Development Level

Tbio 136 | 10,625
Tdark 30 | 7,003
Tchem 14 | 1,890
Tclin 7 | 602

Collection

Eligible Kinase Proteins 2 | 134
Eligible Ion Channel Proteins 1 | 117

IMPC Term

preweaning lethality, complete... 23 | 633
embryonic lethality prior to t... 7 | 187
abnormal behavior 5 | 226
decreased body weight 5 | 174
decreased bone mineral content 5 | 157
abnormal embryo size 4 | 112
decreased lean body mass 4 | 195
preweaning lethality, incomple... 4 | 260
abnormal embryo turning 3 | 15
abnormal head morphology 3 | 10
decreased circulating choleste... 3 | 85
decreased lumbar vertebrae num... 3 | 62
decreased total body fat amoun... 3 | 186
embryonic lethality prior to o... 3 | 148
increased circulating alkaline... 3 | 119
increased fasted circulating g... 3 | 68
increased sacral vertebrae num... 3 | 62
male infertility 3 | 62
abnormal cranium morphology 2 | 32
abnormal hindbrain development 2 | 24
abnormal humerus morphology 2 | 11
abnormal midbrain development 2 | 22
abnormal neural tube closure 2 | 37
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 49
decreased circulating calcium ... 2 | 33
decreased circulating serum al... 2 | 79
decreased circulating total pr... 2 | 41
decreased eosinophil cell numb... 2 | 41
hyperactivity 2 | 108
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating choleste... 2 | 53
increased circulating glycerol... 2 | 11
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased leukocyte cell numbe... 2 | 37
increased mean corpuscular hem... 2 | 93
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased prepulse inhibition 2 | 21
increased total body fat amoun... 2 | 57
abnormal QRS complex 1 | 25
abnormal behavioral response t... 1 | 52
abnormal cervical vertebrae mo... 1 | 4
abnormal femur morphology 1 | 14
abnormal gait 1 | 51
abnormal joint morphology 1 | 14
abnormal kidney morphology 1 | 30
abnormal lens morphology 1 | 73
abnormal pelvic girdle bone mo... 1 | 11
abnormal pericardium morpholog... 1 | 11
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 30
abnormal vertebrae morphology 1 | 14
cardiovascular system phenotyp... 1 | 35
decreased CD4-positive, alpha ... 1 | 19
decreased basophil cell number 1 | 11
decreased body length 1 | 108
decreased circulating bilirubi... 1 | 14
decreased circulating chloride... 1 | 32
decreased circulating sodium l... 1 | 18
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased heart rate variabili... 1 | 11
decreased neutrophil cell numb... 1 | 37
decreased red blood cell distr... 1 | 11
embryonic growth retardation 1 | 28
enlarged lymph nodes 1 | 27
hydrometra 1 | 13
increased B cell number 1 | 23
increased body weight 1 | 42
increased circulating alanine ... 1 | 11
increased circulating amylase ... 1 | 13
increased circulating aspartat... 1 | 17
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating magnesiu... 1 | 10
increased heart rate variabili... 1 | 4
increased heart weight 1 | 37
increased hematocrit 1 | 36
increased hemoglobin content 1 | 45
increased rib number 1 | 41
polydactyly 1 | 22
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
small superior vagus ganglion 1 | 20
small testis 1 | 37
thrombocytopenia 1 | 46
vertebral fusion 1 | 23

Disease

ovarian cancer 119 | 8,484
osteosarcoma 92 | 7,933
medulloblastoma, large-cell 71 | 6,234
glioblastoma 63 | 5,572
psoriasis 63 | 6,685
posterior fossa group B ependymoma 58 | 1,530
atypical teratoid / rhabdoid tumor 51 | 4,369
lung cancer 51 | 4,466
Polydactyly 41 | 93
primitive neuroectodermal tumor 41 | 3,031
malignant mesothelioma 38 | 3,162
Ciliopathy 37 | 57
group 3 medulloblastoma 37 | 2,254
oligodendroglioma 37 | 2,849
Breast cancer 35 | 3,094
ependymoma 35 | 2,514
pediatric high grade glioma 35 | 2,712
Pick disease 34 | 1,893
Carcinoma 32 | 2,147
Nephronophthisis 32 | 74
Intellectual disability 31 | 573
astrocytic glioma 31 | 2,241
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,289
pilocytic astrocytoma 28 | 3,086
Bardet-Biedl Syndrome 27 | 40
Obesity 26 | 616
Retinitis pigmentosa 26 | 153
non-small cell lung cancer 26 | 2,798
Joubert syndrome 25 | 61
invasive ductal carcinoma 25 | 2,950
Multiple myeloma 24 | 1,327
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,988
chronic rhinosinusitis 22 | 512
sonic hedgehog group medulloblastoma 22 | 1,482
atypical teratoid/rhabdoid tumor 20 | 1,095
colon cancer 20 | 1,475
Asphyxiating thoracic dystrophy 19 | 32
adult high grade glioma 19 | 2,148
lung adenocarcinoma 19 | 2,713
medulloblastoma 19 | 1,524
Fundus dystrophy 18 | 77
Meckel syndrome 18 | 48
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,956
nasopharyngeal carcinoma 18 | 1,056
pancreatic ductal adenocarcinoma liver metastasis 18 | 1,795
Senior-Loken syndrome 17 | 21
progressive supranuclear palsy 17 | 674
breast carcinoma 16 | 1,614
pancreatic cancer 16 | 2,300
diabetes mellitus 15 | 1,663
non primary Sjogren syndrome sicca 15 | 840
subependymal giant cell astrocytoma 15 | 2,287
Microcephaly 14 | 149
dermatomyositis 14 | 933
tuberculosis 14 | 1,557
Cancer 13 | 2,346
Cystic kidney disease 13 | 25
Waldenstrons macroglobulinemia 13 | 765
acute quadriplegic myopathy 13 | 1,157
astrocytoma 13 | 1,493
juvenile dermatomyositis 13 | 1,189
tuberculosis and treatment for 6 months 13 | 686
Cone dystrophy 12 | 57
ductal carcinoma in situ 12 | 1,745
Rheumatoid Arthritis 11 | 1,160
group 4 medulloblastoma 11 | 1,875
lung carcinoma 11 | 2,844
ulcerative colitis 11 | 2,087
Orofaciodigital syndrome 10 | 19
Sensenbrenner syndrome 10 | 15
adrenocortical carcinoma 10 | 1,427
Ellis-Van Creveld syndrome 9 | 18
Meckel-Gruber syndrome 9 | 15
Polycystic kidney disease 9 | 54
Renal dysplasia and retinal aplasia (disorder) 9 | 10
cystic fibrosis and chronic rhinosinusitis 9 | 213
pituitary cancer 9 | 1,972
Jeune thoracic dystrophy 8 | 9
Leber congenital amaurosis 8 | 72
Situs Inversus 8 | 48
hepatocellular carcinoma 8 | 532
posterior fossa group A ependymoma 8 | 1,511
Familial aplasia of the vermis 7 | 8
Hydrolethalus syndrome 7 | 128
Neurodegenerative disease 7 | 383
Schizophrenia 7 | 501
acute myeloid leukemia 7 | 780
gastric cancer 7 | 430
interstitial cystitis 7 | 2,299
primary pancreatic ductal adenocarcinoma 7 | 1,271
Alzheimer's disease 6 | 644
Amyotrophic Lateral Sclerosis 6 | 431
Coloboma 6 | 51
Duchenne muscular dystrophy 6 | 602
Retinal Degeneration 6 | 49
active Crohn's disease 6 | 918
active ulcerative colitis 6 | 477
autosomal dominant Emery-Dreifuss muscular dystrophy 6 | 499
cone-rod dystrophy 6 | 56
pancreatic carcinoma 6 | 567

Tissue

Blood and immune system 187 | 17,995
Nervous System 187 | 18,561
Cardiovascular System 186 | 17,958
Digestive Tract 186 | 18,473
Endocrine System 186 | 18,512
Female tissues 186 | 18,647
Liver and Pancreas 186 | 18,136
Urinary Tract 186 | 18,444
Male tissues 185 | 17,969
Respiratory system 185 | 17,484
Skin and soft tissues 185 | 18,115

Target Family

Non-IDG 154 | 11,971
Enzyme 14 | 4,146
Kinase 9 | 634
GPCR 4 | 406
Ion Channel 4 | 341
Epigenetic 2 | 242

Reactome Pathway

Cilium Assembly 187 | 187
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Exocyst complex component 7 EXOC7 Tbio Non-IDG -1.72231 55.8 158
Centrosomal protein of 164 kDa CEP164 Tbio Non-IDG -0.96655 10.2 84
Bardet-Biedl syndrome 7 protein BBS7 Tbio Non-IDG -1.02867 11.1 125
Dynein light chain 1, cytoplasmic DYNLL1 Tbio Non-IDG -2.65303 525.6 142
Ras-related protein Rab-11A RAB11A Tbio Enzyme -2.60207 398.9 288
Centrosomal protein of 290 kDa CEP290 Tbio Non-IDG -1.97186 101.3 125
Centrosomal protein of 152 kDa CEP152 Tbio Non-IDG -1.23739 18.0 90
Alpha-centractin ACTR1A Tbio Non-IDG -0.72323 6.08 149
Kinesin-like protein KIF3B KIF3B Tbio Non-IDG -1.33400 20.0 84
Rab11 family-interacting protein 3 RAB11FIP3 Tbio Non-IDG -0.81358 5.58 60