Development Level

Tbio 58 | 10,625
Tdark 18 | 7,003
Tchem 7 | 1,890
Tclin 3 | 602

IMPC Term

preweaning lethality, complete... 11 | 633
embryonic lethality prior to o... 4 | 148
prenatal lethality prior to he... 3 | 64
abnormal embryo size 2 | 112
abnormal retina morphology 2 | 100
decreased total body fat amoun... 2 | 186
embryonic lethality prior to t... 2 | 187
polydactyly 2 | 22
abnormal digit morphology 1 | 13
abnormal embryo turning 1 | 15
abnormal lens morphology 1 | 73
abnormal maxilla morphology 1 | 16
abnormal pharyngeal arch morph... 1 | 2
abnormal rib morphology 1 | 28
abnormal tail morphology 1 | 17
abnormal tooth morphology 1 | 24
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased body length 1 | 108
decreased body weight 1 | 174
decreased circulating free fat... 1 | 39
decreased circulating iron lev... 1 | 25
embryonic growth retardation 1 | 28
increased bone mineral content 1 | 92
increased circulating HDL chol... 1 | 63
increased circulating bilirubi... 1 | 16
increased circulating sodium l... 1 | 71
increased granulocyte number 1 | 8
increased heart weight 1 | 37
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased mean platelet volume 1 | 19
increased sacral vertebrae num... 1 | 62
short tibia 1 | 82

Disease

ovarian cancer 44 | 8,484
psoriasis 40 | 6,685
lung cancer 37 | 4,466
medulloblastoma, large-cell 34 | 6,234
non-small cell lung cancer 34 | 2,798
Breast cancer 31 | 3,094
group 3 medulloblastoma 31 | 2,254
malignant mesothelioma 29 | 3,162
osteosarcoma 29 | 7,933
glioblastoma 28 | 5,572
primitive neuroectodermal tumor 26 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
lung adenocarcinoma 23 | 2,713
invasive ductal carcinoma 22 | 2,950
ductal carcinoma in situ 21 | 1,745
intraductal papillary-mucinous carcinoma (IPMC) 21 | 2,988
adrenocortical carcinoma 20 | 1,427
pediatric high grade glioma 20 | 2,712
colon cancer 18 | 1,475
atypical teratoid / rhabdoid tumor 17 | 4,369
nasopharyngeal carcinoma 14 | 1,056
Multiple myeloma 13 | 1,327
Waldenstrons macroglobulinemia 13 | 765
breast carcinoma 13 | 1,614
posterior fossa group A ependymoma 12 | 1,511
sonic hedgehog group medulloblastoma 12 | 1,482
Cancer 11 | 2,346
Endometriosis 11 | 535
atypical teratoid/rhabdoid tumor 11 | 1,095
pancreatic cancer 9 | 2,300
pituitary cancer 9 | 1,972
IGA Glomerulonephritis 8 | 454
oligodendroglioma 8 | 2,849
Dyskeratosis congenita 7 | 24
cystic fibrosis 7 | 1,665
non-small cell lung carcinoma 7 | 413
subependymal giant cell astrocytoma 7 | 2,287
diabetes mellitus 6 | 1,663
Pick disease 5 | 1,893
Seckel syndrome 5 | 34
acute myeloid leukemia 5 | 780
cutaneous lupus erythematosus 5 | 1,056
dermatomyositis 5 | 933
intraductal papillary-mucinous adenoma (IPMA) 5 | 2,956
lung carcinoma 5 | 2,844
ulcerative colitis 5 | 2,087
Atopic dermatitis 4 | 944
Carcinoma 4 | 2,147
Chronic Lymphocytic Leukemia 4 | 242
Colorectal Neoplasms 4 | 217
HOYERAAL-HREIDARSSON SYNDROME 4 | 6
Mammary Neoplasms 4 | 410
astrocytoma 4 | 1,493
ependymoma 4 | 2,514
group 4 medulloblastoma 4 | 1,875
interstitial cystitis 4 | 2,299
non primary Sjogren syndrome sicca 4 | 840
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,795
primary Sjogren syndrome 4 | 789
Acute lymphoid leukemia 3 | 25
Acute myeloid leukemia, disease 3 | 16
Acute promyelocytic leukemia, FAB M3 3 | 10
Adenocarcinoma of pancreas 3 | 12
Anemia 3 | 252
Ataxia telangiectasia 3 | 31
Cleft palate 3 | 125
Connective tissue disease 3 | 59
Leishmaniasis 3 | 49
Lupus erythematosus 3 | 80
Lymphomatous meningitis 3 | 3
Malignant tumor of ovary 3 | 25
Meningeal Leukemia 3 | 7
Metastatic Breast Carcinoma 3 | 21
Werner syndrome 3 | 29
Xeroderma pigmentosum 3 | 41
acute quadriplegic myopathy 3 | 1,157
pilocytic astrocytoma 3 | 3,086
posterior fossa group B ependymoma 3 | 1,530
primary pancreatic ductal adenocarcinoma 3 | 1,271
tuberculosis and treatment for 6 months 3 | 686
Acquired metabolic disease 2 | 267
Adenoma 2 | 165
Bipolar Disorder 2 | 266
Bladder Neoplasm 2 | 109
Cockayne syndrome 2 | 54
Colonic Neoplasms 2 | 126
Down syndrome 2 | 548
Fanconi's anemia 2 | 50
Lung Neoplasms 2 | 171
Testicular cancer 2 | 24
active Crohn's disease 2 | 918
adult high grade glioma 2 | 2,148
aldosterone-producing adenoma 2 | 664
astrocytic glioma 2 | 2,241
gastric carcinoma 2 | 832
glioblastoma multiforme 2 | 347
hepatocellular carcinoma 2 | 532
pancreatic carcinoma 2 | 567
spina bifida 2 | 1,064
tuberculosis 2 | 1,557

Tissue

Female tissues 86 | 18,647
Male tissues 86 | 17,969
Blood and immune system 85 | 17,995
Cardiovascular System 85 | 17,958
Digestive Tract 85 | 18,473
Endocrine System 85 | 18,512
Nervous System 85 | 18,561
Urinary Tract 85 | 18,444
Liver and Pancreas 84 | 18,136
Respiratory system 84 | 17,484
Skin and soft tissues 78 | 18,115

Target Family

Non-IDG 66 | 11,971
Enzyme 17 | 4,146
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Chromosome Maintenance 86 | 86
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Histone H3-like centromeric protein A CENPA Tbio Non-IDG -2.68837 532.8 347
Protein Mis18-alpha MIS18A Tdark Non-IDG -2.10690 101.0 41
Replication factor C subunit 2 RFC2 Tbio Non-IDG -1.34287 19.7 194
Replication factor C subunit 1 RFC1 Tbio Non-IDG -1.40675 26.5 184
DNA primase large subunit PRIM2 Tbio Enzyme 0.00000 76
DNA primase small subunit PRIM1 Tbio Enzyme -0.88906 8.05 121