Development Level

Tbio 146 | 11,178
Tdark 19 | 6,569
Tchem 14 | 1,885
Tclin 7 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
Ion Channel: IDG Consortium (T... 1 | 99

IMPC Phenotype

preweaning lethality, complete... 30 | 979
embryonic lethality prior to t... 9 | 278
abnormal embryo size 8 | 220
preweaning lethality, incomple... 8 | 499
abnormal behavior 6 | 298
male infertility 6 | 123
decreased bone mineral content 5 | 151
embryonic growth retardation 5 | 106
abnormal embryo turning 4 | 31
decreased body weight 4 | 161
decreased lean body mass 4 | 135
decreased total body fat amoun... 4 | 207
embryonic lethality prior to o... 4 | 239
abnormal head morphology 3 | 10
decreased caudal vertebrae num... 3 | 53
decreased circulating choleste... 3 | 93
decreased circulating serum al... 3 | 82
decreased circulating total pr... 3 | 49
hypoactivity 3 | 132
increased fasted circulating g... 3 | 76
increased lean body mass 3 | 172
increased mean corpuscular hem... 3 | 96
increased mean corpuscular vol... 3 | 92
prenatal lethality prior to he... 3 | 87
abnormal cranium morphology 2 | 36
abnormal humerus morphology 2 | 11
abnormal pericardium morpholog... 2 | 26
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
decreased body length 2 | 101
decreased bone mineral density 2 | 126
decreased circulating calcium ... 2 | 36
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased vertical activity 2 | 208
edema 2 | 59
hydrometra 2 | 53
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased circulating creatini... 2 | 38
increased grip strength 2 | 41
increased total body fat amoun... 2 | 134
persistence of hyaloid vascula... 2 | 33
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal embryo development 1 | 7
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal hindbrain morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal pelvic girdle bone mo... 1 | 12
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
absent startle reflex 1 | 24
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased heart rate variabili... 1 | 13
decreased heart weight 1 | 27
decreased red blood cell distr... 1 | 41
enlarged lymph nodes 1 | 37
enlarged uterus 1 | 11
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating fructosa... 1 | 13
increased circulating glucose ... 1 | 24
increased circulating glycerol... 1 | 9
increased circulating magnesiu... 1 | 10
increased heart rate variabili... 1 | 7
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
long tibia 1 | 25
microphthalmia 1 | 26
short tibia 1 | 97
small testis 1 | 58
vertebral fusion 1 | 23

Disease

Carcinoma 138 | 11,192
ovarian cancer 118 | 8,297
osteosarcoma 91 | 7,766
ependymoma 80 | 4,559
medulloblastoma, large-cell 71 | 6,086
atypical teratoid / rhabdoid tumor 68 | 4,971
glioblastoma 63 | 5,635
group 3 medulloblastoma 61 | 4,002
psoriasis 61 | 6,514
lung cancer 55 | 4,607
Intellectual disability 49 | 998
Polydactyly 45 | 106
Kidney cancer 41 | 2,548
primitive neuroectodermal tumor 41 | 2,957
Breast cancer 40 | 3,469
Ciliopathy 39 | 71
adult high grade glioma 39 | 3,701
malignant mesothelioma 38 | 3,135
Autosomal recessive predisposition 37 | 1,407
oligodendroglioma 37 | 2,768
Nephronophthisis 35 | 79
Pick disease 34 | 1,856
Bardet-Biedl syndrome 33 | 51
Obesity 33 | 655
Dull intelligence 32 | 634
Low intelligence 32 | 634
Mental Retardation 32 | 634
Mental deficiency 32 | 634
Poor school performance 32 | 634
astrocytic glioma 32 | 2,530
intraductal papillary-mucinous neoplasm (IPMN) 30 | 3,204
Joubert syndrome 29 | 66
Retinitis Pigmentosa 29 | 223
Short stature 29 | 514
Cognitive delay 28 | 596
Global developmental delay 28 | 596
Mental and motor retardation 28 | 596
Astrocytoma, Pilocytic 27 | 3,006
non-small cell lung cancer 26 | 2,799
Nystagmus 25 | 309
invasive ductal carcinoma 25 | 2,867
Multiple myeloma 24 | 1,296
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,902
chronic rhinosinusitis 22 | 505
Asphyxiating thoracic dystrophy 21 | 44
Congenital hypoplasia of penis 20 | 168
Electroretinogram abnormal 20 | 94
Retinal Degeneration 20 | 103
colon cancer 20 | 1,428
Hypertensive disease 19 | 278
Hypogonadism 19 | 169
Increase in blood pressure 19 | 118
diabetes mellitus 19 | 1,683
lung adenocarcinoma 19 | 2,627
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,911
tuberculosis 19 | 1,963
Meckel syndrome 18 | 46
Senior-Loken syndrome 18 | 22
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,872
nasopharyngeal carcinoma 18 | 1,024
Bardet-Biedl syndrome 1 17 | 22
Cataract 17 | 290
Fundus dystrophy 17 | 80
Ulnar polydactyly of fingers 17 | 46
progressive supranuclear palsy 17 | 656
Lens Opacities 16 | 227
Multicystic Dysplastic Kidney 16 | 51
breast carcinoma 16 | 1,589
pancreatic cancer 16 | 2,322
posterior fossa group B ependymoma 16 | 406
Anteverted nostril 15 | 186
Small head 15 | 366
non primary Sjogren syndrome sicca 15 | 861
pediatric high grade glioma 15 | 1,035
subependymal giant cell astrocytoma 15 | 2,230
Abnormality of retinal pigmentation 14 | 109
Brachydactyly 14 | 154
Cerebellar Ataxia 14 | 302
Cystic kidney disease 14 | 25
Microcephaly 14 | 166
Muscle hypotonia 14 | 562
Retinal pigment epithelial abnormality 14 | 109
Schizophrenia 14 | 1,136
dermatomyositis 14 | 941
Cone dystrophy 13 | 68
Glaucoma 13 | 232
Waldenstrons macroglobulinemia 13 | 742
acute quadriplegic myopathy 13 | 1,133
juvenile dermatomyositis 13 | 1,147
Cancer 12 | 2,388
Congenital hypoplasia of ovary 12 | 30
Hypoplastic ovary 12 | 30
Optic Atrophy 12 | 239
astrocytoma 12 | 1,113
ductal carcinoma in situ 12 | 1,686
medulloblastoma 12 | 702
Hypoplastic mandible condyle 11 | 273
Mandibular hypoplasia 11 | 273
Micrognathism 11 | 273
lung carcinoma 11 | 2,755

Tissue

Endocrine System 185 | 18,159
Nervous System 184 | 16,725
Digestive Tract 183 | 17,369
Female tissues 183 | 17,400
Liver and Pancreas 183 | 16,750
Male tissues 183 | 17,142
Skin and soft tissues 183 | 17,230
Urinary Tract 183 | 16,678
Blood and immune system 182 | 16,909
Respiratory system 182 | 16,393
Cardiovascular System 179 | 15,192

Target Family

Non-IDG 153 | 12,091
Enzyme 14 | 4,145
Kinase 9 | 634
GPCR 4 | 408
Ion Channel 4 | 344
Epigenetic 2 | 242

Reactome Pathway

Cilium Assembly 186 | 186
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Transmembrane protein 216 TMEM216 Tbio Non-IDG -1.05847 10.9 0
Kinesin-like protein KIF17 KIF17 Tbio Non-IDG -2.01401 107.8 73
Tubulin beta-4B chain TUBB4B Tclin Non-IDG -0.95954 8.09 107
ADP-ribosylation factor 4 ARF4 Tbio Enzyme -1.67012 46.6 163
Protein SFI1 homolog SFI1 Tdark Non-IDG -1.48977 32.1 21
Cytoskeleton-associated protein 5 CKAP5 Tbio Non-IDG -2.12618 129.3 77
Centrosomal protein of 192 kDa CEP192 Tbio Non-IDG -1.15560 13.3 34
Dynein light chain roadblock-type 2 DYNLRB2 Tbio Non-IDG -0.65444 2.59 77
TRAF3-interacting protein 1 TRAF3IP1 Tbio Non-IDG -0.90740 11.2 169
Tau-tubulin kinase 2 TTBK2 Tbio Kinase -1.26107 19.5 146