Development Level

Tbio 214 | 11,651
Tchem 36 | 1,388
Tdark 15 | 6,593
Tclin 5 | 612

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 41 | 979
embryonic lethality prior to o... 17 | 239
embryonic lethality prior to t... 15 | 278
abnormal embryo size 10 | 220
embryonic growth retardation 7 | 106
preweaning lethality, incomple... 7 | 499
abnormal heart morphology 5 | 162
cataract 4 | 92
decreased circulating choleste... 4 | 93
increased mean corpuscular vol... 4 | 92
abnormal lens morphology 3 | 81
abnormal seminal vesicle morph... 3 | 114
decreased circulating glucose ... 3 | 126
decreased vertical activity 3 | 208
edema 3 | 59
enlarged heart 3 | 210
increased fasted circulating g... 3 | 76
prolonged QT interval 3 | 38
prolonged ST segment 3 | 36
abnormal behavior 2 | 298
abnormal behavioral response t... 2 | 66
abnormal blood vessel morpholo... 2 | 5
abnormal bone structure 2 | 187
abnormal embryo turning 2 | 31
abnormal lung morphology 2 | 26
abnormal neural tube closure 2 | 46
abnormal placenta morphology 2 | 5
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
abnormal skin morphology 2 | 50
abnormal tail morphology 2 | 25
abnormal testis morphology 2 | 43
anophthalmia 2 | 33
decreased caudal vertebrae num... 2 | 53
decreased circulating alanine ... 2 | 47
decreased fasted circulating g... 2 | 65
decreased heart left ventricle... 2 | 28
decreased mean corpuscular hem... 2 | 31
decreased red blood cell distr... 2 | 41
enlarged lymph nodes 2 | 37
increased circulating HDL chol... 2 | 80
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
increased hematocrit 2 | 46
microphthalmia 2 | 26
pallor 2 | 34
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
small testis 2 | 58
syndactyly 2 | 23
abnormal chorioallantoic fusio... 1 | 8
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal forebrain development 1 | 20
abnormal head shape 1 | 10
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal locomotor behavior 1 | 24
abnormal midbrain development 1 | 20
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
abnormal retina morphology 1 | 71
abnormal somite shape 1 | 5
abnormal spleen morphology 1 | 55
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased grip strength 1 | 116
decreased heart rate variabili... 1 | 13
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hemorrhage 1 | 23
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased circulating alanine ... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating glucose ... 1 | 24
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
long tibia 1 | 25
male infertility 1 | 123
pale yolk sac 1 | 25
prenatal lethality 1 | 28
thrombocytosis 1 | 27
urinary bladder obstruction 1 | 4

Disease

ovarian cancer 181 | 8,520
Carcinoma 160 | 11,493
lung cancer 138 | 4,740
psoriasis 128 | 6,694
glioblastoma 125 | 5,792
medulloblastoma, large-cell 123 | 6,241
osteosarcoma 121 | 7,950
group 3 medulloblastoma 114 | 4,104
atypical teratoid / rhabdoid tumor 108 | 5,112
Breast cancer 106 | 3,578
non-small cell lung cancer 95 | 2,890
malignant mesothelioma 92 | 3,232
primitive neuroectodermal tumor 87 | 3,035
intraductal papillary-mucinous neoplasm (IPMN) 84 | 3,291
Cancer 79 | 2,499
adult high grade glioma 74 | 3,801
ependymoma 74 | 4,679
adrenocortical carcinoma 73 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 70 | 2,989
invasive ductal carcinoma 69 | 2,951
lung adenocarcinoma 68 | 2,716
ductal carcinoma in situ 56 | 1,745
Multiple myeloma 54 | 1,332
colon cancer 49 | 1,478
breast carcinoma 47 | 1,638
nasopharyngeal carcinoma 45 | 1,058
oligodendroglioma 45 | 2,850
pancreatic cancer 43 | 2,398
Endometriosis 37 | 540
Kidney cancer 34 | 2,613
Waldenstrons macroglobulinemia 34 | 765
astrocytic glioma 33 | 2,597
Atopic dermatitis 32 | 952
dermatomyositis 31 | 966
Pick disease 30 | 1,894
Astrocytoma, Pilocytic 28 | 3,081
pancreatic ductal adenocarcinoma liver metastasis 28 | 1,962
subependymal giant cell astrocytoma 26 | 2,287
Autosomal recessive predisposition 23 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
ulcerative colitis 23 | 1,819
astrocytoma 22 | 1,146
Intellectual disability 21 | 1,016
Small head 21 | 374
Breast Neoplasms 20 | 445
Mammary Neoplasms 20 | 425
acute quadriplegic myopathy 20 | 1,158
diabetes mellitus 20 | 1,728
pituitary cancer 20 | 1,972
interstitial cystitis 19 | 2,312
pediatric high grade glioma 19 | 1,064
tuberculosis 19 | 2,010
Ataxia telangiectasia 17 | 34
HIV Infections 17 | 102
active Crohn's disease 17 | 922
juvenile dermatomyositis 17 | 1,187
non primary Sjogren syndrome sicca 17 | 891
Dull intelligence 16 | 645
Hypoplastic mandible condyle 16 | 275
Low intelligence 16 | 645
Mandibular hypoplasia 16 | 275
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Micrognathism 16 | 275
Poor school performance 16 | 645
Schizophrenia 16 | 1,160
Short stature 16 | 531
lung carcinoma 16 | 2,843
primary Sjogren syndrome 16 | 735
Microcephaly 15 | 166
Seckel syndrome 14 | 34
Cognitive delay 13 | 608
Epilepsy 13 | 792
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
Nijmegen breakage syndrome 13 | 24
Rheumatoid arthritis 13 | 1,191
Seizures 13 | 596
cutaneous lupus erythematosus 13 | 1,057
Fetal Growth Retardation 12 | 189
Infant, Small for Gestational Age 12 | 176
Intrauterine retardation 12 | 176
group 4 medulloblastoma 12 | 1,855
Fanconi anemia 11 | 56
Liver Cirrhosis, Experimental 11 | 769
gastric carcinoma 11 | 807
Bloom syndrome 10 | 29
Glaucoma 10 | 239
Prostatic Neoplasms 10 | 495
Stomach Neoplasms 10 | 300
acute myeloid leukemia 10 | 783
cystic fibrosis 10 | 1,696
esophageal adenocarcinoma 10 | 737
hepatocellular carcinoma 10 | 547
tuberculosis and treatment for 6 months 10 | 409
Cleft Palate 9 | 271
Delayed bone age 9 | 136
Liver cancer 9 | 604
Melanoma 9 | 711
progressive supranuclear palsy 9 | 676

Tissue

Endocrine System 268 | 18,159
Blood and immune system 265 | 16,909
Digestive Tract 265 | 17,369
Female tissues 265 | 17,400
Male tissues 265 | 17,142
Nervous System 265 | 16,725
Respiratory system 265 | 16,393
Urinary Tract 265 | 16,678
Liver and Pancreas 264 | 16,750
Skin and soft tissues 264 | 17,230
Cardiovascular System 258 | 15,192

Target Family

Non-IDG 169 | 12,091
Enzyme 81 | 4,145
Kinase 14 | 634
Epigenetic 3 | 242
Transcription Factor 2 | 1,400
TF/Epigenetic 1 | 38

Reactome Pathway

Cell Cycle Checkpoints 270 | 270
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cell Cycle, Mitotic 488 | 488
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform PPP2R1B Tbio Enzyme -1.20793 16.9 203
BRISC and BRCA1-A complex member 1 BABAM1 Tbio Non-IDG -1.20557 16.7 162
Cytoplasmic dynein 1 light intermediate chain 1 DYNC1LI1 Tbio Non-IDG -1.67860 45.9 100
Cell cycle checkpoint control protein RAD9B RAD9B Tdark Non-IDG -0.07767 1.44 35
BRCA1-A complex subunit RAP80 UIMC1 Tbio Non-IDG -1.69622 52.7 176
ATR-interacting protein ATRIP Tbio Non-IDG -1.60828 43.0 359
Centromere protein O CENPO Tbio Non-IDG -0.67552 5.22 124
26S proteasome regulatory subunit 6A PSMC3 Tbio Enzyme -1.29086 19.3 302
Origin recognition complex subunit 6 ORC6 Tbio Non-IDG -1.38268 26.3 165
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482