Development Level

Tbio 11 | 11,445
Tchem 2 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

decreased body weight 2 | 161
preweaning lethality, complete... 2 | 979
abnormal eating behavior 1 | 1
abnormal forced expiratory flo... 1 | 1
abnormal vertebrae morphology 1 | 18
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased body temperature 1 | 2
decreased circulating amylase ... 1 | 28
decreased grip strength 1 | 116
decreased prepulse inhibition 1 | 82
decreased tidal volume 1 | 1
increased blood urea nitrogen ... 1 | 48
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased monocyte cell number 1 | 63
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 9 | 11,493
Cancer 8 | 2,499
glioblastoma 8 | 5,792
medulloblastoma, large-cell 7 | 6,241
ependymoma 6 | 4,679
lung cancer 6 | 4,740
ovarian cancer 6 | 8,520
primitive neuroectodermal tumor 6 | 3,035
Astrocytoma, Pilocytic 5 | 3,081
Breast Neoplasms 5 | 445
Mammary Neoplasms 5 | 425
atypical teratoid / rhabdoid tumor 5 | 5,112
lung carcinoma 5 | 2,843
osteosarcoma 5 | 7,950
Breast cancer 4 | 3,578
group 3 medulloblastoma 4 | 4,104
juvenile dermatomyositis 4 | 1,187
pancreatic cancer 4 | 2,398
primary pancreatic ductal adenocarcinoma 4 | 1,109
psoriasis 4 | 6,694
Alzheimer's disease 3 | 658
Anemia 3 | 365
Brachydactyly 3 | 156
Carcinoma, Pancreatic Ductal 3 | 20
Cataract 3 | 297
Failure to gain weight 3 | 365
Kidney cancer 3 | 2,613
Lens Opacities 3 | 231
Liver Cirrhosis 3 | 181
Pediatric failure to thrive 3 | 365
Schizophrenia 3 | 1,160
Short distal phalanges 3 | 50
Strabismus 3 | 270
Syndactyly 3 | 88
Tetralogy of Fallot 3 | 63
acute myeloid leukemia 3 | 783
adult high grade glioma 3 | 3,801
astrocytic glioma 3 | 2,597
astrocytoma 3 | 1,146
diabetes mellitus 3 | 1,728
gastric carcinoma 3 | 807
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
oligodendroglioma 3 | 2,850
Abnormality of pulmonary valve 2 | 23
Abnormality of the metacarpal bones 2 | 17
Abnormally small eyeball 2 | 97
Absent toes 2 | 4
Adams Oliver syndrome 2 | 6
Adams-Oliver Syndrome 1 2 | 6
Adams-Oliver syndrome 2 | 15
Adenoid Cystic Carcinoma 2 | 99
Aplasia Cutis Congenita 2 | 14
Atopic dermatitis 2 | 952
Calvarial defect 2 | 10
Carcinoma, Adenoid Cystic 2 | 99
Claw hand 2 | 26
Cleft Palate 2 | 271
Congenital absence of hand 2 | 3
Congenital atresia of pulmonary artery 2 | 5
Congenital scar 2 | 13
Cranial defect 2 | 10
Craniofacial Abnormalities 2 | 151
Cutis marmorata 2 | 32
Decreased size of eyeball 2 | 97
Duchenne muscular dystrophy 2 | 601
Hydrocephalus 2 | 152
Liver disease 2 | 237
Microphthalmos 2 | 100
Myofibrillar myopathy 1 2 | 6
Myofibrillar myopathy 3 2 | 5
Pick's disease 2 | 15
Rheumatoid arthritis 2 | 1,191
Seizures 2 | 596
Skull defect 2 | 10
Sparse hair 2 | 59
Syndactyly of fingers 2 | 48
Talipes 2 | 20
Talipes foot deformities 2 | 20
Thin, sparse hair 2 | 59
Ventricular Septal Defects 2 | 119
active Crohn's disease 2 | 922
adrenocortical carcinoma 2 | 1,428
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 510
group 4 medulloblastoma 2 | 1,855
non-small cell lung cancer 2 | 2,890
pediatric high grade glioma 2 | 1,064
progressive supranuclear palsy 2 | 676
sonic hedgehog group medulloblastoma 2 | 467
subependymal giant cell astrocytoma 2 | 2,287
ulcerative colitis 2 | 1,819
Corneal abrasion 1 | 5
Cyclitis 1 | 5
Diagnostic Test for Cushing's Syndrome 1 | 5
Discoid lupus erythematosus 1 | 7
Erythroblastic Anemia 1 | 5
Granuloma annulare 1 | 5
Löffler's syndrome 1 | 5
Pruritus of genital organs 1 | 5
Punctate keratopathy 1 | 5
Synovitis due to Osteoarthritis 1 | 5

Tissue

Blood and immune system 14 | 16,909
Cardiovascular System 14 | 15,192
Digestive Tract 14 | 17,369
Endocrine System 14 | 18,159
Female tissues 14 | 17,400
Liver and Pancreas 14 | 16,750
Male tissues 14 | 17,142
Nervous System 14 | 16,725
Respiratory system 14 | 16,393
Skin and soft tissues 14 | 17,230
Urinary Tract 14 | 16,678

Target Family

Non-IDG 9 | 12,091
Enzyme 5 | 4,145

Reactome Pathway

Constitutive Signaling by NOTC... 14 | 14
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E3 ubiquitin-protein ligase NEURL1 NEURL1 Tbio Enzyme -1.09204 13.1 165
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Polyubiquitin-C UBC Tbio Non-IDG -2.90157 61.9 143
E3 ubiquitin-protein ligase MIB1 MIB1 Tbio Enzyme -1.18767 13.9 219
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.12534 131.4 181
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG -1.66231 61.9 139
E3 ubiquitin-protein ligase NEURL1B NEURL1B Tdark Enzyme -0.33579 2.62 35
E3 ubiquitin-protein ligase MIB2 MIB2 Tbio Enzyme -1.66894 46.6 56
Protein jagged-1 JAG1 Tbio Non-IDG -3.09216 1190.8 473
Disintegrin and metalloproteinase domain-containing protein 17 ADAM17 Tchem Enzyme -3.55216 3569.0 718