Development Level

Tbio 143 | 10,625
Tchem 59 | 1,890
Tdark 27 | 7,003
Tclin 8 | 602

IMPC Term

preweaning lethality, complete... 16 | 633
decreased body weight 8 | 174
decreased lean body mass 8 | 195
abnormal behavior 7 | 226
decreased total body fat amoun... 6 | 186
preweaning lethality, incomple... 5 | 260
abnormal bone mineralization 4 | 55
decreased bone mineral density 4 | 126
decreased circulating HDL chol... 4 | 77
decreased hemoglobin content 4 | 53
increased grip strength 4 | 83
increased sacral vertebrae num... 4 | 62
abnormal embryo size 3 | 112
decreased body length 3 | 108
decreased circulating choleste... 3 | 85
decreased circulating iron lev... 3 | 25
decreased erythrocyte cell num... 3 | 43
decreased hematocrit 3 | 25
decreased leukocyte cell numbe... 3 | 54
decreased prepulse inhibition 3 | 52
embryonic lethality prior to o... 3 | 148
female infertility 3 | 34
increased B cell number 3 | 23
increased body weight 3 | 42
increased circulating alkaline... 3 | 119
increased circulating creatini... 3 | 29
increased circulating triglyce... 3 | 24
short tibia 3 | 82
abnormal cornea morphology 2 | 24
abnormal eye morphology 2 | 38
abnormal gait 2 | 51
abnormal locomotor activation 2 | 26
abnormal startle reflex 2 | 14
decreased CD8-positive, alpha-... 2 | 26
decreased T cell number 2 | 31
decreased bone mineral content 2 | 157
decreased circulating LDL chol... 2 | 37
decreased circulating alkaline... 2 | 41
decreased circulating glucose ... 2 | 121
decreased eosinophil cell numb... 2 | 41
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular vol... 2 | 50
decreased thermal nociceptive ... 2 | 4
embryonic lethality prior to t... 2 | 187
hydrops fetalis 2 | 22
hypoactivity 2 | 89
increased blood urea nitrogen ... 2 | 44
increased bone mineral content 2 | 92
increased circulating HDL chol... 2 | 63
increased circulating amylase ... 2 | 13
increased lean body mass 2 | 107
increased mean corpuscular vol... 2 | 91
increased startle reflex 2 | 38
limb grasping 2 | 35
male infertility 2 | 62
thrombocytopenia 2 | 46
abnormal behavioral response t... 1 | 52
abnormal coat appearance 1 | 25
abnormal coat/ hair morphology 1 | 18
abnormal coping response 1 | 12
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal thoracic vertebrae mo... 1 | 16
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
corneal opacity 1 | 25
decreased CD4-positive, alpha ... 1 | 19
decreased Ly6C high monocyte n... 1 | 18
decreased NK cell number 1 | 16
decreased alpha-beta T cell nu... 1 | 12
decreased caudal vertebrae num... 1 | 49
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased effector memory CD8-... 1 | 24
decreased grip strength 1 | 123
decreased mean corpuscular hem... 1 | 34
decreased mean platelet volume 1 | 12
decreased spleen weight 1 | 13
enlarged spleen 1 | 26
hydrometra 1 | 13
increased CD4-positive, CD25-p... 1 | 18
increased body length 1 | 20
increased bone mineral density 1 | 52
increased circulating glycerol... 1 | 11
increased circulating magnesiu... 1 | 10
increased effector memory CD4-... 1 | 15
increased granulocyte number 1 | 8
increased lactate dehydrogenas... 1 | 3
increased mean platelet volume 1 | 19
increased rib number 1 | 41
long tibia 1 | 13
microphthalmia 1 | 15
oligodactyly 1 | 14
prenatal lethality prior to he... 1 | 64
small kidney 1 | 10
small spleen 1 | 11
tremors 1 | 34
trunk curl 1 | 15

Disease

ovarian cancer 135 | 8,484
osteosarcoma 130 | 7,933
psoriasis 83 | 6,685
medulloblastoma, large-cell 77 | 6,234
Cancer 74 | 2,346
glioblastoma 74 | 5,572
lung cancer 71 | 4,466
atypical teratoid / rhabdoid tumor 61 | 4,369
Carcinoma 57 | 2,147
Breast cancer 53 | 3,094
malignant mesothelioma 51 | 3,162
primitive neuroectodermal tumor 44 | 3,031
group 3 medulloblastoma 38 | 2,254
ependymoma 37 | 2,514
Multiple myeloma 36 | 1,327
oligodendroglioma 36 | 2,849
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,956
lung adenocarcinoma 33 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 32 | 2,988
Intellectual disability 31 | 573
Rheumatoid Arthritis 31 | 1,160
astrocytoma 31 | 1,493
invasive ductal carcinoma 31 | 2,950
pediatric high grade glioma 31 | 2,712
non-small cell lung cancer 30 | 2,798
subependymal giant cell astrocytoma 28 | 2,287
Pick disease 27 | 1,893
group 4 medulloblastoma 24 | 1,875
sonic hedgehog group medulloblastoma 24 | 1,482
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,795
dermatomyositis 22 | 933
spina bifida 21 | 1,064
medulloblastoma 20 | 1,524
tuberculosis 20 | 1,557
acute myeloid leukemia 19 | 780
juvenile dermatomyositis 19 | 1,189
ductal carcinoma in situ 18 | 1,745
pancreatic cancer 18 | 2,300
pilocytic astrocytoma 18 | 3,086
Adenoid Cystic Carcinoma 17 | 99
adult high grade glioma 17 | 2,148
pituitary cancer 17 | 1,972
breast carcinoma 16 | 1,614
colon cancer 16 | 1,475
cystic fibrosis 16 | 1,665
acute quadriplegic myopathy 15 | 1,157
astrocytic glioma 15 | 2,241
atypical teratoid/rhabdoid tumor 15 | 1,095
diabetes mellitus 15 | 1,663
Mammary Neoplasms 14 | 410
Waldenstrons macroglobulinemia 13 | 765
posterior fossa group B ependymoma 12 | 1,530
Alzheimer's disease 10 | 644
Endometriosis 10 | 535
Leukemia 10 | 88
adrenocortical carcinoma 10 | 1,427
gastric cancer 10 | 430
hepatocellular carcinoma 10 | 532
lung carcinoma 10 | 2,844
primary pancreatic ductal adenocarcinoma 10 | 1,271
ulcerative colitis 10 | 2,087
Kidney cancer 9 | 118
nasopharyngeal carcinoma 9 | 1,056
posterior fossa group A ependymoma 9 | 1,511
progressive supranuclear palsy 9 | 674
Carcinoma, Transitional Cell 8 | 31
Liver carcinoma 8 | 217
Peripheral T-cell lymphoma 8 | 24
Schizophrenia 8 | 501
aldosterone-producing adenoma 8 | 664
non primary Sjogren syndrome sicca 8 | 840
non-small cell lung carcinoma 8 | 413
tuberculosis and treatment for 6 months 8 | 686
Bladder Neoplasm 7 | 109
Coffin-Siris syndrome 7 | 17
Down syndrome 7 | 548
Kabuki syndrome 7 | 27
Lymphoid leukemia 7 | 69
Melanoma 7 | 261
Obesity 7 | 616
Primary cutaneous T-cell lymphoma 7 | 24
Sezary Syndrome 7 | 26
Spinocerebellar ataxia type 7 7 | 13
Squamous cell carcinoma of esophagus 7 | 82
Lung Neoplasms 6 | 171
Prostatic Neoplasms 6 | 471
active Crohn's disease 6 | 918
cutaneous lupus erythematosus 6 | 1,056
interstitial cystitis 6 | 2,299
Amyotrophic Lateral Sclerosis 5 | 431
Autistic Disorder 5 | 320
Bipolar Disorder 5 | 266
Crohn's disease 5 | 304
Endometrial Neoplasms 5 | 50
Gaucher disease type 1 5 | 171
IGA Glomerulonephritis 5 | 454
Male infertility 5 | 170
Stomach Neoplasms 5 | 282
pancreatic carcinoma 5 | 567

Tissue

Cardiovascular System 235 | 17,958
Female tissues 235 | 18,647
Nervous System 234 | 18,561
Digestive Tract 233 | 18,473
Endocrine System 233 | 18,512
Liver and Pancreas 233 | 18,136
Male tissues 233 | 17,969
Blood and immune system 232 | 17,995
Urinary Tract 232 | 18,444
Respiratory system 231 | 17,484
Skin and soft tissues 222 | 18,115

Target Family

Non-IDG 93 | 11,971
Epigenetic 85 | 242
Transcription Factor 23 | 1,400
Enzyme 18 | 4,146
TF/Epigenetic 16 | 38
Kinase 2 | 634

Reactome Pathway

Chromatin organization 237 | 237
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Lysine-specific demethylase 3B KDM3B Tbio Epigenetic -0.92399 9.25 269
Histone-lysine N-methyltransferase SETD1B SETD1B Tbio Epigenetic -1.20916 14.6 78
Ubiquitin carboxyl-terminal hydrolase 22 USP22 Tbio Enzyme -1.59877 51.0 199
Host cell factor 1 HCFC1 Tbio Non-IDG -2.50024 341.6 160
Lysine-specific histone demethylase 1B KDM1B Tbio Epigenetic -1.39308 24.2 69
Transcriptional repressor p66-alpha GATAD2A Tbio Non-IDG -0.79314 7.11 142
PHD finger protein 20 PHF20 Tbio Epigenetic -2.79926 660.7 91
Lysine-specific demethylase 6B KDM6B Tchem Epigenetic -2.06838 144.7 243
Histone-lysine N-methyltransferase SETD1A SETD1A Tbio Epigenetic -2.53375 346.3 108
Lysine-specific demethylase PHF2 PHF2 Tbio Epigenetic -0.67973 5.14 73