Development Level

Tbio 57 | 11,445
Tchem 9 | 1,598
Tdark 8 | 6,588
Tclin 1 | 613

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 4 | 499
abnormal behavior 2 | 298
decreased grip strength 2 | 116
decreased mean corpuscular hem... 2 | 50
tremors 2 | 39
abnormal bone structure 1 | 187
abnormal brain morphology 1 | 13
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal limb morphology 1 | 13
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal sensory capabilities-... 1 | 8
abnormal tail morphology 1 | 25
abnormal vibrissa morphology 1 | 25
cyanosis 1 | 7
decreased IgE level 1 | 6
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased basophil cell number 1 | 16
decreased blood urea nitrogen ... 1 | 51
decreased body weight 1 | 161
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular vol... 1 | 79
decreased threshold for audito... 1 | 26
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged lymph nodes 1 | 37
hemorrhage 1 | 23
hydroencephaly 1 | 14
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating calcium ... 1 | 34
increased circulating free fat... 1 | 20
increased circulating phosphat... 1 | 26
increased circulating total pr... 1 | 28
increased lean body mass 1 | 172
increased mature B cell number 1 | 1
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
limb grasping 1 | 41
male infertility 1 | 123
pale yolk sac 1 | 25
pallor 1 | 34
respiratory system phenotype 1 | 2
thin ventricular wall 1 | 24
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 59 | 11,493
osteosarcoma 46 | 7,950
ovarian cancer 44 | 8,520
medulloblastoma, large-cell 39 | 6,241
glioblastoma 34 | 5,792
atypical teratoid / rhabdoid tumor 32 | 5,112
Kidney cancer 26 | 2,613
adult high grade glioma 26 | 3,801
ependymoma 26 | 4,679
psoriasis 25 | 6,694
lung cancer 24 | 4,740
Cancer 23 | 2,499
group 3 medulloblastoma 23 | 4,104
primitive neuroectodermal tumor 22 | 3,035
Astrocytoma, Pilocytic 19 | 3,081
astrocytic glioma 19 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
Breast cancer 18 | 3,578
non-small cell lung cancer 18 | 2,890
oligodendroglioma 18 | 2,850
subependymal giant cell astrocytoma 18 | 2,287
group 4 medulloblastoma 16 | 1,855
invasive ductal carcinoma 16 | 2,951
lung adenocarcinoma 16 | 2,716
malignant mesothelioma 16 | 3,232
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
Alzheimer's disease 13 | 658
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
lung carcinoma 13 | 2,843
pituitary cancer 13 | 1,972
ulcerative colitis 13 | 1,819
Pick disease 12 | 1,894
pancreatic cancer 12 | 2,398
ductal carcinoma in situ 11 | 1,745
tuberculosis 11 | 2,010
Intellectual disability 10 | 1,016
breast carcinoma 10 | 1,638
cystic fibrosis 9 | 1,696
Schizophrenia 8 | 1,160
aldosterone-producing adenoma 8 | 665
spina bifida 8 | 1,074
Amyotrophic lateral sclerosis 7 | 451
Depressive disorder 7 | 409
diabetes mellitus 7 | 1,728
Liver cancer 6 | 604
Melanoma 6 | 711
Mental Depression 6 | 333
Neurodegenerative disease 6 | 414
Neuropathy 6 | 261
Prostatic Neoplasms 6 | 495
Seizures 6 | 596
astrocytoma 6 | 1,146
colon cancer 6 | 1,478
cutaneous lupus erythematosus 6 | 1,057
interstitial cystitis 6 | 2,312
primary pancreatic ductal adenocarcinoma 6 | 1,109
progressive supranuclear palsy 6 | 676
Down syndrome 5 | 499
Multiple myeloma 5 | 1,332
Nerve Degeneration 5 | 121
Rheumatoid arthritis 5 | 1,191
Toxic encephalopathy 5 | 141
Waldenstrons macroglobulinemia 5 | 765
acute quadriplegic myopathy 5 | 1,158
adrenocortical carcinoma 5 | 1,428
medulloblastoma 5 | 720
mucosa-associated lymphoid tissue lymphoma 5 | 484
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,962
pediatric high grade glioma 5 | 1,064
Aarskog syndrome 4 | 12
Alzheimer Disease 4 | 83
Bipolar Disorder 4 | 666
Cardiovascular system disease 4 | 246
Cryptorchidism 4 | 296
Dementia 4 | 175
Downward slant of palpebral fissure 4 | 158
Dysarthria 4 | 192
Endometrial cancer 4 | 311
Endometriosis 4 | 540
Epilepsy 4 | 792
Excess nuchal skin 4 | 30
Huntington's disease 4 | 76
Neurodegenerative Disorders 4 | 79
Orbital separation excessive 4 | 244
Short neck 4 | 140
Skin cancer 4 | 469
acute myeloid leukemia 4 | 783
dermatomyositis 4 | 966
gastric cancer 4 | 459
hepatocellular carcinoma 4 | 547
Arthritis 3 | 290
Atopic dermatitis 3 | 952
Curvature of spine 3 | 282
Strabismus 3 | 270
Vascular disease 3 | 319
esophageal adenocarcinoma 3 | 737
gastric carcinoma 3 | 807
juvenile dermatomyositis 3 | 1,187
nasopharyngeal carcinoma 3 | 1,058
pancreatic carcinoma 3 | 562

Tissue

Blood and immune system 75 | 16,909
Digestive Tract 75 | 17,369
Endocrine System 75 | 18,159
Female tissues 75 | 17,400
Liver and Pancreas 75 | 16,750
Male tissues 75 | 17,142
Respiratory system 75 | 16,393
Urinary Tract 75 | 16,678
Cardiovascular System 74 | 15,192
Nervous System 74 | 16,725
Skin and soft tissues 74 | 17,230

Target Family

Non-IDG 62 | 12,091
Enzyme 9 | 4,145
Kinase 4 | 634

Reactome Pathway

Cell death signalling via NRAG... 75 | 75
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Melanoma-associated antigen D1 MAGED1 Tbio Non-IDG -1.55131 46.3 245
Rho guanine nucleotide exchange factor 33 ARHGEF33 Tdark Non-IDG 1.00 0.05 51
Rho guanine nucleotide exchange factor 10-like protein ARHGEF10L Tdark Non-IDG 0.19 0.86 25
Rho guanine nucleotide exchange factor 17 ARHGEF17 Tbio Non-IDG -1.38408 25.0 61
Caspase-2 CASP2 Tchem Enzyme -2.62373 431.8 571
T-lymphoma invasion and metastasis-inducing protein 2 TIAM2 Tbio Non-IDG -1.27322 19.7 151
Rho guanine nucleotide exchange factor 18 ARHGEF18 Tbio Non-IDG -0.76671 7.19 177
Rho guanine nucleotide exchange factor 11 ARHGEF11 Tbio Non-IDG -1.61227 42.0 183
Guanine nucleotide exchange factor DBS MCF2L Tbio Non-IDG -0.98363 12.4 115
Rho guanine nucleotide exchange factor 5 ARHGEF5 Tbio Non-IDG -0.48804 5.75 249