Development Level

Tbio 317 | 10,625
Tdark 69 | 7,003
Tchem 38 | 1,890
Tclin 7 | 602

IMPC Term

preweaning lethality, complete... 16 | 633
decreased lean body mass 12 | 195
preweaning lethality, incomple... 12 | 260
abnormal behavior 11 | 226
decreased bone mineral content 10 | 157
decreased grip strength 9 | 123
decreased total body fat amoun... 8 | 186
increased or absent threshold ... 8 | 128
decreased bone mineral density 7 | 126
decreased body weight 6 | 174
decreased heart weight 6 | 44
decreased body length 5 | 108
decreased circulating triglyce... 5 | 83
embryonic lethality prior to t... 5 | 187
abnormal bone structure 4 | 131
decreased circulating HDL chol... 4 | 77
decreased circulating alanine ... 4 | 53
embryonic lethality prior to o... 4 | 148
hypoactivity 4 | 89
increased mean corpuscular vol... 4 | 91
male infertility 4 | 62
short tibia 4 | 82
abnormal embryo size 3 | 112
abnormal eye morphology 3 | 38
abnormal retina morphology 3 | 100
decreased circulating LDL chol... 3 | 37
decreased circulating amylase ... 3 | 24
decreased circulating choleste... 3 | 85
decreased hemoglobin content 3 | 53
decreased rib number 3 | 59
decreased startle reflex 3 | 48
increased circulating HDL chol... 3 | 63
increased circulating choleste... 3 | 53
increased lean body mass 3 | 107
increased total body fat amoun... 3 | 57
trunk curl 3 | 15
abnormal gait 2 | 51
abnormal heart left ventricle ... 2 | 20
abnormal spleen morphology 2 | 36
absent startle reflex 2 | 15
anophthalmia 2 | 20
cardiovascular system phenotyp... 2 | 35
decreased blood urea nitrogen ... 2 | 31
decreased circulating alkaline... 2 | 41
decreased circulating aspartat... 2 | 27
decreased circulating chloride... 2 | 32
decreased circulating free fat... 2 | 39
decreased circulating fructosa... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating insulin ... 2 | 75
decreased eosinophil cell numb... 2 | 41
decreased erythrocyte cell num... 2 | 43
decreased mean corpuscular vol... 2 | 50
decreased prepulse inhibition 2 | 52
embryonic growth retardation 2 | 28
enlarged spleen 2 | 26
hyperactivity 2 | 108
increased B cell number 2 | 23
increased NK cell number 2 | 19
increased bone mineral content 2 | 92
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased effector memory CD8-... 2 | 14
increased exploration in new e... 2 | 56
increased grip strength 2 | 83
increased heart rate 2 | 17
increased heart weight 2 | 37
increased hematocrit 2 | 36
increased mean corpuscular hem... 2 | 93
increased monocyte cell number 2 | 27
increased startle reflex 2 | 38
persistence of hyaloid vascula... 2 | 22
small liver 2 | 8
tremors 2 | 34
abnormal behavioral response t... 1 | 52
abnormal coping response 1 | 12
abnormal neural tube closure 1 | 37
abnormal retinal pigmentation 1 | 61
abnormal skin morphology 1 | 23
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased NK cell number 1 | 16
decreased effector memory CD8-... 1 | 24
decreased mean corpuscular hem... 1 | 34
female infertility 1 | 34
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating triglyce... 1 | 24
increased effector memory CD4-... 1 | 15
increased mean platelet volume 1 | 19
increased rib number 1 | 41
limb grasping 1 | 35
prenatal lethality 1 | 16
small thymus 1 | 11
stereotypic behavior 1 | 3
straub tail 1 | 26

Disease

ovarian cancer 236 | 8,484
psoriasis 190 | 6,685
osteosarcoma 184 | 7,933
glioblastoma 140 | 5,572
medulloblastoma, large-cell 139 | 6,234
Cancer 127 | 2,346
lung cancer 103 | 4,466
atypical teratoid / rhabdoid tumor 98 | 4,369
diabetes mellitus 95 | 1,663
Multiple myeloma 81 | 1,327
Ankylosing spondylitis 76 | 138
pilocytic astrocytoma 72 | 3,086
Rheumatoid Arthritis 70 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,289
Arthritis 66 | 248
Breast cancer 61 | 3,094
Hypersensitivity reaction type II disease 61 | 235
intraductal papillary-mucinous adenoma (IPMA) 60 | 2,956
subependymal giant cell astrocytoma 59 | 2,287
Acquired immunodeficiency syndrome 58 | 164
Behcet's disease 58 | 74
Uveitis 58 | 103
intraductal papillary-mucinous carcinoma (IPMC) 58 | 2,988
Juvenile rheumatoid arthritis 56 | 104
ependymoma 56 | 2,514
juvenile dermatomyositis 56 | 1,189
malignant mesothelioma 56 | 3,162
lung carcinoma 55 | 2,844
oligodendroglioma 55 | 2,849
astrocytic glioma 53 | 2,241
primitive neuroectodermal tumor 53 | 3,031
Psoriatic arthritis 52 | 83
pediatric high grade glioma 52 | 2,712
adult high grade glioma 50 | 2,148
invasive ductal carcinoma 50 | 2,950
group 4 medulloblastoma 49 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 48 | 1,795
pancreatic cancer 45 | 2,300
non-small cell lung cancer 44 | 2,798
ulcerative colitis 43 | 2,087
Stevens-Johnson syndrome 42 | 78
dermatomyositis 42 | 933
lung adenocarcinoma 41 | 2,713
tuberculosis 41 | 1,557
astrocytoma 40 | 1,493
Pick disease 39 | 1,893
Congenital adrenal hyperplasia 35 | 74
Multiple Sclerosis 35 | 498
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
interstitial cystitis 35 | 2,299
Carcinoma 34 | 2,147
cutaneous lupus erythematosus 34 | 1,056
Kidney disease 33 | 396
acute quadriplegic myopathy 33 | 1,157
medulloblastoma 33 | 1,524
group 3 medulloblastoma 32 | 2,254
posterior fossa group A ependymoma 31 | 1,511
active Crohn's disease 29 | 918
Waldenstrons macroglobulinemia 28 | 765
spina bifida 28 | 1,064
pituitary cancer 27 | 1,972
primary Sjogren syndrome 27 | 789
Liver disease 25 | 219
breast carcinoma 25 | 1,614
Anemia 24 | 252
Hemochromatosis 24 | 55
Leprosy 24 | 77
adrenocortical carcinoma 24 | 1,427
tuberculosis and treatment for 6 months 24 | 686
Skin disease 23 | 65
cystic fibrosis 23 | 1,665
non primary Sjogren syndrome sicca 23 | 840
primary pancreatic ductal adenocarcinoma 23 | 1,271
Hepatitis B 22 | 103
IGA Glomerulonephritis 22 | 454
Primary immunodeficiency disease 22 | 52
esophageal adenocarcinoma 22 | 737
posterior fossa group B ependymoma 21 | 1,530
Duchenne muscular dystrophy 20 | 602
sonic hedgehog group medulloblastoma 20 | 1,482
Atopic dermatitis 19 | 944
acute myeloid leukemia 18 | 780
HIV Infections 17 | 100
Human immunodeficiency virus infectious disease 17 | 92
gastric carcinoma 17 | 832
pre-eclampsia 16 | 67
Parkinson's disease 15 | 364
hepatocellular carcinoma 15 | 532
Intellectual disability 14 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 499
colon cancer 13 | 1,475
ductal carcinoma in situ 13 | 1,745
Amyotrophic Lateral Sclerosis 12 | 431
progressive supranuclear palsy 12 | 674
Obesity 11 | 616
Prostatic Neoplasms 11 | 471
gastric cancer 11 | 430
inflammatory breast cancer 11 | 404
pancreatic carcinoma 11 | 567

Tissue

Female tissues 367 | 18,647
Nervous System 367 | 18,561
Urinary Tract 367 | 18,444
Blood and immune system 366 | 17,995
Digestive Tract 366 | 18,473
Liver and Pancreas 366 | 18,136
Cardiovascular System 365 | 17,958
Endocrine System 365 | 18,512
Male tissues 365 | 17,969
Respiratory system 361 | 17,484
Skin and soft tissues 356 | 18,115

Target Family

Non-IDG 273 | 11,971
Enzyme 151 | 4,146
Kinase 4 | 634
Transcription Factor 2 | 1,400
Ion Channel 1 | 341

Reactome Pathway

Class I MHC mediated antigen p... 431 | 431
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

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