Development Level

Tbio 148 | 11,178
Tchem 60 | 1,885
Tdark 20 | 6,569
Tclin 8 | 612

IMPC Phenotype

preweaning lethality, complete... 38 | 979
preweaning lethality, incomple... 14 | 499
abnormal behavior 10 | 298
decreased body weight 9 | 161
increased lean body mass 8 | 172
increased startle reflex 8 | 112
increased total body fat amoun... 6 | 134
abnormal embryo size 5 | 220
decreased bone mineral density 5 | 126
decreased hemoglobin content 5 | 68
decreased lean body mass 5 | 135
decreased total body fat amoun... 5 | 207
decreased vertical activity 5 | 208
embryonic lethality prior to o... 5 | 239
female infertility 5 | 60
increased circulating alkaline... 5 | 122
abnormal cornea morphology 4 | 31
abnormal retinal blood vessel ... 4 | 26
decreased circulating glucose ... 4 | 126
decreased heart left ventricle... 4 | 28
decreased prepulse inhibition 4 | 82
embryonic lethality prior to t... 4 | 278
hypoactivity 4 | 132
increased circulating HDL chol... 4 | 80
male infertility 4 | 123
abnormal bone structure 3 | 187
abnormal retinal vasculature m... 3 | 27
corneal opacity 3 | 32
decreased body length 3 | 101
decreased bone mineral content 3 | 151
decreased circulating choleste... 3 | 93
decreased circulating iron lev... 3 | 32
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
decreased hematocrit 3 | 46
increased blood urea nitrogen ... 3 | 48
increased bone mineral content 3 | 108
increased circulating creatini... 3 | 38
increased mean corpuscular vol... 3 | 92
short tibia 3 | 97
abnormal bone mineralization 2 | 38
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal iris morphology 2 | 13
abnormal lens morphology 2 | 81
abnormal locomotor activation 2 | 16
abnormal maxilla morphology 2 | 17
abnormal seminal vesicle morph... 2 | 114
abnormal startle reflex 2 | 15
abnormal tooth morphology 2 | 24
cardiovascular system phenotyp... 2 | 36
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased caudal vertebrae num... 2 | 53
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating alanine ... 2 | 47
decreased circulating alkaline... 2 | 46
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased fasted circulating g... 2 | 65
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 31
decreased mean corpuscular vol... 2 | 79
decreased mean platelet volume 2 | 25
edema 2 | 59
hyperactivity 2 | 148
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased body length 2 | 32
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased circulating amylase ... 2 | 25
increased circulating calcium ... 2 | 34
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased mean platelet volume 2 | 45
increased thermal nociceptive ... 2 | 9
irregularly shaped pupil 2 | 7
limb grasping 2 | 41
small spleen 2 | 19
small testis 2 | 58
thrombocytopenia 2 | 56
tremors 2 | 39
trunk curl 2 | 16
abnormal cranium morphology 1 | 36
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal spleen morphology 1 | 55
decreased T cell number 1 | 15
decreased circulating amylase ... 1 | 28
decreased circulating potassiu... 1 | 20
decreased neutrophil cell numb... 1 | 42
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
enlarged spleen 1 | 41
increased heart weight 1 | 62
microphthalmia 1 | 26
thin ventricular wall 1 | 24

Disease

Carcinoma 169 | 11,192
ovarian cancer 132 | 8,297
osteosarcoma 128 | 7,766
psoriasis 83 | 6,514
lung cancer 80 | 4,607
Cancer 75 | 2,388
glioblastoma 75 | 5,635
medulloblastoma, large-cell 75 | 6,086
group 3 medulloblastoma 71 | 4,002
atypical teratoid / rhabdoid tumor 68 | 4,971
Breast cancer 65 | 3,469
Kidney cancer 62 | 2,548
malignant mesothelioma 56 | 3,135
ependymoma 51 | 4,559
primitive neuroectodermal tumor 45 | 2,957
Intellectual disability 37 | 998
oligodendroglioma 36 | 2,768
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,204
Multiple myeloma 34 | 1,296
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,902
adult high grade glioma 33 | 3,701
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,872
lung adenocarcinoma 33 | 2,627
non-small cell lung cancer 33 | 2,799
invasive ductal carcinoma 32 | 2,867
Rheumatoid arthritis 30 | 1,156
subependymal giant cell astrocytoma 29 | 2,230
Pick disease 27 | 1,856
Schizophrenia 26 | 1,136
astrocytoma 25 | 1,113
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,911
spina bifida 22 | 1,053
tuberculosis 22 | 1,963
dermatomyositis 21 | 941
pancreatic cancer 21 | 2,322
Liver cancer 19 | 589
astrocytic glioma 19 | 2,530
ductal carcinoma in situ 19 | 1,686
juvenile dermatomyositis 19 | 1,147
pituitary cancer 18 | 1,915
Adenoid Cystic Carcinoma 17 | 90
Astrocytoma, Pilocytic 17 | 3,006
Carcinoma, Adenoid Cystic 17 | 90
acute myeloid leukemia 17 | 760
breast carcinoma 17 | 1,589
Breast Neoplasms 16 | 423
Dull intelligence 16 | 634
Low intelligence 16 | 634
Mental Retardation 16 | 634
Mental deficiency 16 | 634
Muscle hypotonia 16 | 562
Poor school performance 16 | 634
acute quadriplegic myopathy 16 | 1,133
colon cancer 16 | 1,428
cystic fibrosis 16 | 1,629
pediatric high grade glioma 16 | 1,035
Epilepsy 15 | 775
Mammary Neoplasms 15 | 403
Seizures 15 | 584
Cryptorchidism 14 | 287
Small head 14 | 366
Strabismus 14 | 265
diabetes mellitus 14 | 1,683
group 4 medulloblastoma 14 | 1,806
Cognitive delay 13 | 596
Endometrial cancer 13 | 301
Global developmental delay 13 | 596
Lymphoid leukemia 13 | 156
Melanoma 13 | 689
Mental and motor retardation 13 | 596
Short stature 13 | 514
Waldenstrons macroglobulinemia 13 | 742
medulloblastoma 13 | 702
Immune system cancer 12 | 136
Acquired scoliosis 11 | 274
Congenital deafness 11 | 180
Curvature of spine 11 | 275
Deafness 11 | 193
Feeding difficulties in infancy 11 | 174
Hearing Loss, Partial 11 | 180
Leukemia 11 | 103
adrenocortical carcinoma 11 | 1,385
hearing impairment 11 | 194
hepatocellular carcinoma 11 | 536
Broad flat nasal bridge 10 | 232
Endometriosis 10 | 521
Nasal bridge wide 10 | 232
gastric cancer 10 | 445
Neurodevelopmental Disorders 9 | 70
lung carcinoma 9 | 2,755
non primary Sjogren syndrome sicca 9 | 861
progressive supranuclear palsy 9 | 656
sonic hedgehog group medulloblastoma 9 | 459
Alzheimer's disease 8 | 640
Bipolar Disorder 8 | 646
Failure to gain weight 8 | 359
Pediatric failure to thrive 8 | 359
aldosterone-producing adenoma 8 | 646
nasopharyngeal carcinoma 8 | 1,024
primary pancreatic ductal adenocarcinoma 8 | 1,071

Tissue

Endocrine System 233 | 18,159
Skin and soft tissues 232 | 17,230
Blood and immune system 231 | 16,909
Digestive Tract 231 | 17,369
Liver and Pancreas 231 | 16,750
Female tissues 230 | 17,400
Male tissues 230 | 17,142
Urinary Tract 230 | 16,678
Nervous System 229 | 16,725
Respiratory system 227 | 16,393
Cardiovascular System 226 | 15,192

Target Family

Non-IDG 91 | 12,091
Epigenetic 85 | 242
Transcription Factor 23 | 1,400
Enzyme 18 | 4,145
TF/Epigenetic 17 | 38
Kinase 2 | 634

Reactome Pathway

Chromatin organization 236 | 236
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Histone-lysine N-methyltransferase 2A KMT2A Tchem Epigenetic -2.88228 736.0 334
Microspherule protein 1 MCRS1 Tbio Non-IDG -1.40659 32.1 99
KAT8 regulatory NSL complex subunit 2 KANSL2 Tbio Non-IDG -0.72700 5.47 32
Histone H2B type 3-B HIST3H2BB Tbio Non-IDG -0.72238 5.02 53
Transcription initiation factor TFIID subunit 9 TAF9 Tbio Non-IDG -2.18859 223.1 83
Retinoblastoma-binding protein 5 RBBP5 Tchem Non-IDG -1.40059 20.2 180
AT-rich interactive domain-containing protein 4B ARID4B Tbio TF/Epigenetic -1.25831 18.5 133