Development Level

Tbio 64 | 11,178
Tdark 12 | 6,569
Tchem 7 | 1,885
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 13 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
increased mean corpuscular vol... 2 | 92
prenatal lethality prior to he... 2 | 87
abnormal embryo turning 1 | 31
abnormal maxilla morphology 1 | 17
abnormal pharyngeal arch morph... 1 | 8
abnormal tail morphology 1 | 25
abnormal tooth morphology 1 | 24
decreased body weight 1 | 161
decreased circulating free fat... 1 | 31
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
embryonic growth retardation 1 | 106
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
increased red blood cell distr... 1 | 34

Disease

ovarian cancer 45 | 8,297
group 3 medulloblastoma 42 | 4,002
psoriasis 41 | 6,514
Carcinoma 38 | 11,192
lung cancer 37 | 4,607
non-small cell lung cancer 36 | 2,799
medulloblastoma, large-cell 35 | 6,086
Breast cancer 32 | 3,469
glioblastoma 30 | 5,635
malignant mesothelioma 29 | 3,135
osteosarcoma 29 | 7,766
atypical teratoid / rhabdoid tumor 27 | 4,971
primitive neuroectodermal tumor 27 | 2,957
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,204
invasive ductal carcinoma 23 | 2,867
lung adenocarcinoma 23 | 2,627
ductal carcinoma in situ 22 | 1,686
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,902
adrenocortical carcinoma 21 | 1,385
colon cancer 18 | 1,428
ependymoma 16 | 4,559
Cancer 15 | 2,388
nasopharyngeal carcinoma 15 | 1,024
adult high grade glioma 14 | 3,701
breast carcinoma 14 | 1,589
Multiple myeloma 13 | 1,296
Waldenstrons macroglobulinemia 13 | 742
Endometriosis 12 | 521
pancreatic cancer 10 | 2,322
Intellectual disability 9 | 998
Kidney cancer 9 | 2,548
Short stature 9 | 514
pediatric high grade glioma 9 | 1,035
pituitary cancer 9 | 1,915
Cognitive delay 8 | 596
Global developmental delay 8 | 596
Mental and motor retardation 8 | 596
oligodendroglioma 8 | 2,768
Dull intelligence 7 | 634
Low intelligence 7 | 634
Mental Retardation 7 | 634
Mental deficiency 7 | 634
Poor school performance 7 | 634
cystic fibrosis 7 | 1,629
diabetes mellitus 7 | 1,683
Abnormality of the fingernails 6 | 51
Dyskeratosis congenita 6 | 24
Hypodontia 6 | 81
Recurrent respiratory infections 6 | 138
Small head 6 | 366
Urethral Stricture 6 | 17
non-small cell lung carcinoma 6 | 302
subependymal giant cell astrocytoma 6 | 2,230
Abnormal blistering of the skin 5 | 52
Anemia 5 | 353
Atopic dermatitis 5 | 915
Autosomal recessive predisposition 5 | 1,407
Blister of skin 5 | 52
Blood Coagulation Disorders 5 | 41
Bone marrow hypocellularity 5 | 20
Cellular immunodeficiency 5 | 17
Coagulation abnormalities 5 | 27
Decreased platelet count 5 | 110
Dental caries 5 | 157
Dystrophia unguium 5 | 52
Esophageal Stenosis 5 | 14
Frequent fractures 5 | 52
Gingival Diseases 5 | 19
Hemoglobin low 5 | 123
Hemorrhagic Disorders 5 | 29
Hyperhidrosis disorder 5 | 78
Hyperpigmented macules 5 | 41
Hypoplastic-absent toenails 5 | 11
Increased fracture rate 5 | 52
Increased sweating 5 | 78
Intrauterine retardation 5 | 174
Leukokeratosis 5 | 19
Leukoplakia, Oral 5 | 20
Malabsorption 5 | 81
Neutrophil abnormality 5 | 20
Osteoporosis 5 | 348
Periodontal Diseases 5 | 21
Pick disease 5 | 1,856
Skin Ulcer 5 | 48
Skin bulla 5 | 52
Sparse hair 5 | 59
Sweating 5 | 78
Taurodontism 5 | 14
Telangiectasia of the skin 5 | 38
Thin, sparse hair 5 | 59
Thrombocytopenia 5 | 193
Tracheoesophageal Fistula 5 | 33
Varying degree of multiple fractures 5 | 52
acute myeloid leukemia 5 | 760
cutaneous lupus erythematosus 5 | 1,016
dermatomyositis 5 | 941
hypopigmented skin patch 5 | 59
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,872
lung carcinoma 5 | 2,755
periodontitis 5 | 280

Tissue

Endocrine System 86 | 18,159
Blood and immune system 85 | 16,909
Digestive Tract 85 | 17,369
Female tissues 84 | 17,400
Skin and soft tissues 84 | 17,230
Liver and Pancreas 83 | 16,750
Male tissues 83 | 17,142
Nervous System 83 | 16,725
Respiratory system 83 | 16,393
Urinary Tract 83 | 16,678
Cardiovascular System 82 | 15,192

Target Family

Non-IDG 66 | 12,091
Enzyme 17 | 4,145
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Chromosome Maintenance 86 | 86
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Centromere protein N CENPN Tbio Non-IDG -0.88756 6.97 80
Histone H3.1t HIST3H3 Tbio Non-IDG -1.05426 10.9 1265
Histone H2B type 3-B HIST3H2BB Tbio Non-IDG -0.72238 5.02 53
Histone H2A type 1-D HIST1H2AD Tdark Non-IDG 0.17 0.32 11
Centromere protein Q CENPQ Tbio Non-IDG -0.47122 2.25 73
Histone H2B type 1-K HIST1H2BK Tbio Non-IDG -0.50219 4.04 29
Telomeric repeat-binding factor 2 TERF2 Tbio Transcription Factor -2.23836 174.6 367