Development Level

Tbio 84 | 10,625
Tdark 59 | 7,003
Tchem 37 | 1,890
Tclin 17 | 602

IMPC Term

preweaning lethality, incomple... 4 | 260
decreased circulating creatini... 2 | 31
decreased circulating glucose ... 2 | 121
decreased circulating triglyce... 2 | 83
decreased total body fat amoun... 2 | 186
increased or absent threshold ... 2 | 128
preweaning lethality, complete... 2 | 633
tremors 2 | 34
abnormal QRS complex 1 | 25
abnormal behavior 1 | 226
abnormal coat/hair pigmentatio... 1 | 54
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal eye anterior chamber ... 1 | 3
abnormal femur morphology 1 | 14
abnormal iris morphology 1 | 12
abnormal lens morphology 1 | 73
abnormal retinal pigmentation 1 | 61
abnormal sleep behavior 1 | 63
abnormal vibrissa morphology 1 | 17
abnormal vitreous body morphol... 1 | 7
abnormal whole-body plethysmog... 1 | 4
convulsive seizures 1 | 11
decreased blood urea nitrogen ... 1 | 31
decreased body weight 1 | 174
decreased circulating alanine ... 1 | 53
decreased circulating insulin ... 1 | 75
decreased circulating magnesiu... 1 | 11
decreased circulating phosphat... 1 | 15
decreased circulating serum al... 1 | 79
decreased lumbar vertebrae num... 1 | 62
decreased pulmonary respirator... 1 | 4
decreased rib number 1 | 59
decreased startle reflex 1 | 48
decreased threshold for audito... 1 | 32
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
enlarged spleen 1 | 26
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
increased circulating alkaline... 1 | 119
increased circulating glycerol... 1 | 11
increased circulating potassiu... 1 | 31
increased circulating sodium l... 1 | 71
increased circulating thyroxin... 1 | 7
increased eosinophil cell numb... 1 | 9
increased erythrocyte cell num... 1 | 26
increased exploration in new e... 1 | 56
increased fasted circulating g... 1 | 68
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased lymphocyte cell numb... 1 | 9
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased rib number 1 | 41
increased spleen weight 1 | 3
increased tidal volume 1 | 1
irregularly shaped pupil 1 | 7
mydriasis 1 | 9

Disease

osteosarcoma 97 | 7,933
Cancer 76 | 2,346
psoriasis 75 | 6,685
ovarian cancer 71 | 8,484
lung cancer 68 | 4,466
glioblastoma 62 | 5,572
medulloblastoma, large-cell 57 | 6,234
invasive ductal carcinoma 56 | 2,950
interstitial cystitis 55 | 2,299
non-small cell lung cancer 53 | 2,798
lung carcinoma 50 | 2,844
lung adenocarcinoma 48 | 2,713
malignant mesothelioma 47 | 3,162
ulcerative colitis 47 | 2,087
Breast cancer 46 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 40 | 2,988
pancreatic cancer 40 | 2,300
atypical teratoid / rhabdoid tumor 39 | 4,369
pediatric high grade glioma 39 | 2,712
pilocytic astrocytoma 39 | 3,086
tuberculosis 36 | 1,557
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,956
cutaneous lupus erythematosus 34 | 1,056
cystic fibrosis 32 | 1,665
diabetes mellitus 31 | 1,663
ductal carcinoma in situ 31 | 1,745
subependymal giant cell astrocytoma 27 | 2,287
colon cancer 26 | 1,475
astrocytoma 25 | 1,493
breast carcinoma 25 | 1,614
oligodendroglioma 25 | 2,849
primary Sjogren syndrome 24 | 789
Carcinoma 22 | 2,147
primary pancreatic ductal adenocarcinoma 22 | 1,271
juvenile dermatomyositis 21 | 1,189
dermatomyositis 20 | 933
mucosa-associated lymphoid tissue lymphoma 19 | 480
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,795
periodontitis 19 | 269
pituitary cancer 19 | 1,972
Rheumatoid Arthritis 18 | 1,160
posterior fossa group A ependymoma 18 | 1,511
IGA Glomerulonephritis 17 | 454
primitive neuroectodermal tumor 17 | 3,031
Down syndrome 16 | 548
ependymoma 16 | 2,514
group 3 medulloblastoma 16 | 2,254
Duchenne muscular dystrophy 15 | 602
Multiple myeloma 15 | 1,327
Vascular disease 15 | 281
adrenocortical carcinoma 15 | 1,427
adult high grade glioma 15 | 2,148
gastric carcinoma 15 | 832
non-small cell lung carcinoma 15 | 413
Atherosclerosis 14 | 275
Hypersensitivity reaction type II disease 14 | 235
astrocytic glioma 14 | 2,241
pancreatic carcinoma 14 | 567
Arthritis 13 | 248
Coronary artery disease 13 | 240
esophageal adenocarcinoma 13 | 737
group 4 medulloblastoma 13 | 1,875
nasopharyngeal carcinoma 13 | 1,056
Kidney disease 12 | 396
acute myeloid leukemia 12 | 780
chronic lymphosyte leukemia 12 | 232
sonic hedgehog group medulloblastoma 12 | 1,482
Atopic dermatitis 11 | 944
Cerebrovascular disease 11 | 231
Hypertension 11 | 287
Multiple Sclerosis 11 | 498
Waldenstrons macroglobulinemia 11 | 765
medulloblastoma 11 | 1,524
Malaria 10 | 140
Mammary Neoplasms 10 | 410
Pick disease 10 | 1,893
active Crohn's disease 10 | 918
nephrosclerosis 10 | 329
Anemia 9 | 252
Heart disease 9 | 279
Lung disease 9 | 132
Neoplasm Metastasis 9 | 138
Peripheral Neuropathy 9 | 303
Stomach Neoplasms 9 | 282
Thrombocytopenia 9 | 105
Thrombosis 9 | 42
active ulcerative colitis 9 | 477
acute quadriplegic myopathy 9 | 1,157
Asthma 8 | 349
Liver disease 8 | 219
Lung Neoplasms 8 | 171
Neoplasm Invasiveness 8 | 127
Prostatic Neoplasms 8 | 471
Thrombophilia 8 | 36
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
posterior fossa group B ependymoma 8 | 1,530
sarcoidosis 8 | 358
spina bifida 8 | 1,064
Endometriosis 7 | 535

Tissue

Female tissues 181 | 18,647
Digestive Tract 180 | 18,473
Liver and Pancreas 179 | 18,136
Skin and soft tissues 179 | 18,115
Urinary Tract 178 | 18,444
Nervous System 177 | 18,561
Endocrine System 176 | 18,512
Cardiovascular System 175 | 17,958
Blood and immune system 174 | 17,995
Respiratory system 171 | 17,484
Male tissues 167 | 17,969

Target Family

Non-IDG 159 | 11,971
Enzyme 14 | 4,146
Transporter 14 | 473
Kinase 10 | 634

Reactome Pathway

Cell surface interactions at t... 197 | 197
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Immunoglobulin kappa variable 3-11 IGKV3-11 Tdark Non-IDG 0.00000 0
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682
Natural killer cell receptor 2B4 CD244 Tbio Non-IDG -2.27438 190.1 418
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Pregnancy-specific beta-1-glycoprotein 11 PSG11 Tdark Non-IDG -0.71117 5.22 20
Glycophorin-A GYPA Tbio Non-IDG -3.07931 1160.8 704
Platelet factor 4 PF4 Tbio Non-IDG -3.28845 2045.5 243
Fibronectin FN1 Tchem Non-IDG -3.04098 1121.3 1253