Development Level

Tbio 110 | 11,651
Tchem 13 | 1,388
Tclin 9 | 612
Tdark 3 | 6,593

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 12 | 979
decreased total body fat amoun... 6 | 207
preweaning lethality, incomple... 6 | 499
decreased mean corpuscular hem... 4 | 50
embryonic lethality prior to t... 4 | 278
abnormal embryo size 3 | 220
decreased leukocyte cell numbe... 3 | 73
decreased mean corpuscular vol... 3 | 79
decreased vertical activity 3 | 208
embryonic lethality prior to o... 3 | 239
increased circulating HDL chol... 3 | 80
abnormal behavior 2 | 298
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
abnormal heart shape 2 | 5
abnormal seminal vesicle morph... 2 | 114
cardiovascular system phenotyp... 2 | 36
decreased bone mineral density 2 | 126
decreased neutrophil cell numb... 2 | 42
decreased prepulse inhibition 2 | 82
embryonic growth retardation 2 | 106
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
hydrometra 2 | 53
improved glucose tolerance 2 | 79
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased circulating potassiu... 2 | 29
increased circulating total pr... 2 | 28
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular vol... 2 | 92
increased startle reflex 2 | 112
persistence of hyaloid vascula... 2 | 33
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal eye size 1 | 7
abnormal hair texture 1 | 4
abnormal lens morphology 1 | 81
abnormal liver size 1 | 5
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
abnormal urinary bladder morph... 1 | 11
absent pinna reflex 1 | 23
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating fructosa... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased circulating unsatura... 1 | 2
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
decreased large unstained cell... 1 | 11
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased monocyte cell number 1 | 8
edema 1 | 59
enlarged cecum 1 | 5
enlarged kidney 1 | 14
enlarged seminal vesicle 1 | 10
hydrops fetalis 1 | 1
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired righting response 1 | 26
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating free fat... 1 | 20
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased circulating thyroxin... 1 | 7
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
small seminal vesicle 1 | 10
small spleen 1 | 19
small thymus 1 | 16
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 93 | 11,493
ovarian cancer 85 | 8,520
osteosarcoma 75 | 7,950
psoriasis 68 | 6,694
glioblastoma 60 | 5,792
medulloblastoma, large-cell 58 | 6,241
atypical teratoid / rhabdoid tumor 47 | 5,112
lung cancer 44 | 4,740
ependymoma 42 | 4,679
Astrocytoma, Pilocytic 34 | 3,081
astrocytic glioma 34 | 2,597
adult high grade glioma 33 | 3,801
Cancer 32 | 2,499
malignant mesothelioma 32 | 3,232
subependymal giant cell astrocytoma 32 | 2,287
Breast cancer 31 | 3,578
lung carcinoma 31 | 2,843
oligodendroglioma 31 | 2,850
group 3 medulloblastoma 30 | 4,104
invasive ductal carcinoma 30 | 2,951
pancreatic cancer 29 | 2,398
Pick disease 26 | 1,894
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
primitive neuroectodermal tumor 25 | 3,035
Kidney cancer 24 | 2,613
non-small cell lung cancer 24 | 2,890
Multiple myeloma 23 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
acute quadriplegic myopathy 19 | 1,158
lung adenocarcinoma 19 | 2,716
Autosomal recessive predisposition 18 | 1,442
Schizophrenia 18 | 1,160
ductal carcinoma in situ 18 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
pituitary cancer 18 | 1,972
diabetes mellitus 17 | 1,728
Alzheimer's disease 16 | 658
interstitial cystitis 16 | 2,312
Rheumatoid arthritis 15 | 1,191
cystic fibrosis 15 | 1,696
juvenile dermatomyositis 15 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Waldenstrons macroglobulinemia 14 | 765
primary pancreatic ductal adenocarcinoma 14 | 1,109
tuberculosis 14 | 2,010
breast carcinoma 12 | 1,638
dermatomyositis 12 | 966
esophageal adenocarcinoma 12 | 737
spina bifida 12 | 1,074
Cataract 8 multiple types 11 | 33
adrenocortical carcinoma 11 | 1,428
astrocytoma 11 | 1,146
cutaneous lupus erythematosus 11 | 1,057
Bipolar Disorder 10 | 666
Epilepsy 10 | 792
Kidney disease 10 | 430
Parkinson's disease 10 | 392
aldosterone-producing adenoma 10 | 665
group 4 medulloblastoma 10 | 1,855
primary Sjogren syndrome 10 | 735
progressive supranuclear palsy 10 | 676
ulcerative colitis 10 | 1,819
Atopic dermatitis 9 | 952
pancreatic carcinoma 9 | 562
pediatric high grade glioma 9 | 1,064
Alcoholic Intoxication, Chronic 8 | 289
Depressive disorder 8 | 409
Diarrhea 8 | 253
Hypertensive disease 8 | 292
Intellectual disability 8 | 1,016
Neurodegenerative disease 8 | 414
Obesity 8 | 678
Oculocerebrorenal syndrome 8 | 29
acute myeloid leukemia 8 | 783
gastric carcinoma 8 | 807
non primary Sjogren syndrome sicca 8 | 891
Dull intelligence 7 | 645
Hypertension 7 | 396
Low intelligence 7 | 645
Major Depressive Disorder 7 | 301
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
gastric cancer 7 | 459
Amyotrophic lateral sclerosis 6 | 451
Down syndrome 6 | 499
Duchenne muscular dystrophy 6 | 601
Failure to gain weight 6 | 365
Liver Cirrhosis, Experimental 6 | 769
Liver cancer 6 | 604
Melanoma 6 | 711
Multiple Sclerosis 6 | 540
Pediatric failure to thrive 6 | 365
Prostatic Neoplasms 6 | 495
Seizures 6 | 596
Unipolar Depression 6 | 250
Vascular disease 6 | 319
colon cancer 6 | 1,478
medulloblastoma 6 | 720
mucosa-associated lymphoid tissue lymphoma 6 | 484

Tissue

Skin and soft tissues 135 | 17,230
Digestive Tract 134 | 17,369
Endocrine System 134 | 18,159
Female tissues 134 | 17,400
Urinary Tract 134 | 16,678
Male tissues 133 | 17,142
Blood and immune system 132 | 16,909
Liver and Pancreas 132 | 16,750
Respiratory system 132 | 16,393
Nervous System 130 | 16,725
Cardiovascular System 126 | 15,192

Target Family

Non-IDG 106 | 12,091
Enzyme 14 | 4,145
GPCR 6 | 408
Kinase 6 | 634
Transporter 2 | 473
Ion Channel 1 | 344

Reactome Pathway

Clathrin-mediated endocytosis 135 | 135
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Stonin-2 STON2 Tbio Non-IDG -1.43585 30.0 11
Epsin-1 EPN1 Tbio Non-IDG -1.52389 32.5 163
Vesicle-associated membrane protein 8 VAMP8 Tbio Non-IDG -1.79654 64.6 107
Sorting nexin-9 SNX9 Tbio Non-IDG -2.00279 102.8 241
Protein kinase C and casein kinase substrate in neurons protein 3 PACSIN3 Tbio Enzyme -0.67239 5.43 259
Synaptotagmin-11 SYT11 Tbio Non-IDG -1.00759 12.5 125
Endophilin-A1 SH3GL2 Tbio Non-IDG -1.79540 59.9 248
Endophilin-A3 SH3GL3 Tbio Non-IDG -1.03962 9.87 97
Vasopressin-neurophysin 2-copeptin AVP Tbio Non-IDG -3.92570 8381.2 203
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978