Development Level

Tclin 47 | 602
Tbio 6 | 10,625
Tdark 2 | 7,003

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal behavior 1 | 226
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal tail movements 1 | 12
abnormal visceral yolk sac mor... 1 | 2
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased follicular B cell nu... 1 | 4
decreased lactate dehydrogenas... 1 | 14
decreased late germinal center... 1 | 2
decreased red blood cell distr... 1 | 11
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
hypoactivity 1 | 89
increased CD4-positive, CD25-p... 1 | 18
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased body weight 1 | 42
increased early germinal cente... 1 | 2
increased grip strength 1 | 83
increased heart weight 1 | 37
increased lean body mass 1 | 107
prenatal lethality prior to he... 1 | 64

Disease

Diabetes mellitus type 2 47 | 69
Treatment Refractory Type 2 Diabetes Mellitus 47 | 53
ovarian cancer 36 | 8,484
MITOCHONDRIAL COMPLEX I DEFICIENCY 30 | 37
Leigh disease 27 | 81
Multiple myeloma 24 | 1,327
NADH:Q(1) Oxidoreductase deficiency 19 | 20
osteosarcoma 17 | 7,933
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 13 | 14
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
astrocytic glioma 10 | 2,241
glioblastoma 10 | 5,572
lung cancer 10 | 4,466
medulloblastoma, large-cell 9 | 6,234
psoriasis 9 | 6,685
ependymoma 8 | 2,514
Leber hereditary optic neuropathy 7 | 17
acute myeloid leukemia 7 | 780
atypical teratoid / rhabdoid tumor 7 | 4,369
Mitochondrial myopathy 6 | 23
Optic Atrophy, Hereditary, Leber 6 | 14
astrocytoma 6 | 1,493
non primary Sjogren syndrome sicca 6 | 840
tuberculosis and treatment for 6 months 6 | 686
MELAS syndrome 5 | 17
Pick disease 5 | 1,893
Waldenstrons macroglobulinemia 5 | 765
Alzheimer's disease 4 | 644
LEBER OPTIC ATROPHY AND DYSTONIA 4 | 4
Lactic acidosis 4 | 42
Mitochondrial encephalomyopathy 4 | 18
diabetes mellitus 4 | 1,663
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
medulloblastoma 4 | 1,524
oligodendroglioma 4 | 2,849
3-methylglutaconic aciduria 3 | 29
Cancer 3 | 2,346
Disease Progression 3 | 125
Dystonia 3 | 77
Optic atrophy 3 | 43
Parkinson's disease 3 | 364
Retinitis pigmentosa 3 | 153
Stomach Neoplasms 3 | 282
adult high grade glioma 3 | 2,148
aldosterone-producing adenoma 3 | 664
hereditary spastic paraplegia 3 | 313
malignant mesothelioma 3 | 3,162
subependymal giant cell astrocytoma 3 | 2,287
ALZHEIMER DISEASE, SUSCEPTIBILITY TO, MITOCHONDRIAL 2 | 2
Amyloidosis 2 | 68
Anemia 2 | 252
Breast cancer 2 | 3,094
Cardiomyopathies 2 | 90
Cardiomyopathy 2 | 110
Degenerative polyarthritis 2 | 93
Hypertrophic Cardiomyopathy 2 | 56
Lown-Ganong-Levine syndrome 2 | 3
Mitochondrial Encephalomyopathies 2 | 11
Multiple Sclerosis 2 | 498
Neurodegenerative disease 2 | 383
Neuropathy 2 | 210
Optic Atrophies, Hereditary 2 | 2
PARKINSON DISEASE, LATE-ONSET 2 | 18
Parkinson Disease 6, Autosomal Recessive Early-Onset 2 | 3
Pneumonia 2 | 133
Polycystic Ovary Syndrome 2 | 332
Rheumatoid Arthritis 2 | 1,160
Schizophrenia 2 | 501
Wolff-Parkinson-White syndrome 2 | 11
active ulcerative colitis 2 | 477
breast carcinoma 2 | 1,614
hepatocellular carcinoma 2 | 532
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
invasive ductal carcinoma 2 | 2,950
lung adenocarcinoma 2 | 2,713
pediatric high grade glioma 2 | 2,712
primitive neuroectodermal tumor 2 | 3,031
tuberculosis 2 | 1,557
Arsenic Poisoning 1 | 59
Bipolar Disorder 1 | 266
Colon Carcinoma 1 | 25
Congenital adrenal hyperplasia 1 | 74
Dermatologic disorders 1 | 65
Diabetes Mellitus, Experimental 1 | 106
Echinococcosis 1 | 28
Epicondylitis 1 | 19
Kabuki syndrome 1 | 27
Lung squamous cell carcinoma 1 | 10
Mammary Neoplasms 1 | 410
Neutropenia 1 | 78
Osgood-Schlatter's disease 1 | 6
Osteoarthritis 1 | 96
Papillary thyroid carcinoma 1 | 37
Paralytic poliomyelitis 1 | 3
Placenta praevia 1 | 9
Staphyloenterotoxemia 1 | 20
Sudden infant death syndrome 1 | 33
Toxoplasmosis 1 | 16
Weight Gain 1 | 87
hand, foot and mouth disease 1 | 11

Tissue

Blood and immune system 55 | 17,995
Cardiovascular System 55 | 17,958
Digestive Tract 55 | 18,473
Endocrine System 55 | 18,512
Female tissues 55 | 18,647
Liver and Pancreas 55 | 18,136
Male tissues 55 | 17,969
Nervous System 55 | 18,561
Respiratory system 55 | 17,484
Skin and soft tissues 55 | 18,115
Urinary Tract 55 | 18,444

Target Family

Enzyme 48 | 4,146
Non-IDG 7 | 11,971

Reactome Pathway

Complex I biogenesis 55 | 55
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..