Development Level

Tbio 60 | 11,445
Tchem 13 | 1,598
Tclin 6 | 613
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal embryo size 2 | 220
decreased circulating choleste... 2 | 93
female infertility 2 | 60
male infertility 2 | 123
preweaning lethality, incomple... 2 | 499
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal epididymis morphology 1 | 42
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal urinary bladder morph... 1 | 11
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating insulin ... 1 | 76
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased mean corpuscular hem... 1 | 50
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hyperactivity 1 | 148
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytosis 1 | 27

Disease

ovarian cancer 60 | 8,520
Carcinoma 38 | 11,493
lung cancer 38 | 4,740
osteosarcoma 36 | 7,950
Cancer 35 | 2,499
psoriasis 34 | 6,694
glioblastoma 32 | 5,792
Multiple myeloma 30 | 1,332
medulloblastoma, large-cell 24 | 6,241
atypical teratoid / rhabdoid tumor 20 | 5,112
Breast cancer 19 | 3,578
group 3 medulloblastoma 19 | 4,104
malignant mesothelioma 19 | 3,232
ependymoma 16 | 4,679
HIV Infections 15 | 102
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
adult high grade glioma 14 | 3,801
dermatomyositis 13 | 966
non-small cell lung cancer 13 | 2,890
primitive neuroectodermal tumor 13 | 3,035
subependymal giant cell astrocytoma 13 | 2,287
oligodendroglioma 12 | 2,850
Astrocytoma, Pilocytic 11 | 3,081
Waldenstrons macroglobulinemia 11 | 765
astrocytoma 11 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
invasive ductal carcinoma 11 | 2,951
lung adenocarcinoma 10 | 2,716
Carcinoma, Hepatocellular 9 | 228
Liver carcinoma 9 | 240
adrenocortical carcinoma 9 | 1,428
colon cancer 9 | 1,478
nasopharyngeal carcinoma 9 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Liver Cirrhosis, Experimental 8 | 769
ductal carcinoma in situ 8 | 1,745
non primary Sjogren syndrome sicca 8 | 891
Pick disease 7 | 1,894
acute myeloid leukemia 7 | 783
astrocytic glioma 7 | 2,597
diabetes mellitus 7 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
lung carcinoma 7 | 2,843
pancreatic cancer 7 | 2,398
primary Sjogren syndrome 7 | 735
tuberculosis 7 | 2,010
Animal Mammary Neoplasms 6 | 136
Breast Neoplasms 6 | 445
Mammary Neoplasms 6 | 425
Mammary Neoplasms, Animal 6 | 136
Mammary Neoplasms, Experimental 6 | 154
Mantle cell lymphoma 6 | 23
juvenile dermatomyositis 6 | 1,187
Bladder Neoplasm 5 | 112
Esophageal Squamous Cell Carcinoma 5 | 77
Kidney cancer 5 | 2,613
Lung Neoplasms 5 | 232
Ovarian Neoplasms 5 | 102
Squamous cell carcinoma of esophagus 5 | 77
Stomach Neoplasms 5 | 300
Urinary Bladder Neoplasms 5 | 114
active Crohn's disease 5 | 922
acute quadriplegic myopathy 5 | 1,158
cystic fibrosis 5 | 1,696
interstitial cystitis 5 | 2,312
medulloblastoma 5 | 720
ovarian neoplasm 5 | 99
ulcerative colitis 5 | 1,819
Adenoma 4 | 167
Anemia 4 | 365
Intellectual disability 4 | 1,016
Liver neoplasms 4 | 130
Osteoporosis 4 | 363
Prostatic Neoplasms 4 | 495
Retinoblastoma 4 | 19
cutaneous lupus erythematosus 4 | 1,057
esophageal adenocarcinoma 4 | 737
pituitary cancer 4 | 1,972
primary pancreatic ductal adenocarcinoma 4 | 1,109
Atopic dermatitis 3 | 952
Chronic Lymphocytic Leukemia 3 | 262
Cockayne syndrome 3 | 60
Colonic Neoplasms 3 | 142
Diarrhea 3 | 253
Endometriosis 3 | 540
Epilepsy 3 | 792
Hyperparathyroidism 3 | 48
Melanoma 3 | 711
Mesothelioma, Malignant 3 | 105
Polycystic ovary syndrome 3 | 360
Rheumatoid arthritis 3 | 1,191
Seizures 3 | 596
Urinary bladder cancer 3 | 36
Vascular disease 3 | 319
breast carcinoma 3 | 1,638
hepatocellular carcinoma 3 | 547
non-small cell lung carcinoma 3 | 317
pediatric high grade glioma 3 | 1,064
posterior fossa group B ependymoma 3 | 416
progressive supranuclear palsy 3 | 676

Tissue

Blood and immune system 81 | 16,909
Cardiovascular System 81 | 15,192
Digestive Tract 81 | 17,369
Endocrine System 81 | 18,159
Female tissues 81 | 17,400
Liver and Pancreas 81 | 16,750
Male tissues 81 | 17,142
Nervous System 81 | 16,725
Respiratory system 81 | 16,393
Skin and soft tissues 81 | 17,230
Urinary Tract 81 | 16,678

Target Family

Enzyme 44 | 4,145
Non-IDG 24 | 12,091
Kinase 7 | 634
Transcription Factor 7 | 1,400

Reactome Pathway

Cyclin E associated events dur... 82 | 82
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proteasome activator complex subunit 2 PSME2 Tbio Non-IDG -1.47440 29.1 305
Proteasome subunit beta type-10 PSMB10 Tchem Enzyme -1.88722 74.3 178
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
Putative protein SEM1, isoform 2 SEM1 Tbio Non-IDG 0.30 0.49 109
26S proteasome regulatory subunit 10B PSMC6 Tbio Enzyme -2.65165 339.0 214
Proteasome subunit alpha type-7 PSMA7 Tbio Enzyme -2.71627 496.7 288
Proteasome subunit alpha type-6 PSMA6 Tbio Enzyme -2.80973 614.4 288