Development Level

Tbio 84 | 10,625
Tdark 59 | 7,003
Tchem 37 | 1,890
Tclin 17 | 602

IMPC Phenotype

preweaning lethality, incomple... 4 | 260
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased total body fat amoun... 2 | 186
increased or absent threshold ... 2 | 128
preweaning lethality, complete... 2 | 633
tremors 2 | 34
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal coat-hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal eye anterior chamber ... 1 | 3
abnormal femur morphology 1 | 14
abnormal iris morphology 1 | 12
abnormal lens morphology 1 | 73
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal vibrissa morphology 1 | 17
abnormal vitreous body morphol... 1 | 7
abnormal whole-body plethysmog... 1 | 4
convulsive seizures 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased circulating alanine ... 1 | 53
decreased circulating insulin ... 1 | 75
decreased circulating magnesiu... 1 | 11
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased lumbar vertebrae num... 1 | 62
decreased pulmonary respirator... 1 | 4
decreased rib number 1 | 59
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
enlarged spleen 1 | 26
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
increased circulating alkaline... 1 | 119
increased circulating glycerol... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating thyroxin... 1 | 7
increased eosinophil cell numb... 1 | 9
increased erythrocyte cell num... 1 | 26
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
increased spleen weight 1 | 3
increased tidal volume 1 | 1
irregularly shaped pupil 1 | 7
mydriasis 1 | 9

Disease

osteosarcoma 97 | 7,933
Cancer 76 | 2,346
psoriasis 75 | 6,685
ovarian cancer 72 | 8,491
lung cancer 68 | 4,473
glioblastoma 62 | 5,572
medulloblastoma, large-cell 57 | 6,234
invasive ductal carcinoma 56 | 2,950
interstitial cystitis 55 | 2,299
non-small cell lung cancer 53 | 2,798
lung carcinoma 50 | 2,844
lung adenocarcinoma 48 | 2,714
malignant mesothelioma 47 | 3,163
ulcerative colitis 47 | 2,087
Breast cancer 46 | 3,098
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,988
pancreatic cancer 40 | 2,300
atypical teratoid / rhabdoid tumor 39 | 4,369
pediatric high grade glioma 39 | 2,712
pilocytic astrocytoma 39 | 3,086
tuberculosis 36 | 1,563
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,956
cutaneous lupus erythematosus 34 | 1,056
cystic fibrosis 32 | 1,670
diabetes mellitus 31 | 1,663
ductal carcinoma in situ 31 | 1,745
subependymal giant cell astrocytoma 27 | 2,287
colon cancer 26 | 1,475
astrocytoma 25 | 1,493
breast carcinoma 25 | 1,614
oligodendroglioma 25 | 2,849
primary Sjogren syndrome 24 | 788
Carcinoma 22 | 2,147
primary pancreatic ductal adenocarcinoma 22 | 1,271
juvenile dermatomyositis 21 | 1,189
dermatomyositis 20 | 966
mucosa-associated lymphoid tissue lymphoma 19 | 480
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
periodontitis 19 | 269
pituitary cancer 19 | 1,972
Rheumatoid Arthritis 18 | 1,170
posterior fossa group A ependymoma 18 | 1,511
IGA Glomerulonephritis 17 | 454
primitive neuroectodermal tumor 17 | 3,031
Down syndrome 16 | 548
ependymoma 16 | 2,514
group 3 medulloblastoma 16 | 2,254
Duchenne muscular dystrophy 15 | 602
Multiple myeloma 15 | 1,327
Vascular disease 15 | 281
adrenocortical carcinoma 15 | 1,427
adult high grade glioma 15 | 2,148
gastric carcinoma 15 | 832
non-small cell lung carcinoma 15 | 413
Atherosclerosis 14 | 275
Hypersensitivity reaction type II disease 14 | 235
astrocytic glioma 14 | 2,241
pancreatic carcinoma 14 | 567
Arthritis 13 | 248
Coronary artery disease 13 | 240
esophageal adenocarcinoma 13 | 737
group 4 medulloblastoma 13 | 1,875
nasopharyngeal carcinoma 13 | 1,056
Kidney disease 12 | 397
acute myeloid leukemia 12 | 785
chronic lymphosyte leukemia 12 | 232
sonic hedgehog group medulloblastoma 12 | 1,482
Atopic dermatitis 11 | 944
Cerebrovascular disease 11 | 231
Hypertension 11 | 293
Multiple Sclerosis 11 | 498
Waldenstrons macroglobulinemia 11 | 764
medulloblastoma 11 | 1,524
Malaria 10 | 140
Mammary Neoplasms 10 | 410
Pick disease 10 | 1,893
active Crohn's disease 10 | 918
nephrosclerosis 10 | 329
Anemia 9 | 252
Heart disease 9 | 279
Lung disease 9 | 136
Neoplasm Metastasis 9 | 138
Peripheral Neuropathy 9 | 303
Stomach Neoplasms 9 | 282
Thrombocytopenia 9 | 105
Thrombosis 9 | 42
active ulcerative colitis 9 | 477
acute quadriplegic myopathy 9 | 1,157
Asthma 8 | 349
Liver disease 8 | 219
Lung Neoplasms 8 | 171
Neoplasm Invasiveness 8 | 127
Prostatic Neoplasms 8 | 471
Thrombophilia 8 | 37
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
posterior fossa group B ependymoma 8 | 1,530
sarcoidosis 8 | 368
spina bifida 8 | 1,064
chronic lymphocytic leukemia 7 | 244

Tissue

Female tissues 181 | 18,646
Digestive Tract 180 | 18,472
Liver and Pancreas 179 | 18,135
Skin and soft tissues 179 | 18,114
Urinary Tract 178 | 18,443
Nervous System 177 | 18,560
Endocrine System 176 | 18,511
Cardiovascular System 175 | 17,957
Blood and immune system 174 | 17,994
Respiratory system 171 | 17,483
Male tissues 167 | 17,968

Target Family

Non-IDG 159 | 11,969
Enzyme 14 | 4,146
Transporter 14 | 473
Kinase 10 | 634

Reactome Pathway

Cell surface interactions at t... 197 | 197
Signal Transduction 2,515 | 2,515
Immune System 2,183 | 2,183
Metabolism 2,131 | 2,131
Gene Expression 1,754 | 1,754
Metabolism of proteins 1,544 | 1,544
Innate Immune System 1,375 | 1,375
Signaling by GPCR 1,329 | 1,329
Developmental Biology 1,028 | 1,028
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,004 | 1,004
Adaptive Immune System 938 | 938
Disease 855 | 855
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 803 | 803
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 668 | 668
Membrane Trafficking 608 | 608
Cell Cycle 572 | 572
Neutrophil degranulation 542 | 542
Axon guidance 541 | 541
Signaling by Interleukins 500 | 500
Cell Cycle, Mitotic 470 | 470
Signalling by NGF 467 | 467
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 435 | 435
Class I MHC mediated antigen p... 430 | 430
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 423 | 423
Cellular responses to stress 415 | 415
DAP12 interactions 409 | 409
Infectious disease 391 | 391
NGF signalling via TRKA from t... 378 | 378
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 367 | 367
Diseases of signal transductio... 359 | 359
Transcriptional Regulation by ... 356 | 356
Signaling by EGFR 355 | 355
Metabolism of amino acids and ... 353 | 353
DAP12 signaling 346 | 346
Downstream signal transduction 343 | 343
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 329 | 329
Signaling by SCF-KIT 327 | 327
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 321 | 321
FCERI mediated MAPK activation 316 | 316
Signaling by Insulin receptor 312 | 312
Antigen processing: Ubiquitina... 301 | 301
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 290 | 290
Signaling by Wnt 290 | 290
IGF1R signaling cascade 289 | 289
IRS-related events triggered b... 289 | 289
Insulin receptor signalling ca... 288 | 288
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 285 | 285
MAPK family signaling cascades 283 | 283
Asparagine N-linked glycosylat... 282 | 282
Signaling by the B Cell Recept... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 277 | 277
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 268 | 268
M Phase 266 | 266
Interleukin-3, 5 and GM-CSF si... 262 | 262
RET signaling 261 | 261
Signalling to ERKs 254 | 254
Interleukin-2 signaling 253 | 253
Immunoregulatory interactions ... 252 | 252
RHO GTPase Effectors 249 | 249
VEGFR2 mediated cell prolifera... 249 | 249
Signalling to RAS 247 | 247
Interleukin receptor SHC signa... 246 | 246
G alpha (i) signalling events 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Signaling by Leptin 244 | 244
Prolonged ERK activation event... 243 | 243
MAPK1/MAPK3 signaling 242 | 242
Frs2-mediated activation 241 | 241
HIV Infection 241 | 241
ARMS-mediated activation 240 | 240
Signalling to p38 via RIT and ... 240 | 240
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 236 | 236
RAF/MAP kinase cascade 236 | 236
SHC1 events in EGFR signaling 236 | 236
SOS-mediated signalling 236 | 236
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Phospholipid metabolism 202 | 202

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
E-selectin SELE Tchem Non-IDG -3.43650 2598.8 820
Large neutral amino acids transporter small subunit 1 SLC7A5 Tbio Transporter -1.84839 135.6 220
Monocarboxylate transporter 1 SLC16A1 Tchem Transporter -2.42636 263.7 235
Sodium/potassium-transporting ATPase subunit beta-3 ATP1B3 Tclin Transporter -1.08214 10.9 189
Pregnancy-specific beta-1-glycoprotein 4 PSG4 Tbio Non-IDG -0.81013 9.85 60
Pregnancy-specific beta-1-glycoprotein 9 PSG9 Tbio Non-IDG -1.57508 37.9 145
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Endothelial protein C receptor PROCR Tbio Non-IDG -2.67797 519.6 324
Macrophage migration inhibitory factor MIF Tchem Non-IDG -3.18923 1481.9 433
L-selectin SELL Tchem Non-IDG -3.45880 2781.0 888