Development Level

Tbio 93 | 11,178
Tchem 51 | 1,885
Tdark 12 | 6,569
Tclin 3 | 612

IMPC Phenotype

preweaning lethality, complete... 14 | 979
abnormal embryo size 9 | 220
abnormal heart morphology 5 | 162
embryonic lethality prior to t... 5 | 278
preweaning lethality, incomple... 5 | 499
embryonic growth retardation 4 | 106
enlarged heart 4 | 210
abnormal behavior 3 | 298
abnormal bone structure 3 | 187
anophthalmia 3 | 33
edema 3 | 59
embryonic lethality prior to o... 3 | 239
microphthalmia 3 | 26
abnormal craniofacial morpholo... 2 | 33
abnormal eye morphology 2 | 68
abnormal joint morphology 2 | 23
abnormal lens morphology 2 | 81
abnormal neural tube closure 2 | 46
abnormal optic disc morphology 2 | 10
abnormal placenta size 2 | 20
cataract 2 | 92
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased circulating insulin ... 2 | 76
decreased mean corpuscular hem... 2 | 31
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
hemorrhage 2 | 23
hyperactivity 2 | 148
increased grip strength 2 | 41
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
persistence of hyaloid vascula... 2 | 33
small superior vagus ganglion 2 | 74
abnormal cornea morphology 1 | 31
abnormal embryo turning 1 | 31
abnormal epididymis morphology 1 | 42
abnormal head shape 1 | 10
abnormal iris morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal neural tube morpholog... 1 | 12
abnormal pelvic girdle bone mo... 1 | 12
abnormal placenta morphology 1 | 5
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
brachydactyly 1 | 19
corneal opacity 1 | 32
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
female infertility 1 | 60
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
increased bone mineral content 1 | 108
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
male infertility 1 | 123
pallor 1 | 34
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small testis 1 | 58
syndactyly 1 | 23
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 96 | 8,297
Carcinoma 95 | 11,192
Cancer 74 | 2,388
osteosarcoma 72 | 7,766
psoriasis 71 | 6,514
glioblastoma 70 | 5,635
lung cancer 70 | 4,607
atypical teratoid / rhabdoid tumor 58 | 4,971
medulloblastoma, large-cell 57 | 6,086
Breast cancer 52 | 3,469
malignant mesothelioma 45 | 3,135
ependymoma 44 | 4,559
group 3 medulloblastoma 43 | 4,002
oligodendroglioma 36 | 2,768
primitive neuroectodermal tumor 34 | 2,957
lung adenocarcinoma 33 | 2,627
adult high grade glioma 32 | 3,701
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,204
invasive ductal carcinoma 32 | 2,867
pancreatic cancer 32 | 2,322
non-small cell lung cancer 31 | 2,799
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,902
Pick disease 25 | 1,856
ductal carcinoma in situ 25 | 1,686
Astrocytoma, Pilocytic 24 | 3,006
Breast Neoplasms 24 | 423
Mammary Neoplasms 24 | 403
astrocytic glioma 24 | 2,530
breast carcinoma 24 | 1,589
diabetes mellitus 23 | 1,683
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,872
Kidney cancer 22 | 2,548
ulcerative colitis 22 | 1,765
Schizophrenia 21 | 1,136
pituitary cancer 21 | 1,915
colon cancer 19 | 1,428
group 4 medulloblastoma 19 | 1,806
subependymal giant cell astrocytoma 19 | 2,230
tuberculosis 19 | 1,963
Multiple myeloma 18 | 1,296
Rheumatoid arthritis 18 | 1,156
adrenocortical carcinoma 18 | 1,385
cystic fibrosis 18 | 1,629
lung carcinoma 17 | 2,755
Melanoma 16 | 689
astrocytoma 16 | 1,113
primary pancreatic ductal adenocarcinoma 16 | 1,071
Intellectual disability 15 | 998
Stomach Neoplasms 15 | 287
Vascular disease 15 | 294
acute myeloid leukemia 15 | 760
acute quadriplegic myopathy 15 | 1,133
juvenile dermatomyositis 15 | 1,147
Carcinoma, Hepatocellular 14 | 217
Liver carcinoma 14 | 229
Lung Neoplasms 13 | 217
dermatomyositis 13 | 941
Brain Ischemia 12 | 107
Endometriosis 12 | 521
Prostatic Neoplasms 12 | 472
Short stature 12 | 514
gastric cancer 12 | 445
hepatocellular carcinoma 12 | 536
medulloblastoma 12 | 702
non-small cell lung carcinoma 12 | 302
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,911
progressive supranuclear palsy 12 | 656
Alzheimer's disease 11 | 640
Kidney disease 11 | 411
Mesothelioma, Malignant 11 | 103
Multiple Sclerosis 11 | 527
cutaneous lupus erythematosus 11 | 1,016
interstitial cystitis 11 | 2,237
Arthritis 10 | 276
Atopic dermatitis 10 | 915
Cell Transformation, Neoplastic 10 | 90
Liver cancer 10 | 589
Neoplasm Metastasis 10 | 160
Neoplastic Cell Transformation 10 | 83
Reperfusion Injury 10 | 84
nasopharyngeal carcinoma 10 | 1,024
Amyotrophic lateral sclerosis 9 | 437
Anemia 9 | 353
Asthma 9 | 370
Chronic Lymphocytic Leukemia 9 | 254
Depressive disorder 9 | 401
Diarrhea 9 | 245
Dull intelligence 9 | 634
Immune system cancer 9 | 136
Low intelligence 9 | 634
Lymphoid leukemia 9 | 156
Mental Retardation 9 | 634
Mental deficiency 9 | 634
Neoplasm Invasiveness 9 | 151
Poor school performance 9 | 634
Waldenstrons macroglobulinemia 9 | 742
active ulcerative colitis 9 | 736
non primary Sjogren syndrome sicca 9 | 861
Autosomal recessive predisposition 8 | 1,407
Polycystic ovary syndrome 8 | 348

Tissue

Blood and immune system 157 | 16,909
Endocrine System 157 | 18,159
Digestive Tract 156 | 17,369
Female tissues 156 | 17,400
Skin and soft tissues 156 | 17,230
Liver and Pancreas 155 | 16,750
Male tissues 155 | 17,142
Nervous System 155 | 16,725
Respiratory system 155 | 16,393
Urinary Tract 155 | 16,678
Cardiovascular System 151 | 15,192

Target Family

Non-IDG 82 | 12,091
Kinase 26 | 634
Transcription Factor 21 | 1,400
Enzyme 20 | 4,145
Epigenetic 10 | 242

Reactome Pathway

Cellular Senescence 159 | 159
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Histone H3.1t HIST3H3 Tbio Non-IDG -1.05426 10.9 1265
Histone H2B type 3-B HIST3H2BB Tbio Non-IDG -0.72238 5.02 53
Ribosomal protein S6 kinase alpha-2 RPS6KA2 Tchem Kinase -2.17609 136.7 406
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
Ribosomal protein S6 kinase alpha-1 RPS6KA1 Tchem Kinase -2.57872 338.0 1158
Histone H2A type 1-D HIST1H2AD Tdark Non-IDG 0.17 0.32 11
Histone H2B type 1-K HIST1H2BK Tbio Non-IDG -0.50219 4.04 29