Development Level

Tchem 117 | 1,598
Tbio 112 | 11,445
Tclin 86 | 613
Tdark 7 | 6,588

Collection

GPCR: IDG Consortium (Targets) 30 | 126
RFA-RM-18-021 27 | 328
GPCR: IDG Consortium (Complete... 9 | 25

IMPC Phenotype

decreased vertical activity 11 | 208
abnormal behavior 8 | 298
enlarged heart 7 | 210
preweaning lethality, complete... 7 | 979
prolonged QT interval 7 | 38
prolonged ST segment 7 | 36
abnormal kidney morphology 6 | 65
decreased bone mineral content 6 | 151
preweaning lethality, incomple... 6 | 499
abnormal heart morphology 5 | 162
decreased total body fat amoun... 5 | 207
hyperactivity 5 | 148
hypoactivity 5 | 132
increased circulating sodium l... 5 | 71
increased total body fat amoun... 5 | 134
improved glucose tolerance 4 | 79
abnormal epididymis morphology 3 | 42
abnormal seminal vesicle morph... 3 | 114
abnormal skin morphology 3 | 50
decreased circulating insulin ... 3 | 76
decreased fasted circulating g... 3 | 65
decreased lean body mass 3 | 135
decreased neutrophil cell numb... 3 | 42
increased bone mineral content 3 | 108
increased fasted circulating g... 3 | 76
increased lean body mass 3 | 172
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal sleep behavior 2 | 70
absent testes 2 | 6
decreased body weight 2 | 161
decreased bone mineral density 2 | 126
decreased circulating alanine ... 2 | 47
decreased heart rate 2 | 18
decreased prepulse inhibition 2 | 82
decreased startle reflex 2 | 75
enlarged epididymis 2 | 31
female infertility 2 | 60
increased circulating calcium ... 2 | 34
increased circulating total pr... 2 | 28
increased erythrocyte cell num... 2 | 39
increased hemoglobin content 2 | 45
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular vol... 2 | 92
male infertility 2 | 123
polycystic kidney 2 | 15
prolonged RR interval 2 | 8
small superior vagus ganglion 2 | 74
abnormal gait 1 | 69
abnormal liver morphology 1 | 17
abnormal lymph node morphology 1 | 3
abnormal retinal blood vessel ... 1 | 26
abnormal skin coloration 1 | 25
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
abnormal whole-body plethysmog... 1 | 4
cardiovascular system phenotyp... 1 | 36
convulsive seizures 1 | 13
decreased IgE level 1 | 6
decreased T cell number 1 | 15
decreased anxiety-related resp... 1 | 12
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased eosinophil cell numb... 1 | 24
decreased grip strength 1 | 116
decreased pulmonary respirator... 1 | 5
decreased total retina thickne... 1 | 17
decreased urine magnesium leve... 1 | 3
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged uterus 1 | 11
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating iron lev... 1 | 30
increased circulating lipase l... 1 | 3
increased circulating magnesiu... 1 | 10
increased circulating serum al... 1 | 22
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
premature death 1 | 5
small kidney 1 | 16
small spleen 1 | 19
small testis 1 | 58
small thymus 1 | 16
tremors 1 | 39
urinary bladder obstruction 1 | 4

Disease

Carcinoma 186 | 11,493
psoriasis 143 | 6,694
osteosarcoma 101 | 7,950
ovarian cancer 95 | 8,520
medulloblastoma, large-cell 83 | 6,241
Cancer 80 | 2,499
glioblastoma 80 | 5,792
ependymoma 77 | 4,679
Schizophrenia 73 | 1,160
lung cancer 73 | 4,740
interstitial cystitis 71 | 2,312
atypical teratoid / rhabdoid tumor 69 | 5,112
Astrocytoma, Pilocytic 67 | 3,081
Obesity 64 | 678
adult high grade glioma 64 | 3,801
lung carcinoma 62 | 2,843
malignant mesothelioma 60 | 3,232
lung adenocarcinoma 59 | 2,716
Depressive disorder 58 | 409
invasive ductal carcinoma 58 | 2,951
non-small cell lung cancer 53 | 2,890
Bipolar Disorder 52 | 666
diabetes mellitus 52 | 1,728
tuberculosis 52 | 2,010
ulcerative colitis 52 | 1,819
group 3 medulloblastoma 51 | 4,104
Asthma 50 | 385
oligodendroglioma 48 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 47 | 2,955
Hypertension 46 | 396
Breast cancer 45 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 45 | 2,989
primitive neuroectodermal tumor 44 | 3,035
Alcoholic Intoxication, Chronic 43 | 289
Mental Depression 43 | 333
pancreatic cancer 43 | 2,398
Mood Disorders 39 | 184
astrocytic glioma 39 | 2,597
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
colon cancer 37 | 1,478
Major Depressive Disorder 36 | 301
ductal carcinoma in situ 36 | 1,745
breast carcinoma 35 | 1,638
cutaneous lupus erythematosus 35 | 1,057
Multiple Sclerosis 33 | 540
Parkinson's disease 33 | 392
cystic fibrosis 32 | 1,696
Rheumatoid arthritis 31 | 1,191
pituitary cancer 31 | 1,972
Pain 29 | 103
adrenocortical carcinoma 29 | 1,428
Atherosclerosis 28 | 291
Autosomal recessive predisposition 28 | 1,442
Pain agnosia 28 | 104
Hypertensive disease 27 | 292
Migraine 27 | 83
Cerebrovascular disease 26 | 238
Epilepsy 26 | 792
Kidney disease 26 | 430
Seizures 26 | 596
Allergic rhinitis 25 | 94
Kidney cancer 25 | 2,613
Unipolar Depression 25 | 250
primary Sjogren syndrome 25 | 735
Alzheimer's disease 24 | 658
Liver Cirrhosis, Experimental 24 | 769
Constipation 23 | 181
Coronary artery disease 23 | 268
Hypotension 23 | 82
subependymal giant cell astrocytoma 23 | 2,287
Alcohol dependence 22 | 107
Hyperalgesia 22 | 83
group 4 medulloblastoma 22 | 1,855
Pick disease 21 | 1,894
hepatocellular carcinoma 21 | 547
Cocaine-Related Disorders 20 | 92
Endometriosis 20 | 540
Substance Withdrawal Syndrome 20 | 55
mucosa-associated lymphoid tissue lymphoma 20 | 484
Arthritis 19 | 290
Bradycardia 18 | 36
Common cold 18 | 67
Heart disease 18 | 306
Nasal congestion 18 | 21
Nasal discharge 18 | 24
Vascular disease 18 | 319
astrocytoma 18 | 1,146
Hypogonadism 17 | 173
Lung disease 17 | 142
Opiate dependence 17 | 29
gastric carcinoma 17 | 807
head and neck cancer and chronic obstructive pulmonary disease 17 | 239
Attention deficit hyperactivity disorder 16 | 278
Autistic Disorder 16 | 364
Dermatitis 16 | 157
Diarrhea 16 | 253
Hypersensitivity reaction type II disease 16 | 253
Inflammatory bowel disease 16 | 151
fibroadenoma 16 | 559
head and neck cancer 16 | 271

Tissue

Endocrine System 306 | 18,159
Digestive Tract 286 | 17,369
Female tissues 282 | 17,400
Nervous System 279 | 16,725
Skin and soft tissues 273 | 17,230
Male tissues 270 | 17,142
Blood and immune system 263 | 16,909
Liver and Pancreas 259 | 16,750
Urinary Tract 257 | 16,678
Respiratory system 250 | 16,393
Cardiovascular System 201 | 15,192

Target Family

GPCR 221 | 408
Non-IDG 91 | 12,091
Enzyme 10 | 4,145

Reactome Pathway

Class A/1 (Rhodopsin-like rece... 322 | 322
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5-hydroxytryptamine receptor 1F HTR1F Tchem GPCR -2.39159 244.1 131
5-hydroxytryptamine receptor 2B HTR2B Tclin GPCR -2.66641 486.3 265
5-hydroxytryptamine receptor 4 HTR4 Tclin GPCR -2.87235 796.4 248
Histamine H3 receptor HRH3 Tclin GPCR -2.76107 570.2 318
Relaxin receptor 2 RXFP2 Tbio GPCR -1.97913 85.3 207
Melanocyte-stimulating hormone receptor MC1R Tclin GPCR -2.90014 829.2 194
Adrenocorticotropic hormone receptor MC2R Tclin GPCR -2.22640 172.4 223
Trace amine-associated receptor 6 TAAR6 Tbio GPCR -2.06244 115.1 64
Urotensin-2 receptor UTS2R Tchem GPCR -1.95094 62.5 182
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278