Development Level

Tbio 90 | 10,625
Tchem 51 | 1,890
Tdark 15 | 7,003
Tclin 3 | 602

IMPC Term

preweaning lethality, complete... 10 | 633
abnormal embryo size 5 | 112
decreased lean body mass 4 | 195
embryonic growth retardation 4 | 28
abnormal bone structure 3 | 131
decreased body weight 3 | 174
decreased total body fat amoun... 3 | 186
increased grip strength 3 | 83
increased lean body mass 3 | 107
preweaning lethality, incomple... 3 | 260
abnormal behavior 2 | 226
abnormal lens morphology 2 | 73
abnormal neural tube closure 2 | 37
anophthalmia 2 | 20
cataract 2 | 26
decreased bone mineral content 2 | 157
decreased caudal vertebrae num... 2 | 49
decreased circulating insulin ... 2 | 75
decreased rib number 2 | 59
embryonic lethality prior to o... 2 | 148
embryonic lethality prior to t... 2 | 187
increased circulating alkaline... 2 | 119
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 24
increased erythrocyte cell num... 2 | 26
increased mean corpuscular hem... 2 | 93
microphthalmia 2 | 15
abnormal cornea morphology 1 | 24
abnormal craniofacial morpholo... 1 | 12
abnormal embryo turning 1 | 15
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal forebrain morphology 1 | 4
abnormal head shape 1 | 4
abnormal heart morphology 1 | 51
abnormal hindbrain morphology 1 | 2
abnormal joint morphology 1 | 14
abnormal maxilla morphology 1 | 16
abnormal midbrain morphology 1 | 2
abnormal neural tube morpholog... 1 | 8
abnormal optic disc morphology 1 | 10
abnormal pelvic girdle bone mo... 1 | 11
abnormal placenta morphology 1 | 4
abnormal placenta size 1 | 10
abnormal skin coloration 1 | 18
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 36
abnormal testis morphology 1 | 30
abnormal tibia morphology 1 | 14
abnormal tooth morphology 1 | 24
corneal opacity 1 | 25
decreased CD4-positive, CD25-p... 1 | 24
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating alkaline... 1 | 41
decreased circulating amylase ... 1 | 24
decreased circulating aspartat... 1 | 27
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating creatini... 1 | 31
decreased circulating glucose ... 1 | 121
decreased circulating iron lev... 1 | 25
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased mean corpuscular hem... 1 | 19
decreased thermal nociceptive ... 1 | 4
edema 1 | 11
enlarged epididymis 1 | 27
enlarged heart 1 | 111
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
hyperactivity 1 | 108
hypoactivity 1 | 89
increased bone mineral content 1 | 92
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating alanine ... 1 | 11
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased exploration in new e... 1 | 56
increased hematocrit 1 | 36
increased leukocyte cell numbe... 1 | 37
increased mean platelet volume 1 | 19
increased or absent threshold ... 1 | 128
increased sacral vertebrae num... 1 | 62
increased thermal nociceptive ... 1 | 9
male infertility 1 | 62
pallor 1 | 13
persistence of hyaloid vascula... 1 | 22
prenatal lethality 1 | 16
short tibia 1 | 82
small testis 1 | 37

Disease

ovarian cancer 96 | 8,484
Cancer 72 | 2,346
osteosarcoma 72 | 7,933
psoriasis 72 | 6,685
glioblastoma 69 | 5,572
lung cancer 69 | 4,466
medulloblastoma, large-cell 56 | 6,234
atypical teratoid / rhabdoid tumor 50 | 4,369
Breast cancer 45 | 3,094
malignant mesothelioma 42 | 3,162
oligodendroglioma 36 | 2,849
lung adenocarcinoma 34 | 2,713
primitive neuroectodermal tumor 34 | 3,031
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,289
invasive ductal carcinoma 32 | 2,950
non-small cell lung cancer 31 | 2,798
pancreatic cancer 30 | 2,300
ependymoma 29 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,988
ulcerative colitis 27 | 2,087
Mammary Neoplasms 25 | 410
Pick disease 25 | 1,893
ductal carcinoma in situ 25 | 1,745
pilocytic astrocytoma 25 | 3,086
medulloblastoma 24 | 1,524
pediatric high grade glioma 24 | 2,712
breast carcinoma 23 | 1,614
diabetes mellitus 23 | 1,663
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,956
pituitary cancer 22 | 1,972
astrocytic glioma 21 | 2,241
group 3 medulloblastoma 21 | 2,254
subependymal giant cell astrocytoma 20 | 2,287
Rheumatoid Arthritis 19 | 1,160
adrenocortical carcinoma 19 | 1,427
astrocytoma 19 | 1,493
colon cancer 19 | 1,475
Multiple myeloma 18 | 1,327
cystic fibrosis 18 | 1,665
lung carcinoma 18 | 2,844
group 4 medulloblastoma 17 | 1,875
acute myeloid leukemia 16 | 780
posterior fossa group A ependymoma 16 | 1,511
primary pancreatic ductal adenocarcinoma 16 | 1,271
Carcinoma 15 | 2,147
Stomach Neoplasms 15 | 282
Vascular disease 15 | 281
acute quadriplegic myopathy 15 | 1,157
adult high grade glioma 15 | 2,148
juvenile dermatomyositis 15 | 1,189
tuberculosis 15 | 1,557
Liver carcinoma 14 | 217
sonic hedgehog group medulloblastoma 14 | 1,482
Endometriosis 13 | 535
dermatomyositis 13 | 933
non-small cell lung carcinoma 13 | 413
Alzheimer's disease 12 | 644
Brain Ischemia 12 | 87
Lung Neoplasms 12 | 171
Melanoma 12 | 261
Prostatic Neoplasms 12 | 471
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,795
progressive supranuclear palsy 12 | 674
Arthritis 11 | 248
Kidney disease 11 | 396
Reperfusion Injury 11 | 84
cutaneous lupus erythematosus 11 | 1,056
gastric cancer 11 | 430
hepatocellular carcinoma 11 | 532
interstitial cystitis 11 | 2,299
Atopic dermatitis 10 | 944
Multiple Sclerosis 10 | 498
Waldenstrons macroglobulinemia 10 | 765
nasopharyngeal carcinoma 10 | 1,056
non primary Sjogren syndrome sicca 10 | 840
tuberculosis and treatment for 6 months 10 | 686
Amyotrophic Lateral Sclerosis 9 | 431
Neoplasm Metastasis 9 | 138
Neoplastic Cell Transformation 9 | 81
Toxic encephalopathy 9 | 131
atypical teratoid/rhabdoid tumor 9 | 1,095
gastric carcinoma 9 | 832
inflammatory breast cancer 9 | 404
Asthma 8 | 349
Cardiomyopathies 8 | 90
Chronic Lymphocytic Leukemia 8 | 242
Eye disease 8 | 55
Lung disease 8 | 132
Neoplasm Invasiveness 8 | 127
Obesity 8 | 616
active Crohn's disease 8 | 918
Adenoma 7 | 165
Bladder Neoplasm 7 | 109
Colonic Neoplasms 7 | 126
Down syndrome 7 | 548
Intellectual disability 7 | 573
Juvenile arthritis 7 | 124
aldosterone-producing adenoma 7 | 664
pancreatic carcinoma 7 | 567
primary Sjogren syndrome 7 | 789

Tissue

Endocrine System 158 | 18,512
Blood and immune system 157 | 17,995
Digestive Tract 157 | 18,473
Female tissues 157 | 18,647
Male tissues 157 | 17,969
Nervous System 157 | 18,561
Urinary Tract 157 | 18,444
Cardiovascular System 156 | 17,958
Liver and Pancreas 156 | 18,136
Respiratory system 156 | 17,484
Skin and soft tissues 150 | 18,115

Target Family

Non-IDG 82 | 11,971
Kinase 26 | 634
Transcription Factor 21 | 1,400
Enzyme 20 | 4,146
Epigenetic 10 | 242

Reactome Pathway

Cellular Senescence 159 | 159
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
E3 ubiquitin-protein ligase Mdm2 MDM2 Tchem Enzyme -3.38438 2174.7 1062
Polyhomeotic-like protein 3 PHC3 Tbio Non-IDG -2.68637 475.4 59
Trinucleotide repeat-containing gene 6A protein TNRC6A Tbio Non-IDG -2.03159 112.3 66
Lysine-specific demethylase 6B KDM6B Tchem Epigenetic -2.06838 144.7 243
Ubiquitin-60S ribosomal protein L40 UBA52 Tbio Non-IDG -2.21113 124.2 150
Ubiquitin-40S ribosomal protein S27a RPS27A Tbio Non-IDG 56.7 150
Ubiquitin-conjugating enzyme E2 E1 UBE2E1 Tbio Non-IDG -1.18305 12.0 72
Anaphase-promoting complex subunit 15 ANAPC15 Tdark Enzyme -0.41378 2.22 21