Development Level

Tbio 268 | 10,625
Tchem 107 | 1,890
Tdark 26 | 7,003
Tclin 15 | 602

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 30 | 633
preweaning lethality, incomple... 9 | 260
embryonic lethality prior to o... 8 | 148
decreased lean body mass 7 | 195
decreased total body fat amoun... 7 | 186
abnormal embryo size 6 | 112
embryonic lethality prior to t... 6 | 187
decreased circulating insulin ... 5 | 75
increased grip strength 5 | 83
increased lean body mass 5 | 107
increased or absent threshold ... 5 | 128
abnormal lens morphology 4 | 73
abnormal retinal pigmentation 4 | 61
decreased body weight 4 | 174
embryonic growth retardation 4 | 28
increased mean corpuscular hem... 4 | 93
abnormal bone structure 3 | 131
abnormal skin coloration 3 | 18
abnormal spleen morphology 3 | 36
anophthalmia 3 | 20
cataract 3 | 26
decreased body length 3 | 108
decreased bone mineral content 3 | 157
decreased caudal vertebrae num... 3 | 49
decreased circulating LDL chol... 3 | 37
decreased circulating amylase ... 3 | 24
decreased rib number 3 | 59
enlarged spleen 3 | 26
increased circulating alkaline... 3 | 119
increased exploration in new e... 3 | 56
prenatal lethality prior to he... 3 | 64
abnormal behavior 2 | 226
abnormal epididymis morphology 2 | 31
abnormal heart morphology 2 | 51
abnormal maxilla morphology 2 | 16
abnormal neural tube closure 2 | 37
abnormal snout morphology 2 | 18
abnormal testis morphology 2 | 30
abnormal tooth morphology 2 | 24
decreased blood urea nitrogen ... 2 | 31
decreased circulating HDL chol... 2 | 77
decreased circulating aspartat... 2 | 27
decreased circulating choleste... 2 | 85
decreased circulating glucose ... 2 | 121
decreased circulating iron lev... 2 | 25
decreased circulating serum al... 2 | 79
decreased circulating triglyce... 2 | 83
decreased grip strength 2 | 123
decreased hemoglobin content 2 | 53
decreased mean corpuscular hem... 2 | 19
decreased mean corpuscular vol... 2 | 50
enlarged epididymis 2 | 27
enlarged heart 2 | 111
hypoactivity 2 | 89
impaired glucose tolerance 2 | 52
increased bone mineral content 2 | 92
increased bone mineral density 2 | 52
increased circulating HDL chol... 2 | 63
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 24
increased erythrocyte cell num... 2 | 26
increased mean platelet volume 2 | 19
increased sacral vertebrae num... 2 | 62
increased spleen weight 2 | 3
male infertility 2 | 62
microphthalmia 2 | 15
persistence of hyaloid vascula... 2 | 22
small testis 2 | 37
abnormal behavioral response t... 1 | 52
abnormal cornea morphology 1 | 24
abnormal embryo turning 1 | 15
abnormal locomotor activation 1 | 26
abnormal neural tube morpholog... 1 | 8
abnormal rib morphology 1 | 28
corneal opacity 1 | 25
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased bone mineral density 1 | 126
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased circulating sodium l... 1 | 18
decreased mean corpuscular hem... 1 | 34
female infertility 1 | 34
impaired righting response 1 | 19
increased circulating alanine ... 1 | 11
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating serum al... 1 | 25
increased mean corpuscular vol... 1 | 91
increased total body fat amoun... 1 | 57
prenatal lethality 1 | 16
short tibia 1 | 82
stereotypic behavior 1 | 3
tremors 1 | 34
trunk curl 1 | 15

Disease

ovarian cancer 269 | 8,484
osteosarcoma 196 | 7,933
lung cancer 168 | 4,466
psoriasis 165 | 6,685
glioblastoma 156 | 5,572
Cancer 144 | 2,346
medulloblastoma, large-cell 144 | 6,234
atypical teratoid / rhabdoid tumor 114 | 4,369
Breast cancer 97 | 3,094
malignant mesothelioma 86 | 3,162
Multiple myeloma 85 | 1,327
intraductal papillary-mucinous neoplasm (IPMN) 84 | 3,289
oligodendroglioma 79 | 2,849
invasive ductal carcinoma 76 | 2,950
non-small cell lung cancer 74 | 2,798
primitive neuroectodermal tumor 69 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 66 | 2,988
lung adenocarcinoma 64 | 2,713
pancreatic cancer 63 | 2,300
pediatric high grade glioma 63 | 2,712
diabetes mellitus 61 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 61 | 2,956
pilocytic astrocytoma 58 | 3,086
ependymoma 57 | 2,514
Pick disease 55 | 1,893
astrocytic glioma 53 | 2,241
ulcerative colitis 52 | 2,087
astrocytoma 50 | 1,493
subependymal giant cell astrocytoma 50 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 49 | 1,795
Waldenstrons macroglobulinemia 45 | 765
dermatomyositis 45 | 933
group 3 medulloblastoma 45 | 2,254
ductal carcinoma in situ 43 | 1,745
lung carcinoma 42 | 2,844
acute quadriplegic myopathy 41 | 1,157
medulloblastoma 41 | 1,524
Rheumatoid Arthritis 40 | 1,160
interstitial cystitis 40 | 2,299
pituitary cancer 40 | 1,972
Mammary Neoplasms 39 | 410
adult high grade glioma 39 | 2,148
breast carcinoma 39 | 1,614
colon cancer 39 | 1,475
posterior fossa group A ependymoma 39 | 1,511
Carcinoma 38 | 2,147
tuberculosis 37 | 1,557
adrenocortical carcinoma 36 | 1,427
group 4 medulloblastoma 36 | 1,875
juvenile dermatomyositis 35 | 1,189
cystic fibrosis 34 | 1,665
Vascular disease 33 | 281
primary pancreatic ductal adenocarcinoma 33 | 1,271
sonic hedgehog group medulloblastoma 33 | 1,482
acute myeloid leukemia 32 | 780
Prostatic Neoplasms 27 | 471
non primary Sjogren syndrome sicca 26 | 840
HIV Infections 25 | 100
Alzheimer's disease 24 | 644
hepatocellular carcinoma 24 | 532
spina bifida 24 | 1,064
tuberculosis and treatment for 6 months 24 | 686
Kidney disease 23 | 396
Neurodegenerative disease 23 | 383
Stomach Neoplasms 23 | 282
Amyotrophic Lateral Sclerosis 22 | 431
Liver carcinoma 22 | 217
esophageal adenocarcinoma 22 | 737
Obesity 21 | 616
active Crohn's disease 21 | 918
cutaneous lupus erythematosus 21 | 1,056
non-small cell lung carcinoma 21 | 413
atypical teratoid/rhabdoid tumor 20 | 1,095
gastric cancer 20 | 430
posterior fossa group B ependymoma 20 | 1,530
Atopic dermatitis 19 | 944
Brain Ischemia 19 | 87
Lung Neoplasms 19 | 171
progressive supranuclear palsy 19 | 674
Endometriosis 18 | 535
IGA Glomerulonephritis 18 | 454
Melanoma 18 | 261
Parkinson's disease 18 | 364
Reperfusion Injury 18 | 84
Toxic encephalopathy 18 | 131
nasopharyngeal carcinoma 17 | 1,056
pancreatic carcinoma 17 | 567
Atherosclerosis 16 | 275
Hypertensive disease 16 | 193
Neoplasm Metastasis 16 | 138
Renal Cell Carcinoma 16 | 199
primary Sjogren syndrome 16 | 789
Anemia 15 | 252
Arthritis 15 | 248
Diabetes Mellitus, Experimental 15 | 106
Down syndrome 15 | 548
Intellectual disability 15 | 573
Diabetes Mellitus, Non-Insulin-Dependent 14 | 157
Myocardial Ischemia 14 | 169
aldosterone-producing adenoma 14 | 664

Tissue

Endocrine System 413 | 18,512
Female tissues 412 | 18,647
Nervous System 412 | 18,561
Blood and immune system 411 | 17,995
Digestive Tract 411 | 18,473
Liver and Pancreas 411 | 18,136
Male tissues 411 | 17,969
Urinary Tract 411 | 18,444
Cardiovascular System 408 | 17,958
Respiratory system 407 | 17,484
Skin and soft tissues 403 | 18,115

Target Family

Non-IDG 237 | 11,971
Enzyme 99 | 4,146
Kinase 40 | 634
Transcription Factor 25 | 1,400
Epigenetic 14 | 242
Ion Channel 1 | 341

Reactome Pathway

Cellular responses to stress 416 | 416
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Charged multivesicular body protein 2b CHMP2B Tbio Non-IDG -1.65708 53.0 166
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Cytochrome b-245 light chain CYBA Tbio Non-IDG -2.56294 358.8 154