Development Level

Tbio 349 | 11,651
Tdark 60 | 6,593
Tchem 19 | 1,388
Tclin 7 | 612

IMPC Phenotype

preweaning lethality, complete... 26 | 979
preweaning lethality, incomple... 19 | 499
abnormal behavior 13 | 298
embryonic lethality prior to t... 11 | 278
decreased bone mineral content 9 | 151
decreased body weight 8 | 161
decreased total body fat amoun... 8 | 207
decreased bone mineral density 7 | 126
decreased lean body mass 7 | 135
embryonic lethality prior to o... 7 | 239
male infertility 7 | 123
abnormal embryo size 6 | 220
increased mean corpuscular vol... 6 | 92
abnormal bone structure 5 | 187
decreased blood urea nitrogen ... 5 | 51
decreased hemoglobin content 5 | 68
decreased lymphocyte cell numb... 5 | 83
decreased startle reflex 5 | 75
hypoactivity 5 | 132
increased or absent threshold ... 5 | 101
increased total body fat amoun... 5 | 134
short tibia 5 | 97
abnormal heart morphology 4 | 162
decreased body length 4 | 101
decreased circulating alanine ... 4 | 47
decreased circulating glucose ... 4 | 126
decreased circulating triglyce... 4 | 79
decreased prepulse inhibition 4 | 82
decreased vertical activity 4 | 208
embryonic growth retardation 4 | 106
enlarged heart 4 | 210
female infertility 4 | 60
increased lean body mass 4 | 172
increased mean platelet volume 4 | 45
abnormal gait 3 | 69
abnormal skin morphology 3 | 50
decreased circulating HDL chol... 3 | 68
decreased circulating amylase ... 3 | 28
decreased circulating chloride... 3 | 30
decreased circulating choleste... 3 | 93
decreased circulating creatini... 3 | 39
decreased circulating insulin ... 3 | 76
decreased circulating total pr... 3 | 49
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
decreased heart left ventricle... 3 | 28
decreased hematocrit 3 | 46
decreased mean corpuscular vol... 3 | 79
decreased neutrophil cell numb... 3 | 42
enlarged spleen 3 | 41
hyperactivity 3 | 148
impaired glucose tolerance 3 | 75
increased blood urea nitrogen ... 3 | 48
increased circulating HDL chol... 3 | 80
increased circulating chloride... 3 | 41
increased circulating choleste... 3 | 66
increased circulating creatini... 3 | 38
increased hematocrit 3 | 46
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular hem... 3 | 96
increased monocyte cell number 3 | 63
increased neutrophil cell numb... 3 | 46
increased startle reflex 3 | 112
trunk curl 3 | 16
abnormal behavioral response t... 2 | 66
abnormal kidney morphology 2 | 65
abnormal liver morphology 2 | 17
abnormal spleen morphology 2 | 55
abnormal vibrissa morphology 2 | 25
abnormal vocalization 2 | 21
anophthalmia 2 | 33
cardiovascular system phenotyp... 2 | 36
decreased caudal vertebrae num... 2 | 53
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased circulating aspartat... 2 | 34
decreased circulating free fat... 2 | 31
decreased circulating fructosa... 2 | 30
decreased circulating iron lev... 2 | 32
decreased mean corpuscular hem... 2 | 50
decreased red blood cell distr... 2 | 41
dilated heart left ventricle 2 | 11
impaired righting response 2 | 26
increased body length 2 | 32
increased bone mineral content 2 | 108
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased eosinophil cell numb... 2 | 11
increased fasted circulating g... 2 | 76
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 36
increased prepulse inhibition 2 | 32
increased red blood cell distr... 2 | 34
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
prolonged QT interval 2 | 38
prolonged ST segment 2 | 36
small superior vagus ganglion 2 | 74
thin ventricular wall 2 | 24
tremors 2 | 39

Disease

Carcinoma 259 | 11,493
ovarian cancer 239 | 8,520
psoriasis 189 | 6,694
osteosarcoma 186 | 7,950
glioblastoma 143 | 5,792
medulloblastoma, large-cell 139 | 6,241
Cancer 131 | 2,499
lung cancer 110 | 4,740
atypical teratoid / rhabdoid tumor 106 | 5,112
diabetes mellitus 98 | 1,728
ependymoma 88 | 4,679
adult high grade glioma 86 | 3,801
Multiple myeloma 83 | 1,332
dermatomyositis 77 | 966
tuberculosis 77 | 2,010
Ankylosing spondylitis 76 | 140
Behcet's disease 73 | 89
Astrocytoma, Pilocytic 72 | 3,081
Breast cancer 71 | 3,578
Rheumatoid arthritis 69 | 1,191
Arthritis 68 | 290
intraductal papillary-mucinous neoplasm (IPMN) 68 | 3,291
astrocytic glioma 62 | 2,597
Hypersensitivity reaction type II disease 61 | 253
group 3 medulloblastoma 60 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 60 | 2,955
subependymal giant cell astrocytoma 60 | 2,287
Uveitis 59 | 103
Acquired immunodeficiency syndrome 58 | 197
intraductal papillary-mucinous carcinoma (IPMC) 58 | 2,989
malignant mesothelioma 57 | 3,232
Herpes zoster 56 | 68
Juvenile rheumatoid arthritis 56 | 111
juvenile dermatomyositis 56 | 1,187
oligodendroglioma 56 | 2,850
Stevens-Johnson syndrome 55 | 92
lung carcinoma 55 | 2,843
pancreatic ductal adenocarcinoma liver metastasis 54 | 1,962
Kidney cancer 53 | 2,613
primitive neuroectodermal tumor 53 | 3,035
Human immunodeficiency virus infectious disease 52 | 138
Psoriatic arthritis 52 | 86
invasive ductal carcinoma 51 | 2,951
group 4 medulloblastoma 48 | 1,855
non-small cell lung cancer 47 | 2,890
pancreatic cancer 47 | 2,398
lung adenocarcinoma 40 | 2,716
Pick disease 39 | 1,894
Dermatitis 38 | 157
Behcet's syndrome 37 | 50
Congenital adrenal hyperplasia 35 | 73
Nephritis 35 | 51
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Synovitis 35 | 78
Takayasu's arteritis 35 | 53
drug-induced hepatitis 35 | 44
interstitial cystitis 35 | 2,312
Kidney disease 34 | 430
Multiple Sclerosis 34 | 540
astrocytoma 34 | 1,146
cutaneous lupus erythematosus 34 | 1,057
ulcerative colitis 34 | 1,819
acute quadriplegic myopathy 33 | 1,158
Waldenstrons macroglobulinemia 29 | 765
active Crohn's disease 29 | 922
Autosomal recessive predisposition 28 | 1,442
spina bifida 28 | 1,074
Anemia 27 | 365
Liver disease 27 | 237
pituitary cancer 27 | 1,972
primary Sjogren syndrome 26 | 735
breast carcinoma 25 | 1,638
non primary Sjogren syndrome sicca 25 | 891
Hemochromatosis 24 | 54
adrenocortical carcinoma 24 | 1,428
Leprosy 23 | 73
Skin disease 23 | 66
cystic fibrosis 23 | 1,696
Birdshot chorioretinopathy 22 | 23
Hepatitis B 22 | 108
Primary immunodeficiency disease 22 | 54
esophageal adenocarcinoma 22 | 737
Atopic dermatitis 20 | 952
Duchenne muscular dystrophy 20 | 601
Intellectual disability 19 | 1,016
acute myeloid leukemia 19 | 783
primary pancreatic ductal adenocarcinoma 18 | 1,109
HIV Infections 17 | 102
Liver Cirrhosis, Experimental 17 | 769
gastric carcinoma 17 | 807
tuberculosis and treatment for 6 months 17 | 409
Parkinson's disease 16 | 392
Pre-Eclampsia 16 | 68
Schizophrenia 16 | 1,160
medulloblastoma 16 | 720
pediatric high grade glioma 16 | 1,064
Bipolar Disorder 15 | 666
Hypertension 15 | 396
hepatocellular carcinoma 15 | 547

Tissue

Endocrine System 364 | 18,159
Female tissues 358 | 17,400
Digestive Tract 357 | 17,369
Skin and soft tissues 357 | 17,230
Male tissues 356 | 17,142
Urinary Tract 356 | 16,678
Nervous System 355 | 16,725
Respiratory system 355 | 16,393
Blood and immune system 353 | 16,909
Liver and Pancreas 353 | 16,750
Cardiovascular System 352 | 15,192

Target Family

Non-IDG 279 | 12,091
Enzyme 149 | 4,145
Kinase 4 | 634
Transcription Factor 2 | 1,400
Ion Channel 1 | 344

Reactome Pathway

Class I MHC mediated antigen p... 435 | 435
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -2.09381 115.1 104
GTP-binding protein SAR1b SAR1B Tbio Enzyme -1.91051 79.7 184
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
HLA class I histocompatibility antigen, B-51 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
Tripeptidyl-peptidase 2 TPP2 Tbio Enzyme -1.97332 108.2 72
E3 ubiquitin-protein ligase RNF182 RNF182 Tdark Enzyme 0.06 0.73 104
Probable E3 ubiquitin-protein ligase HERC1 HERC1 Tbio Enzyme -1.02371 5.75 39
Ankyrin repeat and SOCS box protein 10 ASB10 Tbio Non-IDG -0.85286 7.76 117
E3 ubiquitin-protein ligase DZIP3 DZIP3 Tbio Enzyme -0.24304 1.68 116