Development Level

Tbio 534 | 11,651
Tchem 134 | 1,388
Tclin 66 | 612
Tdark 18 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 37 | 979
preweaning lethality, incomple... 24 | 499
enlarged heart 14 | 210
abnormal seminal vesicle morph... 13 | 114
decreased vertical activity 11 | 208
embryonic lethality prior to o... 10 | 239
embryonic lethality prior to t... 10 | 278
abnormal heart morphology 9 | 162
male infertility 9 | 123
abnormal bone structure 8 | 187
decreased total body fat amoun... 8 | 207
increased neutrophil cell numb... 8 | 46
decreased circulating creatini... 7 | 39
increased mean corpuscular hem... 7 | 96
abnormal embryo size 6 | 220
decreased bone mineral content 6 | 151
decreased lean body mass 6 | 135
decreased mean corpuscular vol... 6 | 79
female infertility 6 | 60
increased lean body mass 6 | 172
increased mean corpuscular vol... 6 | 92
increased monocyte cell number 6 | 63
abnormal sleep behavior 5 | 70
decreased circulating glucose ... 5 | 126
increased circulating alkaline... 5 | 122
increased lymphocyte cell numb... 5 | 32
short tibia 5 | 97
abnormal behavior 4 | 298
abnormal retina morphology 4 | 71
abnormal spleen morphology 4 | 55
decreased hemoglobin content 4 | 68
decreased lymphocyte cell numb... 4 | 83
decreased mean corpuscular hem... 4 | 50
embryonic growth retardation 4 | 106
hydrometra 4 | 53
improved glucose tolerance 4 | 79
increased bone mineral content 4 | 108
increased bone mineral density 4 | 72
increased leukocyte cell numbe... 4 | 47
increased or absent threshold ... 4 | 101
small superior vagus ganglion 4 | 74
thrombocytopenia 4 | 56
abnormal epididymis morphology 3 | 42
abnormal gait 3 | 69
abnormal skin morphology 3 | 50
decreased body weight 3 | 161
decreased circulating choleste... 3 | 93
decreased circulating insulin ... 3 | 76
decreased erythrocyte cell num... 3 | 62
decreased hematocrit 3 | 46
decreased mean corpuscular hem... 3 | 31
enlarged epididymis 3 | 31
enlarged lymph nodes 3 | 37
hyperactivity 3 | 148
impaired glucose tolerance 3 | 75
increased blood urea nitrogen ... 3 | 48
increased hematocrit 3 | 46
increased total body fat amoun... 3 | 134
limb grasping 3 | 41
small testis 3 | 58
abnormal eye anterior chamber ... 2 | 9
abnormal femur morphology 2 | 14
abnormal humerus morphology 2 | 11
abnormal kidney morphology 2 | 65
abnormal lens morphology 2 | 81
abnormal lung morphology 2 | 26
abnormal neural tube closure 2 | 46
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased circulating HDL chol... 2 | 68
decreased circulating aspartat... 2 | 34
decreased circulating bilirubi... 2 | 19
decreased circulating calcium ... 2 | 36
decreased circulating chloride... 2 | 30
decreased circulating serum al... 2 | 82
decreased circulating sodium l... 2 | 22
decreased circulating triglyce... 2 | 79
decreased heart weight 2 | 27
decreased large unstained cell... 2 | 11
decreased mature B cell number 2 | 7
decreased neutrophil cell numb... 2 | 42
decreased red blood cell distr... 2 | 41
decreased startle reflex 2 | 75
edema 2 | 59
enlarged spleen 2 | 41
hypoactivity 2 | 132
increased circulating chloride... 2 | 41
increased circulating sodium l... 2 | 71
increased erythrocyte cell num... 2 | 39
increased fasted circulating g... 2 | 76
increased grip strength 2 | 41
increased heart weight 2 | 62
increased hemoglobin content 2 | 45
increased large unstained cell... 2 | 5
increased mean corpuscular hem... 2 | 36
increased prepulse inhibition 2 | 32
increased spleen weight 2 | 10
abnormal cornea morphology 1 | 31
abnormal vertebrae morphology 1 | 18

Disease

Carcinoma 441 | 11,493
psoriasis 394 | 6,694
Cancer 377 | 2,499
ovarian cancer 366 | 8,520
osteosarcoma 324 | 7,950
glioblastoma 296 | 5,792
lung cancer 294 | 4,740
medulloblastoma, large-cell 239 | 6,241
diabetes mellitus 192 | 1,728
tuberculosis 192 | 2,010
malignant mesothelioma 191 | 3,232
lung carcinoma 186 | 2,843
Rheumatoid arthritis 180 | 1,191
atypical teratoid / rhabdoid tumor 180 | 5,112
ependymoma 170 | 4,679
adult high grade glioma 168 | 3,801
Astrocytoma, Pilocytic 163 | 3,081
Breast cancer 162 | 3,578
interstitial cystitis 158 | 2,312
invasive ductal carcinoma 150 | 2,951
ulcerative colitis 145 | 1,819
subependymal giant cell astrocytoma 144 | 2,287
Arthritis 143 | 290
intraductal papillary-mucinous neoplasm (IPMN) 141 | 3,291
dermatomyositis 140 | 966
pancreatic cancer 140 | 2,398
Hypersensitivity reaction type II disease 139 | 253
group 3 medulloblastoma 139 | 4,104
Multiple Sclerosis 136 | 540
non-small cell lung cancer 135 | 2,890
cutaneous lupus erythematosus 120 | 1,057
Multiple myeloma 118 | 1,332
intraductal papillary-mucinous carcinoma (IPMC) 115 | 2,989
juvenile dermatomyositis 115 | 1,187
cystic fibrosis 112 | 1,696
lung adenocarcinoma 112 | 2,716
Schizophrenia 109 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 103 | 2,955
Asthma 100 | 385
pituitary cancer 97 | 1,972
breast carcinoma 94 | 1,638
primitive neuroectodermal tumor 92 | 3,035
Ankylosing spondylitis 91 | 140
Liver Cirrhosis, Experimental 90 | 769
oligodendroglioma 90 | 2,850
primary Sjogren syndrome 89 | 735
pancreatic ductal adenocarcinoma liver metastasis 88 | 1,962
Acquired immunodeficiency syndrome 86 | 197
astrocytoma 85 | 1,146
Dermatitis 83 | 157
group 4 medulloblastoma 83 | 1,855
Kidney cancer 82 | 2,613
Kidney disease 81 | 430
Human immunodeficiency virus infectious disease 80 | 138
Juvenile rheumatoid arthritis 77 | 111
Uveitis 76 | 103
astrocytic glioma 76 | 2,597
Behcet's disease 75 | 89
Autosomal recessive predisposition 73 | 1,442
ductal carcinoma in situ 72 | 1,745
active Crohn's disease 71 | 922
colon cancer 71 | 1,478
Anemia 69 | 365
Inflammatory bowel disease 69 | 151
active ulcerative colitis 67 | 764
Psoriatic arthritis 66 | 86
Atopic dermatitis 65 | 952
Pick disease 65 | 1,894
Waldenstrons macroglobulinemia 64 | 765
Liver disease 63 | 237
Herpes zoster 62 | 68
Stevens-Johnson syndrome 62 | 92
Vascular disease 61 | 319
acute quadriplegic myopathy 61 | 1,158
Influenza 58 | 142
Lung disease 58 | 142
Obesity 57 | 678
esophageal adenocarcinoma 56 | 737
Pneumonia 55 | 174
Systemic lupus erythematosus 55 | 194
nasopharyngeal carcinoma 55 | 1,058
Synovitis 54 | 78
primary pancreatic ductal adenocarcinoma 54 | 1,109
sarcoidosis 54 | 370
adrenocortical carcinoma 53 | 1,428
pediatric high grade glioma 53 | 1,064
Hepatitis B 52 | 108
Bipolar Disorder 51 | 666
Prostatic Neoplasms 51 | 495
Breast Neoplasms 48 | 445
Depressive disorder 48 | 409
Hypertension 47 | 396
Myocardial Ischemia 47 | 169
hepatocellular carcinoma 47 | 547
Alzheimer's disease 46 | 658
Atherosclerosis 46 | 291
Mammary Neoplasms 46 | 425
Inflammation 45 | 120
gastric carcinoma 45 | 807
Crohn's disease 44 | 321

Tissue

Digestive Tract 641 | 17,369
Blood and immune system 640 | 16,909
Endocrine System 638 | 18,159
Skin and soft tissues 635 | 17,230
Female tissues 634 | 17,400
Liver and Pancreas 631 | 16,750
Urinary Tract 630 | 16,678
Male tissues 626 | 17,142
Respiratory system 623 | 16,393
Nervous System 605 | 16,725
Cardiovascular System 585 | 15,192

Target Family

Non-IDG 487 | 12,091
Enzyme 139 | 4,145
Kinase 64 | 634
Transcription Factor 47 | 1,400
GPCR 8 | 408
Epigenetic 3 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38
Transporter 1 | 473

Reactome Pathway

Cytokine Signaling in Immune s... 752 | 752
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Interleukin-9 IL9 Tbio Non-IDG -2.50811 334.4 459
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
HLA class I histocompatibility antigen, B-51 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Tumor necrosis factor receptor superfamily member 4 TNFRSF4 Tbio Non-IDG -2.60147 430.2 524
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
E3 ubiquitin-protein ligase ARIH1 ARIH1 Tbio Enzyme -2.26078 179.2 81