Development Level

Tchem 8 | 1,598
Tbio 4 | 11,445

IMPC Phenotype

preweaning lethality, incomple... 2 | 499
abnormal embryo size 1 | 220
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
decreased mean corpuscular hem... 1 | 50
edema 1 | 59
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
increased circulating sodium l... 1 | 71
preweaning lethality, complete... 1 | 979
short tibia 1 | 97

Disease

atypical teratoid / rhabdoid tumor 11 | 5,112
medulloblastoma, large-cell 11 | 6,241
glioblastoma 9 | 5,792
ovarian cancer 9 | 8,520
Breast cancer 8 | 3,578
Cancer 8 | 2,499
adult high grade glioma 8 | 3,801
ependymoma 8 | 4,679
lung adenocarcinoma 8 | 2,716
lung cancer 7 | 4,740
primitive neuroectodermal tumor 7 | 3,035
psoriasis 7 | 6,694
Carcinoma 6 | 11,493
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
oligodendroglioma 6 | 2,850
Astrocytoma, Pilocytic 5 | 3,081
group 3 medulloblastoma 5 | 4,104
malignant mesothelioma 5 | 3,232
non-small cell lung cancer 5 | 2,890
osteosarcoma 5 | 7,950
pancreatic cancer 5 | 2,398
Schizophrenia 4 | 1,160
astrocytic glioma 4 | 2,597
ductal carcinoma in situ 4 | 1,745
interstitial cystitis 4 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 4 | 2,989
Ataxia telangiectasia 3 | 34
Bipolar Disorder 3 | 666
Endometriosis 3 | 540
Liver Cirrhosis, Experimental 3 | 769
Multiple myeloma 3 | 1,332
Waldenstrons macroglobulinemia 3 | 765
acute quadriplegic myopathy 3 | 1,158
adrenocortical carcinoma 3 | 1,428
breast carcinoma 3 | 1,638
colon cancer 3 | 1,478
dermatomyositis 3 | 966
group 4 medulloblastoma 3 | 1,855
invasive ductal carcinoma 3 | 2,951
primary pancreatic ductal adenocarcinoma 3 | 1,109
Atopic dermatitis 2 | 952
Breast Neoplasms 2 | 445
Mammary Neoplasms 2 | 425
Nijmegen breakage syndrome 2 | 24
Parkinson's disease 2 | 392
Pick disease 2 | 1,894
Sarcoma 2 | 62
astrocytoma 2 | 1,146
cystic fibrosis 2 | 1,696
diabetes mellitus 2 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,955
juvenile dermatomyositis 2 | 1,187
nasopharyngeal carcinoma 2 | 1,058
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
pediatric high grade glioma 2 | 1,064
tuberculosis 2 | 2,010
tuberculosis and treatment for 6 months 2 | 409
ulcerative colitis 2 | 1,819
Abnormality of metabolism/homeostasis 1 | 134
Agyria 1 | 15
Alkaline phosphatase serum increased 1 | 29
Animal Mammary Neoplasms 1 | 136
Carcinoma, Squamous Cell 1 | 110
Carcinoma, squamous cell of head and neck 1 | 31
Cardiomyopathies 1 | 110
Colorectal Neoplasms 1 | 243
DOID:2627 1 | 94
Diabetes Mellitus, Experimental 1 | 108
Downward slant of palpebral fissure 1 | 158
Esophageal Neoplasms 1 | 69
Esophageal Squamous Cell Carcinoma 1 | 77
Glioma 1 | 74
Hereditary spherocytosis type 1 1 | 23
Juvenile astrocytoma 1 | 3
Keloid 1 | 37
Lymphoma 1 | 81
Lymphoma, Non-Hodgkin 1 | 24
Lytic lesion 1 | 32
Malignant neoplasm of prostate 1 | 11
Malignant tumor of prostate 1 | 26
Mammary Neoplasms, Animal 1 | 136
Mammary Neoplasms, Experimental 1 | 154
Meningioma 1 | 41
Neoplasm Metastasis 1 | 168
Neoplasm Recurrence, Local 1 | 37
Neuronal ceroid lipofuscinosis 1 | 28
Pain 1 | 103
Pick's disease 1 | 15
Prion disease 1 | 16
Renal Cell Carcinoma 1 | 214
Retinoblastoma 1 | 19
Seckel syndrome 1 | 34
Squamous cell carcinoma 1 | 129
Squamous cell carcinoma of esophagus 1 | 77
Squamous cell carcinoma of the head and neck 1 | 29
Tall forehead 1 | 102
Wide nose 1 | 35
Williams-Beuren syndrome 1 | 50
fascioscapulohumeral muscular dystrophy 1 | 100
sarcoidosis 1 | 370

Tissue

Blood and immune system 12 | 16,909
Cardiovascular System 12 | 15,192
Digestive Tract 12 | 17,369
Endocrine System 12 | 18,159
Female tissues 12 | 17,400
Liver and Pancreas 12 | 16,750
Male tissues 12 | 17,142
Nervous System 12 | 16,725
Respiratory system 12 | 16,393
Skin and soft tissues 12 | 17,230
Urinary Tract 12 | 16,678

Target Family

Non-IDG 7 | 12,091
Kinase 4 | 634
Enzyme 1 | 4,145

Reactome Pathway

Chk1/Chk2(Cds1) mediated inact... 12 | 12
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
14-3-3 protein gamma YWHAG Tbio Non-IDG -1.87443 78.9 387
Serine/threonine-protein kinase Chk2 CHEK2 Tchem Kinase -3.00304 978.7 1374
Serine/threonine-protein kinase Chk1 CHEK1 Tchem Kinase -3.04423 1089.6 1375
14-3-3 protein zeta/delta YWHAZ Tbio Non-IDG -2.59435 390.4 689
14-3-3 protein epsilon YWHAE Tbio Non-IDG -2.23108 170.5 348
14-3-3 protein eta YWHAH Tchem Non-IDG -1.62035 42.0 212
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482
14-3-3 protein sigma SFN Tbio Non-IDG -2.56638 391.2 550
Cyclin-dependent kinase 1 CDK1 Tchem Kinase -3.28086 1790.3 1933