Development Level

Tbio 340 | 11,178
Tchem 89 | 1,885
Tdark 35 | 6,569
Tclin 24 | 612

Collection

Kinase: IDG Consortium (Target... 6 | 125
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 63 | 979
embryonic lethality prior to o... 24 | 239
embryonic lethality prior to t... 20 | 278
preweaning lethality, incomple... 14 | 499
abnormal embryo size 13 | 220
embryonic growth retardation 9 | 106
cataract 8 | 92
decreased body weight 8 | 161
decreased circulating choleste... 8 | 93
increased mean corpuscular vol... 8 | 92
abnormal lens morphology 7 | 81
male infertility 7 | 123
decreased lean body mass 6 | 135
decreased total body fat amoun... 6 | 207
abnormal behavior 5 | 298
abnormal bone structure 5 | 187
abnormal heart morphology 5 | 162
decreased bone mineral content 5 | 151
increased circulating HDL chol... 5 | 80
decreased body length 4 | 101
decreased circulating LDL chol... 4 | 38
decreased circulating serum al... 4 | 82
decreased circulating total pr... 4 | 49
edema 4 | 59
increased fasted circulating g... 4 | 76
increased mean corpuscular hem... 4 | 96
prolonged QT interval 4 | 38
prolonged ST segment 4 | 36
abnormal head morphology 3 | 10
abnormal placenta size 3 | 20
abnormal seminal vesicle morph... 3 | 114
abnormal tail morphology 3 | 25
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 53
decreased circulating alanine ... 3 | 47
decreased circulating calcium ... 3 | 36
decreased circulating glucose ... 3 | 126
decreased leukocyte cell numbe... 3 | 73
decreased lymphocyte cell numb... 3 | 83
decreased mean corpuscular hem... 3 | 31
decreased vertical activity 3 | 208
enlarged heart 3 | 210
enlarged lymph nodes 3 | 37
female infertility 3 | 60
hypoactivity 3 | 132
impaired glucose tolerance 3 | 75
increased circulating choleste... 3 | 66
increased neutrophil cell numb... 3 | 46
microphthalmia 3 | 26
prenatal lethality prior to he... 3 | 87
small testis 3 | 58
abnormal behavioral response t... 2 | 66
abnormal coat-hair pigmentatio... 2 | 64
abnormal craniofacial morpholo... 2 | 33
abnormal cranium morphology 2 | 36
abnormal embryo turning 2 | 31
abnormal femur morphology 2 | 14
abnormal joint morphology 2 | 23
abnormal kidney morphology 2 | 65
abnormal locomotor behavior 2 | 24
abnormal lung morphology 2 | 26
abnormal placenta morphology 2 | 5
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
abnormal skin coloration 2 | 25
abnormal spleen morphology 2 | 55
abnormal testis morphology 2 | 43
absent pinna reflex 2 | 23
anophthalmia 2 | 33
cardiovascular system phenotyp... 2 | 36
decreased circulating HDL chol... 2 | 68
decreased circulating triglyce... 2 | 79
decreased grip strength 2 | 116
decreased heart left ventricle... 2 | 28
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular vol... 2 | 79
increased bone mineral content 2 | 108
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased grip strength 2 | 41
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
increased thermal nociceptive ... 2 | 9
short tibia 2 | 97
syndactyly 2 | 23
abnormal cornea morphology 1 | 31
abnormal gait 1 | 69
abnormal retina morphology 1 | 71
abnormal vertebrae morphology 1 | 18
decreased circulating potassiu... 1 | 20
decreased neutrophil cell numb... 1 | 42
enlarged spleen 1 | 41
increased cardiac muscle contr... 1 | 8
increased circulating amylase ... 1 | 25
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
thrombocytosis 1 | 27

Disease

ovarian cancer 301 | 8,297
Carcinoma 294 | 11,192
osteosarcoma 234 | 7,766
medulloblastoma, large-cell 228 | 6,086
lung cancer 220 | 4,607
psoriasis 217 | 6,514
group 3 medulloblastoma 213 | 4,002
glioblastoma 206 | 5,635
atypical teratoid / rhabdoid tumor 192 | 4,971
Breast cancer 176 | 3,469
primitive neuroectodermal tumor 161 | 2,957
malignant mesothelioma 154 | 3,135
non-small cell lung cancer 152 | 2,799
intraductal papillary-mucinous neoplasm (IPMN) 151 | 3,204
intraductal papillary-mucinous carcinoma (IPMC) 134 | 2,902
adult high grade glioma 133 | 3,701
Cancer 130 | 2,388
ependymoma 130 | 4,559
adrenocortical carcinoma 117 | 1,385
lung adenocarcinoma 116 | 2,627
invasive ductal carcinoma 112 | 2,867
colon cancer 89 | 1,428
ductal carcinoma in situ 87 | 1,686
oligodendroglioma 87 | 2,768
Kidney cancer 85 | 2,548
nasopharyngeal carcinoma 84 | 1,024
breast carcinoma 77 | 1,589
Multiple myeloma 73 | 1,296
pancreatic cancer 69 | 2,322
Atopic dermatitis 63 | 915
astrocytic glioma 62 | 2,530
Astrocytoma, Pilocytic 61 | 3,006
Endometriosis 61 | 521
intraductal papillary-mucinous adenoma (IPMA) 61 | 2,872
Pick disease 53 | 1,856
Waldenstrons macroglobulinemia 53 | 742
Intellectual disability 50 | 998
astrocytoma 49 | 1,113
subependymal giant cell astrocytoma 49 | 2,230
tuberculosis 45 | 1,963
dermatomyositis 43 | 941
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,911
ulcerative colitis 40 | 1,765
pediatric high grade glioma 38 | 1,035
Rheumatoid arthritis 37 | 1,156
Cognitive delay 36 | 596
Global developmental delay 36 | 596
Mental and motor retardation 36 | 596
diabetes mellitus 36 | 1,683
Small head 35 | 366
Autosomal recessive predisposition 34 | 1,407
interstitial cystitis 34 | 2,237
Dull intelligence 33 | 634
Low intelligence 33 | 634
Mental Retardation 33 | 634
Mental deficiency 33 | 634
Poor school performance 33 | 634
Short stature 33 | 514
group 4 medulloblastoma 33 | 1,806
acute quadriplegic myopathy 32 | 1,133
pituitary cancer 32 | 1,915
Microcephaly 31 | 166
primary Sjogren syndrome 30 | 710
Schizophrenia 28 | 1,136
acute myeloid leukemia 27 | 760
Breast Neoplasms 26 | 423
Hypoplastic mandible condyle 26 | 273
Mammary Neoplasms 26 | 403
Mandibular hypoplasia 26 | 273
Micrognathism 26 | 273
juvenile dermatomyositis 26 | 1,147
non primary Sjogren syndrome sicca 26 | 861
Epilepsy 23 | 775
esophageal adenocarcinoma 23 | 696
lung carcinoma 23 | 2,755
Seizures 22 | 584
Fetal Growth Retardation 21 | 186
Infant, Small for Gestational Age 21 | 174
Intrauterine retardation 21 | 174
cutaneous lupus erythematosus 20 | 1,016
cystic fibrosis 20 | 1,629
spina bifida 20 | 1,053
active Crohn's disease 19 | 882
posterior fossa group A ependymoma 19 | 456
progressive supranuclear palsy 19 | 656
Glaucoma 18 | 232
Stomach Neoplasms 18 | 287
gastric carcinoma 18 | 781
pancreatic carcinoma 18 | 555
Lung Neoplasms 17 | 217
Seckel syndrome 17 | 34
medulloblastoma 17 | 702
Colorectal Neoplasms 16 | 235
Obesity 16 | 655
Prostatic Neoplasms 16 | 472
Amyotrophic lateral sclerosis 15 | 437
Bipolar Disorder 15 | 646
HIV Infections 15 | 94
primary pancreatic ductal adenocarcinoma 15 | 1,071
Failure to gain weight 14 | 359

Tissue

Endocrine System 483 | 18,159
Blood and immune system 480 | 16,909
Digestive Tract 480 | 17,369
Female tissues 480 | 17,400
Male tissues 479 | 17,142
Nervous System 479 | 16,725
Respiratory system 479 | 16,393
Skin and soft tissues 479 | 17,230
Urinary Tract 479 | 16,678
Liver and Pancreas 478 | 16,750
Cardiovascular System 471 | 15,192

Target Family

Non-IDG 303 | 12,091
Enzyme 122 | 4,145
Kinase 45 | 634
Transcription Factor 13 | 1,400
Epigenetic 5 | 242

Reactome Pathway

Cell Cycle, Mitotic 488 | 488
Signal Transduction 2,657 | 2,657
Immune System 2,101 | 2,101
Metabolism of proteins 2,091 | 2,091
Metabolism 2,081 | 2,081
Post-translational protein mod... 1,398 | 1,398
Gene expression (Transcription... 1,369 | 1,369
RNA Polymerase II Transcriptio... 1,228 | 1,228
Signaling by GPCR 1,217 | 1,217
Innate Immune System 1,176 | 1,176
GPCR downstream signalling 1,157 | 1,157
Generic Transcription Pathway 1,108 | 1,108
Developmental Biology 1,026 | 1,026
Adaptive Immune System 892 | 892
Disease 879 | 879
Cytokine Signaling in Immune s... 752 | 752
Metabolism of lipids 739 | 739
Vesicle-mediated transport 720 | 720
Transport of small molecules 717 | 717
Metabolism of RNA 682 | 682
Hemostasis 666 | 666
Membrane Trafficking 608 | 608
Cell Cycle 590 | 590
G alpha (s) signalling events 574 | 574
Neutrophil degranulation 539 | 539
Axon guidance 533 | 533
Cellular responses to external... 463 | 463
GPCR ligand binding 459 | 459
Signaling by Interleukins 448 | 448
Class I MHC mediated antigen p... 435 | 435
Signaling by Receptor Tyrosine... 430 | 430
Olfactory Signaling Pathway 428 | 428
Infectious disease 404 | 404
G alpha (i) signalling events 394 | 394
Cellular responses to stress 386 | 386
Signaling by Rho GTPases 386 | 386
Metabolism of amino acids and ... 370 | 370
Diseases of signal transductio... 367 | 367
Neuronal System 367 | 367
Transcriptional Regulation by ... 365 | 365
M Phase 344 | 344
Class A/1 (Rhodopsin-like rece... 322 | 322
Antigen processing: Ubiquitina... 306 | 306
Extracellular matrix organizat... 297 | 297
Translation 297 | 297
Signaling by WNT 293 | 293
Intracellular signaling by sec... 289 | 289
DNA Repair 288 | 288
Asparagine N-linked glycosylat... 287 | 287
MAPK family signaling cascades 285 | 285
Deubiquitination 276 | 276
Interferon Signaling 275 | 275
Immunoregulatory interactions ... 272 | 272
Metabolism of carbohydrates 271 | 271
Cell Cycle Checkpoints 270 | 270
Organelle biogenesis and maint... 261 | 261
PIP3 activates AKT signaling 259 | 259
RHO GTPase Effectors 257 | 257
Platelet activation, signaling... 256 | 256
HIV Infection 254 | 254
MAPK1/MAPK3 signaling 244 | 244
SLC-mediated transmembrane tra... 243 | 243
Processing of Capped Intron-Co... 238 | 238
RAF/MAP kinase cascade 238 | 238
Chromatin modifying enzymes 236 | 236
Chromatin organization 236 | 236
Neddylation 234 | 234
Transmission across Chemical S... 221 | 221
Biological oxidations 220 | 220
Signaling by ROBO receptors 219 | 219
Keratinization 216 | 216
rRNA processing 216 | 216
G alpha (q) signalling events 211 | 211
Cell surface interactions at t... 210 | 210
Phospholipid metabolism 209 | 209
Fc epsilon receptor (FCERI) si... 204 | 204
Transcriptional regulation by ... 203 | 203
Ub-specific processing proteas... 203 | 203
TCF dependent signaling in res... 199 | 199
Muscle contraction 198 | 198
rRNA processing in the nucleus... 192 | 192
Metabolism of vitamins and cof... 188 | 188
Peptide ligand-binding recepto... 188 | 188
mRNA Splicing 187 | 187
Cilium Assembly 186 | 186
Intra-Golgi and retrograde Gol... 186 | 186
Mitotic G2-G2/M phases 184 | 184
Mitotic Metaphase and Anaphase 183 | 183
G2/M Transition 182 | 182
Major pathway of rRNA processi... 182 | 182
Mitotic Anaphase 182 | 182
Mitotic Prometaphase 181 | 181
Fatty acid metabolism 180 | 180
mRNA Splicing - Major Pathway 179 | 179
Ion channel transport 177 | 177
Signaling by the B Cell Recept... 176 | 176
Regulation of expression of SL... 173 | 173
Programmed Cell Death 172 | 172
Interferon gamma signaling 171 | 171
Separation of Sister Chromatid... 170 | 170

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Histone H2A type 2-A HIST2H2AA3 Tbio Non-IDG -3.04065 999.3 88
Histone H2A type 2-C HIST2H2AC Tbio Non-IDG -3.03938 994.7 101
Histone H2B type 2-E HIST2H2BE Tbio Non-IDG -3.48425 2920.0 135
Protein RCC2 RCC2 Tbio Non-IDG -1.49831 31.4 148
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform PPP2R5B Tbio Enzyme -0.59131 2.64 81
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform PPP2R5A Tchem Enzyme -0.54568 3.09 202
Centromere protein N CENPN Tbio Non-IDG -0.88756 6.97 80
Histone H3.1t HIST3H3 Tbio Non-IDG -1.05426 10.9 1265
Tubulin beta-4B chain TUBB4B Tclin Non-IDG -0.95954 8.09 107
Serine/threonine-protein kinase greatwall MASTL Tbio Kinase -2.17166 152.5 259