Development Level

Tbio 43 | 10,625
Tchem 25 | 1,890
Tclin 14 | 602
Tdark 4 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

decreased body weight 2 | 174
decreased circulating LDL chol... 2 | 37
decreased lean body mass 2 | 195
increased circulating LDL chol... 2 | 15
preweaning lethality, complete... 2 | 633
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 5
abnormal respiratory quotient 1 | 9
abnormal retinal pigmentation 1 | 61
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased neutrophil cell numb... 1 | 37
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
embryonic lethality prior to t... 1 | 187
increased CD4-positive, alpha ... 1 | 15
increased blood urea nitrogen ... 1 | 44
increased cardiac stroke volum... 1 | 1
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular hem... 1 | 93
increased neutrophil cell numb... 1 | 15
increased or absent threshold ... 1 | 128
male infertility 1 | 62
prenatal lethality prior to he... 1 | 64
small superior vagus ganglion 1 | 20
thrombocytosis 1 | 23

Disease

osteosarcoma 39 | 7,933
ovarian cancer 37 | 8,484
Cancer 32 | 2,346
psoriasis 31 | 6,685
lung cancer 27 | 4,466
lung carcinoma 25 | 2,844
medulloblastoma, large-cell 23 | 6,234
diabetes mellitus 22 | 1,663
interstitial cystitis 22 | 2,299
invasive ductal carcinoma 22 | 2,950
Rheumatoid Arthritis 21 | 1,160
glioblastoma 21 | 5,572
subependymal giant cell astrocytoma 16 | 2,287
Breast cancer 15 | 3,094
cutaneous lupus erythematosus 15 | 1,056
non-small cell lung cancer 15 | 2,798
breast carcinoma 14 | 1,614
primary Sjogren syndrome 14 | 789
Hypersensitivity reaction type II disease 13 | 235
atypical teratoid / rhabdoid tumor 13 | 4,369
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
pilocytic astrocytoma 13 | 3,086
tuberculosis 13 | 1,557
Multiple Sclerosis 12 | 498
adult high grade glioma 12 | 2,148
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,289
juvenile dermatomyositis 12 | 1,189
malignant mesothelioma 12 | 3,162
ulcerative colitis 12 | 2,087
Asthma 11 | 349
Celiac disease 11 | 112
cystic fibrosis 11 | 1,665
dermatomyositis 10 | 933
oligodendroglioma 10 | 2,849
pancreatic cancer 10 | 2,300
Carcinoma 9 | 2,147
Waldenstrons macroglobulinemia 9 | 765
astrocytic glioma 9 | 2,241
group 4 medulloblastoma 9 | 1,875
intraductal papillary-mucinous adenoma (IPMA) 9 | 2,956
pediatric high grade glioma 9 | 2,712
sarcoidosis 9 | 358
Multiple myeloma 8 | 1,327
Narcolepsy 8 | 58
Pick disease 8 | 1,893
active Crohn's disease 8 | 918
ductal carcinoma in situ 8 | 1,745
ependymoma 8 | 2,514
medulloblastoma 8 | 1,524
Type 1 diabetes mellitus 7 | 101
astrocytoma 7 | 1,493
lung adenocarcinoma 7 | 2,713
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,795
pituitary cancer 7 | 1,972
Atopic dermatitis 6 | 944
Blastic phase chronic myeloid leukemia 6 | 58
Chronic Myelocytic Leukemia Accelerated Phase 6 | 59
Hepatitis B 6 | 103
Hypersensitivity 6 | 63
IGA Glomerulonephritis 6 | 454
Intellectual disability 6 | 573
Juvenile rheumatoid arthritis 6 | 104
Liver disease 6 | 219
Lupus Erythematosus, Systemic 6 | 73
Schizophrenia 6 | 501
adrenocortical carcinoma 6 | 1,427
group 3 medulloblastoma 6 | 2,254
primitive neuroectodermal tumor 6 | 3,031
Addison's disease 5 | 29
Adult T-Cell Lymphoma/Leukemia 5 | 30
Autoimmune thyroiditis 5 | 24
Chronic Lymphocytic Leukemia 5 | 242
Chronic phase chronic myeloid leukemia 5 | 45
Diabetes Mellitus, Insulin-Dependent 5 | 76
Down syndrome 5 | 548
Graves' disease 5 | 25
Liver carcinoma 5 | 217
Mammary Neoplasms 5 | 410
Philadelphia Chromosome Positive Chronic Myelocytic Leukemia 5 | 45
Philadelphia chromosome-positive acute lymphoblastic leukemia 5 | 47
Renal Cell Carcinoma 5 | 199
Renal transplant rejection 5 | 13
Systemic scleroderma 5 | 66
active ulcerative colitis 5 | 477
colon cancer 5 | 1,475
esophageal adenocarcinoma 5 | 737
head and neck cancer and chronic obstructive pulmonary disease 5 | 237
pancreatic carcinoma 5 | 567
posterior fossa group A ependymoma 5 | 1,511
systemic lupus erythematosus 5 | 156
tuberculosis and treatment for 6 months 5 | 686
Allergic hypersensitivity disease 4 | 123
Dermatitis 4 | 107
Duchenne muscular dystrophy 4 | 602
Obesity 4 | 616
Vasculitis 4 | 64
gastric carcinoma 4 | 832
nasopharyngeal carcinoma 4 | 1,056
nephrosclerosis 4 | 329
primary pancreatic ductal adenocarcinoma 4 | 1,271

Tissue

Blood and immune system 71 | 17,995
Digestive Tract 71 | 18,473
Endocrine System 71 | 18,512
Female tissues 71 | 18,647
Liver and Pancreas 71 | 18,136
Male tissues 71 | 17,969
Nervous System 71 | 18,561
Respiratory system 71 | 17,484
Urinary Tract 71 | 18,444
Cardiovascular System 70 | 17,958
Skin and soft tissues 66 | 18,115

Target Family

Non-IDG 51 | 11,971
Kinase 19 | 634
Enzyme 16 | 4,146

Reactome Pathway

Costimulation by the CD28 fami... 86 | 86
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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