Development Level

Tbio 56 | 11,445
Tdark 7 | 6,588
Tchem 3 | 1,598

IMPC Phenotype

decreased grip strength 3 | 116
decreased total body fat amoun... 3 | 207
abnormal femur morphology 2 | 14
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
impaired glucose tolerance 2 | 75
abnormal bone structure 1 | 187
abnormal ear morphology 1 | 9
abnormal embryo size 1 | 220
abnormal humerus morphology 1 | 11
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal limb position 1 | 3
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal radius morphology 1 | 8
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal tibia morphology 1 | 14
abnormal ulna morphology 1 | 8
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased heart rate 1 | 18
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
dilated heart left ventricle 1 | 11
embryonic lethality prior to o... 1 | 239
enlarged lymph nodes 1 | 37
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating triglyce... 1 | 42
increased fasted circulating g... 1 | 76
increased grip strength 1 | 41
increased heart weight 1 | 62
increased large unstained cell... 1 | 5
increased mean corpuscular hem... 1 | 36
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased total body fat amoun... 1 | 134
increased vertical activity 1 | 24
persistence of hyaloid vascula... 1 | 33
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
prolonged RR interval 1 | 8
short tibia 1 | 97
thin skin 1 | 2

Disease

Carcinoma 60 | 11,493
ovarian cancer 54 | 8,520
glioblastoma 42 | 5,792
Astrocytoma, Pilocytic 39 | 3,081
Kidney cancer 34 | 2,613
atypical teratoid / rhabdoid tumor 34 | 5,112
ependymoma 34 | 4,679
lung cancer 32 | 4,740
Breast cancer 30 | 3,578
osteosarcoma 30 | 7,950
medulloblastoma, large-cell 29 | 6,241
psoriasis 29 | 6,694
lung adenocarcinoma 27 | 2,716
pancreatic cancer 27 | 2,398
non-small cell lung cancer 25 | 2,890
pituitary cancer 25 | 1,972
adult high grade glioma 24 | 3,801
interstitial cystitis 24 | 2,312
malignant mesothelioma 24 | 3,232
Autosomal recessive predisposition 23 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
invasive ductal carcinoma 22 | 2,951
primitive neuroectodermal tumor 20 | 3,035
Duchenne muscular dystrophy 19 | 601
gastric carcinoma 19 | 807
cystic fibrosis 18 | 1,696
breast carcinoma 17 | 1,638
nasopharyngeal carcinoma 17 | 1,058
ulcerative colitis 17 | 1,819
Acquired scoliosis 16 | 281
Curvature of spine 16 | 282
Myopia 16 | 176
Short stature 16 | 531
Skin cancer 16 | 469
autosomal dominant Emery-Dreifuss muscular dystrophy 16 | 510
ductal carcinoma in situ 15 | 1,745
group 3 medulloblastoma 15 | 4,104
primary pancreatic ductal adenocarcinoma 15 | 1,109
Degenerative polyarthritis 14 | 115
Hypoplastic mandible condyle 14 | 275
Mandibular hypoplasia 14 | 275
Melanoma 14 | 711
Micrognathism 14 | 275
subependymal giant cell astrocytoma 14 | 2,287
Becker muscular dystrophy 13 | 191
Liver Cirrhosis, Experimental 13 | 769
Platyspondyly 13 | 56
juvenile dermatomyositis 13 | 1,187
urothelial carcinoma 13 | 318
Hyperkyphosis 12 | 111
Kyphosis deformity of spine 12 | 114
Osteoarthritis 12 | 184
group 4 medulloblastoma 12 | 1,855
lung carcinoma 12 | 2,843
oligodendroglioma 12 | 2,850
Cataract 11 | 297
Joint hyperflexibility 11 | 78
Osteogenesis imperfecta 11 | 34
Pick disease 11 | 1,894
adrenocortical carcinoma 11 | 1,428
interstitial lung disease 11 | 298
limb girdle muscular dystrophy 2A 11 | 213
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
pediatric high grade glioma 11 | 1,064
Blue sclera 10 | 32
Ehlers-Danlos syndrome 10 | 43
Hernia, Inguinal 10 | 89
Hypotrophic malar bone 10 | 129
Lens Opacities 10 | 231
Liver cancer 10 | 604
Malar flattening 10 | 129
Respiratory Insufficiency 10 | 132
Respiratory function loss 10 | 121
esophageal adenocarcinoma 10 | 737
Abortion, Spontaneous 9 | 109
Congenital clubfoot 9 | 109
Generalized osteopenia 9 | 99
Joint laxity 9 | 54
Micromelia 9 | 58
Osteopenia 9 | 99
Spontaneous abortion 9 | 113
colon cancer 9 | 1,478
diabetes mellitus 9 | 1,728
fibroadenoma 9 | 559
pterygium 9 | 76
Atopic dermatitis 8 | 952
Congenital deafness 8 | 185
Contracture 8 | 96
Contracture of joint 8 | 93
Deafness 8 | 198
Flat face 8 | 52
Flexion contracture 8 | 93
Flexion contractures of joints 8 | 93
Hearing Loss, Partial 8 | 185
Pectus excavatum 8 | 100
Sensorineural Hearing Loss (disorder) 8 | 284
active Crohn's disease 8 | 922
astrocytoma 8 | 1,146

Tissue

Endocrine System 66 | 18,159
Female tissues 66 | 17,400
Male tissues 66 | 17,142
Blood and immune system 65 | 16,909
Digestive Tract 65 | 17,369
Skin and soft tissues 65 | 17,230
Liver and Pancreas 64 | 16,750
Nervous System 64 | 16,725
Urinary Tract 63 | 16,678
Cardiovascular System 61 | 15,192
Respiratory system 60 | 16,393

Target Family

Non-IDG 49 | 12,091
Enzyme 17 | 4,145

Reactome Pathway

Collagen biosynthesis and modi... 66 | 66
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Collagen alpha-1(XXIII) chain COL23A1 Tbio Non-IDG -0.49550 1.85 112
Collagen alpha-1(XXI) chain COL21A1 Tbio Non-IDG -0.67130 4.90 89
Collagen alpha-1(XII) chain COL12A1 Tbio Non-IDG -1.36571 21.4 38
Collagen alpha-1(XV) chain COL15A1 Tbio Non-IDG -1.18716 15.5 74
Collagen alpha-1(XVIII) chain COL18A1 Tbio Non-IDG -3.18339 1561.4 433
Collagen alpha-1(VI) chain COL6A1 Tbio Non-IDG -2.03348 104.7 204
Collagen alpha-1(XI) chain COL11A1 Tbio Non-IDG -2.15516 138.4 96
Collagen alpha-2(VI) chain COL6A2 Tbio Non-IDG -1.80531 59.2 151
Prolyl 3-hydroxylase 2 P3H2 Tbio Enzyme -2.49306 295.2 60
A disintegrin and metalloproteinase with thrombospondin motifs 3 ADAMTS3 Tbio Enzyme -0.75603 4.50 45