Development Level

Tbio 320 | 10,625
Tchem 88 | 1,890
Tdark 44 | 7,003
Tclin 19 | 602

Collection

Eligible Kinase Proteins 7 | 134

IMPC Term

preweaning lethality, complete... 48 | 633
embryonic lethality prior to o... 14 | 148
embryonic lethality prior to t... 12 | 187
decreased body weight 9 | 174
decreased lean body mass 7 | 195
decreased total body fat amoun... 7 | 186
abnormal embryo size 6 | 112
abnormal lens morphology 6 | 73
embryonic growth retardation 6 | 28
decreased body length 5 | 108
decreased bone mineral content 5 | 157
decreased circulating choleste... 5 | 85
decreased circulating serum al... 5 | 79
increased mean corpuscular vol... 5 | 91
decreased circulating LDL chol... 4 | 37
increased circulating alkaline... 4 | 119
increased mean corpuscular hem... 4 | 93
abnormal coat/hair pigmentatio... 3 | 54
abnormal head morphology 3 | 10
abnormal retina morphology 3 | 100
cataract 3 | 26
decreased bone mineral density 3 | 126
decreased caudal vertebrae num... 3 | 49
decreased circulating alanine ... 3 | 53
decreased circulating calcium ... 3 | 33
decreased circulating total pr... 3 | 41
increased circulating HDL chol... 3 | 63
increased circulating sodium l... 3 | 71
increased fasted circulating g... 3 | 68
increased grip strength 3 | 83
male infertility 3 | 62
preweaning lethality, incomple... 3 | 260
abnormal craniofacial morpholo... 2 | 12
abnormal cranium morphology 2 | 32
abnormal placenta morphology 2 | 4
abnormal placenta size 2 | 10
abnormal respiratory quotient 2 | 9
abnormal spleen morphology 2 | 36
abnormal testis morphology 2 | 30
anophthalmia 2 | 20
decreased circulating HDL chol... 2 | 77
decreased eosinophil cell numb... 2 | 41
decreased mean corpuscular hem... 2 | 34
enlarged lymph nodes 2 | 27
hypoactivity 2 | 89
increased circulating LDL chol... 2 | 15
increased circulating chloride... 2 | 43
increased heart weight 2 | 37
increased leukocyte cell numbe... 2 | 37
increased or absent threshold ... 2 | 128
increased sacral vertebrae num... 2 | 62
increased thermal nociceptive ... 2 | 9
microphthalmia 2 | 15
narrow eye opening 2 | 15
polydactyly 2 | 22
prenatal lethality prior to he... 2 | 64
small testis 2 | 37
thrombocytosis 2 | 23
abnormal cornea morphology 1 | 24
abnormal embryo turning 1 | 15
abnormal eye morphology 1 | 38
abnormal heart morphology 1 | 51
abnormal kidney morphology 1 | 30
abnormal neural tube closure 1 | 37
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal snout morphology 1 | 18
abnormal tail movements 1 | 12
abnormal vertebrae morphology 1 | 14
abnormal vocalization 1 | 21
absent pinna reflex 1 | 21
corneal opacity 1 | 25
decreased circulating chloride... 1 | 32
decreased circulating iron lev... 1 | 25
decreased circulating potassiu... 1 | 17
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased grip strength 1 | 123
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular vol... 1 | 50
decreased neutrophil cell numb... 1 | 37
enlarged spleen 1 | 26
female infertility 1 | 34
hydrometra 1 | 13
hydrops fetalis 1 | 22
increased CD4-positive, CD25-p... 1 | 18
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating amylase ... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating triglyce... 1 | 24
increased lean body mass 1 | 107
increased mean platelet volume 1 | 19
prenatal lethality 1 | 16
vertebral fusion 1 | 23

Disease

ovarian cancer 304 | 8,484
osteosarcoma 230 | 7,933
medulloblastoma, large-cell 227 | 6,234
psoriasis 223 | 6,685
lung cancer 219 | 4,466
glioblastoma 200 | 5,572
primitive neuroectodermal tumor 162 | 3,031
Breast cancer 156 | 3,094
malignant mesothelioma 152 | 3,162
non-small cell lung cancer 149 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 147 | 3,289
atypical teratoid / rhabdoid tumor 145 | 4,369
group 3 medulloblastoma 137 | 2,254
intraductal papillary-mucinous carcinoma (IPMC) 135 | 2,988
pediatric high grade glioma 132 | 2,712
Cancer 124 | 2,346
lung adenocarcinoma 116 | 2,713
adrenocortical carcinoma 114 | 1,427
invasive ductal carcinoma 113 | 2,950
colon cancer 89 | 1,475
oligodendroglioma 88 | 2,849
ductal carcinoma in situ 86 | 1,745
Multiple myeloma 84 | 1,327
nasopharyngeal carcinoma 84 | 1,056
breast carcinoma 74 | 1,614
posterior fossa group A ependymoma 72 | 1,511
pancreatic cancer 69 | 2,300
sonic hedgehog group medulloblastoma 66 | 1,482
ependymoma 63 | 2,514
Atopic dermatitis 62 | 944
Carcinoma 61 | 2,147
pilocytic astrocytoma 61 | 3,086
Endometriosis 59 | 535
Waldenstrons macroglobulinemia 59 | 765
intraductal papillary-mucinous adenoma (IPMA) 59 | 2,956
astrocytic glioma 53 | 2,241
Pick disease 52 | 1,893
astrocytoma 52 | 1,493
atypical teratoid/rhabdoid tumor 52 | 1,095
dermatomyositis 46 | 933
subependymal giant cell astrocytoma 46 | 2,287
IGA Glomerulonephritis 43 | 454
ulcerative colitis 43 | 2,087
pancreatic ductal adenocarcinoma liver metastasis 42 | 1,795
Rheumatoid Arthritis 39 | 1,160
adult high grade glioma 36 | 2,148
medulloblastoma 36 | 1,524
interstitial cystitis 34 | 2,299
primary Sjogren syndrome 34 | 789
diabetes mellitus 33 | 1,663
pituitary cancer 33 | 1,972
acute quadriplegic myopathy 31 | 1,157
group 4 medulloblastoma 31 | 1,875
tuberculosis 31 | 1,557
Intellectual disability 29 | 573
Microcephaly 28 | 149
non primary Sjogren syndrome sicca 28 | 840
acute myeloid leukemia 27 | 780
juvenile dermatomyositis 25 | 1,189
Mammary Neoplasms 24 | 410
esophageal adenocarcinoma 24 | 737
posterior fossa group B ependymoma 24 | 1,530
lung carcinoma 23 | 2,844
tuberculosis and treatment for 6 months 21 | 686
active Crohn's disease 20 | 918
pancreatic carcinoma 20 | 567
HIV Infections 19 | 100
cutaneous lupus erythematosus 19 | 1,056
cystic fibrosis 19 | 1,665
inflammatory breast cancer 19 | 404
progressive supranuclear palsy 19 | 674
spina bifida 19 | 1,064
Seckel syndrome 18 | 34
gastric carcinoma 17 | 832
primary pancreatic ductal adenocarcinoma 17 | 1,271
non-small cell lung carcinoma 16 | 413
Colorectal Neoplasms 15 | 217
Lung Neoplasms 15 | 171
Obesity 15 | 616
Prostatic Neoplasms 15 | 471
Stomach Neoplasms 15 | 282
Liver carcinoma 14 | 217
Amyotrophic Lateral Sclerosis 13 | 431
Polycystic Ovary Syndrome 13 | 332
Schizophrenia 13 | 501
gastric cancer 13 | 430
Bladder Neoplasm 12 | 109
Down syndrome 12 | 548
Peripheral Neuropathy 12 | 303
Squamous cell carcinoma of esophagus 12 | 82
ovarian neoplasm 12 | 97
Adenoma 11 | 165
Neurodegenerative disease 11 | 383
aldosterone-producing adenoma 11 | 664
chronic rhinosinusitis 11 | 512
hereditary spastic paraplegia 11 | 313
Colonic Neoplasms 10 | 126
Duchenne muscular dystrophy 10 | 602
Lissencephaly 10 | 61
hepatocellular carcinoma 10 | 532

Tissue

Endocrine System 470 | 18,512
Female tissues 470 | 18,647
Male tissues 470 | 17,969
Blood and immune system 469 | 17,995
Nervous System 469 | 18,561
Cardiovascular System 468 | 17,958
Digestive Tract 467 | 18,473
Liver and Pancreas 467 | 18,136
Urinary Tract 467 | 18,444
Respiratory system 463 | 17,484
Skin and soft tissues 457 | 18,115

Target Family

Non-IDG 294 | 11,971
Enzyme 120 | 4,146
Kinase 40 | 634
Transcription Factor 12 | 1,400
Epigenetic 5 | 242

Reactome Pathway

Cell Cycle, Mitotic 471 | 471
Signal Transduction 2,516 | 2,516
Immune System 2,184 | 2,184
Metabolism 2,132 | 2,132
Gene Expression 1,755 | 1,755
Metabolism of proteins 1,545 | 1,545
Innate Immune System 1,376 | 1,376
Signaling by GPCR 1,330 | 1,330
Developmental Biology 1,029 | 1,029
GPCR downstream signaling 1,015 | 1,015
Post-translational protein mod... 1,005 | 1,005
Adaptive Immune System 939 | 939
Disease 856 | 856
Generic Transcription Pathway 852 | 852
Cytokine Signaling in Immune s... 804 | 804
Metabolism of lipids and lipop... 797 | 797
Vesicle-mediated transport 705 | 705
Hemostasis 669 | 669
Transmembrane transport of sma... 669 | 669
Membrane Trafficking 608 | 608
Cell Cycle 573 | 573
Axon guidance 542 | 542
Neutrophil degranulation 542 | 542
Signaling by Interleukins 501 | 501
Signalling by NGF 468 | 468
GPCR ligand binding 456 | 456
Gastrin-CREB signalling pathwa... 436 | 436
Class I MHC mediated antigen p... 431 | 431
Olfactory Signaling Pathway 430 | 430
Fc epsilon receptor (FCERI) si... 424 | 424
Cellular responses to stress 416 | 416
DAP12 interactions 410 | 410
Infectious disease 392 | 392
NGF signalling via TRKA from t... 379 | 379
Signaling by Rho GTPases 378 | 378
Signaling by PDGF 368 | 368
Diseases of signal transductio... 360 | 360
Signaling by EGFR 356 | 356
Transcriptional Regulation by ... 356 | 356
Metabolism of amino acids and ... 354 | 354
DAP12 signaling 347 | 347
Downstream signal transduction 344 | 344
Neuronal System 343 | 343
Organelle biogenesis and maint... 334 | 334
Signaling by VEGF 330 | 330
Signaling by SCF-KIT 328 | 328
Class A/1 (Rhodopsin-like rece... 322 | 322
VEGFA-VEGFR2 Pathway 322 | 322
FCERI mediated MAPK activation 317 | 317
Signaling by Insulin receptor 313 | 313
Antigen processing: Ubiquitina... 302 | 302
Extracellular matrix organizat... 292 | 292
Signaling by Type 1 Insulin-li... 291 | 291
Signaling by Wnt 291 | 291
IGF1R signaling cascade 290 | 290
IRS-related events triggered b... 290 | 290
Insulin receptor signalling ca... 289 | 289
Metabolism of carbohydrates 288 | 288
DNA Repair 286 | 286
IRS-mediated signalling 286 | 286
MAPK family signaling cascades 284 | 284
Signaling by the B Cell Recept... 283 | 283
Asparagine N-linked glycosylat... 282 | 282
SLC-mediated transmembrane tra... 280 | 280
Deubiquitination 278 | 278
Interferon Signaling 275 | 275
Platelet activation, signaling... 274 | 274
NCAM signaling for neurite out... 269 | 269
M Phase 267 | 267
Interleukin-3, 5 and GM-CSF si... 263 | 263
RET signaling 262 | 262
Signalling to ERKs 255 | 255
Interleukin-2 signaling 254 | 254
Immunoregulatory interactions ... 252 | 252
VEGFR2 mediated cell prolifera... 250 | 250
RHO GTPase Effectors 249 | 249
Signalling to RAS 248 | 248
Interleukin receptor SHC signa... 247 | 247
G alpha (i) signalling events 245 | 245
Signaling by Leptin 245 | 245
Fatty acid, triacylglycerol, a... 244 | 244
Prolonged ERK activation event... 244 | 244
MAPK1/MAPK3 signaling 243 | 243
Frs2-mediated activation 242 | 242
HIV Infection 242 | 242
ARMS-mediated activation 241 | 241
Signalling to p38 via RIT and ... 241 | 241
Chromatin modifying enzymes 237 | 237
Chromatin organization 237 | 237
GRB2 events in EGFR signaling 237 | 237
RAF/MAP kinase cascade 237 | 237
SHC1 events in EGFR signaling 237 | 237
SOS-mediated signalling 237 | 237
Processing of Capped Intron-Co... 235 | 235
Biological oxidations 215 | 215
Keratinization 213 | 213
Transmission across Chemical S... 210 | 210
rRNA processing 209 | 209
Ion channel transport 204 | 204
Ub-specific processing proteas... 203 | 203

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Nucleoprotein TPR TPR Tbio Non-IDG -2.07876 130.9 158
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.10426 11.5 1277
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.76828 59.7 468
Kinetochore protein Nuf2 NUF2 Tbio Non-IDG -1.66072 48.8 98
Replication factor C subunit 3 RFC3 Tbio Non-IDG -1.28299 19.5 161
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.02728 11.1 64
Nuclear pore complex protein Nup98-Nup96 NUP98 Tbio Enzyme -2.21148 186.3 172
Centrosomal protein of 164 kDa CEP164 Tbio Non-IDG -0.96655 10.2 84