Development Level

Tbio 118 | 10,625
Tchem 109 | 1,890
Tclin 86 | 602
Tdark 9 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 35 | 143

IMPC Term

preweaning lethality, complete... 5 | 633
decreased bone mineral content 4 | 157
improved glucose tolerance 4 | 56
preweaning lethality, incomple... 4 | 260
abnormal behavior 3 | 226
abnormal epididymis morphology 3 | 31
abnormal kidney morphology 3 | 30
decreased body weight 3 | 174
decreased circulating glucose ... 3 | 121
decreased circulating insulin ... 3 | 75
decreased fasted circulating g... 3 | 49
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
hypoactivity 3 | 89
increased circulating HDL chol... 3 | 63
increased circulating sodium l... 3 | 71
abnormal behavioral response t... 2 | 52
abnormal bone structure 2 | 131
abnormal coat/hair pigmentatio... 2 | 54
abnormal seminal vesicle morph... 2 | 47
abnormal skin morphology 2 | 23
absent testes 2 | 2
decreased CD8-positive, alpha-... 2 | 26
decreased NK T cell number 2 | 28
decreased circulating alanine ... 2 | 53
decreased heart weight 2 | 44
decreased prepulse inhibition 2 | 52
decreased vertical activity 2 | 22
enlarged epididymis 2 | 27
enlarged heart 2 | 111
increased circulating alkaline... 2 | 119
increased circulating calcium ... 2 | 32
increased circulating total pr... 2 | 20
increased erythrocyte cell num... 2 | 26
increased fasted circulating g... 2 | 68
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 91
increased monocyte cell number 2 | 27
increased total body fat amoun... 2 | 57
male infertility 2 | 62
abnormal coat appearance 1 | 25
abnormal coping response 1 | 12
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal liver morphology 1 | 5
abnormal lymph node morphology 1 | 3
abnormal optic disc morphology 1 | 10
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal testis morphology 1 | 30
abnormal vibrissa morphology 1 | 17
abnormal whole-body plethysmog... 1 | 4
cardiovascular system phenotyp... 1 | 35
convulsive seizures 1 | 11
decreased IgE level 1 | 3
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased anxiety-related resp... 1 | 12
decreased basophil cell number 1 | 11
decreased bone mineral density 1 | 126
decreased brain size 1 | 4
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating triglyce... 1 | 83
decreased lumbar vertebrae num... 1 | 62
decreased neutrophil cell numb... 1 | 37
female infertility 1 | 34
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating serum al... 1 | 25
increased effector memory T-he... 1 | 5
increased gamma-delta T cell n... 1 | 16
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
no abnormal phenotype detected 1 | 3
oligodactyly 1 | 14
premature death 1 | 5
short tail 1 | 4
short tibia 1 | 82
small heart 1 | 8
small kidney 1 | 10
small liver 1 | 8
small spleen 1 | 11
small stomach 1 | 3
small superior vagus ganglion 1 | 20
small testis 1 | 37
small thymus 1 | 11
tremors 1 | 34
urinary bladder obstruction 1 | 2
vertebral transformation 1 | 12

Disease

psoriasis 144 | 6,685
osteosarcoma 102 | 7,933
ovarian cancer 96 | 8,484
medulloblastoma, large-cell 84 | 6,234
Cancer 77 | 2,346
glioblastoma 75 | 5,572
interstitial cystitis 71 | 2,299
lung cancer 69 | 4,466
pilocytic astrocytoma 68 | 3,086
ulcerative colitis 62 | 2,087
lung carcinoma 61 | 2,844
Obesity 60 | 616
invasive ductal carcinoma 59 | 2,950
lung adenocarcinoma 59 | 2,713
atypical teratoid / rhabdoid tumor 58 | 4,369
malignant mesothelioma 55 | 3,162
diabetes mellitus 52 | 1,663
Asthma 51 | 349
non-small cell lung cancer 51 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 48 | 2,956
oligodendroglioma 48 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 46 | 2,988
primitive neuroectodermal tumor 44 | 3,031
Schizophrenia 43 | 501
pancreatic cancer 43 | 2,300
tuberculosis 43 | 1,557
Breast cancer 42 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,289
pediatric high grade glioma 40 | 2,712
adult high grade glioma 37 | 2,148
colon cancer 37 | 1,475
ductal carcinoma in situ 37 | 1,745
breast carcinoma 36 | 1,614
cutaneous lupus erythematosus 34 | 1,056
ependymoma 34 | 2,514
Hypertension 33 | 287
posterior fossa group A ependymoma 33 | 1,511
Parkinson's disease 32 | 364
pituitary cancer 32 | 1,972
cystic fibrosis 31 | 1,665
astrocytic glioma 30 | 2,241
Multiple Sclerosis 29 | 498
Pain 29 | 70
Pain agnosia 29 | 99
Rheumatoid Arthritis 29 | 1,160
primary Sjogren syndrome 29 | 789
Atherosclerosis 28 | 275
adrenocortical carcinoma 28 | 1,427
Hypertensive disease 27 | 193
Migraine 27 | 79
astrocytoma 27 | 1,493
Allergic rhinitis 26 | 91
Kidney disease 26 | 396
Cerebrovascular disease 25 | 231
medulloblastoma 25 | 1,524
posterior fossa group B ependymoma 25 | 1,530
subependymal giant cell astrocytoma 24 | 2,287
Alzheimer's disease 23 | 644
Carcinoma 23 | 2,147
Epilepsy 23 | 346
Alcohol dependence 22 | 107
Hyperalgesia 22 | 71
Hypotension 22 | 53
Seizures 22 | 95
sonic hedgehog group medulloblastoma 22 | 1,482
Bipolar Disorder 21 | 266
Common cold 21 | 63
Nasal congestion 21 | 24
Pick disease 21 | 1,893
gastric carcinoma 21 | 832
group 3 medulloblastoma 21 | 2,254
Cocaine-Related Disorders 20 | 88
Coronary artery disease 20 | 240
Endometriosis 20 | 535
Nasal discharge 20 | 26
Substance Withdrawal Syndrome 20 | 52
group 4 medulloblastoma 20 | 1,875
hepatocellular carcinoma 20 | 532
mucosa-associated lymphoid tissue lymphoma 20 | 480
Vascular disease 19 | 281
atypical teratoid/rhabdoid tumor 19 | 1,095
Arthritis 18 | 248
Bradycardia 18 | 24
Heart disease 18 | 279
Major Depressive Disorder 18 | 106
Hypersensitivity reaction type II disease 17 | 235
Inflammatory bowel disease 17 | 142
Lung disease 17 | 132
Attention deficit hyperactivity disorder 16 | 156
Constipation 16 | 43
fibroadenoma 16 | 557
head and neck cancer 16 | 270
head and neck cancer and chronic obstructive pulmonary disease 16 | 237
primary pancreatic ductal adenocarcinoma 16 | 1,271
Atopic dermatitis 15 | 944
Autistic Disorder 15 | 320
Down syndrome 15 | 548
Hypersensitivity 15 | 63
Infertility 15 | 163
pancreatic carcinoma 15 | 567

Tissue

Female tissues 308 | 18,647
Nervous System 308 | 18,561
Digestive Tract 306 | 18,473
Endocrine System 306 | 18,512
Urinary Tract 305 | 18,444
Skin and soft tissues 302 | 18,115
Liver and Pancreas 292 | 18,136
Cardiovascular System 286 | 17,958
Blood and immune system 280 | 17,995
Respiratory system 279 | 17,484
Male tissues 276 | 17,969

Target Family

GPCR 221 | 406
Non-IDG 91 | 11,971
Enzyme 10 | 4,146

Reactome Pathway

Class A/1 (Rhodopsin-like rece... 322 | 322
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Pro-neuropeptide Y NPY Tbio Non-IDG -3.81741 7285.3 401
Short-wave-sensitive opsin 1 OPN1SW Tbio GPCR -1.90084 81.3 15
5-hydroxytryptamine receptor 6 HTR6 Tchem GPCR -2.29395 203.8 55
Neuropeptides B/W receptor type 1 NPBWR1 Tchem GPCR -1.34565 19.5 151
Neuropeptides B/W receptor type 2 NPBWR2 Tbio GPCR -1.14202 8.84 57
Platelet factor 4 PF4 Tbio Non-IDG -3.28845 2045.5 243
Platelet basic protein PPBP Tbio Non-IDG -3.18113 1540.1 348
Endothelin B receptor EDNRB Tclin GPCR -3.24561 1672.0 289
Alpha-1B adrenergic receptor ADRA1B Tclin GPCR -2.30072 198.4 327