Development Level

Tbio 95 | 11,651
Tdark 71 | 6,593
Tchem 26 | 1,388
Tclin 18 | 612

IMPC Phenotype

preweaning lethality, incomple... 8 | 499
preweaning lethality, complete... 5 | 979
decreased total body fat amoun... 3 | 207
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased startle reflex 2 | 75
embryonic lethality prior to t... 2 | 278
increased circulating glucose ... 2 | 24
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
abnormal behavior 1 | 298
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal eye anterior chamber ... 1 | 9
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal maxilla morphology 1 | 17
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal vitreous body morphol... 1 | 10
cataract 1 | 92
convulsive seizures 1 | 13
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased fasted circulating g... 1 | 65
decreased glycosylated hemoglo... 1 | 1
decreased hemoglobin content 1 | 68
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased red blood cell distr... 1 | 41
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged spleen 1 | 41
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased circulating alkaline... 1 | 122
increased circulating glycerol... 1 | 9
increased circulating sodium l... 1 | 71
increased circulating thyroxin... 1 | 7
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
male infertility 1 | 123
mydriasis 1 | 6
pale yolk sac 1 | 25
prenatal lethality 1 | 28
short tibia 1 | 97
thrombocytopenia 1 | 56
tremors 1 | 39

Disease

osteosarcoma 97 | 7,950
Carcinoma 89 | 11,493
Cancer 80 | 2,499
psoriasis 77 | 6,694
ovarian cancer 72 | 8,520
lung cancer 68 | 4,740
glioblastoma 66 | 5,792
Breast cancer 57 | 3,578
interstitial cystitis 57 | 2,312
medulloblastoma, large-cell 57 | 6,241
invasive ductal carcinoma 55 | 2,951
non-small cell lung cancer 54 | 2,890
lung carcinoma 49 | 2,843
lung adenocarcinoma 48 | 2,716
malignant mesothelioma 47 | 3,232
atypical teratoid / rhabdoid tumor 44 | 5,112
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,291
pancreatic cancer 41 | 2,398
ulcerative colitis 41 | 1,819
tuberculosis 40 | 2,010
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,989
Astrocytoma, Pilocytic 37 | 3,081
adult high grade glioma 35 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,955
cutaneous lupus erythematosus 34 | 1,057
ependymoma 34 | 4,679
cystic fibrosis 31 | 1,696
diabetes mellitus 31 | 1,728
ductal carcinoma in situ 30 | 1,745
group 3 medulloblastoma 28 | 4,104
subependymal giant cell astrocytoma 27 | 2,287
breast carcinoma 26 | 1,638
colon cancer 25 | 1,478
oligodendroglioma 25 | 2,850
Schizophrenia 24 | 1,160
Autosomal recessive predisposition 23 | 1,442
primary Sjogren syndrome 23 | 735
astrocytoma 21 | 1,146
juvenile dermatomyositis 21 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
periodontitis 21 | 293
Kidney cancer 20 | 2,613
dermatomyositis 20 | 966
mucosa-associated lymphoid tissue lymphoma 20 | 484
primary pancreatic ductal adenocarcinoma 20 | 1,109
Rheumatoid arthritis 18 | 1,191
astrocytic glioma 18 | 2,597
pediatric high grade glioma 18 | 1,064
pituitary cancer 18 | 1,972
Arthritis 17 | 290
primitive neuroectodermal tumor 17 | 3,035
Hypersensitivity reaction type II disease 16 | 253
Liver Cirrhosis, Experimental 16 | 769
Multiple myeloma 16 | 1,332
Vascular disease 16 | 319
group 4 medulloblastoma 16 | 1,855
Coronary artery disease 15 | 268
Down syndrome 15 | 499
Duchenne muscular dystrophy 15 | 601
active ulcerative colitis 15 | 764
adrenocortical carcinoma 15 | 1,428
Atherosclerosis 14 | 291
gastric carcinoma 14 | 807
pancreatic carcinoma 14 | 562
Anemia 13 | 365
Kidney disease 13 | 430
esophageal adenocarcinoma 13 | 737
nasopharyngeal carcinoma 13 | 1,058
non-small cell lung carcinoma 13 | 317
Hypertension 12 | 396
acute myeloid leukemia 12 | 783
Atopic dermatitis 11 | 952
Stomach Neoplasms 11 | 300
Waldenstrons macroglobulinemia 11 | 765
Breast Neoplasms 10 | 445
Cerebrovascular disease 10 | 238
Heart disease 10 | 306
Lung Neoplasms 10 | 232
Malaria 10 | 160
Mammary Neoplasms 10 | 425
Multiple Sclerosis 10 | 540
Neoplasm Metastasis 10 | 168
Pick disease 10 | 1,894
Thrombocytopenia 10 | 197
active Crohn's disease 10 | 922
chronic lymphosyte leukemia 10 | 204
nephrosclerosis 10 | 333
Chronic Lymphocytic Leukemia 9 | 262
Lung disease 9 | 142
Lymphoproliferative syndrome 9 | 58
Muscle hypotonia 9 | 571
Renal Cell Carcinoma 9 | 214
Squamous cell carcinoma 9 | 129
Thrombosis 9 | 46
acute quadriplegic myopathy 9 | 1,158
Asthma 8 | 385
Epilepsy 8 | 792
Prostatic Neoplasms 8 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 510
spina bifida 8 | 1,074

Tissue

Blood and immune system 130 | 16,909
Female tissues 130 | 17,400
Skin and soft tissues 130 | 17,230
Digestive Tract 128 | 17,369
Endocrine System 128 | 18,159
Respiratory system 125 | 16,393
Male tissues 124 | 17,142
Urinary Tract 124 | 16,678
Liver and Pancreas 119 | 16,750
Nervous System 118 | 16,725
Cardiovascular System 107 | 15,192

Target Family

Non-IDG 172 | 12,091
Enzyme 14 | 4,145
Transporter 14 | 473
Kinase 10 | 634

Reactome Pathway

Cell surface interactions at t... 210 | 210
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Syndecan-4 SDC4 Tbio Non-IDG -2.39649 274.8 297
Integrin alpha-3 ITGA3 Tbio Non-IDG -2.08360 104.1 587
Monocarboxylate transporter 3 SLC16A8 Tbio Transporter -1.52718 33.5 105
Pre-B lymphocyte protein 3 VPREB3 Tbio Non-IDG -0.73715 7.27 71
E-selectin SELE Tchem Non-IDG -3.44926 2672.1 919
Platelet glycoprotein VI GP6 Tbio Non-IDG -2.73714 584.5 201
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222