Development Level

Tbio 43 | 11,178
Tchem 23 | 1,885
Tclin 15 | 612
Tdark 4 | 6,569

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 979
increased neutrophil cell numb... 3 | 46
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
decreased body weight 2 | 161
decreased circulating LDL chol... 2 | 38
decreased neutrophil cell numb... 2 | 42
embryonic lethality prior to t... 2 | 278
increased blood urea nitrogen ... 2 | 48
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased spleen weight 2 | 10
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal locomotor behavior 1 | 24
abnormal maxilla morphology 1 | 17
abnormal retina morphology 1 | 71
anophthalmia 1 | 33
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
enlarged kidney 1 | 14
hypoactivity 1 | 132
increased CD4-positive, alpha ... 1 | 4
increased cardiac stroke volum... 1 | 1
increased circulating choleste... 1 | 66
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality prior to he... 1 | 87
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 40 | 11,192
osteosarcoma 39 | 7,766
ovarian cancer 37 | 8,297
Cancer 34 | 2,388
psoriasis 33 | 6,514
Rheumatoid arthritis 32 | 1,156
lung cancer 28 | 4,607
lung carcinoma 25 | 2,755
glioblastoma 24 | 5,635
diabetes mellitus 23 | 1,683
medulloblastoma, large-cell 23 | 6,086
interstitial cystitis 22 | 2,237
invasive ductal carcinoma 22 | 2,867
sarcoidosis 19 | 357
Narcolepsy 18 | 70
Systemic lupus erythematosus 17 | 191
adult high grade glioma 17 | 3,701
tuberculosis 17 | 1,963
Berylliosis 16 | 26
Breast cancer 16 | 3,469
subependymal giant cell astrocytoma 16 | 2,230
Multiple Sclerosis, Susceptibility to 15 | 15
breast carcinoma 15 | 1,589
cutaneous lupus erythematosus 15 | 1,016
non-small cell lung cancer 15 | 2,799
Hypersensitivity reaction type II disease 14 | 245
Narcolepsy-cataplexy 14 | 20
atypical teratoid / rhabdoid tumor 14 | 4,971
follicular lymphoma 14 | 20
Astrocytoma, Pilocytic 13 | 3,006
Diffuse cutaneous systemic sclerosis 13 | 17
Multiple Sclerosis 13 | 527
Rheumatoid Arthritis, Systemic Juvenile 13 | 16
Sarcoidosis 1 13 | 14
ependymoma 13 | 4,559
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,902
limited scleroderma 13 | 19
Autosomal recessive predisposition 12 | 1,407
Schizophrenia 12 | 1,136
cystic fibrosis 12 | 1,629
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,204
juvenile dermatomyositis 12 | 1,147
malignant mesothelioma 12 | 3,135
primary Sjogren syndrome 12 | 710
Celiac disease 11 | 110
group 3 medulloblastoma 11 | 4,002
group 4 medulloblastoma 11 | 1,806
Kidney cancer 10 | 2,548
oligodendroglioma 10 | 2,768
pancreatic cancer 10 | 2,322
ulcerative colitis 10 | 1,765
Hepatitis B 9 | 105
Immunologic Deficiency Syndromes 9 | 110
Juvenile rheumatoid arthritis 9 | 110
Waldenstrons macroglobulinemia 9 | 742
astrocytic glioma 9 | 2,530
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,872
Asthma 8 | 370
Autoimmune Diseases 8 | 64
Epilepsy 8 | 775
Multiple myeloma 8 | 1,296
Pick disease 8 | 1,856
active Crohn's disease 8 | 882
ductal carcinoma in situ 8 | 1,686
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,911
Arthritis, Rheumatoid 7 | 169
Intellectual disability 7 | 998
Recurrent respiratory infections 7 | 138
Seizures 7 | 584
Type 1 diabetes mellitus 7 | 106
active ulcerative colitis 7 | 736
astrocytoma 7 | 1,113
dermatomyositis 7 | 941
lung adenocarcinoma 7 | 2,627
pituitary cancer 7 | 1,915
Atopic dermatitis 6 | 915
Blastic phase chronic myeloid leukemia 6 | 58
Chronic Myelocytic Leukemia Accelerated Phase 6 | 59
Diarrhea 6 | 245
Hypersensitivity 6 | 62
Orbital separation excessive 6 | 240
Proteinuria 6 | 143
Renal Cell Carcinoma 6 | 211
adrenocortical carcinoma 6 | 1,385
primitive neuroectodermal tumor 6 | 2,957
Bipolar Disorder 5 | 646
Carcinoma, Hepatocellular 5 | 217
Down syndrome 5 | 480
Failure to gain weight 5 | 359
Hepatomegaly 5 | 280
Infantile onset 5 | 236
Liver Cirrhosis, Experimental 5 | 733
Liver carcinoma 5 | 229
Pediatric failure to thrive 5 | 359
Vasculitis 5 | 76
Ventricular Septal Defects 5 | 113
Weight decreased 5 | 101
colon cancer 5 | 1,428
esophageal adenocarcinoma 5 | 696
pancreatic carcinoma 5 | 555

Tissue

Blood and immune system 65 | 16,909
Liver and Pancreas 65 | 16,750
Respiratory system 65 | 16,393
Skin and soft tissues 65 | 17,230
Digestive Tract 64 | 17,369
Endocrine System 64 | 18,159
Female tissues 64 | 17,400
Male tissues 64 | 17,142
Urinary Tract 64 | 16,678
Cardiovascular System 62 | 15,192
Nervous System 62 | 16,725

Target Family

Non-IDG 51 | 12,091
Kinase 18 | 634
Enzyme 16 | 4,145

Reactome Pathway

Costimulation by the CD28 fami... 85 | 85
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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