Development Level

Tbio 68 | 11,651
Tchem 22 | 1,388
Tdark 5 | 6,593
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 15 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
decreased blood urea nitrogen ... 2 | 51
decreased circulating glucose ... 2 | 126
decreased lean body mass 2 | 135
decreased total body fat amoun... 2 | 207
increased lean body mass 2 | 172
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal clavicle morphology 1 | 6
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal optic disc morphology 1 | 10
abnormal placenta size 1 | 20
abnormal retina morphology 1 | 71
abnormal skin coloration 1 | 25
abnormal sleep behavior 1 | 70
abnormal snout morphology 1 | 23
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
enlarged heart 1 | 210
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased total body fat amoun... 1 | 134
male infertility 1 | 123
tremors 1 | 39

Disease

Carcinoma 69 | 11,493
ovarian cancer 65 | 8,520
osteosarcoma 50 | 7,950
lung cancer 43 | 4,740
medulloblastoma, large-cell 43 | 6,241
atypical teratoid / rhabdoid tumor 39 | 5,112
glioblastoma 38 | 5,792
group 3 medulloblastoma 36 | 4,104
Breast cancer 33 | 3,578
psoriasis 32 | 6,694
Cancer 28 | 2,499
ependymoma 25 | 4,679
adult high grade glioma 23 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
oligodendroglioma 23 | 2,850
Kidney cancer 21 | 2,613
primitive neuroectodermal tumor 21 | 3,035
Pick disease 20 | 1,894
non-small cell lung cancer 19 | 2,890
Multiple myeloma 18 | 1,332
Waldenstrons macroglobulinemia 18 | 765
astrocytic glioma 18 | 2,597
malignant mesothelioma 18 | 3,232
invasive ductal carcinoma 17 | 2,951
dermatomyositis 16 | 966
intraductal papillary-mucinous carcinoma (IPMC) 16 | 2,989
Astrocytoma, Pilocytic 15 | 3,081
Schizophrenia 15 | 1,160
astrocytoma 14 | 1,146
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
lung adenocarcinoma 14 | 2,716
tuberculosis 14 | 2,010
acute quadriplegic myopathy 13 | 1,158
diabetes mellitus 13 | 1,728
pancreatic cancer 13 | 2,398
colon cancer 12 | 1,478
subependymal giant cell astrocytoma 12 | 2,287
Bipolar Disorder 11 | 666
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Major Depressive Disorder 10 | 301
Prostatic Neoplasms 10 | 495
Rheumatoid arthritis 10 | 1,191
breast carcinoma 10 | 1,638
cystic fibrosis 10 | 1,696
ductal carcinoma in situ 10 | 1,745
esophageal adenocarcinoma 10 | 737
interstitial cystitis 10 | 2,312
non primary Sjogren syndrome sicca 10 | 891
Amyotrophic lateral sclerosis 9 | 451
Neurodegenerative disease 9 | 414
Parkinson's disease 9 | 392
Vascular disease 9 | 319
pediatric high grade glioma 9 | 1,064
pituitary cancer 9 | 1,972
HIV Infections 8 | 102
Unipolar Depression 8 | 250
juvenile dermatomyositis 8 | 1,187
lung carcinoma 8 | 2,843
spina bifida 8 | 1,074
Alzheimer's disease 7 | 658
Carcinoma, Squamous Cell 7 | 110
Depressive disorder 7 | 409
Epilepsy 7 | 792
Short stature 7 | 531
Squamous cell carcinoma 7 | 129
Stomach Neoplasms 7 | 300
ulcerative colitis 7 | 1,819
Acquired scoliosis 6 | 281
Atopic dermatitis 6 | 952
Autosomal recessive predisposition 6 | 1,442
Breast Neoplasms 6 | 445
Curvature of spine 6 | 282
Huntington's disease 6 | 76
Intellectual disability 6 | 1,016
Mammary Neoplasms 6 | 425
Mental Depression 6 | 333
Seizures 6 | 596
Toxic encephalopathy 6 | 141
adrenocortical carcinoma 6 | 1,428
Cataract 5 | 297
Dull intelligence 5 | 645
Endometrial cancer 5 | 311
Hypoplastic mandible condyle 5 | 275
Kidney disease 5 | 430
Low intelligence 5 | 645
Low set ears 5 | 181
Mandibular hypoplasia 5 | 275
Melanoma 5 | 711
Mental Retardation 5 | 645
Mental deficiency 5 | 645
Micrognathism 5 | 275
Myopathy 5 | 185
Obesity 5 | 678
Poor school performance 5 | 645
acute myeloid leukemia 5 | 783
fibroadenoma 5 | 559
group 4 medulloblastoma 5 | 1,855
medulloblastoma 5 | 720
pancreatic carcinoma 5 | 562
progressive supranuclear palsy 5 | 676

Tissue

Blood and immune system 96 | 16,909
Endocrine System 96 | 18,159
Digestive Tract 95 | 17,369
Male tissues 95 | 17,142
Respiratory system 94 | 16,393
Urinary Tract 94 | 16,678
Female tissues 93 | 17,400
Nervous System 93 | 16,725
Skin and soft tissues 93 | 17,230
Cardiovascular System 92 | 15,192
Liver and Pancreas 92 | 16,750

Target Family

Non-IDG 76 | 12,091
Kinase 11 | 634
Enzyme 5 | 4,145
Epigenetic 4 | 242
Transcription Factor 2 | 1,400

Reactome Pathway

Cellular response to heat stre... 98 | 98
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-binding death effector domain-containing protein 2 DEDD2 Tbio Non-IDG -0.55115 3.37 164
Beta-crystallin A4 CRYBA4 Tbio Non-IDG -1.25788 15.5 105
Active regulator of SIRT1 RPS19BP1 Tbio Non-IDG -1.70998 49.5 84
Nuclear pore complex protein Nup50 NUP50 Tbio Non-IDG -1.18445 15.9 270
BAG family molecular chaperone regulator 5 BAG5 Tbio Non-IDG -1.25287 18.4 376
Heat shock protein beta-8 HSPB8 Tbio Non-IDG -2.37457 247.4 439
Heat shock factor protein 1 HSF1 Tbio Transcription Factor -2.27852 217.0 1246
Nucleoporin p58/p45 NUP58 Tdark Non-IDG -0.69756 4.39 42
Heat shock 70 kDa protein 14 HSPA14 Tbio Non-IDG -1.55790 37.5 84
Prorelaxin H1 RLN1 Tbio Non-IDG -1.28478 17.8 180