Development Level

Tbio 74 | 11,178
Tchem 7 | 1,885
Tdark 5 | 6,569
Tclin 1 | 612

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal behavior 3 | 298
abnormal embryo size 3 | 220
preweaning lethality, incomple... 3 | 499
abnormal bone mineralization 2 | 38
decreased body length 2 | 101
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
increased body weight 2 | 25
increased bone mineral density 2 | 72
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
abnormal behavioral response t... 1 | 66
abnormal bone structure 1 | 187
abnormal head morphology 1 | 10
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal skin morphology 1 | 50
abnormal sleep behavior 1 | 70
abnormal startle reflex 1 | 15
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
decreased NK cell number 1 | 2
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating sodium l... 1 | 22
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased coping response 1 | 8
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
enlarged pancreas 1 | 2
hyperactivity 1 | 148
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased bone mineral content 1 | 108
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased startle reflex 1 | 112
male infertility 1 | 123
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality 1 | 28
short tibia 1 | 97
shortened PR interval 1 | 6
shortened RR interval 1 | 17
thrombocytopenia 1 | 56

Disease

Carcinoma 56 | 11,192
ovarian cancer 43 | 8,297
osteosarcoma 42 | 7,766
atypical teratoid / rhabdoid tumor 40 | 4,971
psoriasis 40 | 6,514
glioblastoma 36 | 5,635
Cancer 35 | 2,388
medulloblastoma, large-cell 32 | 6,086
pancreatic cancer 32 | 2,322
ependymoma 31 | 4,559
Breast cancer 29 | 3,469
non-small cell lung cancer 29 | 2,799
Kidney cancer 28 | 2,548
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,902
lung adenocarcinoma 28 | 2,627
lung cancer 28 | 4,607
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,204
malignant mesothelioma 27 | 3,135
interstitial cystitis 26 | 2,237
adult high grade glioma 25 | 3,701
Astrocytoma, Pilocytic 24 | 3,006
invasive ductal carcinoma 23 | 2,867
lung carcinoma 22 | 2,755
primitive neuroectodermal tumor 20 | 2,957
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,872
pituitary cancer 18 | 1,915
breast carcinoma 17 | 1,589
ductal carcinoma in situ 17 | 1,686
Autosomal recessive predisposition 15 | 1,407
cystic fibrosis 15 | 1,629
group 3 medulloblastoma 15 | 4,002
oligodendroglioma 14 | 2,768
astrocytic glioma 13 | 2,530
group 4 medulloblastoma 13 | 1,806
primary pancreatic ductal adenocarcinoma 13 | 1,071
subependymal giant cell astrocytoma 13 | 2,230
colon cancer 12 | 1,428
pediatric high grade glioma 12 | 1,035
tuberculosis 12 | 1,963
active Crohn's disease 11 | 882
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,911
ulcerative colitis 11 | 1,765
Dystrophia unguium 10 | 52
Liver cancer 10 | 589
active ulcerative colitis 10 | 736
esophageal adenocarcinoma 10 | 696
Alcoholic Intoxication, Chronic 9 | 283
Endometrial cancer 9 | 301
Epidermolysis bullosa 9 | 21
Melanoma 9 | 689
Nail dysplasia 9 | 51
Prostatic Neoplasms 9 | 472
cutaneous lupus erythematosus 9 | 1,016
ANONYCHIA 8 | 20
Atrophic scar 8 | 18
Breast Neoplasms 8 | 423
Dental Enamel Hypoplasia 8 | 42
Dental caries 8 | 157
Oral mucosal blistering 8 | 10
Rotting teeth 8 | 69
Skin cancer 8 | 451
gastric carcinoma 8 | 781
medulloblastoma 8 | 702
spina bifida 8 | 1,053
Aplasia Cutis Congenita 7 | 14
Congenital scar 7 | 13
Defective enamel matrix 7 | 34
Dysplasia of tooth enamel 7 | 34
Failure to gain weight 7 | 359
Hypodontia 7 | 81
Mammary Neoplasms 7 | 403
Milium Cyst 7 | 15
Pediatric failure to thrive 7 | 359
Rheumatoid arthritis 7 | 1,156
Scarring alopecia of scalp 7 | 11
Sparse body hair 7 | 31
Thin dental enamel 7 | 34
diabetes mellitus 7 | 1,683
Abnormal pigmentation 6 | 24
Anemia 6 | 353
Barrett's esophagus 6 | 173
Bipolar Disorder 6 | 646
Death in early childhood 6 | 82
Death in infancy 6 | 82
Flexion contracture of proximal interphalangeal joint 6 | 74
Hemoglobin low 6 | 123
Junctional split 6 | 6
Liver Cirrhosis, Experimental 6 | 733
Multiple Sclerosis 6 | 527
Plantar hyperkeratosis 6 | 7
Prenatal onset 6 | 137
Skin Erosion 6 | 12
adrenocortical carcinoma 6 | 1,385
dermatomyositis 6 | 941
interstitial lung disease 6 | 287
nasopharyngeal carcinoma 6 | 1,024
Down syndrome 5 | 480
Mental Depression 5 | 325
Schizophrenia 5 | 1,136
astrocytoma 5 | 1,113

Tissue

Digestive Tract 85 | 17,369
Endocrine System 85 | 18,159
Female tissues 85 | 17,400
Male tissues 83 | 17,142
Nervous System 82 | 16,725
Skin and soft tissues 82 | 17,230
Liver and Pancreas 81 | 16,750
Respiratory system 81 | 16,393
Urinary Tract 81 | 16,678
Blood and immune system 78 | 16,909
Cardiovascular System 68 | 15,192

Target Family

Non-IDG 83 | 12,091
Kinase 3 | 634
Enzyme 1 | 4,145

Reactome Pathway

Cell junction organization 87 | 87
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Afadin AFDN Tbio Non-IDG -2.16280 151.2 200
Plectin PLEC Tbio Non-IDG -2.50749 337.2 130
Claudin-5 CLDN5 Tbio Non-IDG -2.58968 349.4 300
Protein sidekick-2 SDK2 Tdark Non-IDG -0.42720 2.61 17
Claudin-14 CLDN14 Tbio Non-IDG -1.58115 36.2 206
Claudin-22 CLDN22 Tdark Non-IDG 0.69 0.37 53
Cadherin-6 CDH6 Tbio Non-IDG -1.77700 58.8 286
Cadherin-4 CDH4 Tbio Non-IDG -1.95165 92.7 193
Cadherin-12 CDH12 Tbio Non-IDG -1.26700 18.7 205
Cadherin-11 CDH11 Tbio Non-IDG -2.20308 178.4 626