Development Level

Tclin 47 | 602
Tbio 6 | 10,625
Tdark 2 | 7,003

IMPC Phenotype

preweaning lethality, complete... 5 | 633
abnormal behavior 1 | 226
abnormal embryo size 1 | 112
abnormal embryo turning 1 | 15
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal tail movements 1 | 12
abnormal visceral yolk sac mor... 1 | 2
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased follicular B cell nu... 1 | 4
decreased lactate dehydrogenas... 1 | 14
decreased late germinal center... 1 | 2
decreased red blood cell distr... 1 | 11
decreased total retina thickne... 1 | 20
embryonic growth retardation 1 | 28
embryonic lethality prior to o... 1 | 148
hypoactivity 1 | 89
increased CD4-positive, CD25-p... 1 | 18
increased T cell number 1 | 15
increased alpha-beta T cell nu... 1 | 9
increased body weight 1 | 42
increased early germinal cente... 1 | 2
increased grip strength 1 | 83
increased heart weight 1 | 37
increased lean body mass 1 | 107
prenatal lethality prior to he... 1 | 64

Disease

Diabetes mellitus type 2 47 | 69
Treatment Refractory Type 2 Diabetes Mellitus 47 | 53
ovarian cancer 36 | 8,491
Mitochondrial complex I deficiency 30 | 37
Leigh disease 27 | 81
Mitochondrial Complex 1 Deficiency 26 | 28
Multiple myeloma 24 | 1,327
NADH:Q(1) Oxidoreductase deficiency 19 | 20
Leigh syndrome 18 | 34
osteosarcoma 17 | 7,933
LEIGH SYNDROME DUE TO MITOCHONDRIAL COMPLEX I DEFICIENCY 13 | 14
pancreatic ductal adenocarcinoma liver metastasis 13 | 1,795
astrocytic glioma 10 | 2,241
glioblastoma 10 | 5,572
lung cancer 10 | 4,473
medulloblastoma, large-cell 9 | 6,234
psoriasis 9 | 6,685
ependymoma 8 | 2,514
Leber hereditary optic neuropathy 7 | 17
acute myeloid leukemia 7 | 785
atypical teratoid / rhabdoid tumor 7 | 4,369
Leber's optic atrophy 6 | 10
Mitochondrial myopathy 6 | 24
Optic Atrophy, Hereditary, Leber 6 | 14
astrocytoma 6 | 1,493
non primary Sjogren syndrome sicca 6 | 840
tuberculosis and treatment for 6 months 6 | 686
MELAS syndrome 5 | 17
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes 5 | 9
Pick disease 5 | 1,893
Waldenstrons macroglobulinemia 5 | 764
Alzheimer's disease 4 | 644
LEBER OPTIC ATROPHY AND DYSTONIA 4 | 4
Lactic acidosis 4 | 43
Mitochondrial encephalomyopathy 4 | 18
Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome 4 | 5
diabetes mellitus 4 | 1,663
intraductal papillary-mucinous neoplasm (IPMN) 4 | 3,289
medulloblastoma 4 | 1,524
oligodendroglioma 4 | 2,849
3-methylglutaconic aciduria 3 | 29
Cancer 3 | 2,346
Disease Progression 3 | 125
Dystonia 3 | 77
Optic atrophy 3 | 43
Parkinson's disease 3 | 364
Retinitis pigmentosa 3 | 156
Stomach Neoplasms 3 | 282
adult high grade glioma 3 | 2,148
aldosterone-producing adenoma 3 | 664
hereditary spastic paraplegia 3 | 313
malignant mesothelioma 3 | 3,163
subependymal giant cell astrocytoma 3 | 2,287
ALZHEIMER DISEASE, SUSCEPTIBILITY TO, MITOCHONDRIAL 2 | 2
Alzheimer disease mitochondrial 2 | 2
Amyloidosis 2 | 68
Anemia 2 | 252
Breast cancer 2 | 3,098
Cardiomyopathies 2 | 90
Cardiomyopathy 2 | 110
Degenerative polyarthritis 2 | 93
Hypertrophic Cardiomyopathy 2 | 56
Leber hereditary optic neuropathy with dystonia 2 | 2
Lown-Ganong-Levine syndrome 2 | 3
Mitochondrial Encephalomyopathies 2 | 11
Multiple Sclerosis 2 | 498
Neurodegenerative disease 2 | 383
Neuropathy 2 | 210
Optic Atrophies, Hereditary 2 | 2
PARKINSON DISEASE, LATE-ONSET 2 | 20
Parkinson Disease 6, Autosomal Recessive Early-Onset 2 | 3
Pneumonia 2 | 133
Polycystic Ovary Syndrome 2 | 334
Rheumatoid Arthritis 2 | 1,170
Schizophrenia 2 | 503
Wolff-Parkinson-White syndrome 2 | 11
active ulcerative colitis 2 | 477
breast carcinoma 2 | 1,614
hepatocellular carcinoma 2 | 550
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
invasive ductal carcinoma 2 | 2,950
lung adenocarcinoma 2 | 2,714
pediatric high grade glioma 2 | 2,712
primitive neuroectodermal tumor 2 | 3,031
tuberculosis 2 | 1,563
Carcinoma of colon 1 | 32
Colon Carcinoma 1 | 25
Congenital adrenal hyperplasia 1 | 74
Diabetes Mellitus, Experimental 1 | 106
Echinococcosis 1 | 28
Epicondylitis 1 | 19
Lung squamous cell carcinoma 1 | 10
Osgood-Schlatter's disease 1 | 6
Osteoarthritis 1 | 96
Papillary thyroid carcinoma 1 | 37
Placenta praevia 1 | 9
Staphyloenterotoxemia 1 | 20
Sudden infant death syndrome 1 | 34
Toxoplasmosis 1 | 16
hand, foot and mouth disease 1 | 11

Tissue

Blood and immune system 55 | 17,994
Cardiovascular System 55 | 17,957
Digestive Tract 55 | 18,472
Endocrine System 55 | 18,511
Female tissues 55 | 18,646
Liver and Pancreas 55 | 18,135
Male tissues 55 | 17,968
Nervous System 55 | 18,560
Respiratory system 55 | 17,483
Skin and soft tissues 55 | 18,114
Urinary Tract 55 | 18,443

Target Family

Enzyme 48 | 4,146
Non-IDG 7 | 11,969

Reactome Pathway

Complex I biogenesis 55 | 55
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

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