Development Level

Tbio 11 | 11,445
Tdark 3 | 6,588

IMPC Phenotype

narrow eye opening 1 | 12

Disease

Carcinoma 6 | 11,493
lung cancer 6 | 4,740
osteosarcoma 5 | 7,950
ovarian cancer 5 | 8,520
astrocytic glioma 4 | 2,597
Waldenstrons macroglobulinemia 3 | 765
adult high grade glioma 3 | 3,801
ependymoma 3 | 4,679
oligodendroglioma 3 | 2,850
3-methylglutaconic aciduria 2 | 29
Cancer 2 | 2,499
Cardiomyopathy 2 | 116
Cerebellar Ataxia 2 | 304
Leigh disease 2 | 100
Mitochondrial myopathy 2 | 26
Multiple myeloma 2 | 1,332
Optic Atrophy 2 | 242
Schizophrenia 2 | 1,160
atypical teratoid / rhabdoid tumor 2 | 5,112
glioblastoma 2 | 5,792
lung adenocarcinoma 2 | 2,716
non-small cell lung cancer 2 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
psoriasis 2 | 6,694
Abnormal vision 1 | 52
Abnormality of retinal pigmentation 1 | 111
Anemia, Sideroblastic 1 | 7
Anterior hypopituitarism 1 | 18
Autoimmune Diseases 1 | 67
Blind Vision 1 | 111
Blind spot located at fixation point 1 | 21
Blindness, Legal 1 | 110
Blurred vision 1 | 19
CREST Syndrome 1 | 16
Carcinoma, Renal Cell 1 | 124
Cardiac Arrhythmia 1 | 103
Cardiac conduction abnormalities 1 | 78
Chronic schizophrenia 1 | 16
Conduction disorder of the heart 1 | 79
Congenital deafness 1 | 185
Deafness 1 | 198
Decreased to absent deep tendon reflexes 1 | 42
Decreased visual acuity, slowly progressive 1 | 13
Degenerative polyarthritis 1 | 115
Diphyllobothriasis 1 | 6
Dystonia 1 | 164
Dystonic disease 1 | 106
EKG abnormalities 1 | 78
Echinococcosis 1 | 26
Electrocardiogram abnormal 1 | 81
Electrocardiogram change 1 | 78
Electromyogram abnormal 1 | 49
Enterocolitis, Necrotizing 1 | 17
Fatty liver disease 1 | 103
Glucose Intolerance 1 | 19
HIV Infections 1 | 102
Hearing Loss, Partial 1 | 185
Hypertrophy 1 | 17
Impaired glucose tolerance 1 | 28
Kearns-Sayre syndrome 1 | 7
Lactic acidosis 1 | 51
Leber hereditary optic neuropathy 1 | 14
Leigh syndrome 1 | 28
Liver disease 1 | 237
Melioidosis 1 | 17
Meningitis 1 | 67
Mitochondrial Myopathies 1 | 21
Mitochondrial respiratory chain defects 1 | 15
Necrotizing Enterocolitis 1 | 17
Neurogenic Muscular Atrophy 1 | 139
Neurogenic muscle atrophy, especially in the lower limbs 1 | 139
Optic Neuropathy 1 | 12
Osteoarthritis 1 | 184
Parkinson Disease 1 | 64
Pasteurellosis 1 | 12
Peripheral Neuropathy 1 | 134
Polyneuropathy 1 | 64
Proximal muscle weakness 1 | 47
Proximal neurogenic muscle weakness 1 | 47
Ragged-red fibers 1 | 21
Renal Cell Carcinoma 1 | 214
Retinal pigment epithelial abnormality 1 | 111
Retinal telangiectasia 1 | 12
STRIATONIGRAL DEGENERATION, INFANTILE (disorder) 1 | 3
Salt and pepper retinal pigmentation 1 | 8
Scotoma, Central 1 | 21
Scotoma, Centrocecal 1 | 11
Sensory neuropathy 1 | 20
Sideroblastic anemia 1 | 20
Skeletal muscle atrophy 1 | 139
Slow decrease in visual acuity 1 | 13
Static Tremor 1 | 21
Striatonigral Degeneration, Infantile 1 | 4
Tortuous retinal vessels 1 | 15
Uveitis 1 | 103
Wolf-Hirschhorn syndrome 1 | 32
Xeroderma pigmentosum group B 1 | 20
hearing impairment 1 | 199
muscle degeneration 1 | 139
tuberculosis and treatment for 6 months 1 | 409

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Non-IDG 11 | 12,091
Enzyme 3 | 4,145

Reactome Pathway

Cristae formation 14 | 14
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MICOS complex subunit MIC19 CHCHD3 Tbio Non-IDG -1.16714 14.1 178
MICOS complex subunit MIC25 CHCHD6 Tbio Non-IDG -1.55591 35.0 155
ATP synthase subunit s, mitochondrial ATP5S Tdark Enzyme -0.41218 1.48 122
MICOS complex subunit MIC10 MINOS1 Tdark Non-IDG -0.09691 1.46 56
Sorting and assembly machinery component 50 homolog SAMM50 Tbio Non-IDG -2.09079 120.9 124
ATP synthase protein 8 MT-ATP8 Tbio Enzyme -2.35771 201.5 23
MICOS complex subunit MIC60 IMMT Tbio Non-IDG -2.81178 611.6 222
ATP synthase subunit a MT-ATP6 Tbio Enzyme -2.74832 542.1 40
MICOS complex subunit MIC27 APOOL Tbio Non-IDG -0.75265 5.04 95
Metaxin-1 MTX1 Tbio Non-IDG -1.93920 85.1 64