Development Level

Tbio 45 | 11,445
Tchem 2 | 1,598
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 4 | 499
abnormal eye morphology 2 | 68
decreased lymphocyte cell numb... 2 | 83
preweaning lethality, complete... 2 | 979
abnormal QT variability 1 | 10
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
absent startle reflex 1 | 24
cataract 1 | 92
decreased body length 1 | 101
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased exploration in new e... 1 | 11
decreased leukocyte cell numbe... 1 | 73
decreased red blood cell distr... 1 | 41
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged kidney 1 | 14
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased circulating triglyce... 1 | 42
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased startle reflex 1 | 112
mydriasis 1 | 6
small adrenal glands 1 | 16
small kidney 1 | 16
thick skin 1 | 4

Disease

Carcinoma 38 | 11,493
glioblastoma 31 | 5,792
ovarian cancer 29 | 8,520
atypical teratoid / rhabdoid tumor 23 | 5,112
medulloblastoma, large-cell 23 | 6,241
psoriasis 22 | 6,694
ependymoma 20 | 4,679
osteosarcoma 20 | 7,950
Astrocytoma, Pilocytic 18 | 3,081
Breast cancer 18 | 3,578
invasive ductal carcinoma 16 | 2,951
group 3 medulloblastoma 15 | 4,104
lung cancer 15 | 4,740
adult high grade glioma 14 | 3,801
malignant mesothelioma 14 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,989
pituitary cancer 13 | 1,972
primitive neuroectodermal tumor 13 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
lung carcinoma 12 | 2,843
Autosomal recessive predisposition 11 | 1,442
interstitial cystitis 11 | 2,312
lung adenocarcinoma 11 | 2,716
ductal carcinoma in situ 10 | 1,745
pancreatic cancer 10 | 2,398
ulcerative colitis 10 | 1,819
Cancer 9 | 2,499
cystic fibrosis 9 | 1,696
diabetes mellitus 9 | 1,728
gastric carcinoma 9 | 807
oligodendroglioma 9 | 2,850
Concave bridge of nose 8 | 195
Depressed nasal bridge 8 | 195
Depressed nasal root/bridge 8 | 195
Short neck 8 | 140
astrocytic glioma 8 | 2,597
cutaneous lupus erythematosus 8 | 1,057
group 4 medulloblastoma 8 | 1,855
tuberculosis 8 | 2,010
Big calvaria 7 | 147
Congenital clubfoot 7 | 109
Duchenne muscular dystrophy 7 | 601
Ehlers-Danlos syndrome 7 | 43
Hernia, Inguinal 7 | 89
Hydrocephalus 7 | 152
Increased head circumference 7 | 147
Increased size of cranium 7 | 147
Increased size of skull 7 | 147
Kidney cancer 7 | 2,613
Short stature 7 | 531
Umbilical hernia 7 | 93
adrenocortical carcinoma 7 | 1,428
non-small cell lung cancer 7 | 2,890
subependymal giant cell astrocytoma 7 | 2,287
Acquired scoliosis 6 | 281
Broad flat nasal bridge 6 | 236
Coarse facial features 6 | 108
Congenital deafness 6 | 185
Craniofacial Abnormalities 6 | 151
Curvature of spine 6 | 282
Deafness 6 | 198
Hearing Loss, Partial 6 | 185
Macroglossia 6 | 65
Mucopolysaccharidosis 6 | 26
Muscle hypotonia 6 | 571
Nasal bridge wide 6 | 236
Thickened facial skin with coarse facial features 6 | 108
aldosterone-producing adenoma 6 | 665
breast carcinoma 6 | 1,638
hearing impairment 6 | 199
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
primary pancreatic ductal adenocarcinoma 6 | 1,109
Atopic dermatitis 5 | 952
Cleft Palate 5 | 271
Cryptorchidism 5 | 296
Downward slant of palpebral fissure 5 | 158
Frontal bossing 5 | 157
Hepatomegaly 5 | 285
Radioulnar synostosis 5 | 35
Rheumatoid arthritis 5 | 1,191
Schizophrenia 5 | 1,160
Simpson-Golabi-Behmel syndrome 5 | 19
Splenomegaly 5 | 190
Uranostaphyloschisis 5 | 167
active Crohn's disease 5 | 922
astrocytoma 5 | 1,146
pediatric high grade glioma 5 | 1,064
sonic hedgehog group medulloblastoma 5 | 467
Congenital Epicanthus 4 | 177
Pick disease 4 | 1,894
Ventricular Septal Defects 4 | 119
active ulcerative colitis 4 | 764
autosomal dominant Emery-Dreifuss muscular dystrophy 4 | 510
colon cancer 4 | 1,478
dermatomyositis 4 | 966
esophageal adenocarcinoma 4 | 737
juvenile dermatomyositis 4 | 1,187
limb girdle muscular dystrophy 2A 4 | 213
spina bifida 4 | 1,074

Tissue

Endocrine System 49 | 18,159
Nervous System 49 | 16,725
Blood and immune system 48 | 16,909
Digestive Tract 48 | 17,369
Female tissues 48 | 17,400
Liver and Pancreas 48 | 16,750
Male tissues 48 | 17,142
Respiratory system 48 | 16,393
Skin and soft tissues 48 | 17,230
Urinary Tract 48 | 16,678
Cardiovascular System 46 | 15,192

Target Family

Enzyme 32 | 4,145
Non-IDG 17 | 12,091

Reactome Pathway

Chondroitin sulfate/dermatan s... 49 | 49
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dermatan-sulfate epimerase DSE Tbio Enzyme -2.57112 360.0 44
Xylosyltransferase 1 XYLT1 Tbio Enzyme -2.10436 129.4 88
Glypican-6 GPC6 Tbio Non-IDG -1.33560 21.9 125
Chondroitin sulfate synthase 1 CHSY1 Tbio Enzyme -1.69082 48.5 101
Arylsulfatase B ARSB Tbio Enzyme -2.51626 314.5 216
Dermatan-sulfate epimerase-like protein DSEL Tdark Enzyme -0.86717 7.99 3
Syndecan-3 SDC3 Tbio Non-IDG -1.86172 78.8 179
Versican core protein VCAN Tbio Non-IDG -2.88501 795.4 190
Chondroitin sulfate proteoglycan 5 CSPG5 Tbio Non-IDG -2.55925 360.8 181
Chondroitin sulfate proteoglycan 4 CSPG4 Tbio Non-IDG -2.20166 186.1 395