Development Level

Tbio 10 | 11,445
Tchem 5 | 1,598
Tdark 4 | 6,588
Tclin 1 | 613

IMPC Phenotype

cardiovascular system phenotyp... 1 | 36
preweaning lethality, complete... 1 | 979
preweaning lethality, incomple... 1 | 499
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

Carcinoma 17 | 11,493
psoriasis 9 | 6,694
Hyperglycemia 8 | 137
Hypoglycemia 8 | 152
diabetes mellitus 8 | 1,728
Breast cancer 7 | 3,578
lung adenocarcinoma 7 | 2,716
osteosarcoma 7 | 7,950
ovarian cancer 7 | 8,520
Obesity 6 | 678
adult high grade glioma 5 | 3,801
ependymoma 5 | 4,679
group 3 medulloblastoma 5 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 5 | 3,291
lung carcinoma 5 | 2,843
Kidney disease 4 | 430
glioblastoma 4 | 5,792
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
invasive ductal carcinoma 4 | 2,951
lung cancer 4 | 4,740
medulloblastoma, large-cell 4 | 6,241
pancreatic cancer 4 | 2,398
Autosomal recessive predisposition 3 | 1,442
Breast Neoplasms 3 | 445
Cancer 3 | 2,499
Diabetes Mellitus, Non-Insulin-Dependent 3 | 145
Diabetes Mellitus, Type 2 3 | 142
Diabetes mellitus type 2 3 | 69
Glycosuria 3 | 29
Hyperinsulinism 3 | 133
Mammary Neoplasms 3 | 425
ductal carcinoma in situ 3 | 1,745
interstitial cystitis 3 | 2,312
malignant mesothelioma 3 | 3,232
non-small cell lung cancer 3 | 2,890
pituitary cancer 3 | 1,972
Abdomen distended 2 | 43
Acute cystitis 2 | 35
Alzheimer's disease 2 | 658
Astrocytoma, Pilocytic 2 | 3,081
Balanitis 2 | 4
Carcinoma, Hepatocellular 2 | 228
Cognitive delay 2 | 608
Diabetes Mellitus, Experimental 2 | 108
Failure to gain weight 2 | 365
Global developmental delay 2 | 608
Liver carcinoma 2 | 240
Mental and motor retardation 2 | 608
Parkinson's disease 2 | 392
Pediatric failure to thrive 2 | 365
Vascular disease 2 | 319
Vulvovaginitis 2 | 6
astrocytic glioma 2 | 2,597
atypical teratoid / rhabdoid tumor 2 | 5,112
colon cancer 2 | 1,478
cystic fibrosis 2 | 1,696
mucosa-associated lymphoid tissue lymphoma 2 | 484
non-small cell lung carcinoma 2 | 317
oligodendroglioma 2 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
primary pancreatic ductal adenocarcinoma 2 | 1,109
primitive neuroectodermal tumor 2 | 3,035
tuberculosis 2 | 2,010
Alkaline phosphatase serum increased 1 | 29
Anemia, Hemolytic 1 | 55
Aortic aneurysm 1 | 38
Arterial tortuosity syndrome 1 | 7
Ataxia 1 | 15
Carcinoma, Renal Cell 1 | 124
Cardiomegaly 1 | 116
Cell Transformation, Neoplastic 1 | 97
Congenital hemolytic anemia 1 | 32
Developmental Disabilities 1 | 23
Diabetes Mellitus, Noninsulin-Dependent 1 | 31
Fanconi syndrome 1 | 14
Fatty Liver 1 | 70
Galactosemia 1 | 19
Gastroenteritis 1 | 41
Giardiasis 1 | 9
Hemangioma 1 | 69
Hyperuricemia 1 | 49
Hypokalemia 1 | 52
Hypophosphatemia 1 | 40
Insulin Resistance 1 | 72
Lactose intolerance 1 | 7
Lipoidosis 1 | 19
Metabolic acidosis 1 | 90
Neoplasms, Germ Cell and Embryonal 1 | 15
Neoplastic Cell Transformation 1 | 89
Osteomalacia 1 | 35
Ovarian Neoplasms 1 | 102
Polyuria 1 | 23
Renal Cell Carcinoma 1 | 214
Rickets 1 | 49
Short bowel syndrome 1 | 16
Vitiligo 1 | 73
chronic kidney disease 1 | 90
maturity-onset diabetes of the young 1 | 32
ovarian neoplasm 1 | 99

Tissue

Digestive Tract 20 | 17,369
Endocrine System 19 | 18,159
Skin and soft tissues 19 | 17,230
Urinary Tract 19 | 16,678
Female tissues 18 | 17,400
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 17 | 16,393
Blood and immune system 16 | 16,909
Cardiovascular System 16 | 15,192

Target Family

Transporter 19 | 473
Non-IDG 1 | 12,091

Reactome Pathway

Cellular hexose transport 20 | 20
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

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