Development Level

Tbio 56 | 11,445
Tchem 9 | 1,598
Tdark 6 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 5 | 499
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
decreased total body fat amoun... 3 | 207
decreased vertical activity 3 | 208
increased or absent threshold ... 3 | 101
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal heart morphology 2 | 162
abnormal seminal vesicle morph... 2 | 114
cardiovascular system phenotyp... 2 | 36
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating choleste... 2 | 93
decreased mean corpuscular hem... 2 | 50
decreased prepulse inhibition 2 | 82
enlarged heart 2 | 210
enlarged lymph nodes 2 | 37
hyperactivity 2 | 148
hypoactivity 2 | 132
increased circulating alkaline... 2 | 122
increased startle reflex 2 | 112
abnormal behavioral response t... 1 | 66
abnormal coat-hair pigmentatio... 1 | 64
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal iris pigmentation 1 | 4
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
absent adrenal gland 1 | 2
convulsive seizures 1 | 13
decreased bone mineral content 1 | 151
decreased cardiac output 1 | 3
decreased cardiac stroke volum... 1 | 6
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating bilirubi... 1 | 19
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased respiratory quotient 1 | 16
embryonic growth retardation 1 | 106
enlarged spleen 1 | 41
hemorrhage 1 | 23
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating chloride... 1 | 41
increased circulating fructosa... 1 | 13
increased circulating thyroxin... 1 | 7
increased circulating total pr... 1 | 28
increased coping response 1 | 4
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased kidney weight 1 | 6
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased prepulse inhibition 1 | 32
limb grasping 1 | 41
premature death 1 | 5
prenatal lethality 1 | 28
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

ovarian cancer 44 | 8,520
Carcinoma 40 | 11,493
osteosarcoma 39 | 7,950
medulloblastoma, large-cell 34 | 6,241
psoriasis 31 | 6,694
atypical teratoid / rhabdoid tumor 30 | 5,112
glioblastoma 30 | 5,792
ependymoma 25 | 4,679
Multiple myeloma 18 | 1,332
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,291
astrocytic glioma 17 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
lung cancer 17 | 4,740
lung carcinoma 17 | 2,843
Breast cancer 16 | 3,578
Astrocytoma, Pilocytic 15 | 3,081
adult high grade glioma 15 | 3,801
group 4 medulloblastoma 15 | 1,855
malignant mesothelioma 15 | 3,232
oligodendroglioma 13 | 2,850
Autosomal recessive predisposition 12 | 1,442
Kidney cancer 12 | 2,613
invasive ductal carcinoma 12 | 2,951
subependymal giant cell astrocytoma 12 | 2,287
tuberculosis 12 | 2,010
group 3 medulloblastoma 11 | 4,104
non-small cell lung cancer 11 | 2,890
Cancer 10 | 2,499
Intellectual disability 10 | 1,016
Pick disease 10 | 1,894
Schizophrenia 10 | 1,160
cystic fibrosis 10 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 10 | 1,962
Cataract 8 multiple types 9 | 33
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
Neurodegenerative disease 9 | 414
Waldenstrons macroglobulinemia 9 | 765
acute quadriplegic myopathy 9 | 1,158
adrenocortical carcinoma 9 | 1,428
lung adenocarcinoma 9 | 2,716
pancreatic cancer 9 | 2,398
Epilepsy 8 | 792
ductal carcinoma in situ 8 | 1,745
juvenile dermatomyositis 8 | 1,187
pediatric high grade glioma 8 | 1,064
primitive neuroectodermal tumor 8 | 3,035
Coarse facial features 7 | 108
Hermansky-Pudlak syndrome 7 | 42
Prenatal onset 7 | 139
Rheumatoid arthritis 7 | 1,191
Seizures 7 | 596
Thickened facial skin with coarse facial features 7 | 108
diabetes mellitus 7 | 1,728
Alzheimer's disease 6 | 658
Depressive disorder 6 | 409
Down syndrome 6 | 499
Gaucher disease type 1 6 | 180
Liver Cirrhosis, Experimental 6 | 769
Parkinson's disease 6 | 392
Platelet storage pool deficiency 6 | 21
astrocytoma 6 | 1,146
dermatomyositis 6 | 966
esophageal adenocarcinoma 6 | 737
interstitial cystitis 6 | 2,312
pituitary cancer 6 | 1,972
Babinski Reflex 5 | 100
Dilated ventricles (finding) 5 | 121
Dull intelligence 5 | 645
Hyperreflexia 5 | 209
Low intelligence 5 | 645
Macrostomia 5 | 72
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Poor school performance 5 | 645
Small head 5 | 374
Tetanus 5 | 68
acute myeloid leukemia 5 | 783
gastric carcinoma 5 | 807
primary pancreatic ductal adenocarcinoma 5 | 1,109
progressive supranuclear palsy 5 | 676
spina bifida 5 | 1,074
ulcerative colitis 5 | 1,819
Bipolar Disorder 4 | 666
Contracture 4 | 96
Contracture of joint 4 | 93
Major Depressive Disorder 4 | 301
Microcephaly 4 | 166
Paraplegia 4 | 74
Polycystic ovary syndrome 4 | 360
Prostatic Neoplasms 4 | 495
Severe mental retardation (I.Q. 20-34) 4 | 99
Unipolar Depression 4 | 250
active Crohn's disease 4 | 922
breast carcinoma 4 | 1,638
colon cancer 4 | 1,478
hereditary spastic paraplegia 4 | 318
mucosa-associated lymphoid tissue lymphoma 4 | 484

Tissue

Digestive Tract 71 | 17,369
Endocrine System 71 | 18,159
Female tissues 71 | 17,400
Male tissues 71 | 17,142
Nervous System 71 | 16,725
Skin and soft tissues 71 | 17,230
Blood and immune system 70 | 16,909
Cardiovascular System 70 | 15,192
Liver and Pancreas 70 | 16,750
Respiratory system 70 | 16,393
Urinary Tract 70 | 16,678

Target Family

Non-IDG 60 | 12,091
Enzyme 9 | 4,145
Kinase 2 | 634

Reactome Pathway

Clathrin derived vesicle buddi... 71 | 71
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Sorting nexin-5 SNX5 Tbio Non-IDG -1.23706 20.8 141
Alpha-soluble NSF attachment protein NAPA Tbio Non-IDG -1.91664 86.4 148
Biogenesis of lysosome-related organelles complex 1 subunit 4 BLOC1S4 Tdark Non-IDG 0.00000 53
Biogenesis of lysosome-related organelles complex 1 subunit 3 BLOC1S3 Tbio Non-IDG -0.81676 0.00000 66
Biogenesis of lysosome-related organelles complex 1 subunit 1 BLOC1S1 Tbio Non-IDG -1.17005 16.2 49
Transferrin receptor protein 1 TFRC Tbio Non-IDG -3.43851 2558.3 1677
Ferritin light chain FTL Tbio Non-IDG -2.36162 227.3 549
Golgin subfamily B member 1 GOLGB1 Tbio Non-IDG -2.75385 540.5 88
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.66258 38.8 231
Clavesin-1 CLVS1 Tbio Non-IDG -0.31702 2.43 61