Development Level

Tbio 29 | 10,625
Tchem 22 | 1,890
Tclin 12 | 602
Tdark 2 | 7,003

IMPC Term

abnormal bone structure 2 | 131
decreased bone mineral content 2 | 157
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 85
decreased lean body mass 2 | 195
decreased mean platelet volume 2 | 12
decreased total body fat amoun... 2 | 186
improved glucose tolerance 2 | 56
increased circulating HDL chol... 2 | 63
increased circulating alkaline... 2 | 119
increased circulating choleste... 2 | 53
small kidney 2 | 10
abnormal behavior 1 | 226
abnormal clavicle morphology 1 | 5
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal cranium morphology 1 | 32
abnormal femur morphology 1 | 14
abnormal fibula morphology 1 | 2
abnormal heart left ventricle ... 1 | 20
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 14
abnormal lens morphology 1 | 73
abnormal pelvic girdle bone mo... 1 | 11
abnormal radius morphology 1 | 8
abnormal retina morphology 1 | 100
abnormal rib morphology 1 | 28
abnormal scapula morphology 1 | 3
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
abnormal vertebrae morphology 1 | 14
absent mammary gland 1 | 1
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased cervical vertebrae n... 1 | 12
decreased circulating HDL chol... 1 | 77
decreased circulating calcium ... 1 | 33
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate 1 | 10
decreased heart weight 1 | 44
decreased leukocyte cell numbe... 1 | 54
decreased skeletal muscle mass 1 | 1
decreased vertical activity 1 | 22
hyperactivity 1 | 108
hypoactivity 1 | 89
impaired glucose tolerance 1 | 52
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating creatini... 1 | 29
increased circulating serum al... 1 | 25
increased circulating triglyce... 1 | 24
increased erythrocyte cell num... 1 | 26
increased fasted circulating g... 1 | 68
increased lactate dehydrogenas... 1 | 3
increased respiratory quotient 1 | 12
increased total body fat amoun... 1 | 57
preweaning lethality, complete... 1 | 633
preweaning lethality, incomple... 1 | 260
short tibia 1 | 82
shortened QRS complex duration 1 | 1
small heart 1 | 8
small ovary 1 | 1
small spleen 1 | 11
small uterus 1 | 1
thin skin 1 | 1

Disease

psoriasis 32 | 6,685
Cancer 24 | 2,346
ovarian cancer 23 | 8,484
medulloblastoma, large-cell 22 | 6,234
osteosarcoma 22 | 7,933
lung cancer 19 | 4,466
Prostatic Neoplasms 17 | 471
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,795
interstitial cystitis 16 | 2,299
glioblastoma 15 | 5,572
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,289
atypical teratoid / rhabdoid tumor 13 | 4,369
lung carcinoma 13 | 2,844
malignant mesothelioma 12 | 3,162
non-small cell lung cancer 12 | 2,798
Breast cancer 11 | 3,094
Congenital adrenal hyperplasia 11 | 74
Liver disease 11 | 219
Hypertension 10 | 287
adrenocortical carcinoma 10 | 1,427
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
Mammary Neoplasms 9 | 410
pituitary cancer 9 | 1,972
tuberculosis 9 | 1,557
Drug-Induced Liver Injury 8 | 118
cystic fibrosis 8 | 1,665
diabetes mellitus 8 | 1,663
group 4 medulloblastoma 8 | 1,875
lung adenocarcinoma 8 | 2,713
pancreatic cancer 8 | 2,300
pediatric high grade glioma 8 | 2,712
pilocytic astrocytoma 8 | 3,086
ulcerative colitis 8 | 2,087
Cholestasis 7 | 93
Peripheral Neuropathy 7 | 303
adult high grade glioma 7 | 2,148
ductal carcinoma in situ 7 | 1,745
invasive ductal carcinoma 7 | 2,950
Adenoma 6 | 165
Endometriosis 6 | 535
Lung Neoplasms 6 | 171
Obesity 6 | 616
Schizophrenia 6 | 501
active Crohn's disease 6 | 918
aldosterone-producing adenoma 6 | 664
astrocytoma 6 | 1,493
chronic rhinosinusitis 6 | 512
cutaneous lupus erythematosus 6 | 1,056
group 3 medulloblastoma 6 | 2,254
oligodendroglioma 6 | 2,849
posterior fossa group A ependymoma 6 | 1,511
Adenocarcinoma 5 | 115
Adrenal cortical adenoma 5 | 10
Antley-Bixler syndrome 5 | 15
Cardiomegaly 5 | 66
Cushing's syndrome 5 | 47
Hyperandrogenism 5 | 32
Pick disease 5 | 1,893
Polycystic Ovary Syndrome 5 | 332
breast carcinoma 5 | 1,614
primary pancreatic ductal adenocarcinoma 5 | 1,271
substance-related disorder 5 | 105
Adverse reaction to drug 4 | 54
Amenorrhea 4 | 60
Atopic dermatitis 4 | 944
Candidiasis of mouth 4 | 5
Candidiasis of skin 4 | 6
Cerebrotendinous xanthomatosis 4 | 12
Colorectal Neoplasms 4 | 217
Congenital adrenal insufficiency 4 | 7
Conn's syndrome 4 | 22
Epilepsy 4 | 346
Fatty Liver 4 | 48
Human immunodeficiency virus infection 4 | 6
Hypogonadism 4 | 70
Hypokalemia 4 | 40
Infertility 4 | 163
Kidney disease 4 | 396
Liver carcinoma 4 | 217
Liver diseases 4 | 66
Male infertility 4 | 170
Pityriasis versicolor 4 | 18
Precursor Cell Lymphoblastic Leukemia Lymphoma 4 | 42
Pseudohermaphroditism 4 | 16
Rheumatoid Arthritis 4 | 1,160
Spontaneous abortion 4 | 108
Tinea corporis 4 | 25
Tinea cruris 4 | 12
Tinea pedis 4 | 30
acute quadriplegic myopathy 4 | 1,157
astrocytic glioma 4 | 2,241
gastric carcinoma 4 | 832
medulloblastoma 4 | 1,524
nephrosclerosis 4 | 329
primitive neuroectodermal tumor 4 | 3,031
Alzheimer's disease 3 | 644
Contact Dermatitis 3 | 80
Prostate cancer 3 | 172
nasopharyngeal carcinoma 3 | 1,056

Tissue

Digestive Tract 65 | 18,473
Endocrine System 65 | 18,512
Female tissues 65 | 18,647
Liver and Pancreas 65 | 18,136
Nervous System 65 | 18,561
Skin and soft tissues 65 | 18,115
Urinary Tract 65 | 18,444
Blood and immune system 64 | 17,995
Cardiovascular System 64 | 17,958
Male tissues 63 | 17,969
Respiratory system 63 | 17,484

Target Family

Non-IDG 31 | 11,971
Enzyme 28 | 4,146
Transcription Factor 3 | 1,400
Nuclear Receptor 2 | 48
Epigenetic 1 | 242

Reactome Pathway

Cytochrome P450 - arranged by ... 65 | 65
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
24-hydroxycholesterol 7-alpha-hydroxylase CYP39A1 Tbio Enzyme -0.95411 6.43 97
Cytochrome P450 4V2 CYP4V2 Tbio Non-IDG -2.66290 481.8 87
Cytochrome P450 4F22 CYP4F22 Tbio Non-IDG -1.98060 100.6 25
Thromboxane-A synthase TBXAS1 Tchem Enzyme -3.06668 1228.9 241
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 Tchem Enzyme -2.65191 464.3 66
Ferredoxin-2, mitochondrial FDX2 Tdark Non-IDG -0.73450 5.89 3
Cytochrome P450 4B1 CYP4B1 Tbio Non-IDG -1.77340 65.4 88
Cytochrome P450 11B1, mitochondrial CYP11B1 Tclin Enzyme -2.62509 411.6 105
Cytochrome P450 2S1 CYP2S1 Tbio Non-IDG -1.30029 25.6 139
Aryl hydrocarbon receptor nuclear translocator ARNT Tbio Transcription Factor -2.49893 243.3 424