Development Level

Tbio 522 | 10,625
Tchem 173 | 1,890
Tclin 86 | 602
Tdark 23 | 7,003

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 29 | 633
enlarged heart 12 | 111
decreased lean body mass 11 | 195
decreased total body fat amoun... 11 | 186
preweaning lethality, incomple... 11 | 260
decreased body weight 9 | 174
decreased bone mineral content 9 | 157
embryonic lethality prior to t... 8 | 187
abnormal bone structure 7 | 131
abnormal embryo size 7 | 112
increased mean corpuscular hem... 7 | 93
abnormal seminal vesicle morph... 6 | 47
decreased body length 6 | 108
decreased circulating HDL chol... 6 | 77
increased lean body mass 6 | 107
increased mean corpuscular vol... 6 | 91
thrombocytopenia 6 | 46
decreased circulating alanine ... 5 | 53
decreased circulating choleste... 5 | 85
decreased circulating glucose ... 5 | 121
decreased lumbar vertebrae num... 5 | 62
embryonic lethality prior to o... 5 | 148
abnormal behavior 4 | 226
abnormal retina morphology 4 | 100
decreased circulating serum al... 4 | 79
decreased circulating triglyce... 4 | 83
decreased grip strength 4 | 123
decreased heart weight 4 | 44
decreased neutrophil cell numb... 4 | 37
improved glucose tolerance 4 | 56
increased circulating HDL chol... 4 | 63
increased circulating alkaline... 4 | 119
increased grip strength 4 | 83
male infertility 4 | 62
abnormal femur morphology 3 | 14
abnormal neural tube closure 3 | 37
abnormal retinal pigmentation 3 | 61
abnormal sleep behavior 3 | 63
decreased CD4-positive, CD25-p... 3 | 24
decreased caudal vertebrae num... 3 | 49
decreased circulating LDL chol... 3 | 37
decreased circulating creatini... 3 | 31
decreased circulating insulin ... 3 | 75
decreased circulating sodium l... 3 | 18
decreased erythrocyte cell num... 3 | 43
decreased kidney weight 3 | 7
decreased lactate dehydrogenas... 3 | 14
decreased monocyte cell number 3 | 28
enlarged epididymis 3 | 27
enlarged lymph nodes 3 | 27
female infertility 3 | 34
hypoactivity 3 | 89
increased body weight 3 | 42
increased bone mineral content 3 | 92
increased hemoglobin content 3 | 45
increased leukocyte cell numbe... 3 | 37
short tibia 3 | 82
abnormal QRS complex 2 | 25
abnormal coat/hair pigmentatio... 2 | 54
abnormal cornea morphology 2 | 24
abnormal gait 2 | 51
abnormal heart morphology 2 | 51
abnormal lens morphology 2 | 73
abnormal spleen morphology 2 | 36
cardiovascular system phenotyp... 2 | 35
cataract 2 | 26
decreased T cell number 2 | 31
decreased bone mineral density 2 | 126
decreased circulating calcium ... 2 | 33
decreased circulating chloride... 2 | 32
decreased circulating free fat... 2 | 39
decreased circulating total pr... 2 | 41
decreased effector memory CD8-... 2 | 24
decreased fasted circulating g... 2 | 49
decreased hematocrit 2 | 25
decreased hemoglobin content 2 | 53
decreased mean corpuscular hem... 2 | 34
decreased mean corpuscular vol... 2 | 50
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased spleen weight 2 | 13
decreased startle reflex 2 | 48
decreased thoracic vertebrae n... 2 | 7
dilated heart left ventricle 2 | 10
enlarged spleen 2 | 26
impaired glucose tolerance 2 | 52
increased NK cell number 2 | 19
increased blood urea nitrogen ... 2 | 44
increased body length 2 | 20
increased bone mineral density 2 | 52
increased circulating chloride... 2 | 43
increased circulating serum al... 2 | 25
increased circulating sodium l... 2 | 71
increased exploration in new e... 2 | 56
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
limb grasping 2 | 35
small superior vagus ganglion 2 | 20
small testis 2 | 37
vertebral fusion 2 | 23

Disease

psoriasis 405 | 6,685
Cancer 386 | 2,346
ovarian cancer 383 | 8,484
osteosarcoma 356 | 7,933
lung cancer 312 | 4,466
glioblastoma 299 | 5,572
medulloblastoma, large-cell 254 | 6,234
lung carcinoma 195 | 2,844
malignant mesothelioma 191 | 3,162
diabetes mellitus 185 | 1,663
pilocytic astrocytoma 183 | 3,086
ulcerative colitis 183 | 2,087
interstitial cystitis 175 | 2,299
invasive ductal carcinoma 171 | 2,950
Rheumatoid Arthritis 164 | 1,160
atypical teratoid / rhabdoid tumor 163 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 162 | 3,289
Breast cancer 154 | 3,094
subependymal giant cell astrocytoma 153 | 2,287
pancreatic cancer 152 | 2,300
tuberculosis 151 | 1,557
non-small cell lung cancer 149 | 2,798
pediatric high grade glioma 137 | 2,712
Hypersensitivity reaction type II disease 133 | 235
lung adenocarcinoma 133 | 2,713
Multiple Sclerosis 132 | 498
Arthritis 131 | 248
cutaneous lupus erythematosus 122 | 1,056
intraductal papillary-mucinous adenoma (IPMA) 122 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 122 | 2,988
cystic fibrosis 120 | 1,665
oligodendroglioma 115 | 2,849
juvenile dermatomyositis 113 | 1,189
Multiple myeloma 111 | 1,327
pituitary cancer 110 | 1,972
astrocytoma 108 | 1,493
ependymoma 102 | 2,514
breast carcinoma 99 | 1,614
dermatomyositis 99 | 933
Carcinoma 97 | 2,147
primitive neuroectodermal tumor 94 | 3,031
adult high grade glioma 93 | 2,148
primary Sjogren syndrome 92 | 789
Asthma 91 | 349
group 4 medulloblastoma 91 | 1,875
Ankylosing spondylitis 90 | 138
posterior fossa group A ependymoma 90 | 1,511
group 3 medulloblastoma 88 | 2,254
ductal carcinoma in situ 86 | 1,745
Acquired immunodeficiency syndrome 82 | 164
Kidney disease 82 | 396
astrocytic glioma 81 | 2,241
pancreatic ductal adenocarcinoma liver metastasis 81 | 1,795
colon cancer 80 | 1,475
Uveitis 73 | 103
Pick disease 72 | 1,893
primary pancreatic ductal adenocarcinoma 72 | 1,271
Juvenile rheumatoid arthritis 71 | 104
active Crohn's disease 70 | 918
Atopic dermatitis 66 | 944
Psoriatic arthritis 64 | 83
gastric carcinoma 62 | 832
Liver disease 61 | 219
Behcet's disease 60 | 74
adrenocortical carcinoma 60 | 1,427
esophageal adenocarcinoma 60 | 737
Inflammatory bowel disease 59 | 142
Mammary Neoplasms 57 | 410
medulloblastoma 57 | 1,524
Anemia 56 | 252
nasopharyngeal carcinoma 56 | 1,056
Influenza 55 | 142
Obesity 54 | 616
Waldenstrons macroglobulinemia 54 | 765
Lung disease 53 | 132
Prostatic Neoplasms 52 | 471
acute quadriplegic myopathy 51 | 1,157
Hepatitis B 50 | 103
Vascular disease 50 | 281
Atherosclerosis 49 | 275
Stevens-Johnson syndrome 48 | 78
hepatocellular carcinoma 48 | 532
spina bifida 48 | 1,064
sarcoidosis 46 | 358
Stomach Neoplasms 45 | 282
Endometriosis 44 | 535
IGA Glomerulonephritis 44 | 454
Myocardial Ischemia 44 | 169
pancreatic carcinoma 44 | 567
Crohn's disease 43 | 304
Dermatitis 43 | 107
Duchenne muscular dystrophy 43 | 602
Lung Neoplasms 43 | 171
atypical teratoid/rhabdoid tumor 43 | 1,095
inflammatory breast cancer 43 | 404
mucosa-associated lymphoid tissue lymphoma 43 | 480
non-small cell lung carcinoma 43 | 413
Alzheimer's disease 42 | 644
Schizophrenia 42 | 501
sonic hedgehog group medulloblastoma 41 | 1,482

Tissue

Nervous System 726 | 18,561
Female tissues 722 | 18,647
Digestive Tract 721 | 18,473
Urinary Tract 720 | 18,444
Endocrine System 718 | 18,512
Blood and immune system 713 | 17,995
Liver and Pancreas 712 | 18,136
Cardiovascular System 705 | 17,958
Skin and soft tissues 704 | 18,115
Male tissues 696 | 17,969
Respiratory system 693 | 17,484

Target Family

Non-IDG 535 | 11,971
Enzyme 141 | 4,146
Kinase 72 | 634
Transcription Factor 37 | 1,400
GPCR 8 | 406
Ion Channel 5 | 341
Epigenetic 3 | 242
Nuclear Receptor 2 | 48
TF/Epigenetic 1 | 38

Reactome Pathway

Cytokine Signaling in Immune s... 804 | 804
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
HLA class II histocompatibility antigen, DRB1-14 beta chain HLA-DRB1 Tbio Non-IDG 0.00000 337
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748