Development Level

Tbio 9 | 11,445

IMPC Phenotype

abnormal sleep behavior 1 | 70
convulsive seizures 1 | 13
increased body length 1 | 32
increased fasted circulating g... 1 | 76

Disease

Astrocytoma, Pilocytic 7 | 3,081
glioblastoma 7 | 5,792
ovarian cancer 7 | 8,520
Breast cancer 6 | 3,578
Carcinoma 6 | 11,493
atypical teratoid / rhabdoid tumor 6 | 5,112
primitive neuroectodermal tumor 6 | 3,035
Duchenne muscular dystrophy 5 | 601
adult high grade glioma 5 | 3,801
ependymoma 5 | 4,679
interstitial cystitis 5 | 2,312
malignant mesothelioma 5 | 3,232
pancreatic cancer 5 | 2,398
ulcerative colitis 5 | 1,819
gastric carcinoma 4 | 807
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
juvenile dermatomyositis 4 | 1,187
non-small cell lung cancer 4 | 2,890
primary pancreatic ductal adenocarcinoma 4 | 1,109
psoriasis 4 | 6,694
Kidney cancer 3 | 2,613
Liver Cirrhosis, Experimental 3 | 769
cystic fibrosis 3 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
medulloblastoma, large-cell 3 | 6,241
osteosarcoma 3 | 7,950
Biliary cirrhosis 2 | 45
Bladder Neoplasm 2 | 112
Cancer 2 | 2,499
Hepatitis B 2 | 108
Hepatitis C 2 | 94
Hepatolenticular Degeneration 2 | 24
Irregular astigmatism 2 | 12
Liver Cirrhosis 2 | 181
Liver Cirrhosis, Biliary 2 | 33
Polycystic ovary syndrome 2 | 360
Prenatal Injuries 2 | 11
Urinary Bladder Neoplasms 2 | 114
astrocytic glioma 2 | 2,597
cystic fibrosis and chronic rhinosinusitis 2 | 214
esophageal adenocarcinoma 2 | 737
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,291
limb girdle muscular dystrophy 2A 2 | 213
lung adenocarcinoma 2 | 2,716
lung cancer 2 | 4,740
lung carcinoma 2 | 2,843
medulloblastoma 2 | 720
oligodendroglioma 2 | 2,850
pediatric high grade glioma 2 | 1,064
pituitary cancer 2 | 1,972
Acquired metabolic disease 1 | 336
Allergic hypersensitivity disease 1 | 126
Allergic rhinitis 1 | 94
Aortic Valve Insufficiency 1 | 40
Aortic aneurysm 1 | 38
Arthritis 1 | 290
Atherosclerosis 1 | 291
Atopic dermatitis 1 | 952
Atrial Septal Defects 1 | 85
Autosomal recessive non-syndromic intellectual disability 1 | 7
Breast Neoplasms 1 | 445
Cardiomegaly 1 | 116
Cardiovascular system disease 1 | 246
Chemical and Drug Induced Liver Injury 1 | 195
Chest Pain 1 | 38
Coronary artery disease 1 | 268
Cutis Laxa 1 | 39
Cutis Laxa, Autosomal Recessive, Type I 1 | 3
Ellis-Van Creveld syndrome 1 | 19
Esophageal Squamous Cell Carcinoma 1 | 77
Gaucher disease type 3 1 | 67
Keratoconus 1 | 113
Leukemia, Myelocytic, Acute 1 | 120
Leukemia, Myeloid, Acute 1 | 105
Liver cancer 1 | 604
Malformed pinnae 1 | 37
Mammary Neoplasms 1 | 425
Melanoma 1 | 711
Multiple Sclerosis 1 | 540
Neoplasm Invasiveness 1 | 161
Osteogenesis imperfecta 1 | 34
Pigment dispersion syndrome 1 | 11
Pulmonary hypertension 1 | 85
Skin cancer 1 | 469
Squamous cell carcinoma of esophagus 1 | 77
active Crohn's disease 1 | 922
adrenocortical carcinoma 1 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 1 | 510
breast carcinoma 1 | 1,638
chronic kidney disease 1 | 90
fascioscapulohumeral muscular dystrophy 1 | 100
head and neck cancer 1 | 271
interstitial lung disease 1 | 298
mucosa-associated lymphoid tissue lymphoma 1 | 484
nasopharyngeal carcinoma 1 | 1,058
non-small cell lung carcinoma 1 | 317
posterior fossa group A ependymoma 1 | 468
tuberculosis 1 | 2,010
urothelial carcinoma 1 | 318

Tissue

Blood and immune system 9 | 16,909
Cardiovascular System 9 | 15,192
Digestive Tract 9 | 17,369
Endocrine System 9 | 18,159
Female tissues 9 | 17,400
Liver and Pancreas 9 | 16,750
Male tissues 9 | 17,142
Nervous System 9 | 16,725
Skin and soft tissues 9 | 17,230
Urinary Tract 9 | 16,678
Respiratory system 8 | 16,393

Target Family

Enzyme 6 | 4,145
Non-IDG 3 | 12,091

Reactome Pathway

Crosslinking of collagen fibri... 9 | 9
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lysyl oxidase homolog 1 LOXL1 Tbio Enzyme -2.55611 364.6 174
Peroxidasin homolog PXDN Tbio Non-IDG -2.07697 119.9 42
Tolloid-like protein 1 TLL1 Tbio Non-IDG -1.44490 24.3 83
Procollagen C-endopeptidase enhancer 1 PCOLCE Tbio Enzyme -1.73849 56.6 153
Tolloid-like protein 2 TLL2 Tbio Non-IDG -1.00652 6.10 35
Lysyl oxidase homolog 2 LOXL2 Tbio Enzyme -2.24186 173.0 274
Protein-lysine 6-oxidase LOX Tbio Enzyme -3.36257 2227.1 513
Lysyl oxidase homolog 3 LOXL3 Tbio Enzyme -1.24444 16.8 108
Lysyl oxidase homolog 4 LOXL4 Tbio Enzyme -1.36310 22.4 159