Development Level

Tbio 58 | 10,625
Tchem 16 | 1,890
Tdark 13 | 7,003
Tclin 8 | 602

Collection

Kinase: IDG Consortium (Targets) 1 | 125

IMPC Phenotype

preweaning lethality, complete... 4 | 633
preweaning lethality, incomple... 4 | 260
abnormal behavior 2 | 226
abnormal spleen morphology 2 | 36
impaired righting response 2 | 19
abnormal lumbar vertebrae morp... 1 | 6
abnormal thyroid gland morphol... 1 | 3
abnormal trachea morphology 1 | 3
absent lymph nodes 1 | 3
absent spleen 1 | 1
anophthalmia 1 | 20
decreased KLRG1+ CD4 alpha bet... 1 | 2
decreased bone mineral content 1 | 157
decreased cardiac muscle contr... 1 | 5
decreased circulating alanine ... 1 | 53
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating sodium l... 1 | 18
decreased circulating total pr... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased lean body mass 1 | 195
decreased respiratory quotient 1 | 12
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
enlarged spleen 1 | 26
hyperactivity 1 | 108
increased CD4-positive, alpha ... 1 | 15
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased exploration in new e... 1 | 56
increased mean corpuscular hem... 1 | 93
increased total body fat amoun... 1 | 57
prenatal lethality prior to he... 1 | 64
small kidney 1 | 10
small superior vagus ganglion 1 | 20

Disease

ovarian cancer 51 | 8,491
medulloblastoma, large-cell 39 | 6,234
osteosarcoma 38 | 7,933
glioblastoma 37 | 5,572
psoriasis 33 | 6,685
lung cancer 27 | 4,473
atypical teratoid / rhabdoid tumor 25 | 4,369
Breast cancer 22 | 3,098
primitive neuroectodermal tumor 22 | 3,031
pilocytic astrocytoma 21 | 3,086
non-small cell lung cancer 20 | 2,798
ependymoma 19 | 2,514
Multiple myeloma 18 | 1,327
pediatric high grade glioma 18 | 2,712
malignant mesothelioma 16 | 3,163
oligodendroglioma 16 | 2,849
astrocytic glioma 15 | 2,241
group 3 medulloblastoma 15 | 2,254
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
lung carcinoma 15 | 2,844
subependymal giant cell astrocytoma 15 | 2,287
breast carcinoma 14 | 1,614
colon cancer 14 | 1,475
invasive ductal carcinoma 14 | 2,950
pancreatic cancer 14 | 2,300
intraductal papillary-mucinous carcinoma (IPMC) 13 | 2,988
lung adenocarcinoma 13 | 2,714
ulcerative colitis 13 | 2,087
Pick disease 12 | 1,893
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
Cancer 11 | 2,346
astrocytoma 11 | 1,493
posterior fossa group A ependymoma 11 | 1,511
sonic hedgehog group medulloblastoma 11 | 1,482
Rheumatoid Arthritis 10 | 1,170
adult high grade glioma 10 | 2,148
dermatomyositis 10 | 966
diabetes mellitus 10 | 1,663
Waldenstrons macroglobulinemia 9 | 764
juvenile dermatomyositis 9 | 1,189
primary pancreatic ductal adenocarcinoma 9 | 1,271
Duchenne muscular dystrophy 8 | 602
active Crohn's disease 8 | 918
acute quadriplegic myopathy 8 | 1,157
interstitial cystitis 8 | 2,299
nasopharyngeal carcinoma 8 | 1,056
Acute lymphoid leukemia 7 | 25
Anaplastic large T-cell systemic malignant lymphoma 7 | 10
Burkitt's lymphoma 7 | 15
Carcinoma of breast 7 | 11
Carcinoma of female breast 7 | 20
Diffuse non-Hodgkin's lymphoma, large cell 7 | 12
Follicular non-Hodgkin's lymphoma 7 | 17
Gestational trophoblastic neoplasia 7 | 14
HER2-positive carcinoma of breast 7 | 10
Hodgkin's disease 7 | 18
Hypertensive disorder 7 | 58
Kaposi's sarcoma 7 | 20
Langerhans cell histiocytosis, disseminated 7 | 10
Liposarcoma 7 | 20
Malignant tumor of head and/or neck 7 | 15
Malignant tumor of ovary 7 | 25
Malignant tumor of prostate 7 | 26
Malignant tumor of stomach 7 | 12
Malignant tumor of testis 7 | 11
Mammary Neoplasms 7 | 410
Metastatic Breast Carcinoma 7 | 21
Metastatic Prostate Carcinoma 7 | 18
Mycosis fungoides 7 | 30
Nephroblastoma 7 | 45
Neuroblastoma 7 | 78
Non-Hodgkin's lymphoma 7 | 22
Ocular hypertension 7 | 27
Open-angle glaucoma 7 | 26
Rhabdomyosarcoma 7 | 29
Secondary malignant neoplasm of pancreas 7 | 10
atypical teratoid/rhabdoid tumor 7 | 1,095
ductal carcinoma in situ 7 | 1,745
medulloblastoma 7 | 1,524
pituitary cancer 7 | 1,972
posterior fossa group B ependymoma 7 | 1,530
transitional cell carcinoma 7 | 20
Condyloma acuminatum 6 | 7
cystic fibrosis 6 | 1,670
group 4 medulloblastoma 6 | 1,875
tuberculosis 6 | 1,563
Amyotrophic Lateral Sclerosis 5 | 432
Intellectual disability 5 | 573
Lissencephaly 5 | 61
Neurodegenerative disease 5 | 383
Squamous cell carcinoma 5 | 96
Stomach Neoplasms 5 | 282
adrenocortical carcinoma 5 | 1,427
autosomal dominant Emery-Dreifuss muscular dystrophy 5 | 499
hepatocellular carcinoma 5 | 550
pancreatic carcinoma 5 | 567
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
Carcinoma 4 | 2,147
Prostatic Neoplasms 4 | 471
cutaneous lupus erythematosus 4 | 1,056

Tissue

Blood and immune system 95 | 17,994
Digestive Tract 95 | 18,472
Endocrine System 95 | 18,511
Female tissues 95 | 18,646
Liver and Pancreas 95 | 18,135
Male tissues 95 | 17,968
Nervous System 95 | 18,560
Skin and soft tissues 95 | 18,114
Urinary Tract 95 | 18,443
Cardiovascular System 94 | 17,957
Respiratory system 93 | 17,483

Target Family

Non-IDG 80 | 11,969
Enzyme 8 | 4,146
Kinase 4 | 634
Transcription Factor 2 | 1,400
Epigenetic 1 | 242

Reactome Pathway

Chaperonin-mediated protein fo... 95 | 95
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
F-box/LRR-repeat protein 3 FBXL3 Tbio Non-IDG -0.94799 9.59 158
F-box/WD repeat-containing protein 2 FBXW2 Tbio Non-IDG -1.99707 87.2 90
T-complex protein 1 subunit alpha TCP1 Tbio Non-IDG -2.24310 169.4 383
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.75815 5706.6 1539
Ubiquitin carboxyl-terminal hydrolase 11 USP11 Tbio Enzyme -1.12593 14.9 210
Tubulin beta-2A chain TUBB2A Tclin Non-IDG -1.58354 36.1 215
Kinesin-like protein KIFC3 KIFC3 Tchem Non-IDG -1.08696 12.5 48
Sphingosine kinase 1 SPHK1 Tchem Kinase -2.67625 514.1 477
Guanine nucleotide-binding protein G(T) subunit gamma-T1 GNGT1 Tbio Non-IDG -1.40499 21.6 57
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 GNG5 Tbio Non-IDG -0.57807 3.96 74