin patch 2 | 59
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
malignant mesothelioma 2 | 3,232
medulloblastoma, large-cell 2 | 6,241
non-small cell lung cancer 2 | 2,890
Abnormal nasal morphology 1 | 16
Baller-Gerold syndrome 1 | 12
Basal cell nevi 1 | 23
Bloom syndrome 1 | 29
Brittle hair 1 | 25
Cerebral calcification 1 | 43
Conjunctivitis 1 | 53
Conjunctivitis, recurrent 1 | 37
Death in childhood 1 | 14
Ectropion 1 | 38
Everted lower lip vermilion 1 | 54
Excessive wrinkled skin 1 | 16
Fractured hair 1 | 25
Fragile hair 1 | 25
Generalized hyperpigmentation 1 | 22
Hereditary Breast and Ovarian Cancer Syndrome 1 | 14
Hyperkyphosis 1 | 111
Hypertriglyceridemia result 1 | 37
Hypoplasia of scrotum 1 | 24
Idiopathic pulmonary fibrosis 1 | 23
Kyphosis deformity of spine 1 | 114
Lipodystrophy 1 | 40
Meningeal Leukemia 1 | 7
Papilloma 1 | 44
Pertussis 1 | 20
Photosensitivity of skin 1 | 51
Poikiloderma 1 | 14
Postnatal growth retardation 1 | 57
Precociously senile appearance 1 | 18
Premature canities 1 | 24
Protruding lower lip 1 | 54
Pulmonary Fibrosis 1 | 106
Reduced tensile strength of hair 1 | 25
Rothmund-Thomson syndrome 1 | 19
Scrapie 1 | 17
Skin Abnormalities 1 | 37
Skin Neoplasms 1 | 69
Skin benign neoplasm 1 | 6
Sparse scalp hair 1 | 42
Steatohepatitis 1 | 44
Tetanus 1 | 68
Xeroderma pigmentosum group F 1 | 22

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Non-IDG 8 | 12,091
Enzyme 4 | 4,145

Reactome Pathway

Cytosolic iron-sulfur cluster ... 12 | 12
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytosolic Fe-S cluster assembly factor NUBP2 NUBP2 Tbio Non-IDG -1.46950 32.1 59
Cytosolic Fe-S cluster assembly factor NUBP1 NUBP1 Tbio Non-IDG -1.31867 20.0 105
Probable cytosolic iron-sulfur protein assembly protein CIAO1 CIAO1 Tbio Non-IDG -1.44311 25.1 161
Regulator of telomere elongation helicase 1 RTEL1 Tbio Enzyme -2.66156 233.0 85
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.81875 78.3 223
TFIIH basal transcription factor complex helicase XPD subunit ERCC2 Tbio Enzyme -2.58326 365.8 191
MMS19 nucleotide excision repair protein homolog MMS19 Tbio Non-IDG -1.66416 46.5 122
Mitotic spindle-associated MMXD complex subunit MIP18 FAM96B Tbio Non-IDG -0.82677 5.83 108
NADPH-dependent diflavin oxidoreductase 1 NDOR1 Tbio Enzyme -0.73362 5.15 159
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225