Development Level

Tbio 74 | 10,625
Tchem 7 | 1,890
Tdark 4 | 7,003
Tclin 1 | 602

Collection

Eligible Kinase Proteins 1 | 134

IMPC Term

preweaning lethality, complete... 5 | 633
abnormal behavior 3 | 226
increased bone mineral density 3 | 52
abnormal bone mineralization 2 | 55
abnormal embryo size 2 | 112
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
embryonic lethality prior to o... 2 | 148
abnormal behavioral response t... 1 | 52
abnormal bone structure 1 | 131
abnormal head morphology 1 | 10
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 100
abnormal skin morphology 1 | 23
abnormal sleep behavior 1 | 63
abnormal startle reflex 1 | 14
abnormal tail movements 1 | 12
abnormal tooth morphology 1 | 24
decreased NK cell number 1 | 16
decreased T cell number 1 | 31
decreased body weight 1 | 174
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 85
decreased circulating free fat... 1 | 39
decreased circulating glucose ... 1 | 121
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating total pr... 1 | 41
decreased circulating triglyce... 1 | 83
decreased coping response 1 | 5
decreased effector memory CD8-... 1 | 24
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased leukocyte cell numbe... 1 | 54
decreased mature B cell number 1 | 25
decreased spleen weight 1 | 13
decreased vertical activity 1 | 22
edema 1 | 11
embryonic lethality prior to t... 1 | 187
enlarged lymph nodes 1 | 27
enlarged pancreas 1 | 1
hyperactivity 1 | 108
increased CD8-positive, naive ... 1 | 3
increased body weight 1 | 42
increased bone mineral content 1 | 92
increased exploration in new e... 1 | 56
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased total body fat amoun... 1 | 57
increased vertical activity 1 | 18
prenatal lethality 1 | 16
short tibia 1 | 82
shortened PQ interval 1 | 6
shortened PR interval 1 | 5
shortened RR interval 1 | 19
thrombocytopenia 1 | 46

Disease

ovarian cancer 43 | 8,484
osteosarcoma 41 | 7,933
psoriasis 40 | 6,685
glioblastoma 37 | 5,572
atypical teratoid / rhabdoid tumor 36 | 4,369
medulloblastoma, large-cell 33 | 6,234
pancreatic cancer 32 | 2,300
Cancer 30 | 2,346
Carcinoma 30 | 2,147
lung adenocarcinoma 29 | 2,713
non-small cell lung cancer 28 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,988
lung cancer 27 | 4,466
interstitial cystitis 26 | 2,299
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,289
malignant mesothelioma 25 | 3,162
pediatric high grade glioma 25 | 2,712
pilocytic astrocytoma 25 | 3,086
invasive ductal carcinoma 22 | 2,950
Breast cancer 21 | 3,094
lung carcinoma 20 | 2,844
primary pancreatic ductal adenocarcinoma 20 | 1,271
primitive neuroectodermal tumor 19 | 3,031
ductal carcinoma in situ 17 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
pituitary cancer 17 | 1,972
ependymoma 16 | 2,514
breast carcinoma 15 | 1,614
cystic fibrosis 15 | 1,665
group 4 medulloblastoma 15 | 1,875
oligodendroglioma 15 | 2,849
subependymal giant cell astrocytoma 14 | 2,287
ulcerative colitis 14 | 2,087
colon cancer 13 | 1,475
adult high grade glioma 12 | 2,148
astrocytic glioma 12 | 2,241
active Crohn's disease 11 | 918
medulloblastoma 11 | 1,524
esophageal adenocarcinoma 10 | 737
posterior fossa group A ependymoma 10 | 1,511
sonic hedgehog group medulloblastoma 10 | 1,482
Epidermolysis bullosa 9 | 21
cutaneous lupus erythematosus 9 | 1,056
gastric carcinoma 9 | 832
tuberculosis 9 | 1,557
Down syndrome 8 | 548
Prostatic Neoplasms 8 | 471
posterior fossa group B ependymoma 8 | 1,530
spina bifida 8 | 1,064
Mammary Neoplasms 7 | 410
Obesity 7 | 616
Rheumatoid Arthritis 7 | 1,160
active ulcerative colitis 7 | 477
astrocytoma 7 | 1,493
dermatomyositis 7 | 933
Barrett's esophagus 6 | 183
Multiple Sclerosis 6 | 498
adrenocortical carcinoma 6 | 1,427
diabetes mellitus 6 | 1,663
interstitial lung disease 6 | 291
nasopharyngeal carcinoma 6 | 1,056
Adult junctional epidermolysis bullosa (disorder) 5 | 5
Alzheimer's disease 5 | 644
Atopic dermatitis 5 | 944
Bullous pemphigoid 5 | 17
Colorectal Neoplasms 5 | 217
Inflammatory bowel disease 5 | 142
Junctional epidermolysis bullosa 5 | 9
Polycystic Ovary Syndrome 5 | 332
atypical teratoid/rhabdoid tumor 5 | 1,095
fibroadenoma 5 | 557
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
tuberculosis and treatment for 3 months 5 | 327
Autistic Disorder 4 | 320
Duchenne muscular dystrophy 4 | 602
Intellectual disability 4 | 573
Myopia 4 | 99
Neoplasm Metastasis 4 | 138
Osteoporosis 4 | 257
Prostate cancer 4 | 172
Vascular disease 4 | 281
acute myeloid leukemia 4 | 780
acute quadriplegic myopathy 4 | 1,157
group 3 medulloblastoma 4 | 2,254
juvenile dermatomyositis 4 | 1,189
non primary Sjogren syndrome sicca 4 | 840
non-small cell lung carcinoma 4 | 413
Adenoma 3 | 165
Endometriosis 3 | 535
Kidney disease 3 | 396
Malignant neoplasm of prostate 3 | 67
Nephrocalcinosis 3 | 18
Pick disease 3 | 1,893
Schizophrenia 3 | 501
Stomach Neoplasms 3 | 282
aldosterone-producing adenoma 3 | 664
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 499
inflammatory breast cancer 3 | 404
pancreatic carcinoma 3 | 567
urothelial carcinoma 3 | 318

Tissue

Digestive Tract 85 | 18,473
Endocrine System 85 | 18,512
Female tissues 85 | 18,647
Nervous System 85 | 18,561
Skin and soft tissues 85 | 18,115
Urinary Tract 85 | 18,444
Blood and immune system 84 | 17,995
Cardiovascular System 84 | 17,958
Liver and Pancreas 84 | 18,136
Male tissues 84 | 17,969
Respiratory system 83 | 17,484

Target Family

Non-IDG 82 | 11,971
Kinase 3 | 634
Enzyme 1 | 4,146

Reactome Pathway

Cell junction organization 86 | 86
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Cell Cycle, Mitotic 471 | 471
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Angiogenin ANG Tbio Enzyme -2.89794 796.0 203
InaD-like protein PATJ Tbio Non-IDG -1.88739 77.1 91
Claudin-3 CLDN3 Tbio Non-IDG -2.30333 205.5 260
Catenin alpha-1 CTNNA1 Tbio Non-IDG -1.91334 73.6 399
Integrin alpha-6 ITGA6 Tchem Non-IDG -2.25486 168.8 756
CD151 antigen CD151 Tbio Non-IDG -2.35980 249.3 307
Vasodilator-stimulated phosphoprotein VASP Tbio Non-IDG -2.92544 883.0 726
Collagen alpha-1(XVII) chain COL17A1 Tbio Non-IDG -2.71126 547.0 90
Laminin subunit gamma-2 LAMC2 Tbio Non-IDG -2.03905 104.8 153
Laminin subunit beta-3 LAMB3 Tbio Non-IDG -2.04164 111.5 149