Development Level

Tbio 105 | 10,625
Tchem 19 | 1,890
Tclin 9 | 602
Tdark 2 | 7,003

Collection

Kinase: IDG Consortium (Complete/Control) 1 | 37

IMPC Phenotype

preweaning lethality, complete... 7 | 633
decreased total body fat amoun... 6 | 186
abnormal behavior 4 | 226
decreased lean body mass 4 | 195
decreased mean corpuscular vol... 4 | 50
preweaning lethality, incomple... 4 | 260
decreased grip strength 3 | 123
decreased mean corpuscular hem... 3 | 34
embryonic lethality prior to t... 3 | 187
increased circulating HDL chol... 3 | 63
increased circulating alkaline... 3 | 119
increased circulating potassiu... 3 | 31
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased or absent threshold ... 3 | 128
abnormal embryo size 2 | 112
abnormal lens morphology 2 | 73
cardiovascular system phenotyp... 2 | 35
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased circulating fructosa... 2 | 31
decreased circulating serum al... 2 | 79
decreased leukocyte cell numbe... 2 | 54
embryonic lethality prior to o... 2 | 148
enlarged lymph nodes 2 | 27
hypoactivity 2 | 89
increased body weight 2 | 42
increased bone mineral content 2 | 92
increased circulating LDL chol... 2 | 15
increased erythrocyte cell num... 2 | 26
increased leukocyte cell numbe... 2 | 37
thrombocytopenia 2 | 46
abnormal QRS complex 1 | 25
abnormal bone structure 1 | 131
abnormal coat appearance 1 | 25
abnormal coat- hair morphology 1 | 18
abnormal coat-hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal eye morphology 1 | 38
abnormal eye size 1 | 11
abnormal forebrain development 1 | 18
abnormal hair growth 1 | 8
abnormal hair texture 1 | 4
abnormal hindbrain development 1 | 24
abnormal liver size 1 | 4
abnormal midbrain development 1 | 22
abnormal neural tube closure 1 | 37
abnormal pericardium morpholog... 1 | 11
abnormal posture 1 | 5
abnormal sleep behavior 1 | 63
abnormal spinal cord morpholog... 1 | 8
absent heartbeat 1 | 6
absent pinna reflex 1 | 21
decreased basophil cell number 1 | 11
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating triglyce... 1 | 83
decreased effector memory CD4-... 1 | 6
decreased eosinophil cell numb... 1 | 41
decreased fasted circulating g... 1 | 49
decreased gamma-delta T cell n... 1 | 18
decreased granulocyte number 1 | 8
decreased heart rate 1 | 10
decreased heart rate variabili... 1 | 11
decreased hematocrit 1 | 25
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 19
decreased monocyte cell number 1 | 28
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
decreased threshold for audito... 1 | 32
decreased vertical activity 1 | 22
enlarged kidney 1 | 7
hydrops fetalis 1 | 22
hyperactivity 1 | 108
impaired righting response 1 | 19
increased B cell number 1 | 23
increased T cell number 1 | 15
increased circulating calcium ... 1 | 32
increased circulating choleste... 1 | 53
increased circulating fructosa... 1 | 11
increased circulating phosphat... 1 | 24
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased grip strength 1 | 83
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased mature B cell number 1 | 12
increased mean corpuscular hem... 1 | 25
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
microphthalmia 1 | 15
persistence of hyaloid vascula... 1 | 22
short tibia 1 | 82
shortened ST segment 1 | 9
thrombocytosis 1 | 23
tremors 1 | 34

Disease

ovarian cancer 84 | 8,491
osteosarcoma 75 | 7,933
psoriasis 68 | 6,685
glioblastoma 61 | 5,572
medulloblastoma, large-cell 59 | 6,234
lung cancer 43 | 4,473
atypical teratoid / rhabdoid tumor 42 | 4,369
pilocytic astrocytoma 37 | 3,086
subependymal giant cell astrocytoma 33 | 2,287
oligodendroglioma 32 | 2,849
invasive ductal carcinoma 30 | 2,950
lung carcinoma 30 | 2,844
Cancer 29 | 2,346
malignant mesothelioma 29 | 3,163
Breast cancer 28 | 3,098
pancreatic cancer 28 | 2,300
pediatric high grade glioma 28 | 2,712
Pick disease 27 | 1,893
astrocytoma 26 | 1,493
ependymoma 26 | 2,514
primitive neuroectodermal tumor 26 | 3,031
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,956
Multiple myeloma 23 | 1,327
non-small cell lung cancer 22 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
Carcinoma 20 | 2,147
astrocytic glioma 20 | 2,241
acute quadriplegic myopathy 19 | 1,157
ductal carcinoma in situ 18 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,988
lung adenocarcinoma 18 | 2,714
Alzheimer's disease 17 | 644
diabetes mellitus 17 | 1,663
pituitary cancer 17 | 1,972
Rheumatoid Arthritis 15 | 1,170
interstitial cystitis 15 | 2,299
juvenile dermatomyositis 15 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,795
primary pancreatic ductal adenocarcinoma 15 | 1,271
Waldenstrons macroglobulinemia 14 | 764
adult high grade glioma 14 | 2,148
cystic fibrosis 14 | 1,670
medulloblastoma 14 | 1,524
group 4 medulloblastoma 13 | 1,875
sonic hedgehog group medulloblastoma 13 | 1,482
breast carcinoma 12 | 1,614
dermatomyositis 12 | 966
esophageal adenocarcinoma 12 | 737
group 3 medulloblastoma 12 | 2,254
posterior fossa group A ependymoma 12 | 1,511
spina bifida 12 | 1,064
adrenocortical carcinoma 11 | 1,427
atypical teratoid/rhabdoid tumor 11 | 1,095
progressive supranuclear palsy 11 | 674
tuberculosis 11 | 1,563
Kidney disease 10 | 397
Parkinson's disease 10 | 364
aldosterone-producing adenoma 10 | 664
cutaneous lupus erythematosus 10 | 1,056
pancreatic carcinoma 9 | 567
primary Sjogren syndrome 9 | 788
ulcerative colitis 9 | 2,087
Atopic dermatitis 8 | 944
Obesity 8 | 616
non primary Sjogren syndrome sicca 8 | 840
posterior fossa group B ependymoma 8 | 1,530
acute myeloid leukemia 7 | 785
gastric cancer 7 | 436
gastric carcinoma 7 | 832
tuberculosis and treatment for 6 months 7 | 686
Down syndrome 6 | 548
Duchenne muscular dystrophy 6 | 602
Gaucher disease type 1 6 | 171
Hypertension 6 | 293
Mammary Neoplasms 6 | 410
Neurodegenerative disease 6 | 383
Prostatic Neoplasms 6 | 471
colon cancer 6 | 1,475
mucosa-associated lymphoid tissue lymphoma 6 | 480
Diarrhea 5 | 155
Heart disease 5 | 279
Schizophrenia 5 | 503
Stomach Neoplasms 5 | 282
Vascular disease 5 | 281
fibroadenoma 5 | 557
hepatocellular carcinoma 5 | 550
interstitial lung disease 5 | 292
Atherosclerosis 4 | 275
Cerebrovascular disease 4 | 231
Coronary artery disease 4 | 240
Hypertensive disease 4 | 193
IGA Glomerulonephritis 4 | 454
Lung disease 4 | 136
Multiple Sclerosis 4 | 498
Polycystic Ovary Syndrome 4 | 334
active Crohn's disease 4 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 499
chronic lymphocytic leukemia 4 | 244
nephrosclerosis 4 | 329
non-small cell lung carcinoma 4 | 413

Tissue

Blood and immune system 135 | 17,994
Cardiovascular System 135 | 17,957
Digestive Tract 135 | 18,472
Endocrine System 135 | 18,511
Female tissues 135 | 18,646
Liver and Pancreas 135 | 18,135
Nervous System 135 | 18,560
Skin and soft tissues 135 | 18,114
Urinary Tract 135 | 18,443
Respiratory system 134 | 17,483
Male tissues 133 | 17,968

Target Family

Non-IDG 105 | 11,969
Enzyme 14 | 4,146
Kinase 7 | 634
GPCR 6 | 408
Transporter 2 | 473
Ion Channel 1 | 341

Reactome Pathway

Clathrin-mediated endocytosis 135 | 135
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adaptin ear-binding coat-associated protein 2 NECAP2 Tdark Non-IDG 0.03 1.26 31
Dynamin-3 DNM3 Tbio Non-IDG -1.39919 21.9 126
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
Low-density lipoprotein receptor LDLR Tchem Non-IDG -3.04462 893.1 512
Disabled homolog 2 DAB2 Tbio Non-IDG -2.24622 174.6 226
Vasopressin-neurophysin 2-copeptin AVP Tbio Non-IDG -3.91847 8071.2 168
COP9 signalosome complex subunit 3 COPS3 Tbio Non-IDG -1.07542 12.3 193
Substance-P receptor TACR1 Tclin GPCR -3.09243 1193.3 417
Ras-related protein Rab-5C RAB5C Tbio Enzyme -1.13690 11.1 135
Formin-binding protein 1 FNBP1 Tbio Non-IDG -1.08779 13.3 127