Development Level

Tbio 42 | 11,445
Tchem 23 | 1,598
Tclin 5 | 613
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased total body fat amoun... 5 | 207
preweaning lethality, incomple... 5 | 499
decreased vertical activity 4 | 208
abnormal behavior 3 | 298
decreased fasted circulating g... 3 | 65
enlarged heart 3 | 210
increased bone mineral content 3 | 108
increased lean body mass 3 | 172
abnormal bone structure 2 | 187
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal heart morphology 2 | 162
decreased lean body mass 2 | 135
decreased neutrophil cell numb... 2 | 42
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
improved glucose tolerance 2 | 79
increased bone mineral density 2 | 72
increased circulating alkaline... 2 | 122
increased mean corpuscular vol... 2 | 92
pale yolk sac 2 | 25
abnormal bone mineralization 1 | 38
abnormal brain morphology 1 | 13
abnormal cecum morphology 1 | 7
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal forebrain development 1 | 20
abnormal heart left ventricle ... 1 | 16
abnormal kidney morphology 1 | 65
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
decreased IgE level 1 | 6
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased cardiac output 1 | 3
decreased circulating HDL chol... 1 | 68
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased large unstained cell... 1 | 11
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
enlarged spleen 1 | 41
enlarged uterus 1 | 11
hydroencephaly 1 | 14
hydrometra 1 | 53
hyperactivity 1 | 148
impaired righting response 1 | 26
increased body length 1 | 32
increased circulating total pr... 1 | 28
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
mammalian phenotype 1 | 17
microphthalmia 1 | 26
pallor 1 | 34
small superior vagus ganglion 1 | 74
small thymus 1 | 16
thin ventricular wall 1 | 24

Disease

Carcinoma 54 | 11,493
ovarian cancer 50 | 8,520
osteosarcoma 46 | 7,950
psoriasis 40 | 6,694
glioblastoma 34 | 5,792
medulloblastoma, large-cell 33 | 6,241
Cancer 29 | 2,499
atypical teratoid / rhabdoid tumor 28 | 5,112
lung cancer 27 | 4,740
malignant mesothelioma 25 | 3,232
ependymoma 22 | 4,679
Bipolar Disorder 21 | 666
adult high grade glioma 20 | 3,801
Schizophrenia 19 | 1,160
invasive ductal carcinoma 19 | 2,951
Breast cancer 18 | 3,578
diabetes mellitus 18 | 1,728
group 3 medulloblastoma 18 | 4,104
primitive neuroectodermal tumor 18 | 3,035
Obesity 16 | 678
astrocytic glioma 16 | 2,597
pituitary cancer 16 | 1,972
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
astrocytoma 14 | 1,146
oligodendroglioma 14 | 2,850
pancreatic cancer 14 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
ulcerative colitis 13 | 1,819
acute quadriplegic myopathy 12 | 1,158
non-small cell lung cancer 12 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Kidney cancer 11 | 2,613
Multiple myeloma 11 | 1,332
subependymal giant cell astrocytoma 11 | 2,287
tuberculosis 11 | 2,010
Autistic Disorder 10 | 364
Depressive disorder 10 | 409
Pick disease 10 | 1,894
Prostatic Neoplasms 10 | 495
acute myeloid leukemia 10 | 783
adrenocortical carcinoma 10 | 1,428
breast carcinoma 10 | 1,638
colon cancer 10 | 1,478
group 4 medulloblastoma 10 | 1,855
interstitial cystitis 10 | 2,312
Astrocytoma, Pilocytic 9 | 3,081
Breast Neoplasms 9 | 445
Major Depressive Disorder 9 | 301
Mammary Neoplasms 9 | 425
Mental Depression 9 | 333
Rheumatoid arthritis 9 | 1,191
ductal carcinoma in situ 9 | 1,745
lung adenocarcinoma 9 | 2,716
spina bifida 9 | 1,074
Atherosclerosis 8 | 291
Atopic dermatitis 8 | 952
Epilepsy 8 | 792
Hyperglycemia 8 | 137
Unipolar Depression 8 | 250
Waldenstrons macroglobulinemia 8 | 765
gastric carcinoma 8 | 807
juvenile dermatomyositis 8 | 1,187
primary pancreatic ductal adenocarcinoma 8 | 1,109
Fatty liver disease 7 | 103
Hypertension 7 | 396
Parkinson's disease 7 | 392
Seasonal affective disorder 7 | 28
cutaneous lupus erythematosus 7 | 1,057
Cerebrovascular disease 6 | 238
Diabetes Mellitus, Experimental 6 | 108
Endometriosis 6 | 540
Fatty Liver 6 | 70
Heart failure 6 | 162
Lipid metabolism disorder 6 | 114
Mood Disorders 6 | 184
Myocardial Infarction 6 | 151
Seizures 6 | 596
cystic fibrosis 6 | 1,696
dermatomyositis 6 | 966
lung carcinoma 6 | 2,843
Amyotrophic lateral sclerosis 5 | 451
Cocaine Dependence 5 | 51
Crohn's disease 5 | 321
Hypertensive disease 5 | 292
Intellectual disability 5 | 1,016
Liver Cirrhosis, Experimental 5 | 769
Muscle hypotonia 5 | 571
Primary cutaneous T-cell lymphoma 5 | 29
active ulcerative colitis 5 | 764
aldosterone-producing adenoma 5 | 665
hepatocellular carcinoma 5 | 547
medulloblastoma 5 | 720
non primary Sjogren syndrome sicca 5 | 891
pediatric high grade glioma 5 | 1,064
Alzheimer's disease 4 | 658
Diabetes Mellitus, Non-Insulin-Dependent 4 | 145
Diabetes Mellitus, Type 2 4 | 142
Vascular disease 4 | 319
chronic lymphosyte leukemia 4 | 204

Tissue

Endocrine System 71 | 18,159
Skin and soft tissues 71 | 17,230
Urinary Tract 71 | 16,678
Blood and immune system 70 | 16,909
Digestive Tract 70 | 17,369
Female tissues 70 | 17,400
Liver and Pancreas 70 | 16,750
Male tissues 70 | 17,142
Nervous System 70 | 16,725
Cardiovascular System 69 | 15,192
Respiratory system 69 | 16,393

Target Family

Non-IDG 26 | 12,091
Transcription Factor 15 | 1,400
Enzyme 10 | 4,145
Epigenetic 8 | 242
Nuclear Receptor 8 | 48
Kinase 3 | 634
TF/Epigenetic 1 | 38

Reactome Pathway

Circadian Clock 71 | 71
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Helicase with zinc finger domain 2 HELZ2 Tdark Enzyme -0.50849 4.27 30