Development Level

Tchem 15 | 1,890
Tbio 7 | 10,625

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

embryonic lethality prior to o... 3 | 148
embryonic lethality prior to t... 3 | 187
preweaning lethality, complete... 3 | 633
decreased circulating serum al... 1 | 79
decreased neutrophil cell numb... 1 | 37
increased neutrophil cell numb... 1 | 15
male infertility 1 | 62
urinary bladder obstruction 1 | 2

Disease

Cancer 17 | 2,346
glioblastoma 15 | 5,572
medulloblastoma, large-cell 15 | 6,234
psoriasis 15 | 6,685
ovarian cancer 14 | 8,491
osteosarcoma 12 | 7,933
Breast cancer 11 | 3,098
adrenocortical carcinoma 11 | 1,427
lung cancer 11 | 4,473
malignant mesothelioma 11 | 3,163
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,289
lung adenocarcinoma 10 | 2,714
non-small cell lung cancer 10 | 2,798
pediatric high grade glioma 10 | 2,712
primitive neuroectodermal tumor 10 | 3,031
atypical teratoid / rhabdoid tumor 8 | 4,369
breast carcinoma 8 | 1,614
ductal carcinoma in situ 8 | 1,745
invasive ductal carcinoma 7 | 2,950
pancreatic cancer 7 | 2,300
posterior fossa group A ependymoma 7 | 1,511
Atopic dermatitis 6 | 944
Endometriosis 6 | 535
colon cancer 6 | 1,475
astrocytic glioma 5 | 2,241
atypical teratoid/rhabdoid tumor 5 | 1,095
group 3 medulloblastoma 5 | 2,254
interstitial cystitis 5 | 2,299
sonic hedgehog group medulloblastoma 5 | 1,482
IGA Glomerulonephritis 4 | 454
Waldenstrons macroglobulinemia 4 | 764
nasopharyngeal carcinoma 4 | 1,056
oligodendroglioma 4 | 2,849
pilocytic astrocytoma 4 | 3,086
primary Sjogren syndrome 4 | 788
ulcerative colitis 4 | 2,087
Multiple myeloma 3 | 1,327
inflammatory breast cancer 3 | 404
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,956
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
tuberculosis 3 | 1,563
Asthma 2 | 349
Carcinoma 2 | 2,147
Intellectual disability 2 | 573
Liver carcinoma 2 | 217
Lung Neoplasms 2 | 171
Melanoma 2 | 261
Peripheral Neuropathy 2 | 303
Photosensitive trichothiodystrophy 2 | 24
active Crohn's disease 2 | 918
adult high grade glioma 2 | 2,148
astrocytoma 2 | 1,493
cutaneous lupus erythematosus 2 | 1,056
diabetes mellitus 2 | 1,663
ependymoma 2 | 2,514
esophageal adenocarcinoma 2 | 737
facioscapulohumeral dystrophy 2 | 286
group 4 medulloblastoma 2 | 1,875
lung carcinoma 2 | 2,844
medulloblastoma 2 | 1,524
pituitary cancer 2 | 1,972
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 6 months 2 | 686
Acquired metabolic disease 1 | 267
Adenoma 1 | 165
Animal Mammary Neoplasms 1 | 135
Bipolar Disorder 1 | 266
Celiac disease 1 | 112
Cockayne syndrome 1 | 54
Degenerative polyarthritis 1 | 93
Disease Progression 1 | 125
Endometrial cancer 1 | 32
Fetal valproate syndrome 1 | 4
Glioma 1 | 66
Influenza 1 | 142
Leukemia 1 | 88
Malaria 1 | 140
Mammary Neoplasms 1 | 410
Mammary Neoplasms, Experimental 1 | 149
Mental depression 1 | 58
Myocardial Ischemia 1 | 169
Neutropenia 1 | 78
Pick disease 1 | 1,893
Polycystic Ovary Syndrome 1 | 334
Squamous cell carcinoma of the head and neck 1 | 24
Stomach Neoplasms 1 | 282
acute quadriplegic myopathy 1 | 1,157
adrenocortical adenoma 1 | 134
aldosterone-producing adenoma 1 | 664
cartilage-hair hypoplasia 1 | 7
chronic rhinosinusitis 1 | 512
cystic fibrosis 1 | 1,670
dermatomyositis 1 | 966
fibroadenoma 1 | 557
gastric carcinoma 1 | 832
hereditary spastic paraplegia 1 | 313
juvenile dermatomyositis 1 | 1,189
non-small cell lung carcinoma 1 | 413
tuberculosis and treatment for 3 months 1 | 327

Tissue

Blood and immune system 22 | 17,994
Cardiovascular System 22 | 17,957
Digestive Tract 22 | 18,472
Endocrine System 22 | 18,511
Female tissues 22 | 18,646
Liver and Pancreas 22 | 18,135
Male tissues 22 | 17,968
Nervous System 22 | 18,560
Respiratory system 22 | 17,483
Skin and soft tissues 22 | 18,114
Urinary Tract 22 | 18,443

Target Family

Enzyme 9 | 4,146
Kinase 6 | 634
Non-IDG 6 | 11,969
Transcription Factor 1 | 1,400

Reactome Pathway

Cyclin A/B1 associated events ... 22 | 22
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform PPP2R2A Tchem Enzyme -1.27308 14.5 115
M-phase inducer phosphatase 1 CDC25A Tchem Enzyme -2.45436 266.0 1243
M-phase inducer phosphatase 2 CDC25B Tchem Enzyme -2.31154 209.2 666
M-phase inducer phosphatase 3 CDC25C Tchem Enzyme -2.51338 295.3 723
Cyclin-dependent kinase 1 CDK1 Tchem Kinase -3.25783 1710.8 1724
Wee1-like protein kinase WEE1 Tchem Kinase -2.47729 288.3 429
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform PPP2R1A Tbio Enzyme -1.40388 25.3 259
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 17.1 179
Cyclin-dependent kinase 2 CDK2 Tchem Kinase -3.41871 2399.0 886
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.11344 1275.4 345