Development Level

Tbio 31 | 10,625
Tdark 7 | 7,003
Tchem 4 | 1,890

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 2 | 633
preweaning lethality, incomple... 2 | 260
abnormal behavior 1 | 226
abnormal spleen morphology 1 | 36
decreased bone mineral content 1 | 157
decreased fasted circulating g... 1 | 49
decreased lean body mass 1 | 195
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
hyperactivity 1 | 108
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating creatini... 1 | 29
increased total body fat amoun... 1 | 57
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

glioblastoma 21 | 5,572
medulloblastoma, large-cell 21 | 6,234
ovarian cancer 21 | 8,491
osteosarcoma 17 | 7,933
lung cancer 14 | 4,473
psoriasis 14 | 6,685
pilocytic astrocytoma 13 | 3,086
atypical teratoid / rhabdoid tumor 12 | 4,369
group 3 medulloblastoma 11 | 2,254
lung carcinoma 11 | 2,844
Breast cancer 10 | 3,098
non-small cell lung cancer 10 | 2,798
pediatric high grade glioma 10 | 2,712
primitive neuroectodermal tumor 10 | 3,031
subependymal giant cell astrocytoma 10 | 2,287
Multiple myeloma 9 | 1,327
invasive ductal carcinoma 9 | 2,950
Pick disease 8 | 1,893
posterior fossa group A ependymoma 8 | 1,511
astrocytic glioma 7 | 2,241
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,289
lung adenocarcinoma 7 | 2,714
malignant mesothelioma 7 | 3,163
oligodendroglioma 7 | 2,849
Waldenstrons macroglobulinemia 6 | 764
breast carcinoma 6 | 1,614
dermatomyositis 6 | 966
ependymoma 6 | 2,514
active Crohn's disease 5 | 918
acute quadriplegic myopathy 5 | 1,157
astrocytoma 5 | 1,493
colon cancer 5 | 1,475
ductal carcinoma in situ 5 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,988
Duchenne muscular dystrophy 4 | 602
Rheumatoid Arthritis 4 | 1,170
adult high grade glioma 4 | 2,148
atypical teratoid/rhabdoid tumor 4 | 1,095
diabetes mellitus 4 | 1,663
group 4 medulloblastoma 4 | 1,875
interstitial cystitis 4 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,956
juvenile dermatomyositis 4 | 1,189
pancreatic cancer 4 | 2,300
pituitary cancer 4 | 1,972
ulcerative colitis 4 | 2,087
HIV Infections 3 | 99
Intellectual disability 3 | 573
Night Blindness 3 | 39
Skin Neoplasms 3 | 49
Squamous cell carcinoma 3 | 96
cystic fibrosis 3 | 1,670
medulloblastoma 3 | 1,524
non primary Sjogren syndrome sicca 3 | 840
posterior fossa group B ependymoma 3 | 1,530
primary pancreatic ductal adenocarcinoma 3 | 1,271
sonic hedgehog group medulloblastoma 3 | 1,482
Adult T-Cell Lymphoma/Leukemia 2 | 30
Amnesia 2 | 17
Bradyopsia 2 | 10
Cone dystrophy 2 | 59
Congenital stationary night blindness 2 | 28
Diabetes Mellitus, Non-Insulin-Dependent 2 | 161
IGA Glomerulonephritis 2 | 454
Mammary Neoplasms 2 | 410
Neuropathy 2 | 210
Obesity 2 | 616
Parkinson's disease 2 | 364
Peripheral Neuropathy 2 | 303
Prostatic Neoplasms 2 | 471
Schizophrenia 2 | 503
Substance Withdrawal Syndrome 2 | 55
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
cutaneous lupus erythematosus 2 | 1,056
non-inflammatory breast cancer 2 | 208
primary Sjogren syndrome 2 | 788
sarcoidosis 2 | 368
Animal Mammary Neoplasms 1 | 135
Blindness 1 | 84
Charcot-Marie-Tooth disease 1 | 74
Colorectal Neoplasms 1 | 217
Depressive disorder 1 | 48
Dyspepsia 1 | 34
Early infantile epileptic encephalopathy with suppression bursts 1 | 18
Esophageal Neoplasms 1 | 67
Gaucher disease type 1 1 | 171
Hemolytic anemia 1 | 70
Heroin dependence 1 | 30
Irritable bowel syndrome 1 | 59
Liver diseases 1 | 66
Lymphoma 1 | 57
Mammary Neoplasms, Experimental 1 | 149
Muscle Weakness 1 | 92
Myopia 1 | 99
Neoplasm Recurrence, Local 1 | 23
Osteoporosis 1 | 259
Retinal Degeneration 1 | 49
Varicocele 1 | 21
Weight Gain 1 | 87
facioscapulohumeral dystrophy 1 | 286

Tissue

Blood and immune system 42 | 17,994
Digestive Tract 42 | 18,472
Endocrine System 42 | 18,511
Female tissues 42 | 18,646
Liver and Pancreas 42 | 18,135
Male tissues 42 | 17,968
Nervous System 42 | 18,560
Skin and soft tissues 42 | 18,114
Urinary Tract 42 | 18,443
Cardiovascular System 41 | 17,957
Respiratory system 40 | 17,483

Target Family

Non-IDG 39 | 11,969
Kinase 3 | 634

Reactome Pathway

Cooperation of PDCL (PhLP1) an... 42 | 42
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

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