Development Level

Tbio 55 | 11,651
Tdark 5 | 6,593
Tchem 2 | 1,388

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 2 | 298
decreased body length 2 | 101
decreased total body fat amoun... 2 | 207
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal embryo size 1 | 220
abnormal head morphology 1 | 10
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
decreased bone mineral content 1 | 151
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased startle reflex 1 | 112
male infertility 1 | 123
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality 1 | 28
shortened PR interval 1 | 6
shortened RR interval 1 | 17
thrombocytopenia 1 | 56

Disease

Carcinoma 39 | 11,493
atypical teratoid / rhabdoid tumor 31 | 5,112
ovarian cancer 29 | 8,520
psoriasis 28 | 6,694
osteosarcoma 27 | 7,950
Cancer 25 | 2,499
medulloblastoma, large-cell 25 | 6,241
ependymoma 21 | 4,679
glioblastoma 21 | 5,792
interstitial cystitis 21 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 19 | 3,291
lung adenocarcinoma 19 | 2,716
non-small cell lung cancer 19 | 2,890
Breast cancer 18 | 3,578
Kidney cancer 18 | 2,613
lung cancer 18 | 4,740
adult high grade glioma 17 | 3,801
pancreatic cancer 17 | 2,398
primitive neuroectodermal tumor 17 | 3,035
malignant mesothelioma 16 | 3,232
invasive ductal carcinoma 15 | 2,951
pituitary cancer 15 | 1,972
group 3 medulloblastoma 14 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
Astrocytoma, Pilocytic 13 | 3,081
ductal carcinoma in situ 13 | 1,745
lung carcinoma 13 | 2,843
breast carcinoma 10 | 1,638
Alcoholic Intoxication, Chronic 9 | 289
Prostatic Neoplasms 9 | 495
active Crohn's disease 9 | 922
cystic fibrosis 9 | 1,696
group 4 medulloblastoma 9 | 1,855
primary pancreatic ductal adenocarcinoma 9 | 1,109
Liver cancer 8 | 604
Melanoma 8 | 711
Skin cancer 8 | 469
oligodendroglioma 8 | 2,850
subependymal giant cell astrocytoma 8 | 2,287
ulcerative colitis 8 | 1,819
Breast Neoplasms 7 | 445
active ulcerative colitis 7 | 764
pediatric high grade glioma 7 | 1,064
Autosomal recessive predisposition 6 | 1,442
Bipolar Disorder 6 | 666
Endometrial cancer 6 | 311
Mammary Neoplasms 6 | 425
astrocytic glioma 6 | 2,597
colon cancer 6 | 1,478
cutaneous lupus erythematosus 6 | 1,057
gastric carcinoma 6 | 807
Inflammatory bowel disease 5 | 151
Multiple Sclerosis 5 | 540
esophageal adenocarcinoma 5 | 737
interstitial lung disease 5 | 298
medulloblastoma 5 | 720
nasopharyngeal carcinoma 5 | 1,058
spina bifida 5 | 1,074
tuberculosis 5 | 2,010
Alopecia 4 | 115
Alzheimer's disease 4 | 658
Atopic dermatitis 4 | 952
Autistic Disorder 4 | 364
Cleft lip-palate-ectodermal dysplasia syndrome 4 | 8
Colorectal Neoplasms 4 | 243
Depressive disorder 4 | 409
Hypotrichosis 4 | 47
Mental Depression 4 | 333
Nephrocalcinosis 4 | 35
Nerve Degeneration 4 | 121
Schizophrenia 4 | 1,160
Sparse eyebrow 4 | 42
Stomach Neoplasms 4 | 300
adrenocortical carcinoma 4 | 1,428
astrocytoma 4 | 1,146
non primary Sjogren syndrome sicca 4 | 891
pancreatic ductal adenocarcinoma liver metastasis 4 | 1,962
Adenoma 3 | 167
Cardiovascular system disease 3 | 246
Diarrhea 3 | 253
Disease Progression 3 | 136
Dull intelligence 3 | 645
Kidney disease 3 | 430
Low intelligence 3 | 645
Mental deficiency 3 | 645
Neoplasm Invasiveness 3 | 161
Nephrolithiasis 3 | 56
Osteoporosis 3 | 363
Polycystic ovary syndrome 3 | 360
Poor school performance 3 | 645
Retinitis Pigmentosa 3 | 226
Rheumatoid arthritis 3 | 1,191
Syndactyly 3 | 88
Vascular disease 3 | 319
aldosterone-producing adenoma 3 | 665
diabetes mellitus 3 | 1,728
fibroadenoma 3 | 559
posterior fossa group B ependymoma 3 | 416
urothelial carcinoma 3 | 318

Tissue

Digestive Tract 60 | 17,369
Endocrine System 60 | 18,159
Female tissues 60 | 17,400
Male tissues 58 | 17,142
Nervous System 57 | 16,725
Skin and soft tissues 57 | 17,230
Liver and Pancreas 56 | 16,750
Respiratory system 56 | 16,393
Urinary Tract 56 | 16,678
Blood and immune system 53 | 16,909
Cardiovascular System 44 | 15,192

Target Family

Non-IDG 60 | 12,091
Enzyme 1 | 4,145
Kinase 1 | 634

Reactome Pathway

Cell-cell junction organizatio... 62 | 62
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Claudin-12 CLDN12 Tbio Non-IDG -1.03235 8.71 137
Claudin-8 CLDN8 Tbio Non-IDG -1.50382 29.7 184
Claudin-6 CLDN6 Tbio Non-IDG -1.76879 66.0 370
Claudin-15 CLDN15 Tbio Non-IDG -1.33932 19.3 154
Protein crumbs homolog 3 CRB3 Tbio Non-IDG -1.22596 16.1 79
Protein kinase C iota type PRKCI Tchem Kinase -1.71694 51.2 148
Cell adhesion molecule 1 CADM1 Tbio Non-IDG -2.77749 549.7 479
Nectin-4 NECTIN4 Tbio Non-IDG -2.04277 114.0 151
Poliovirus receptor PVR Tbio Non-IDG -3.43049 2640.6 432
Partitioning defective 6 homolog beta PARD6B Tbio Non-IDG -0.87032 6.28 107