Development Level

Tbio 64 | 10,625
Tchem 25 | 1,890
Tdark 5 | 7,003
Tclin 3 | 602

IMPC Term

preweaning lethality, complete... 10 | 633
embryonic lethality prior to o... 4 | 148
embryonic lethality prior to t... 4 | 187
abnormal snout morphology 2 | 18
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
increased grip strength 2 | 83
increased lean body mass 2 | 107
increased or absent threshold ... 2 | 128
preweaning lethality, incomple... 2 | 260
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal iris morphology 1 | 12
abnormal joint morphology 1 | 14
abnormal maxilla morphology 1 | 16
abnormal optic disc morphology 1 | 10
abnormal placement of pupils 1 | 4
abnormal retinal pigmentation 1 | 61
abnormal skin coloration 1 | 18
abnormal sleep behavior 1 | 63
abnormal spleen morphology 1 | 36
abnormal tooth morphology 1 | 24
decreased blood urea nitrogen ... 1 | 31
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased mean corpuscular vol... 1 | 50
decreased rib number 1 | 59
increased body weight 1 | 42
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased exploration in new e... 1 | 56
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased sacral vertebrae num... 1 | 62
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
male infertility 1 | 62
narrow eye opening 1 | 15
short tibia 1 | 82
tremors 1 | 34

Disease

ovarian cancer 63 | 8,484
osteosarcoma 49 | 7,933
medulloblastoma, large-cell 42 | 6,234
lung cancer 40 | 4,466
glioblastoma 36 | 5,572
atypical teratoid / rhabdoid tumor 31 | 4,369
psoriasis 30 | 6,685
Cancer 28 | 2,346
Breast cancer 27 | 3,094
oligodendroglioma 22 | 2,849
pediatric high grade glioma 22 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,289
primitive neuroectodermal tumor 21 | 3,031
Pick disease 20 | 1,893
group 3 medulloblastoma 19 | 2,254
Multiple myeloma 18 | 1,327
Waldenstrons macroglobulinemia 18 | 765
non-small cell lung cancer 18 | 2,798
malignant mesothelioma 17 | 3,162
Carcinoma 16 | 2,147
astrocytic glioma 16 | 2,241
dermatomyositis 16 | 933
pilocytic astrocytoma 16 | 3,086
astrocytoma 15 | 1,493
invasive ductal carcinoma 15 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,988
acute quadriplegic myopathy 13 | 1,157
diabetes mellitus 13 | 1,663
ependymoma 12 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,956
lung adenocarcinoma 12 | 2,713
pancreatic cancer 12 | 2,300
subependymal giant cell astrocytoma 12 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
sonic hedgehog group medulloblastoma 11 | 1,482
Rheumatoid Arthritis 10 | 1,160
adult high grade glioma 10 | 2,148
colon cancer 10 | 1,475
interstitial cystitis 10 | 2,299
Parkinson's disease 9 | 364
Prostatic Neoplasms 9 | 471
Vascular disease 9 | 281
breast carcinoma 9 | 1,614
non primary Sjogren syndrome sicca 9 | 840
posterior fossa group B ependymoma 9 | 1,530
HIV Infections 8 | 100
cystic fibrosis 8 | 1,665
ductal carcinoma in situ 8 | 1,745
esophageal adenocarcinoma 8 | 737
group 4 medulloblastoma 8 | 1,875
juvenile dermatomyositis 8 | 1,189
medulloblastoma 8 | 1,524
pituitary cancer 8 | 1,972
ulcerative colitis 8 | 2,087
Alzheimer's disease 7 | 644
Amyotrophic Lateral Sclerosis 7 | 431
Obesity 7 | 616
atypical teratoid/rhabdoid tumor 7 | 1,095
lung carcinoma 7 | 2,844
posterior fossa group A ependymoma 7 | 1,511
spina bifida 7 | 1,064
tuberculosis and treatment for 6 months 7 | 686
Mammary Neoplasms 6 | 410
Neurodegenerative disease 6 | 383
Stomach Neoplasms 6 | 282
tuberculosis 6 | 1,557
tuberculosis and treatment for 3 months 6 | 327
Huntington's disease 5 | 72
Kidney disease 5 | 396
acute myeloid leukemia 5 | 780
adrenocortical carcinoma 5 | 1,427
pancreatic carcinoma 5 | 567
progressive supranuclear palsy 5 | 674
Arthritis 4 | 248
Atopic dermatitis 4 | 944
Cocaine-Related Disorders 4 | 88
IGA Glomerulonephritis 4 | 454
Intellectual disability 4 | 573
Kidney cancer 4 | 118
Liver carcinoma 4 | 217
Melanoma 4 | 261
Neoplasm Metastasis 4 | 138
Schizophrenia 4 | 501
Toxic encephalopathy 4 | 131
active Crohn's disease 4 | 918
cystic fibrosis and chronic rhinosinusitis 4 | 213
fibroadenoma 4 | 557
hereditary spastic paraplegia 4 | 313
interstitial lung disease 4 | 291
ovarian neoplasm 4 | 97
primary pancreatic ductal adenocarcinoma 4 | 1,271
Atherosclerosis 3 | 275
Down syndrome 3 | 548
Hypersensitivity reaction type II disease 3 | 235
Myocardial Ischemia 3 | 169
aldosterone-producing adenoma 3 | 664
chronic rhinosinusitis 3 | 512
cutaneous lupus erythematosus 3 | 1,056
hepatocellular carcinoma 3 | 532
nasopharyngeal carcinoma 3 | 1,056

Tissue

Blood and immune system 96 | 17,995
Endocrine System 96 | 18,512
Female tissues 96 | 18,647
Liver and Pancreas 96 | 18,136
Nervous System 96 | 18,561
Cardiovascular System 95 | 17,958
Digestive Tract 95 | 18,473
Male tissues 95 | 17,969
Skin and soft tissues 95 | 18,115
Urinary Tract 95 | 18,444
Respiratory system 94 | 17,484

Target Family

Non-IDG 75 | 11,971
Kinase 11 | 634
Enzyme 5 | 4,146
Epigenetic 4 | 242
Transcription Factor 2 | 1,400

Reactome Pathway

Cellular response to heat stre... 97 | 97
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.76384 47.5 542
Nucleoporin p58/p45 NUP58 Tdark Non-IDG -0.70757 5.23 31
Heat shock 70 kDa protein 14 HSPA14 Tbio Non-IDG -1.54921 38.4 79
Serpin H1 SERPINH1 Tbio Non-IDG -3.13545 1424.1 295
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -2.94349 567.7 767
Nucleoporin-like protein 2 NUPL2 Tbio Non-IDG -0.99049 10.1 66
DnaJ homolog subfamily B member 6 DNAJB6 Tbio Non-IDG -1.88632 95.9 167