Development Level

Tbio 118 | 10,625
Tchem 109 | 1,890
Tclin 86 | 602
Tdark 9 | 7,003

Collection

GPCR: IDG Consortium (Targets) 31 | 127
GPCR: IDG Consortium (Complete/Control) 9 | 26

IMPC Phenotype

preweaning lethality, complete... 5 | 633
decreased bone mineral content 4 | 157
improved glucose tolerance 4 | 56
preweaning lethality, incomple... 4 | 260
abnormal behavior 3 | 226
abnormal epididymis morphology 3 | 31
abnormal kidney morphology 3 | 30
decreased body weight 3 | 174
decreased circulating glucose ... 3 | 121
decreased circulating insulin ... 3 | 75
decreased fasted circulating g... 3 | 49
decreased grip strength 3 | 123
decreased lean body mass 3 | 195
hypoactivity 3 | 89
increased circulating HDL chol... 3 | 63
increased circulating sodium l... 3 | 71
abnormal behavioral response t... 2 | 52
abnormal bone structure 2 | 131
abnormal coat-hair pigmentatio... 2 | 54
abnormal seminal vesicle morph... 2 | 47
abnormal skin morphology 2 | 23
absent testes 2 | 2
decreased CD8-positive, alpha-... 2 | 26
decreased NK T cell number 2 | 28
decreased circulating alanine ... 2 | 53
decreased heart weight 2 | 44
decreased prepulse inhibition 2 | 52
decreased vertical activity 2 | 22
enlarged epididymis 2 | 27
enlarged heart 2 | 111
increased circulating alkaline... 2 | 119
increased circulating calcium ... 2 | 32
increased circulating total pr... 2 | 20
increased erythrocyte cell num... 2 | 26
increased fasted circulating g... 2 | 68
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased mean corpuscular vol... 2 | 91
increased monocyte cell number 2 | 27
increased total body fat amoun... 2 | 57
male infertility 2 | 62
abnormal coat appearance 1 | 25
abnormal coping response 1 | 12
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal liver morphology 1 | 5
abnormal lymph node morphology 1 | 3
abnormal optic disc morphology 1 | 10
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal testis morphology 1 | 30
abnormal vibrissa morphology 1 | 17
abnormal whole-body plethysmog... 1 | 4
cardiovascular system phenotyp... 1 | 35
convulsive seizures 1 | 11
decreased IgE level 1 | 3
decreased T cell number 1 | 31
decreased alpha-beta T cell nu... 1 | 12
decreased anxiety-related resp... 1 | 12
decreased basophil cell number 1 | 11
decreased bone mineral density 1 | 126
decreased brain size 1 | 4
decreased caudal vertebrae num... 1 | 49
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating creatini... 1 | 31
decreased circulating triglyce... 1 | 83
decreased lumbar vertebrae num... 1 | 62
decreased neutrophil cell numb... 1 | 37
female infertility 1 | 34
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased blood uric acid leve... 1 | 5
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating serum al... 1 | 25
increased effector memory T-he... 1 | 5
increased gamma-delta T cell n... 1 | 16
increased lean body mass 1 | 107
increased mean corpuscular hem... 1 | 25
increased sacral vertebrae num... 1 | 62
increased startle reflex 1 | 38
no abnormal phenotype detected 1 | 3
oligodactyly 1 | 14
premature death 1 | 5
short tail 1 | 4
short tibia 1 | 82
small heart 1 | 8
small kidney 1 | 10
small liver 1 | 8
small spleen 1 | 11
small stomach 1 | 3
small superior vagus ganglion 1 | 20
small testis 1 | 37
small thymus 1 | 11
tremors 1 | 34
urinary bladder obstruction 1 | 2
vertebral transformation 1 | 12

Disease

psoriasis 144 | 6,685
osteosarcoma 102 | 7,933
ovarian cancer 96 | 8,491
medulloblastoma, large-cell 84 | 6,234
Cancer 77 | 2,346
glioblastoma 75 | 5,572
interstitial cystitis 71 | 2,299
lung cancer 69 | 4,473
pilocytic astrocytoma 68 | 3,086
ulcerative colitis 62 | 2,087
lung carcinoma 61 | 2,844
Obesity 60 | 616
invasive ductal carcinoma 59 | 2,950
lung adenocarcinoma 59 | 2,714
atypical teratoid / rhabdoid tumor 58 | 4,369
malignant mesothelioma 55 | 3,163
diabetes mellitus 52 | 1,663
Asthma 51 | 349
non-small cell lung cancer 51 | 2,798
intraductal papillary-mucinous adenoma (IPMA) 48 | 2,956
oligodendroglioma 48 | 2,849
intraductal papillary-mucinous carcinoma (IPMC) 46 | 2,988
primitive neuroectodermal tumor 44 | 3,031
Schizophrenia 43 | 503
pancreatic cancer 43 | 2,300
tuberculosis 43 | 1,563
Breast cancer 42 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,289
pediatric high grade glioma 40 | 2,712
adult high grade glioma 37 | 2,148
colon cancer 37 | 1,475
ductal carcinoma in situ 37 | 1,745
breast carcinoma 36 | 1,614
cutaneous lupus erythematosus 34 | 1,056
ependymoma 34 | 2,514
Hypertension 33 | 293
posterior fossa group A ependymoma 33 | 1,511
Parkinson's disease 32 | 364
cystic fibrosis 32 | 1,670
pituitary cancer 32 | 1,972
astrocytic glioma 30 | 2,241
Multiple Sclerosis 29 | 498
Pain 29 | 70
Pain agnosia 29 | 99
Rheumatoid Arthritis 29 | 1,170
primary Sjogren syndrome 29 | 788
Atherosclerosis 28 | 275
adrenocortical carcinoma 28 | 1,427
Hypertensive disease 27 | 193
Migraine 27 | 79
astrocytoma 27 | 1,493
Allergic rhinitis 26 | 92
Kidney disease 26 | 397
Cerebrovascular disease 25 | 231
medulloblastoma 25 | 1,524
posterior fossa group B ependymoma 25 | 1,530
subependymal giant cell astrocytoma 24 | 2,287
Alzheimer's disease 23 | 644
Carcinoma 23 | 2,147
Epilepsy 23 | 346
Alcohol dependence 22 | 107
Hyperalgesia 22 | 71
Hypotension 22 | 53
Seizures 22 | 95
sonic hedgehog group medulloblastoma 22 | 1,482
Bipolar Disorder 21 | 266
Common cold 21 | 63
Nasal congestion 21 | 24
Pick disease 21 | 1,893
gastric carcinoma 21 | 832
group 3 medulloblastoma 21 | 2,254
hepatocellular carcinoma 21 | 550
Cocaine-Related Disorders 20 | 88
Coronary artery disease 20 | 240
Endometriosis 20 | 535
Nasal discharge 20 | 26
Substance Withdrawal Syndrome 20 | 55
group 4 medulloblastoma 20 | 1,875
mucosa-associated lymphoid tissue lymphoma 20 | 480
Vascular disease 19 | 281
atypical teratoid/rhabdoid tumor 19 | 1,095
Arthritis 18 | 248
Bradycardia 18 | 24
Heart disease 18 | 279
Major Depressive Disorder 18 | 106
Hypersensitivity reaction type II disease 17 | 235
Inflammatory bowel disease 17 | 142
Lung disease 17 | 136
Attention deficit hyperactivity disorder 16 | 156
Constipation 16 | 43
fibroadenoma 16 | 557
head and neck cancer 16 | 270
head and neck cancer and chronic obstructive pulmonary disease 16 | 237
primary pancreatic ductal adenocarcinoma 16 | 1,271
Atopic dermatitis 15 | 944
Autistic Disorder 15 | 320
Down syndrome 15 | 548
Hypersensitivity 15 | 63
Infertility 15 | 163
pancreatic carcinoma 15 | 567

Tissue

Female tissues 308 | 18,646
Nervous System 308 | 18,560
Digestive Tract 306 | 18,472
Endocrine System 306 | 18,511
Urinary Tract 305 | 18,443
Skin and soft tissues 302 | 18,114
Liver and Pancreas 292 | 18,135
Cardiovascular System 286 | 17,957
Blood and immune system 280 | 17,994
Respiratory system 279 | 17,483
Male tissues 276 | 17,968

Target Family

GPCR 221 | 408
Non-IDG 91 | 11,969
Enzyme 10 | 4,146

Reactome Pathway

Class A/1 (Rhodopsin-like rece... 322 | 322
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
5-hydroxytryptamine receptor 1E HTR1E Tchem GPCR -1.54352 34.9 99
Somatostatin receptor type 1 SSTR1 Tclin GPCR -2.13194 126.3 290
Somatostatin receptor type 2 SSTR2 Tclin GPCR -2.51625 341.8 227
G-protein coupled receptor 39 GPR39 Tchem GPCR -1.72902 59.1 216
Motilin receptor MLNR Tchem GPCR -2.15968 125.5 135
Gonadotropin-releasing hormone receptor GNRHR Tclin GPCR -2.61137 425.1 280
Angiotensinogen AGT Tchem Non-IDG -3.23867 1673.4 609
Melanocortin receptor 3 MC3R Tchem GPCR -2.63865 450.0 177
Complement C3 C3 Tbio Non-IDG -3.54548 3337.1 965
Histamine H2 receptor HRH2 Tclin GPCR -3.21045 1579.7 225