Development Level

Tbio 99 | 11,445
Tchem 12 | 1,598
Tdark 5 | 6,588
Tclin 4 | 613

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 8 | 979
preweaning lethality, incomple... 6 | 499
abnormal behavior 4 | 298
decreased body weight 4 | 161
abnormal embryo size 3 | 220
increased body weight 3 | 25
increased lean body mass 3 | 172
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal skin morphology 2 | 50
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating total pr... 2 | 49
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
increased bone mineral density 2 | 72
increased hemoglobin content 2 | 45
increased total body fat amoun... 2 | 134
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal heart morphology 1 | 162
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
anophthalmia 1 | 33
decreased NK cell number 1 | 2
decreased T cell number 1 | 15
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
enlarged pancreas 1 | 2
enlarged spleen 1 | 41
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased bone mineral content 1 | 108
increased circulating triglyce... 1 | 42
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased startle reflex 1 | 112
male infertility 1 | 123
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality 1 | 28
shortened PR interval 1 | 6
shortened RR interval 1 | 17
thrombocytopenia 1 | 56

Disease

Carcinoma 81 | 11,493
ovarian cancer 67 | 8,520
osteosarcoma 63 | 7,950
psoriasis 58 | 6,694
atypical teratoid / rhabdoid tumor 56 | 5,112
glioblastoma 55 | 5,792
medulloblastoma, large-cell 53 | 6,241
Cancer 51 | 2,499
lung cancer 43 | 4,740
ependymoma 42 | 4,679
Breast cancer 41 | 3,578
Kidney cancer 41 | 2,613
pancreatic cancer 41 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 40 | 3,291
non-small cell lung cancer 39 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,989
lung adenocarcinoma 37 | 2,716
adult high grade glioma 36 | 3,801
invasive ductal carcinoma 34 | 2,951
Astrocytoma, Pilocytic 33 | 3,081
interstitial cystitis 32 | 2,312
malignant mesothelioma 32 | 3,232
primitive neuroectodermal tumor 29 | 3,035
lung carcinoma 28 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
oligodendroglioma 26 | 2,850
breast carcinoma 23 | 1,638
ductal carcinoma in situ 23 | 1,745
group 3 medulloblastoma 23 | 4,104
subependymal giant cell astrocytoma 23 | 2,287
pituitary cancer 22 | 1,972
astrocytic glioma 20 | 2,597
primary pancreatic ductal adenocarcinoma 20 | 1,109
Autosomal recessive predisposition 19 | 1,442
group 4 medulloblastoma 19 | 1,855
tuberculosis 19 | 2,010
cystic fibrosis 18 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
ulcerative colitis 15 | 1,819
colon cancer 14 | 1,478
pediatric high grade glioma 14 | 1,064
Liver cancer 13 | 604
Rheumatoid arthritis 13 | 1,191
Schizophrenia 13 | 1,160
astrocytoma 13 | 1,146
esophageal adenocarcinoma 13 | 737
Alcoholic Intoxication, Chronic 12 | 289
Melanoma 12 | 711
cutaneous lupus erythematosus 12 | 1,057
juvenile dermatomyositis 12 | 1,187
spina bifida 12 | 1,074
Endometrial cancer 11 | 311
Liver Cirrhosis, Experimental 11 | 769
Skin cancer 11 | 469
active Crohn's disease 11 | 922
active ulcerative colitis 11 | 764
dermatomyositis 11 | 966
diabetes mellitus 11 | 1,728
gastric carcinoma 11 | 807
Breast Neoplasms 10 | 445
Dystrophia unguium 10 | 53
Prostatic Neoplasms 10 | 495
Epidermolysis bullosa 9 | 21
Failure to gain weight 9 | 365
Intellectual disability 9 | 1,016
Mammary Neoplasms 9 | 425
Nail dysplasia 9 | 52
Pediatric failure to thrive 9 | 365
Pick disease 9 | 1,894
adrenocortical carcinoma 9 | 1,428
medulloblastoma 9 | 720
nasopharyngeal carcinoma 9 | 1,058
ANONYCHIA 8 | 20
Alzheimer's disease 8 | 658
Atrophic scar 8 | 18
Bipolar Disorder 8 | 666
Dental Enamel Hypoplasia 8 | 43
Dental caries 8 | 164
Down syndrome 8 | 499
Duchenne muscular dystrophy 8 | 601
Epilepsy 8 | 792
Hypodontia 8 | 81
Kidney disease 8 | 430
Myopia 8 | 176
Oral mucosal blistering 8 | 10
Rotting teeth 8 | 73
acute myeloid leukemia 8 | 783
Atopic dermatitis 7 | 952
Colorectal Neoplasms 7 | 243
Congenital scar 7 | 13
Death in early childhood 7 | 82
Death in infancy 7 | 82
Dull intelligence 7 | 645
Low intelligence 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Prenatal onset 7 | 139
Seizures 7 | 596
Stomach Neoplasms 7 | 300
Waldenstrons macroglobulinemia 7 | 765

Tissue

Digestive Tract 117 | 17,369
Endocrine System 117 | 18,159
Female tissues 116 | 17,400
Liver and Pancreas 113 | 16,750
Male tissues 113 | 17,142
Nervous System 113 | 16,725
Urinary Tract 113 | 16,678
Skin and soft tissues 112 | 17,230
Respiratory system 110 | 16,393
Blood and immune system 109 | 16,909
Cardiovascular System 97 | 15,192

Target Family

Non-IDG 100 | 12,091
Kinase 11 | 634
Enzyme 9 | 4,145

Reactome Pathway

Cell-Cell communication 120 | 120
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cadherin-7 CDH7 Tbio Non-IDG -1.37829 23.4 123
Cadherin-9 CDH9 Tbio Non-IDG -0.94938 8.77 122
Cadherin-10 CDH10 Tbio Non-IDG -0.86821 9.34 155
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
CD2-associated protein CD2AP Tbio Non-IDG -3.44533 2735.9 82
Claudin-16 CLDN16 Tbio Non-IDG -1.98248 102.4 138
Cadherin-18 CDH18 Tdark Non-IDG -0.64897 4.11 125
Cadherin-24 CDH24 Tbio Non-IDG 0.02 1.02 83
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 MAGI2 Tbio Enzyme -1.54170 33.0 178
Claudin-1 CLDN1 Tbio Non-IDG -2.07626 126.7 593