Development Level

Tbio 522 | 10,625
Tchem 172 | 1,890
Tclin 86 | 602
Tdark 23 | 7,003

Collection

Kinase: IDG Consortium (Complete/Control) 2 | 37
Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 29 | 633
enlarged heart 12 | 111
decreased lean body mass 11 | 195
decreased total body fat amoun... 11 | 186
preweaning lethality, incomple... 11 | 260
decreased body weight 9 | 174
decreased bone mineral content 9 | 157
embryonic lethality prior to t... 8 | 187
abnormal bone structure 7 | 131
abnormal embryo size 7 | 112
increased mean corpuscular hem... 7 | 93
abnormal seminal vesicle morph... 6 | 47
decreased body length 6 | 108
decreased circulating HDL chol... 6 | 77
increased lean body mass 6 | 107
increased mean corpuscular vol... 6 | 91
thrombocytopenia 6 | 46
decreased circulating alanine ... 5 | 53
decreased circulating choleste... 5 | 85
decreased circulating glucose ... 5 | 121
decreased lumbar vertebrae num... 5 | 62
embryonic lethality prior to o... 5 | 148
abnormal behavior 4 | 226
abnormal retina morphology 4 | 100
decreased circulating serum al... 4 | 79
decreased circulating triglyce... 4 | 83
decreased grip strength 4 | 123
decreased heart weight 4 | 44
decreased neutrophil cell numb... 4 | 37
improved glucose tolerance 4 | 56
increased circulating HDL chol... 4 | 63
increased circulating alkaline... 4 | 119
increased grip strength 4 | 83
male infertility 4 | 62
abnormal femur morphology 3 | 14
abnormal neural tube closure 3 | 37
abnormal retinal pigmentation 3 | 61
abnormal sleep behavior 3 | 63
decreased CD4-positive, CD25-p... 3 | 24
decreased caudal vertebrae num... 3 | 49
decreased circulating LDL chol... 3 | 37
decreased circulating creatini... 3 | 31
decreased circulating insulin ... 3 | 75
decreased circulating sodium l... 3 | 18
decreased erythrocyte cell num... 3 | 43
decreased kidney weight 3 | 7
decreased lactate dehydrogenas... 3 | 14
decreased monocyte cell number 3 | 28
enlarged epididymis 3 | 27
enlarged lymph nodes 3 | 27
female infertility 3 | 34
hypoactivity 3 | 89
increased body weight 3 | 42
increased bone mineral content 3 | 92
increased hemoglobin content 3 | 45
increased leukocyte cell numbe... 3 | 37
short tibia 3 | 82
abnormal QRS complex 2 | 25
abnormal coat-hair pigmentatio... 2 | 54
abnormal cornea morphology 2 | 24
abnormal gait 2 | 51
abnormal heart morphology 2 | 51
abnormal lens morphology 2 | 73
abnormal spleen morphology 2 | 36
cardiovascular system phenotyp... 2 | 35
cataract 2 | 26
decreased T cell number 2 | 31
decreased bone mineral density 2 | 126
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating free fat... 2 | 39
decreased circulating total pr... 2 | 41
decreased effector memory CD8-... 2 | 24
decreased fasted circulating g... 2 | 49
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased startle reflex 2 | 48
decreased thoracic vertebrae n... 2 | 7
dilated heart left ventricle 2 | 10
enlarged spleen 2 | 26
impaired glucose tolerance 2 | 52
increased NK cell number 2 | 19
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased bone mineral density 2 | 52
increased circulating chloride... 2 | 43
increased circulating serum al... 2 | 25
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
limb grasping 2 | 35
small superior vagus ganglion 2 | 20
small testis 2 | 37
vertebral fusion 2 | 23

Disease

psoriasis 405 | 6,685
Cancer 386 | 2,346
ovarian cancer 384 | 8,491
osteosarcoma 356 | 7,933
lung cancer 313 | 4,473
glioblastoma 299 | 5,572
medulloblastoma, large-cell 254 | 6,234
lung carcinoma 195 | 2,844
malignant mesothelioma 191 | 3,163
diabetes mellitus 185 | 1,663
pilocytic astrocytoma 183 | 3,086
ulcerative colitis 183 | 2,087
interstitial cystitis 175 | 2,299
Rheumatoid Arthritis 173 | 1,170
invasive ductal carcinoma 171 | 2,950
atypical teratoid / rhabdoid tumor 163 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 162 | 3,289
Breast cancer 154 | 3,098
subependymal giant cell astrocytoma 153 | 2,287
pancreatic cancer 152 | 2,300
tuberculosis 151 | 1,563
non-small cell lung cancer 149 | 2,798
pediatric high grade glioma 137 | 2,712
Hypersensitivity reaction type II disease 133 | 235
lung adenocarcinoma 133 | 2,714
Multiple Sclerosis 132 | 498
dermatomyositis 132 | 966
Arthritis 131 | 248
cutaneous lupus erythematosus 122 | 1,056
intraductal papillary-mucinous adenoma (IPMA) 122 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 122 | 2,988
cystic fibrosis 120 | 1,670
oligodendroglioma 115 | 2,849
juvenile dermatomyositis 113 | 1,189
Multiple myeloma 111 | 1,327
pituitary cancer 110 | 1,972
astrocytoma 108 | 1,493
ependymoma 102 | 2,514
breast carcinoma 99 | 1,614
Carcinoma 97 | 2,147
primitive neuroectodermal tumor 94 | 3,031
adult high grade glioma 93 | 2,148
Asthma 91 | 349
group 4 medulloblastoma 91 | 1,875
primary Sjogren syndrome 91 | 788
Ankylosing spondylitis 90 | 138
posterior fossa group A ependymoma 90 | 1,511
group 3 medulloblastoma 88 | 2,254
ductal carcinoma in situ 86 | 1,745
Acquired immunodeficiency syndrome 82 | 164
Kidney disease 82 | 397
astrocytic glioma 81 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 81 | 1,795
colon cancer 80 | 1,475
Dermatitis 77 | 141
Human immunodeficiency virus infectious disease 76 | 129
Uveitis 73 | 103
Pick disease 72 | 1,893
primary pancreatic ductal adenocarcinoma 72 | 1,271
Juvenile rheumatoid arthritis 71 | 105
active Crohn's disease 70 | 918
Atopic dermatitis 66 | 944
Psoriatic arthritis 65 | 85
gastric carcinoma 62 | 832
Liver disease 61 | 219
Stevens-Johnson syndrome 61 | 91
Behcet's disease 60 | 74
adrenocortical carcinoma 60 | 1,427
esophageal adenocarcinoma 60 | 737
Inflammatory bowel disease 59 | 142
Mammary Neoplasms 57 | 410
medulloblastoma 57 | 1,524
Anemia 56 | 252
nasopharyngeal carcinoma 56 | 1,056
sarcoidosis 56 | 368
Influenza 55 | 142
Obesity 54 | 616
Lung disease 53 | 136
Waldenstrons macroglobulinemia 53 | 764
systemic lupus erythematosus 53 | 172
Prostatic Neoplasms 52 | 471
hepatocellular carcinoma 52 | 550
Synovitis 51 | 72
acute quadriplegic myopathy 51 | 1,157
Hepatitis B 50 | 103
Vascular disease 50 | 281
Atherosclerosis 49 | 275
spina bifida 48 | 1,064
Stomach Neoplasms 45 | 282
Endometriosis 44 | 535
IGA Glomerulonephritis 44 | 454
Myocardial Ischemia 44 | 169
pancreatic carcinoma 44 | 567
Crohn's disease 43 | 304
Duchenne muscular dystrophy 43 | 602
Lung Neoplasms 43 | 171
atypical teratoid/rhabdoid tumor 43 | 1,095
inflammatory breast cancer 43 | 404
mucosa-associated lymphoid tissue lymphoma 43 | 480
non-small cell lung carcinoma 43 | 413

Tissue

Nervous System 725 | 18,560
Female tissues 721 | 18,646
Digestive Tract 720 | 18,472
Urinary Tract 719 | 18,443
Endocrine System 717 | 18,511
Blood and immune system 712 | 17,994
Liver and Pancreas 711 | 18,135
Cardiovascular System 704 | 17,957
Skin and soft tissues 703 | 18,114
Male tissues 695 | 17,968
Respiratory system 692 | 17,483

Target Family

Non-IDG 535 | 11,969
Enzyme 140 | 4,146
Kinase 72 | 634
Transcription Factor 37 | 1,400
GPCR 8 | 408
Ion Channel 5 | 341
Epigenetic 3 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

Reactome Pathway

Cytokine Signaling in Immune s... 803 | 803
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.86495 767.9 361
Interleukin-9 IL9 Tbio Non-IDG -2.46520 301.6 339
Interferon gamma receptor 1 IFNGR1 Tchem Non-IDG -2.19638 160.9 450
Interferon-induced transmembrane protein 3 IFITM3 Tbio Non-IDG -1.87958 126.0 172
Interferon-induced transmembrane protein 2 IFITM2 Tbio Non-IDG -2.21851 158.1 111
E3 ubiquitin-protein ligase TRIM17 TRIM17 Tbio Enzyme -1.93165 73.2 100
Receptor tyrosine-protein kinase erbB-2 ERBB2 Tclin Kinase -4.25806 19000.3 3336
CD40 ligand CD40LG Tchem Non-IDG -4.56976 36580.5 1095
Interleukin-1 receptor-like 1 IL1RL1 Tbio Non-IDG -2.01457 91.7 269
Guanylate-binding protein 4 GBP4 Tbio Non-IDG -1.67376 45.5 102