Development Level

Tbio 67 | 11,445
Tchem 12 | 1,598
Tclin 12 | 613
Tdark 5 | 6,588

Collection

GPCR: IDG Consortium (Targets) 4 | 126

IMPC Phenotype

preweaning lethality, complete... 8 | 979
abnormal bone structure 6 | 187
decreased vertical activity 6 | 208
decreased lean body mass 5 | 135
increased startle reflex 5 | 112
preweaning lethality, incomple... 5 | 499
decreased bone mineral content 4 | 151
embryonic lethality prior to t... 4 | 278
increased heart weight 4 | 62
abnormal heart morphology 3 | 162
decreased bone mineral density 3 | 126
enlarged heart 3 | 210
impaired glucose tolerance 3 | 75
increased total body fat amoun... 3 | 134
decreased body length 2 | 101
decreased grip strength 2 | 116
decreased startle reflex 2 | 75
embryonic lethality prior to o... 2 | 239
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal brain morphology 1 | 13
abnormal cranium morphology 1 | 36
abnormal embryo development 1 | 7
abnormal embryo turning 1 | 31
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal ovary morphology 1 | 7
abnormal pericardium morpholog... 1 | 26
abnormal sleep behavior 1 | 70
abnormal testis morphology 1 | 43
decreased body weight 1 | 161
decreased circulating calcium ... 1 | 36
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
edema 1 | 59
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
hydroencephaly 1 | 14
hydrometra 1 | 53
hydrops fetalis 1 | 1
increased body weight 1 | 25
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating insulin ... 1 | 3
increased fasted circulating g... 1 | 76
increased heart rate variabili... 1 | 7
limb grasping 1 | 41
microphthalmia 1 | 26
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
short tibia 1 | 97
small kidney 1 | 16
small testis 1 | 58
thrombocytopenia 1 | 56

Disease

Carcinoma 54 | 11,493
psoriasis 35 | 6,694
osteosarcoma 34 | 7,950
ovarian cancer 34 | 8,520
Cancer 33 | 2,499
glioblastoma 31 | 5,792
medulloblastoma, large-cell 30 | 6,241
ependymoma 29 | 4,679
atypical teratoid / rhabdoid tumor 26 | 5,112
lung cancer 25 | 4,740
interstitial cystitis 23 | 2,312
Breast cancer 21 | 3,578
lung carcinoma 21 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
Astrocytoma, Pilocytic 19 | 3,081
Obesity 18 | 678
adult high grade glioma 18 | 3,801
group 3 medulloblastoma 17 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
non-small cell lung cancer 17 | 2,890
primitive neuroectodermal tumor 17 | 3,035
astrocytic glioma 16 | 2,597
oligodendroglioma 16 | 2,850
Hypertension 15 | 396
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
invasive ductal carcinoma 15 | 2,951
lung adenocarcinoma 15 | 2,716
pancreatic cancer 15 | 2,398
Osteoporosis 14 | 363
malignant mesothelioma 14 | 3,232
Adenoma 13 | 167
diabetes mellitus 13 | 1,728
breast carcinoma 12 | 1,638
ductal carcinoma in situ 12 | 1,745
group 4 medulloblastoma 12 | 1,855
Bipolar Disorder 11 | 666
Kidney cancer 11 | 2,613
cystic fibrosis 11 | 1,696
pituitary cancer 11 | 1,972
Autosomal recessive predisposition 10 | 1,442
Brachydactyly 10 | 156
Cushing's syndrome 10 | 48
Hypothyroidism 10 | 122
Kidney disease 10 | 430
active Crohn's disease 10 | 922
subependymal giant cell astrocytoma 10 | 2,287
Depressive disorder 9 | 409
Hypoparathyroidism 9 | 41
Intellectual disability 9 | 1,016
Pick disease 9 | 1,894
Schizophrenia 9 | 1,160
Short stature 9 | 531
chronic kidney disease 9 | 90
ulcerative colitis 9 | 1,819
Acromegaly 8 | 51
Hypertensive disease 8 | 292
Hyperthyroidism 8 | 53
Hypoglycemia 8 | 152
Pseudohypoparathyroidism 8 | 18
cutaneous lupus erythematosus 8 | 1,057
fibroadenoma 8 | 559
pediatric high grade glioma 8 | 1,064
Cleft Palate 7 | 271
Hyperparathyroidism 7 | 48
Mental Depression 7 | 333
Mood Disorders 7 | 184
Multiple Endocrine Neoplasia Type 1 7 | 29
active ulcerative colitis 7 | 764
colon cancer 7 | 1,478
tuberculosis 7 | 2,010
Anorexia 6 | 43
Cataract 6 | 297
Cleft Lip 6 | 141
Diarrhea 6 | 253
Hypercalcemia 6 | 59
Hypophosphatemia 6 | 40
Lens Opacities 6 | 231
Liver Cirrhosis, Experimental 6 | 769
Major Depressive Disorder 6 | 301
Orbital separation excessive 6 | 244
Pancreatitis 6 | 123
Pituitary adenoma 6 | 38
Polycystic ovary syndrome 6 | 360
Prostatic Neoplasms 6 | 495
Seizures 6 | 596
Unipolar Depression 6 | 250
adrenocortical carcinoma 6 | 1,428
non primary Sjogren syndrome sicca 6 | 891
Abnormally small eyeball 5 | 97
Decreased size of eyeball 5 | 97
Dull intelligence 5 | 645
Epilepsy 5 | 792
Hypoplastic mandible condyle 5 | 275
Migraine 5 | 83
Poor school performance 5 | 645
Vascular disease 5 | 319
acute myeloid leukemia 5 | 783
juvenile dermatomyositis 5 | 1,187
primary pancreatic ductal adenocarcinoma 5 | 1,109
spina bifida 5 | 1,074

Tissue

Endocrine System 91 | 18,159
Digestive Tract 89 | 17,369
Female tissues 86 | 17,400
Nervous System 84 | 16,725
Skin and soft tissues 84 | 17,230
Urinary Tract 82 | 16,678
Liver and Pancreas 81 | 16,750
Male tissues 81 | 17,142
Blood and immune system 79 | 16,909
Respiratory system 77 | 16,393
Cardiovascular System 65 | 15,192

Target Family

Non-IDG 67 | 12,091
GPCR 29 | 408

Reactome Pathway

Class B/2 (Secretin family rec... 96 | 96
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Urocortin-2 UCN2 Tbio Non-IDG -2.05990 129.7 107
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Smoothened homolog SMO Tclin GPCR -1.17466 14.5 415
Adhesion G protein-coupled receptor E2 ADGRE2 Tbio GPCR -1.67862 48.2 312
Parathyroid hormone-related protein PTHLH Tbio Non-IDG -3.27676 2151.5 283
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 GNG10 Tdark Non-IDG 0.16 0.62 18
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 GNG5 Tbio Non-IDG -0.57807 4.05 87
Protein patched homolog 2 PTCH2 Tbio Non-IDG -1.80541 50.4 92
Calcitonin gene-related peptide 2 CALCB Tbio Non-IDG -1.46590 27.3 32