Development Level

Tbio 54 | 10,625
Tdark 4 | 7,003
Tchem 3 | 1,890

IMPC Term

preweaning lethality, complete... 3 | 633
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
increased bone mineral density 2 | 52
abnormal behavior 1 | 226
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal embryo size 1 | 112
abnormal head morphology 1 | 10
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal tail movements 1 | 12
decreased bone mineral content 1 | 157
decreased circulating free fat... 1 | 39
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased coping response 1 | 5
decreased effector memory CD8-... 1 | 24
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased spleen weight 1 | 13
decreased vertical activity 1 | 22
edema 1 | 11
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
increased CD8-positive, naive ... 1 | 3
increased bone mineral content 1 | 92
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased total body fat amoun... 1 | 57
prenatal lethality 1 | 16
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
shortened RR interval 1 | 19
thrombocytopenia 1 | 46

Disease

atypical teratoid / rhabdoid tumor 29 | 4,369
ovarian cancer 29 | 8,484
psoriasis 28 | 6,685
osteosarcoma 27 | 7,933
medulloblastoma, large-cell 25 | 6,234
Cancer 22 | 2,346
glioblastoma 22 | 5,572
Carcinoma 21 | 2,147
interstitial cystitis 21 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,988
lung adenocarcinoma 19 | 2,713
intraductal papillary-mucinous neoplasm (IPMN) 18 | 3,289
non-small cell lung cancer 18 | 2,798
pancreatic cancer 18 | 2,300
lung cancer 16 | 4,466
malignant mesothelioma 16 | 3,162
primitive neuroectodermal tumor 16 | 3,031
pediatric high grade glioma 15 | 2,712
pilocytic astrocytoma 15 | 3,086
pituitary cancer 15 | 1,972
invasive ductal carcinoma 14 | 2,950
Breast cancer 13 | 3,094
ductal carcinoma in situ 13 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,956
ependymoma 11 | 2,514
lung carcinoma 11 | 2,844
primary pancreatic ductal adenocarcinoma 11 | 1,271
adult high grade glioma 10 | 2,148
group 4 medulloblastoma 10 | 1,875
medulloblastoma 10 | 1,524
ulcerative colitis 10 | 2,087
active Crohn's disease 9 | 918
cystic fibrosis 9 | 1,665
oligodendroglioma 9 | 2,849
Prostatic Neoplasms 8 | 471
breast carcinoma 8 | 1,614
subependymal giant cell astrocytoma 8 | 2,287
posterior fossa group B ependymoma 7 | 1,530
Mammary Neoplasms 6 | 410
Obesity 6 | 616
astrocytic glioma 6 | 2,241
colon cancer 6 | 1,475
cutaneous lupus erythematosus 6 | 1,056
gastric carcinoma 6 | 832
sonic hedgehog group medulloblastoma 6 | 1,482
spina bifida 6 | 1,064
Down syndrome 5 | 548
Inflammatory bowel disease 5 | 142
Multiple Sclerosis 5 | 498
astrocytoma 5 | 1,493
esophageal adenocarcinoma 5 | 737
interstitial lung disease 5 | 291
nasopharyngeal carcinoma 5 | 1,056
posterior fossa group A ependymoma 5 | 1,511
Atopic dermatitis 4 | 944
Autistic Disorder 4 | 320
Colorectal Neoplasms 4 | 217
active ulcerative colitis 4 | 477
adrenocortical carcinoma 4 | 1,427
atypical teratoid/rhabdoid tumor 4 | 1,095
group 3 medulloblastoma 4 | 2,254
non primary Sjogren syndrome sicca 4 | 840
Adenoma 3 | 165
Alzheimer's disease 3 | 644
Barrett's esophagus 3 | 183
Hypotrichosis 3 | 29
Muscle Weakness 3 | 92
Nephrocalcinosis 3 | 18
Nerve Degeneration 3 | 73
No-Reflow Phenomenon 3 | 3
Osteoporosis 3 | 257
Polycystic Ovary Syndrome 3 | 332
Rheumatoid Arthritis 3 | 1,160
Stomach Neoplasms 3 | 282
Vascular disease 3 | 281
aldosterone-producing adenoma 3 | 664
fibroadenoma 3 | 557
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,795
tuberculosis 3 | 1,557
tuberculosis and treatment for 3 months 3 | 327
urothelial carcinoma 3 | 318
Cerebrovascular disease 2 | 231
Disease Progression 2 | 125
Endometriosis 2 | 535
Kidney disease 2 | 396
Liver carcinoma 2 | 217
Mental depression 2 | 58
Nephrolithiasis 2 | 30
Pancreatic Neoplasm 2 | 79
Pellagra 2 | 25
Pick disease 2 | 1,893
Prostate cancer 2 | 172
Substance-Related Disorders 2 | 114
acute myeloid leukemia 2 | 780
acute quadriplegic myopathy 2 | 1,157
autosomal dominant Emery-Dreifuss muscular dystrophy 2 | 499
dermatomyositis 2 | 933
inflammatory breast cancer 2 | 404
juvenile dermatomyositis 2 | 1,189
nephrosclerosis 2 | 329

Tissue

Digestive Tract 60 | 18,473
Endocrine System 60 | 18,512
Female tissues 60 | 18,647
Nervous System 60 | 18,561
Skin and soft tissues 60 | 18,115
Urinary Tract 60 | 18,444
Blood and immune system 59 | 17,995
Cardiovascular System 59 | 17,958
Liver and Pancreas 59 | 18,136
Male tissues 59 | 17,969
Respiratory system 58 | 17,484

Target Family

Non-IDG 59 | 11,971
Enzyme 1 | 4,146
Kinase 1 | 634

Reactome Pathway

Cell-cell junction organizatio... 61 | 61
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Angiogenin ANG Tbio Enzyme -2.89794 796.0 203
InaD-like protein PATJ Tbio Non-IDG -1.88739 77.1 91
Claudin-3 CLDN3 Tbio Non-IDG -2.30333 205.5 260
Catenin alpha-1 CTNNA1 Tbio Non-IDG -1.91334 73.6 399
Protein crumbs homolog 3 CRB3 Tbio Non-IDG -1.16045 14.3 66
Cadherin-10 CDH10 Tbio Non-IDG -0.71916 7.40 135
Cadherin-7 CDH7 Tbio Non-IDG -1.36987 22.8 107
Cadherin-9 CDH9 Tbio Non-IDG -0.85176 6.98 108
Claudin-16 CLDN16 Tbio Non-IDG -1.95188 99.5 103
Protein kinase C iota type PRKCI Tchem Kinase -1.72458 51.8 122